Click here to switch to the map view.

The map label for this gene is uppS

Identifier: 13470839

GI number: 13470839

Start: 507377

End: 508111

Strand: Reverse

Name: uppS

Synonym: mll0640

Alternate gene names: 13470839

Gene position: 508111-507377 (Counterclockwise)

Preceding gene: 13470840

Following gene: 13470838

Centisome position: 7.22

GC content: 65.31

Gene sequence:

>735_bases
ATGACAACGCCCGCGCATGTCGCGATCATCATGGATGGGAATGGACGCTGGGCCAAGGCGCGCGGCATGCCGAGGCTTGC
CGGTCATCGCGCCGGCGTCGAGGCATTGCGCAAGACGGTGCGCGCGGCGCCCGATCTCGGCATCTCGTTCCTGACCGTCT
ATGCGTTCTCGTCGGAGAACTGGTCGCGGCCGAAGGCCGAGGTCAGCGACCTGATGGGGCTGTTGAAGCTGTTCATCCGC
CGTGATCTCGCCGAACTGCACCAGAGCGGCGTGCGGGTCAGGATCATCGGCGACAGGGCAGGGCTGCAGGCCGACATCCG
AGGGTTGCTCGAAGAGGCCGAATCGCTGACCGCCCGTAACGAGTCCCTGACGCTGGTGATCGCCTTCAACTATGGCGGGC
GCGACGAAATCGTCCGCACTGCACGCAAGCTTGCCTCGGCCGCCGCGCGCGGCGAAATCGACGCCGAATCGATCACCGCC
GATAGCTTTGCCGGTGGTCTCGACACGCAAGGCATTCCCGATCCGGAACTGGTCATACGCACCAGCGGCGAGCTTCGCCT
GTCCAACTTCCTGTTGTGGCAGGCCGCCTATAGCGAGCTCGTCTTCCTGCCTTGCTATTGGCCCGACTTCAGCCGCGAGC
ACCTTGCCGAGGCGTTGCGCGAATTTGCCGGCCGCGAGCGCCGTTTCGGAGGATTGGGCCAGCAAGACGTCGCTTCGCGA
CCGGCAGCGGGATGA

Upstream 100 bases:

>100_bases
CCGACGAAACGATCAGCACCATCGATCATCTGCTTTCCGACAAGGAAGCTGAAATCATGCAGGTTTAGGGTTGGCGGCCG
GCTGACCCGAAAGCGAGATC

Downstream 100 bases:

>100_bases
GCAACCTTCAGCTCCGCGTCATTTCAGCGGTCGTGCTTGCCGTCATCGCCCTTGGCCTGACCTGGCTTGGCGGCCTGCCT
TTCCGGCTGCTGTGCGCAGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTTPAHVAIIMDGNGRWAKARGMPRLAGHRAGVEALRKTVRAAPDLGISFLTVYAFSSENWSRPKAEVSDLMGLLKLFIR
RDLAELHQSGVRVRIIGDRAGLQADIRGLLEEAESLTARNESLTLVIAFNYGGRDEIVRTARKLASAAARGEIDAESITA
DSFAGGLDTQGIPDPELVIRTSGELRLSNFLLWQAAYSELVFLPCYWPDFSREHLAEALREFAGRERRFGGLGQQDVASR
PAAG

Sequences:

>Translated_244_residues
MTTPAHVAIIMDGNGRWAKARGMPRLAGHRAGVEALRKTVRAAPDLGISFLTVYAFSSENWSRPKAEVSDLMGLLKLFIR
RDLAELHQSGVRVRIIGDRAGLQADIRGLLEEAESLTARNESLTLVIAFNYGGRDEIVRTARKLASAAARGEIDAESITA
DSFAGGLDTQGIPDPELVIRTSGELRLSNFLLWQAAYSELVFLPCYWPDFSREHLAEALREFAGRERRFGGLGQQDVASR
PAAG
>Mature_243_residues
TTPAHVAIIMDGNGRWAKARGMPRLAGHRAGVEALRKTVRAAPDLGISFLTVYAFSSENWSRPKAEVSDLMGLLKLFIRR
DLAELHQSGVRVRIIGDRAGLQADIRGLLEEAESLTARNESLTLVIAFNYGGRDEIVRTARKLASAAARGEIDAESITAD
SFAGGLDTQGIPDPELVIRTSGELRLSNFLLWQAAYSELVFLPCYWPDFSREHLAEALREFAGRERRFGGLGQQDVASRP
AAG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=222, Percent_Identity=40.0900900900901, Blast_Score=163, Evalue=1e-40,
Organism=Homo sapiens, GI45580742, Length=222, Percent_Identity=40.0900900900901, Blast_Score=163, Evalue=1e-40,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=48.2300884955752, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=224, Percent_Identity=33.9285714285714, Blast_Score=128, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=222, Percent_Identity=34.6846846846847, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=227, Percent_Identity=35.6828193832599, Blast_Score=122, Evalue=6e-29,
Organism=Drosophila melanogaster, GI18857969, Length=215, Percent_Identity=36.7441860465116, Blast_Score=139, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_RHILO (Q98MB9)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102408.1
- ProteinModelPortal:   Q98MB9
- SMR:   Q98MB9
- GeneID:   1225071
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0640
- NMPDR:   fig|266835.1.peg.513
- HOGENOM:   HBG627837
- OMA:   ESLRRCV
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 26691; Mature: 26559

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 12-12

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPAHVAIIMDGNGRWAKARGMPRLAGHRAGVEALRKTVRAAPDLGISFLTVYAFSSEN
CCCCEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
WSRPKAEVSDLMGLLKLFIRRDLAELHQSGVRVRIIGDRAGLQADIRGLLEEAESLTARN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC
ESLTLVIAFNYGGRDEIVRTARKLASAAARGEIDAESITADSFAGGLDTQGIPDPELVIR
CCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHCCCCCCCCCCCCCEEEE
TSGELRLSNFLLWQAAYSELVFLPCYWPDFSREHLAEALREFAGRERRFGGLGQQDVASR
CCCCEEHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHCCHHHCCCCCCHHHCCC
PAAG
CCCC
>Mature Secondary Structure 
TTPAHVAIIMDGNGRWAKARGMPRLAGHRAGVEALRKTVRAAPDLGISFLTVYAFSSEN
CCCEEEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
WSRPKAEVSDLMGLLKLFIRRDLAELHQSGVRVRIIGDRAGLQADIRGLLEEAESLTARN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC
ESLTLVIAFNYGGRDEIVRTARKLASAAARGEIDAESITADSFAGGLDTQGIPDPELVIR
CCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHCCCCCCCCCCCCCEEEE
TSGELRLSNFLLWQAAYSELVFLPCYWPDFSREHLAEALREFAGRERRFGGLGQQDVASR
CCCCEEHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHHHHCCHHHCCCCCCHHHCCC
PAAG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968