Click here to switch to the map view.

The map label for this gene is lpxA

Identifier: 13470832

GI number: 13470832

Start: 500287

End: 501126

Strand: Reverse

Name: lpxA

Synonym: mll0633

Alternate gene names: 13470832

Gene position: 501126-500287 (Counterclockwise)

Preceding gene: 13470833

Following gene: 13470831

Centisome position: 7.12

GC content: 60.6

Gene sequence:

>840_bases
GTGCTTATGAAAATCAAGACTTCAATCCATCCTTCCTCCGTCGTGGAAGAAGGCGCCCAAATCGGTGAGGGTGTACGCAT
TGGGCCGTTCTGCCATATCAGCGCCGATGCCGTGATCGGCGATGGCGTCGAACTGGTCAGCCATGTCTCGGTCATGGGTG
CGACAACCATCGGCGCCTCGACCAAGGTCTATCCGATGGCGACATTGGGTGCGCCGCCGCAGAACACCAAACACAAGGGC
GGCCGCACGACGCTGGTCATTGGCGCGAATTGCACCATCCGCGAAGGCGTCACCATGCATGTCGGCACCGACACCAGCCG
CGGCGAAACGACGGTGGGCGACAATGGCAATTTCCTTGCCTACGCCCACATCGCCCATGATTGCGTGGTCGGCAAGAACG
CCACCTTCGCCAATGGCGCGACGCTGGGCGGCCACTGCGAGATCGGCGACAACGTCTACATAGGCGGCCTCAGTGCCGTT
CATCAATTCGTGCGCGTCGGCGACAACGCCTTTCTTGGCGGGTGCTCGGCTTTCGTTGGTGACGTCATTCCCTATGCCAT
TGCCGTCGGCAACCGCGCCAGCTTGCGCGGTTTGAACATCATCGGCCTCAAGCGCGCCGGTCTGCCGCGTTCCGAAATCT
ATCTGTTGCGCAAAGCCTATAGGACGATCTTCGACCGCTCCCGCACCGTTGGCGAGAACATCGAATTCGCCAAGGCCGAG
TTTGCCTCTTCGCCGACCGCCATGAAGATCATCGACTTCATCAGCAGTCGCGGCAAGCGGCACTATGCGGTGCCGTCGCT
CAAGGGTGGCGATGGCGACGATACCGACGATGAAGACTGA

Upstream 100 bases:

>100_bases
GGCAACCTGCTCAAATTCGCCTGTGAAGCCCTGGTCGATGGCACCAAGGCGGCCGAGGCCGAGATTTCAGCCATGATGGT
CACCGGCGACTGACGATCGA

Downstream 100 bases:

>100_bases
GACGGCTTCTGCCGGTCTTGATCTCCCGCCAGATGCCAGGGTCGGCATCATCGCCGGCGGCGGCAGTCTTCCGGTCGAAG
TCGCGGCCGGCTCGGCCGGG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MLMKIKTSIHPSSVVEEGAQIGEGVRIGPFCHISADAVIGDGVELVSHVSVMGATTIGASTKVYPMATLGAPPQNTKHKG
GRTTLVIGANCTIREGVTMHVGTDTSRGETTVGDNGNFLAYAHIAHDCVVGKNATFANGATLGGHCEIGDNVYIGGLSAV
HQFVRVGDNAFLGGCSAFVGDVIPYAIAVGNRASLRGLNIIGLKRAGLPRSEIYLLRKAYRTIFDRSRTVGENIEFAKAE
FASSPTAMKIIDFISSRGKRHYAVPSLKGGDGDDTDDED

Sequences:

>Translated_279_residues
MLMKIKTSIHPSSVVEEGAQIGEGVRIGPFCHISADAVIGDGVELVSHVSVMGATTIGASTKVYPMATLGAPPQNTKHKG
GRTTLVIGANCTIREGVTMHVGTDTSRGETTVGDNGNFLAYAHIAHDCVVGKNATFANGATLGGHCEIGDNVYIGGLSAV
HQFVRVGDNAFLGGCSAFVGDVIPYAIAVGNRASLRGLNIIGLKRAGLPRSEIYLLRKAYRTIFDRSRTVGENIEFAKAE
FASSPTAMKIIDFISSRGKRHYAVPSLKGGDGDDTDDED
>Mature_279_residues
MLMKIKTSIHPSSVVEEGAQIGEGVRIGPFCHISADAVIGDGVELVSHVSVMGATTIGASTKVYPMATLGAPPQNTKHKG
GRTTLVIGANCTIREGVTMHVGTDTSRGETTVGDNGNFLAYAHIAHDCVVGKNATFANGATLGGHCEIGDNVYIGGLSAV
HQFVRVGDNAFLGGCSAFVGDVIPYAIAVGNRASLRGLNIIGLKRAGLPRSEIYLLRKAYRTIFDRSRTVGENIEFAKAE
FASSPTAMKIIDFISSRGKRHYAVPSLKGGDGDDTDDED

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily

Homologues:

Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=43.8735177865613, Blast_Score=193, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXA_RHILO (Q98MC6)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102401.1
- ProteinModelPortal:   Q98MC6
- SMR:   Q98MC6
- GeneID:   1225064
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0633
- NMPDR:   fig|266835.1.peg.506
- HOGENOM:   HBG659295
- OMA:   DLKYQGE
- ProtClustDB:   PRK05289
- BRENDA:   2.3.1.129
- GO:   GO:0005737
- HAMAP:   MF_00387
- InterPro:   IPR001451
- InterPro:   IPR010137
- InterPro:   IPR011004
- PIRSF:   PIRSF000456
- TIGRFAMs:   TIGR01852

Pfam domain/function: PF00132 Hexapep; SSF51161 Trimer_LpxA_like

EC number: =2.3.1.129

Molecular weight: Translated: 29278; Mature: 29278

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMKIKTSIHPSSVVEEGAQIGEGVRIGPFCHISADAVIGDGVELVSHVSVMGATTIGAS
CEEEEECCCCHHHHHHHHHHHCCCCEECCEEEEECCCEECCCHHHHHHHHHHHHEECCCC
TKVYPMATLGAPPQNTKHKGGRTTLVIGANCTIREGVTMHVGTDTSRGETTVGDNGNFLA
CEEEEEEECCCCCCCCCCCCCCEEEEECCCCEEECCEEEEECCCCCCCCEEECCCCCEEE
YAHIAHDCVVGKNATFANGATLGGHCEIGDNVYIGGLSAVHQFVRVGDNAFLGGCSAFVG
EEEEEHHEEECCCCCCCCCCCCCCEEEECCCEEECCHHHHHHHHHCCCCCEECHHHHHHH
DVIPYAIAVGNRASLRGLNIIGLKRAGLPRSEIYLLRKAYRTIFDRSRTVGENIEFAKAE
HHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
FASSPTAMKIIDFISSRGKRHYAVPSLKGGDGDDTDDED
HCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLMKIKTSIHPSSVVEEGAQIGEGVRIGPFCHISADAVIGDGVELVSHVSVMGATTIGAS
CEEEEECCCCHHHHHHHHHHHCCCCEECCEEEEECCCEECCCHHHHHHHHHHHHEECCCC
TKVYPMATLGAPPQNTKHKGGRTTLVIGANCTIREGVTMHVGTDTSRGETTVGDNGNFLA
CEEEEEEECCCCCCCCCCCCCCEEEEECCCCEEECCEEEEECCCCCCCCEEECCCCCEEE
YAHIAHDCVVGKNATFANGATLGGHCEIGDNVYIGGLSAVHQFVRVGDNAFLGGCSAFVG
EEEEEHHEEECCCCCCCCCCCCCCEEEECCCEEECCHHHHHHHHHCCCCCEECHHHHHHH
DVIPYAIAVGNRASLRGLNIIGLKRAGLPRSEIYLLRKAYRTIFDRSRTVGENIEFAKAE
HHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
FASSPTAMKIIDFISSRGKRHYAVPSLKGGDGDDTDDED
HCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968