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The map label for this gene is pcm1 [H]

Identifier: 13471201

GI number: 13471201

Start: 930382

End: 931050

Strand: Reverse

Name: pcm1 [H]

Synonym: mll1108

Alternate gene names: 13471201

Gene position: 931050-930382 (Counterclockwise)

Preceding gene: 13471202

Following gene: 13471200

Centisome position: 13.23

GC content: 62.93

Gene sequence:

>669_bases
ATGAGCGCTGATTTCTCCGAGCTTCGCGTCAAGATGGTCGACGGTCAGGTGCGCACCACCGACGTGACCAGCGCCCCGCT
GCTGGAAGCCATGCTTACCGTGCCGCGCGAGGTTTTCGTCGGCGACCGCCAGCGTGATCTCGCCTATATCGACGAGGACA
TCCGCATTGCCGACGGCGCCGATGGCGCTCGCTATCTGATGGAAGCATCGCCGCTGGCCAAGCTGATGCAATTGGCCGAG
ATCAATGCGACCGATTCGGCGCTCGATGTCGGCTGTGGCACCGGCTACGCCTCGGCCATCCTGTCGCGACTGGCGAGGTC
GGTCGTGGCGCTCGAAAGCGATTCGGCGCTGGCGCAAACCGCGACATCGACCCTTTCCGGCCTTGGCTACGGCAATGTGA
CCGTGGTCCAGGGCGCGCTGGCGCAGGGCCATGCGGCCAAGGCACCCTATGACGTCATCTTCATCGGCGGCAGTGTCGAG
AAAGTGCCGGCGCCGTTGCTCGATCAGCTCGCCGAAGGCGGCCGACTCGTCGCGGTCGAAGGGCGAGGCAATTCCGGCGT
GGCGCGACTTTTTTTCAAGGCTGGGGGGGTTGTAACCGGGAGAAGGGCATTTAATGCGGCAATTAAGCCACTACCGGGAT
TCGAACGTGAGCATGCTTTTGAATTCTGA

Upstream 100 bases:

>100_bases
AGGCCTCCAATACCCGGGCTCCCGCGCGCTCAGCGCCGGAGCCTGACGTTCTCATCGAAATGAACCGCGGTTCTGGCGCG
GCAAGCGGATTGGTTGGAAC

Downstream 100 bases:

>100_bases
ATGATTTAGCCTTGCAGCAAAGGCTTTGTCATGGTCGCTTACATTTGAACAATCGTTGCTGATCCCAGACTGGGGGCACT
TTGGGACCGAGCGACAGGGA

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase 1; Protein L-isoaspartyl methyltransferase 1; Protein-beta-aspartate methyltransferase 1; PIMT 1 [H]

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MSADFSELRVKMVDGQVRTTDVTSAPLLEAMLTVPREVFVGDRQRDLAYIDEDIRIADGADGARYLMEASPLAKLMQLAE
INATDSALDVGCGTGYASAILSRLARSVVALESDSALAQTATSTLSGLGYGNVTVVQGALAQGHAAKAPYDVIFIGGSVE
KVPAPLLDQLAEGGRLVAVEGRGNSGVARLFFKAGGVVTGRRAFNAAIKPLPGFEREHAFEF

Sequences:

>Translated_222_residues
MSADFSELRVKMVDGQVRTTDVTSAPLLEAMLTVPREVFVGDRQRDLAYIDEDIRIADGADGARYLMEASPLAKLMQLAE
INATDSALDVGCGTGYASAILSRLARSVVALESDSALAQTATSTLSGLGYGNVTVVQGALAQGHAAKAPYDVIFIGGSVE
KVPAPLLDQLAEGGRLVAVEGRGNSGVARLFFKAGGVVTGRRAFNAAIKPLPGFEREHAFEF
>Mature_221_residues
SADFSELRVKMVDGQVRTTDVTSAPLLEAMLTVPREVFVGDRQRDLAYIDEDIRIADGADGARYLMEASPLAKLMQLAEI
NATDSALDVGCGTGYASAILSRLARSVVALESDSALAQTATSTLSGLGYGNVTVVQGALAQGHAAKAPYDVIFIGGSVEK
VPAPLLDQLAEGGRLVAVEGRGNSGVARLFFKAGGVVTGRRAFNAAIKPLPGFEREHAFEF

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789100, Length=187, Percent_Identity=29.9465240641711, Blast_Score=88, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71983477, Length=157, Percent_Identity=33.7579617834395, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193207222, Length=100, Percent_Identity=37, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 23303; Mature: 23172

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADFSELRVKMVDGQVRTTDVTSAPLLEAMLTVPREVFVGDRQRDLAYIDEDIRIADGA
CCCCHHHHEEEEECCEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHCCCEEEECCC
DGARYLMEASPLAKLMQLAEINATDSALDVGCGTGYASAILSRLARSVVALESDSALAQT
CHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
ATSTLSGLGYGNVTVVQGALAQGHAAKAPYDVIFIGGSVEKVPAPLLDQLAEGGRLVAVE
HHHHHHCCCCCCEEEEECHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEE
GRGNSGVARLFFKAGGVVTGRRAFNAAIKPLPGFEREHAFEF
CCCCCCCEEEEECCCCEEECHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SADFSELRVKMVDGQVRTTDVTSAPLLEAMLTVPREVFVGDRQRDLAYIDEDIRIADGA
CCCHHHHEEEEECCEEEECCCCHHHHHHHHHHCCHHHHCCCCCCCHHHHCCCEEEECCC
DGARYLMEASPLAKLMQLAEINATDSALDVGCGTGYASAILSRLARSVVALESDSALAQT
CHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
ATSTLSGLGYGNVTVVQGALAQGHAAKAPYDVIFIGGSVEKVPAPLLDQLAEGGRLVAVE
HHHHHHCCCCCCEEEEECHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHCCCEEEEEE
GRGNSGVARLFFKAGGVVTGRRAFNAAIKPLPGFEREHAFEF
CCCCCCCEEEEECCCCEEECHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA