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The map label for this gene is adk

Identifier: 13470572

GI number: 13470572

Start: 220486

End: 221082

Strand: Direct

Name: adk

Synonym: mlr0322

Alternate gene names: 13470572

Gene position: 220486-221082 (Clockwise)

Preceding gene: 13470571

Following gene: 13470573

Centisome position: 3.13

GC content: 62.98

Gene sequence:

>597_bases
ATGAGGTTGATTTTGCTTGGGCCGCCAGGGGCGGGCAAGGGGACACAAGCACAAAGACTGGTAGAAAAACACGGCATACC
CCAGCTCTCGACGGGAGACATGCTGCGTGCCGCCGTTCAGGCCGGTTCCGAAGTCGGCAAGCGTGCCAAGGCGGTGATGG
ATGCCGGCGAATTGGTGTCGGACGCCATCGTCAACGCCATCGTCGCCGAGCGAATCGACCAGGCCGATTGCGCCAAGGGA
TTCATCCTCGACGGCTACCCGCGCACGCTGGTGCAGGCAGATGCGGTTGAATCGATGCTTTCCGAGCGTGGCATCGGCCT
CGACACGGTCATCGAACTGGTTGTCGATGACAGGGCCCTGGTCGGCCGCATTGTCAAACGCGCCGAGGATGCCAAGGCCG
CCGGCCAGCCGGTACGCAAGGACGACAATCCCGCAGTGTTCGAAGAGCGCCTGCGCGAGTACTACAAGAAGACCGCTCCG
CTGACCGGCTACTATTACGCCAAGGGCAAGCTCAAGACGGTCGACGGCTTGGCCAGCATCGACGCGGTGACCAACGAGAT
CGAAGCCGTGCTTACGGCGGCCGCCGAGGCGCGGTAA

Upstream 100 bases:

>100_bases
TCACGCTCGATACGGTTGCGCAGATTCAGGGCCACCTGATCGCGCACCAGTATGAAGGCTTGATCAAGAAGTCGAAGCTG
CGCGGGGGGAAGAAAGCCAG

Downstream 100 bases:

>100_bases
GGGAATTTAAAGATTAGGCTTGACGGGAGCGGCTCGCTGCGGTATGGCGGCCCGTCTTCCTATCAGGTGCGAACTTTGCT
TGTCCGCAAGGGCAAGGCAG

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MRLILLGPPGAGKGTQAQRLVEKHGIPQLSTGDMLRAAVQAGSEVGKRAKAVMDAGELVSDAIVNAIVAERIDQADCAKG
FILDGYPRTLVQADAVESMLSERGIGLDTVIELVVDDRALVGRIVKRAEDAKAAGQPVRKDDNPAVFEERLREYYKKTAP
LTGYYYAKGKLKTVDGLASIDAVTNEIEAVLTAAAEAR

Sequences:

>Translated_198_residues
MRLILLGPPGAGKGTQAQRLVEKHGIPQLSTGDMLRAAVQAGSEVGKRAKAVMDAGELVSDAIVNAIVAERIDQADCAKG
FILDGYPRTLVQADAVESMLSERGIGLDTVIELVVDDRALVGRIVKRAEDAKAAGQPVRKDDNPAVFEERLREYYKKTAP
LTGYYYAKGKLKTVDGLASIDAVTNEIEAVLTAAAEAR
>Mature_198_residues
MRLILLGPPGAGKGTQAQRLVEKHGIPQLSTGDMLRAAVQAGSEVGKRAKAVMDAGELVSDAIVNAIVAERIDQADCAKG
FILDGYPRTLVQADAVESMLSERGIGLDTVIELVVDDRALVGRIVKRAEDAKAAGQPVRKDDNPAVFEERLREYYKKTAP
LTGYYYAKGKLKTVDGLASIDAVTNEIEAVLTAAAEAR

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=215, Percent_Identity=40, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI4502013, Length=216, Percent_Identity=39.8148148148148, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI4502011, Length=198, Percent_Identity=35.8585858585859, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI19923437, Length=219, Percent_Identity=30.1369863013699, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=29.4416243654822, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=29.4416243654822, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=29.4416243654822, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=29.4416243654822, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI28144899, Length=176, Percent_Identity=32.9545454545455, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI28144897, Length=176, Percent_Identity=32.9545454545455, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI7706497, Length=194, Percent_Identity=28.8659793814433, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI22749187, Length=131, Percent_Identity=31.2977099236641, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=47.4654377880184, Blast_Score=180, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17552384, Length=219, Percent_Identity=37.4429223744292, Blast_Score=148, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=183, Percent_Identity=36.0655737704918, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17533833, Length=193, Percent_Identity=27.4611398963731, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17537943, Length=203, Percent_Identity=31.5270935960591, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17550688, Length=195, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147457, Length=193, Percent_Identity=25.9067357512953, Blast_Score=66, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=42.1319796954315, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321018, Length=200, Percent_Identity=33, Blast_Score=103, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=189, Percent_Identity=29.6296296296296, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22026816, Length=209, Percent_Identity=41.1483253588517, Blast_Score=159, Evalue=8e-40,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=31.9796954314721, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=31.9796954314721, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17647141, Length=167, Percent_Identity=35.9281437125749, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24663208, Length=167, Percent_Identity=35.9281437125749, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221459597, Length=194, Percent_Identity=26.8041237113402, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21356893, Length=194, Percent_Identity=26.8041237113402, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_RHILO (Q98N36)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_102141.1
- ProteinModelPortal:   Q98N36
- SMR:   Q98N36
- GeneID:   1224804
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mlr0322
- NMPDR:   fig|266835.1.peg.246
- HOGENOM:   HBG630208
- OMA:   TRLMEYY
- ProtClustDB:   PRK00279
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21119; Mature: 21119

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLILLGPPGAGKGTQAQRLVEKHGIPQLSTGDMLRAAVQAGSEVGKRAKAVMDAGELVS
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAIVNAIVAERIDQADCAKGFILDGYPRTLVQADAVESMLSERGIGLDTVIELVVDDRAL
HHHHHHHHHHHCCHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
VGRIVKRAEDAKAAGQPVRKDDNPAVFEERLREYYKKTAPLTGYYYAKGKLKTVDGLASI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEHHHHHHHH
DAVTNEIEAVLTAAAEAR
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLILLGPPGAGKGTQAQRLVEKHGIPQLSTGDMLRAAVQAGSEVGKRAKAVMDAGELVS
CEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAIVNAIVAERIDQADCAKGFILDGYPRTLVQADAVESMLSERGIGLDTVIELVVDDRAL
HHHHHHHHHHHCCHHHHHCCCEECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
VGRIVKRAEDAKAAGQPVRKDDNPAVFEERLREYYKKTAPLTGYYYAKGKLKTVDGLASI
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCEEHHHHHHHH
DAVTNEIEAVLTAAAEAR
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968