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The map label for this gene is yphC [C]

Identifier: 13471224

GI number: 13471224

Start: 952157

End: 953197

Strand: Direct

Name: yphC [C]

Synonym: mlr1136

Alternate gene names: 13471224

Gene position: 952157-953197 (Clockwise)

Preceding gene: 13471223

Following gene: 13471226

Centisome position: 13.53

GC content: 64.84

Gene sequence:

>1041_bases
ATGAAAGCCGTCGTCTTCGAGAAATTCGGCGAAGCGCCGACGATCCAGACCGTCCCCGATCCGAAGCCGGCTGCCGATGG
CGTCGTCATCAAGGTCGAGGCGACAGGGCTGTGCCGCAGCGACTGGCATGGCTGGATGGGCCATGATGACGGCATCACCT
TGCCGCACGTTCCCGGACATGAACTTGCAGGCGTCGTCGTCGCCGCCGGCAAGCAGGTCAGCCGCTGGAAGGCCGGCGAC
CGCGTGACGGTGCCGTTTGCCGTCGGCTGCGGCCGCTGCTTCGAATGCAGCTCTGGCAACCATCAGGTCTGCGAGCACCA
GACGCAGCCCGGCTTCACCGGCTGGGGCTCGTTCGCCGAATATGTCGGCATCGAGCATGCCGACACCAACCTCGTGCGCC
TGCCCGACGAGATGGAATACGCCACCGCCGCCAGCCTCGGCTGCCGTTTCGTCACCTCGTTTCGCGCCATTGTCGACCAG
GGGCGGGTCAAGCCCGGCGAATGGGTGGCGGTGCATGGCTGCGGCGGCGTCGGCCTGTCGGCAATCATGATCGCCAGTTC
GATGGGCGCCAACGTGATCGCCATCGACCTCACCGACGAGAAGCTGGAGTTCGCCAGAAAAATCGGCGCCGTGGCGACGA
TCAATGCGTCGACGACGCCGAATGTGGTCAAGGCGGTCAAGCAGATCGCCAATGGCGGCGCGCATATGTCGATGGACGCG
CTCGGCCACCCCACCACCTCGTTCAACTCGATCGCCAATCTGCGCCGGCGCGGCCGCCATGTGCAGGTCGGCCTGATGCT
GGGCGAGCACGCCCGCCCGCAAGTGCCGATGGACAAGATCATCGCCTTCGAGCTCGAGATCCTCGGCAGCCACGGCATGC
AGGCCTATCGCTACCAGGCGATGATGGACATGATCCGCAACGGCAAGCTCAAGCCCGAACTGCTGGTCGGCAAGAAGATC
AGCCTCGACGAGGCGCCCGCGGCCTTGATGGCAATGGGTGGCTTCGAGGGCATTGGCATTGGGGTTGTGACGAAATTCTG
A

Upstream 100 bases:

>100_bases
TCCAGAGCAGCATGTCCGGCGGAATCGATTTCCGCTTGACCAGACAGGGAATCGGCTATCGTTTCCGGCAATGCGTGCCG
TCTTAAGGGTGGAGTGACCG

Downstream 100 bases:

>100_bases
CAGCGATTCGATAGAAATTGCAGAACAGTCCATGCAACCAAGACGCTAGTAGAACCGCTCGACAAGGTTGCGCTAGTCCG
TCAGAACCGACTTCAAGCGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAVVFEKFGEAPTIQTVPDPKPAADGVVIKVEATGLCRSDWHGWMGHDDGITLPHVPGHELAGVVVAAGKQVSRWKAGD
RVTVPFAVGCGRCFECSSGNHQVCEHQTQPGFTGWGSFAEYVGIEHADTNLVRLPDEMEYATAASLGCRFVTSFRAIVDQ
GRVKPGEWVAVHGCGGVGLSAIMIASSMGANVIAIDLTDEKLEFARKIGAVATINASTTPNVVKAVKQIANGGAHMSMDA
LGHPTTSFNSIANLRRRGRHVQVGLMLGEHARPQVPMDKIIAFELEILGSHGMQAYRYQAMMDMIRNGKLKPELLVGKKI
SLDEAPAALMAMGGFEGIGIGVVTKF

Sequences:

>Translated_346_residues
MKAVVFEKFGEAPTIQTVPDPKPAADGVVIKVEATGLCRSDWHGWMGHDDGITLPHVPGHELAGVVVAAGKQVSRWKAGD
RVTVPFAVGCGRCFECSSGNHQVCEHQTQPGFTGWGSFAEYVGIEHADTNLVRLPDEMEYATAASLGCRFVTSFRAIVDQ
GRVKPGEWVAVHGCGGVGLSAIMIASSMGANVIAIDLTDEKLEFARKIGAVATINASTTPNVVKAVKQIANGGAHMSMDA
LGHPTTSFNSIANLRRRGRHVQVGLMLGEHARPQVPMDKIIAFELEILGSHGMQAYRYQAMMDMIRNGKLKPELLVGKKI
SLDEAPAALMAMGGFEGIGIGVVTKF
>Mature_346_residues
MKAVVFEKFGEAPTIQTVPDPKPAADGVVIKVEATGLCRSDWHGWMGHDDGITLPHVPGHELAGVVVAAGKQVSRWKAGD
RVTVPFAVGCGRCFECSSGNHQVCEHQTQPGFTGWGSFAEYVGIEHADTNLVRLPDEMEYATAASLGCRFVTSFRAIVDQ
GRVKPGEWVAVHGCGGVGLSAIMIASSMGANVIAIDLTDEKLEFARKIGAVATINASTTPNVVKAVKQIANGGAHMSMDA
LGHPTTSFNSIANLRRRGRHVQVGLMLGEHARPQVPMDKIIAFELEILGSHGMQAYRYQAMMDMIRNGKLKPELLVGKKI
SLDEAPAALMAMGGFEGIGIGVVTKF

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=272, Percent_Identity=30.1470588235294, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI4501933, Length=362, Percent_Identity=27.3480662983425, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI71743840, Length=287, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI262073058, Length=287, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI34577061, Length=273, Percent_Identity=29.6703296703297, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI4501929, Length=275, Percent_Identity=30.5454545454545, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI71565154, Length=265, Percent_Identity=28.3018867924528, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI156523966, Length=288, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4501939, Length=288, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI194239674, Length=338, Percent_Identity=28.4023668639053, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI13236495, Length=338, Percent_Identity=28.4023668639053, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI194239676, Length=238, Percent_Identity=29.8319327731092, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI156627571, Length=355, Percent_Identity=25.3521126760563, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=28.7425149700599, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1787863, Length=323, Percent_Identity=29.4117647058824, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788073, Length=311, Percent_Identity=27.9742765273312, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI87081918, Length=296, Percent_Identity=33.445945945946, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788075, Length=352, Percent_Identity=25.5681818181818, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790045, Length=341, Percent_Identity=27.5659824046921, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI226510992, Length=296, Percent_Identity=28.3783783783784, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1786825, Length=365, Percent_Identity=25.7534246575342, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786552, Length=349, Percent_Identity=27.5071633237822, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786518, Length=264, Percent_Identity=30.3030303030303, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788407, Length=299, Percent_Identity=28.7625418060201, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=24.6105919003115, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=267, Percent_Identity=31.8352059925094, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17562584, Length=340, Percent_Identity=29.7058823529412, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562582, Length=342, Percent_Identity=29.5321637426901, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=26.9461077844311, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=231, Percent_Identity=30.3030303030303, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562878, Length=335, Percent_Identity=26.865671641791, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71997431, Length=227, Percent_Identity=30.3964757709251, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17565904, Length=206, Percent_Identity=30.0970873786408, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6324486, Length=320, Percent_Identity=30.3125, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=326, Percent_Identity=30.3680981595092, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323729, Length=341, Percent_Identity=28.7390029325513, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319621, Length=331, Percent_Identity=30.5135951661631, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6320033, Length=257, Percent_Identity=29.9610894941634, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6319955, Length=346, Percent_Identity=27.7456647398844, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322619, Length=346, Percent_Identity=27.7456647398844, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319258, Length=359, Percent_Identity=27.0194986072423, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=341, Percent_Identity=27.2727272727273, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323980, Length=206, Percent_Identity=36.4077669902913, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=203, Percent_Identity=33.9901477832512, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319520, Length=255, Percent_Identity=28.6274509803922, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=342, Percent_Identity=25.4385964912281, Blast_Score=73, Evalue=6e-14,
Organism=Drosophila melanogaster, GI17137530, Length=329, Percent_Identity=28.5714285714286, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI17737895, Length=333, Percent_Identity=25.2252252252252, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=27.8443113772455, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36885; Mature: 36885

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVVFEKFGEAPTIQTVPDPKPAADGVVIKVEATGLCRSDWHGWMGHDDGITLPHVPGH
CCCEEEHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
ELAGVVVAAGKQVSRWKAGDRVTVPFAVGCGRCFECSSGNHQVCEHQTQPGFTGWGSFAE
HHCEEEEECCCHHHHHCCCCEEEEEEEECCCCEEECCCCCCHHHCCCCCCCCCCHHHHHH
YVGIEHADTNLVRLPDEMEYATAASLGCRFVTSFRAIVDQGRVKPGEWVAVHGCGGVGLS
HHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
AIMIASSMGANVIAIDLTDEKLEFARKIGAVATINASTTPNVVKAVKQIANGGAHMSMDA
HHHHHHCCCCEEEEEEECHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEHH
LGHPTTSFNSIANLRRRGRHVQVGLMLGEHARPQVPMDKIIAFELEILGSHGMQAYRYQA
CCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHH
MMDMIRNGKLKPELLVGKKISLDEAPAALMAMGGFEGIGIGVVTKF
HHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEECC
>Mature Secondary Structure
MKAVVFEKFGEAPTIQTVPDPKPAADGVVIKVEATGLCRSDWHGWMGHDDGITLPHVPGH
CCCEEEHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
ELAGVVVAAGKQVSRWKAGDRVTVPFAVGCGRCFECSSGNHQVCEHQTQPGFTGWGSFAE
HHCEEEEECCCHHHHHCCCCEEEEEEEECCCCEEECCCCCCHHHCCCCCCCCCCHHHHHH
YVGIEHADTNLVRLPDEMEYATAASLGCRFVTSFRAIVDQGRVKPGEWVAVHGCGGVGLS
HHCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
AIMIASSMGANVIAIDLTDEKLEFARKIGAVATINASTTPNVVKAVKQIANGGAHMSMDA
HHHHHHCCCCEEEEEEECHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCCCEEEEHH
LGHPTTSFNSIANLRRRGRHVQVGLMLGEHARPQVPMDKIIAFELEILGSHGMQAYRYQA
CCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHHEEEEEECCCCCCHHHHHHH
MMDMIRNGKLKPELLVGKKISLDEAPAALMAMGGFEGIGIGVVTKF
HHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]