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The map label for this gene is pepA [H]

Identifier: 13470804

GI number: 13470804

Start: 467883

End: 469391

Strand: Reverse

Name: pepA [H]

Synonym: mll0602

Alternate gene names: 13470804

Gene position: 469391-467883 (Counterclockwise)

Preceding gene: 13470807

Following gene: 13470803

Centisome position: 6.67

GC content: 65.94

Gene sequence:

>1509_bases
ATGCCTCAATCGCCAGTGCCGGTCTTTGAAACGGTGGACGGGATTTCCGCGGAAACCTCGGTCGTCGTGATCTTGCAGAC
TGCCCAGGCAGGGTTTGGCCCGCGGGCGACGGTGCTGGACGCTGAAATGGGCGGGATCCTGTCACGAGCCTGCTCCGACC
CGGCCACGTTGGCCGACTCCGGAACCTGCATCGATCTCATCGCCCCCCAGGGCGTATCGGCCCGGCGCGTGATCGTCCTG
GCCCTGGGCAAAGCCGAGGCCGTAAGCGCCCTGTCATTGGCGCGCGCCGGCGGTCTGCTTGCCGCGCATCTGGAAGGCAA
ATGCGAATGCGCGGCGACGCTTGTCCTCGACCCGATCGACGACATCGGCCGGCCCGCAGCCGAGATCCTGGCCCGCGTCG
CGCTGGGCATGCGGCTGCGGCGCTATCGTTTCGACATGCGCAACCGGCGGCAGGGCGCGGGGGCGGACCGAACCTTGCGG
ATACAGCTGGTCGGAGCAAGCAGCGCGGAGCTGACCCCGGCACTGGCGCGGGTCAATGCCATCGCGGATGGCGTCGAATA
TGCACGCACACTGGTCAACCTGCCGCCAAACCATCTCCATCCCGACAATTTCCATGATCATCTGGAGCCGCTACGCGAGG
CCGGCATCGATGTCGACATACTCGATACGGCGCGGCTGAAAGAACTCGGCATGAACGCGATCCTGGCCGTGGGTTCCGGG
TCGGTGCGGCCGCCGCGTGTCGCTGTCCTGCGCTATCGCGGCAAGGGCGCTCCTTCCCAGCCGATGGCTTTCGTCGGTAA
GGGCGTGTGTTTCGATGCCGGCGGCCTCTGCATCAAGCGCGGCGAGCAGATGTTCGACATGAAAGCCGATATGGGCGGCG
CGGCGGCGGTGGTCGGCCTGCTGATCGCGCTTGCCCGGCAAGGCAGCCCGGTGCATGCCGTCGGCGTTCTCGGCATTGCC
GAGAACATGCCATCCGGCACCGCGCTCAAGTCGCGCGACATCATCACCACGGCATCGGGACAGACGGTCGAGGTGTTCGA
CACGGACGCGGAAGGGCGCCTGATCCTGGCCGATTGCCTCCACTATGCCGCCTCGCGCTTCAACCCCTCGGTGATCGTCG
ATCTGGCGACGCTGACCTATTCGGTGATGCGCGGCCTGGGATCGGTCTTTGCCGGTCTTTTCAGCACCGACGATGCCATC
GCGTCGCAGATGATCGCTGCGGGGGAAACGGTTGGCGAGCGGTTCTGGCAACTGCCGCTCGACAAGGCCTATGACGAGGG
CCTGCAATCGCCCTTCGCGGATCTGCGGCATCACGCCAAGGATATGGAGGATGGCGACGCGCCTTACGCGGCGGCGTTCT
TGCGCCATTTCACCGAGGATCGTCCTTGGGTGCATCTCGATATCGCCGGCAAGGAAATGGCCGACGCGGATCGGCCGCTC
GGCCGCGAAGGCGCCACGGCGTTCGGCGTGCAGATGCTGGAAGAGTGGGTGCAGACCAGGCTGAACTAG

Upstream 100 bases:

>100_bases
GAGACCGGCAACGGGTTTTCGCCATTGGCGAGCGAAGCTTTGCGCGCGATGCAAGCTGCGCCGAGGCCGGAGCCGTCAGC
ACATGGGAGACTGCCAGTCT

Downstream 100 bases:

>100_bases
ACGCCTGCTGTCGGGGACAGAAACGAAATGCGTTTAAACGTGATGGGAACCGGGATGTCGTCAGAGGTCGCTAGCAAAGA
GGGACGAGCCCCGTTCGGCA

Product: leucine aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 502; Mature: 501

Protein sequence:

>502_residues
MPQSPVPVFETVDGISAETSVVVILQTAQAGFGPRATVLDAEMGGILSRACSDPATLADSGTCIDLIAPQGVSARRVIVL
ALGKAEAVSALSLARAGGLLAAHLEGKCECAATLVLDPIDDIGRPAAEILARVALGMRLRRYRFDMRNRRQGAGADRTLR
IQLVGASSAELTPALARVNAIADGVEYARTLVNLPPNHLHPDNFHDHLEPLREAGIDVDILDTARLKELGMNAILAVGSG
SVRPPRVAVLRYRGKGAPSQPMAFVGKGVCFDAGGLCIKRGEQMFDMKADMGGAAAVVGLLIALARQGSPVHAVGVLGIA
ENMPSGTALKSRDIITTASGQTVEVFDTDAEGRLILADCLHYAASRFNPSVIVDLATLTYSVMRGLGSVFAGLFSTDDAI
ASQMIAAGETVGERFWQLPLDKAYDEGLQSPFADLRHHAKDMEDGDAPYAAAFLRHFTEDRPWVHLDIAGKEMADADRPL
GREGATAFGVQMLEEWVQTRLN

Sequences:

>Translated_502_residues
MPQSPVPVFETVDGISAETSVVVILQTAQAGFGPRATVLDAEMGGILSRACSDPATLADSGTCIDLIAPQGVSARRVIVL
ALGKAEAVSALSLARAGGLLAAHLEGKCECAATLVLDPIDDIGRPAAEILARVALGMRLRRYRFDMRNRRQGAGADRTLR
IQLVGASSAELTPALARVNAIADGVEYARTLVNLPPNHLHPDNFHDHLEPLREAGIDVDILDTARLKELGMNAILAVGSG
SVRPPRVAVLRYRGKGAPSQPMAFVGKGVCFDAGGLCIKRGEQMFDMKADMGGAAAVVGLLIALARQGSPVHAVGVLGIA
ENMPSGTALKSRDIITTASGQTVEVFDTDAEGRLILADCLHYAASRFNPSVIVDLATLTYSVMRGLGSVFAGLFSTDDAI
ASQMIAAGETVGERFWQLPLDKAYDEGLQSPFADLRHHAKDMEDGDAPYAAAFLRHFTEDRPWVHLDIAGKEMADADRPL
GREGATAFGVQMLEEWVQTRLN
>Mature_501_residues
PQSPVPVFETVDGISAETSVVVILQTAQAGFGPRATVLDAEMGGILSRACSDPATLADSGTCIDLIAPQGVSARRVIVLA
LGKAEAVSALSLARAGGLLAAHLEGKCECAATLVLDPIDDIGRPAAEILARVALGMRLRRYRFDMRNRRQGAGADRTLRI
QLVGASSAELTPALARVNAIADGVEYARTLVNLPPNHLHPDNFHDHLEPLREAGIDVDILDTARLKELGMNAILAVGSGS
VRPPRVAVLRYRGKGAPSQPMAFVGKGVCFDAGGLCIKRGEQMFDMKADMGGAAAVVGLLIALARQGSPVHAVGVLGIAE
NMPSGTALKSRDIITTASGQTVEVFDTDAEGRLILADCLHYAASRFNPSVIVDLATLTYSVMRGLGSVFAGLFSTDDAIA
SQMIAAGETVGERFWQLPLDKAYDEGLQSPFADLRHHAKDMEDGDAPYAAAFLRHFTEDRPWVHLDIAGKEMADADRPLG
REGATAFGVQMLEEWVQTRLN

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=370, Percent_Identity=35.1351351351351, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI47155554, Length=362, Percent_Identity=33.9779005524862, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1790710, Length=314, Percent_Identity=40.4458598726115, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87082123, Length=317, Percent_Identity=36.2776025236593, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=296, Percent_Identity=34.7972972972973, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=271, Percent_Identity=26.9372693726937, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355725, Length=281, Percent_Identity=33.4519572953737, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24661038, Length=281, Percent_Identity=33.4519572953737, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI20129963, Length=356, Percent_Identity=31.1797752808989, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI19922386, Length=347, Percent_Identity=28.8184438040346, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24662227, Length=291, Percent_Identity=29.2096219931272, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI161077148, Length=350, Percent_Identity=27.7142857142857, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI20130057, Length=350, Percent_Identity=27.7142857142857, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI20129969, Length=291, Percent_Identity=30.2405498281787, Blast_Score=148, Evalue=9e-36,
Organism=Drosophila melanogaster, GI21357381, Length=324, Percent_Identity=31.1728395061728, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379063, Length=324, Percent_Identity=31.1728395061728, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI221379062, Length=324, Percent_Identity=31.1728395061728, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21355645, Length=295, Percent_Identity=26.1016949152542, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24662223, Length=295, Percent_Identity=26.1016949152542, Blast_Score=129, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646701, Length=234, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646703, Length=234, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21358201, Length=234, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53219; Mature: 53087

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQSPVPVFETVDGISAETSVVVILQTAQAGFGPRATVLDAEMGGILSRACSDPATLADS
CCCCCCCHHHHCCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCC
GTCIDLIAPQGVSARRVIVLALGKAEAVSALSLARAGGLLAAHLEGKCECAATLVLDPID
CCEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCHH
DIGRPAAEILARVALGMRLRRYRFDMRNRRQGAGADRTLRIQLVGASSAELTPALARVNA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
IADGVEYARTLVNLPPNHLHPDNFHDHLEPLREAGIDVDILDTARLKELGMNAILAVGSG
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHCCCCEEEEECCC
SVRPPRVAVLRYRGKGAPSQPMAFVGKGVCFDAGGLCIKRGEQMFDMKADMGGAAAVVGL
CCCCCEEEEEEEECCCCCCCCHHHHCCCCEECCCCHHHHCCCHHHHHHCCCCHHHHHHHH
LIALARQGSPVHAVGVLGIAENMPSGTALKSRDIITTASGQTVEVFDTDAEGRLILADCL
HHHHHCCCCCEEEEEEEEHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHHHH
HYAASRFNPSVIVDLATLTYSVMRGLGSVFAGLFSTDDAIASQMIAAGETVGERFWQLPL
HHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
DKAYDEGLQSPFADLRHHAKDMEDGDAPYAAAFLRHFTEDRPWVHLDIAGKEMADADRPL
HHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCCC
GREGATAFGVQMLEEWVQTRLN
CCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQSPVPVFETVDGISAETSVVVILQTAQAGFGPRATVLDAEMGGILSRACSDPATLADS
CCCCCCHHHHCCCCCCCCEEEEEEEECCCCCCCCCEEEECHHHHHHHHHCCCCCCCCCC
GTCIDLIAPQGVSARRVIVLALGKAEAVSALSLARAGGLLAAHLEGKCECAATLVLDPID
CCEEEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCHH
DIGRPAAEILARVALGMRLRRYRFDMRNRRQGAGADRTLRIQLVGASSAELTPALARVNA
HHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHH
IADGVEYARTLVNLPPNHLHPDNFHDHLEPLREAGIDVDILDTARLKELGMNAILAVGSG
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHHCCCCEEEEECCC
SVRPPRVAVLRYRGKGAPSQPMAFVGKGVCFDAGGLCIKRGEQMFDMKADMGGAAAVVGL
CCCCCEEEEEEEECCCCCCCCHHHHCCCCEECCCCHHHHCCCHHHHHHCCCCHHHHHHHH
LIALARQGSPVHAVGVLGIAENMPSGTALKSRDIITTASGQTVEVFDTDAEGRLILADCL
HHHHHCCCCCEEEEEEEEHHCCCCCCCCCCCCCEEEECCCCEEEEEECCCCCCEEHHHHH
HYAASRFNPSVIVDLATLTYSVMRGLGSVFAGLFSTDDAIASQMIAAGETVGERFWQLPL
HHHHHCCCCHHEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
DKAYDEGLQSPFADLRHHAKDMEDGDAPYAAAFLRHFTEDRPWVHLDIAGKEMADADRPL
HHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHCCCCCC
GREGATAFGVQMLEEWVQTRLN
CCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]