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The map label for this gene is aaeR [H]

Identifier: 13470517

GI number: 13470517

Start: 173499

End: 174425

Strand: Direct

Name: aaeR [H]

Synonym: mlr0244

Alternate gene names: 13470517

Gene position: 173499-174425 (Clockwise)

Preceding gene: 13470515

Following gene: 13470519

Centisome position: 2.47

GC content: 60.63

Gene sequence:

>927_bases
ATGGATCGTCTCGCCAGCATGACCGCATTCGTAAAGGCGGCAGAAAGCGGCTCCTTTGCAGCGACGGCATCGGCGCTCGG
CATCTCACCGCAGATGGTGGCCAAGCACGTCACCTATCTGGAGGCACGTTTGGGCGCACGCCTGCTCAACCGCACAACCC
GAAAGCAAAGCCTGACGGTGATCGGCAAGTCCTACTACGATCGGTGCAAAGTGGCGCTGGCCGAGGTCGACTGGGCGGAT
GCAATTGCTGATGAGGCCAGGGGCAAACCGCGAGGGCTCTTGCGCGTCAACGCGGCGGTTTCATTCGGAGCTCACTGCGT
GACACCTGTGGTCGCACGATATTTGAGCAGCCACCCCAGTGTCGATGTCGACCTGGTTCTCAACGACCGCTTTGTCGACC
TTATCGACGACGGGTTTGAGGCGGTGTTCCGGATCGGTCCTCTCGGGGAGTCTAACCTCGGGGCGATAGAGCTCGCACCC
TTTCAGACGATTGCCTGCGGGTCGCCTGCATACCTTAAAGAACGAGGGATGCCCTCGATCGTATCGGATCTGGTCAATCA
TGAATGCCTGCTCTTCGGCAACTGGCCCGAACCAACGTTCAGCGATTGGCTCTTTGTACGGGACGGTCTCACCTCCAAGG
CCTCAGTCCACGGCCGTCTCAAGGTCAACAACCCCGCTTCATTGCTGGAGGCGGCGCTCGCAGGTTTCGGCTTGGCGTTG
ATCGGAGAAGAGGCGGTGCGCACGCACCTCGCGACCGGGCGGCTCGTCCGAGTGTTGCCGAACTACGAAACGCCTCCGCG
TCCCATTCACCTGCTGTTTCACCCTGATCGGCGACAAACGCCGAAGCTGAAGACCTTCATCGAAATGGTGGTGGACCAGC
TGGGCCGGAATGGTCAGGACGGCCGCAGACGCCAACAGGGAGAATGA

Upstream 100 bases:

>100_bases
CGAAGGTGTGGGGATGAGATTGCTTGTGAAGCTATATGACCCCTTGCATTAGATCGATAAATGGCGCCATGAAACCGGCT
CTCCCAACCAGGAGTGTGGA

Downstream 100 bases:

>100_bases
CCCAGTTTGGATATTCTGCGGCCAGATATCGGTGCCGAAGATTCGTCCGAAAAGGCCGGTCTCCGTTACACAAAATCTTG
CACAAACGCTCGGTGGCCCG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MDRLASMTAFVKAAESGSFAATASALGISPQMVAKHVTYLEARLGARLLNRTTRKQSLTVIGKSYYDRCKVALAEVDWAD
AIADEARGKPRGLLRVNAAVSFGAHCVTPVVARYLSSHPSVDVDLVLNDRFVDLIDDGFEAVFRIGPLGESNLGAIELAP
FQTIACGSPAYLKERGMPSIVSDLVNHECLLFGNWPEPTFSDWLFVRDGLTSKASVHGRLKVNNPASLLEAALAGFGLAL
IGEEAVRTHLATGRLVRVLPNYETPPRPIHLLFHPDRRQTPKLKTFIEMVVDQLGRNGQDGRRRQQGE

Sequences:

>Translated_308_residues
MDRLASMTAFVKAAESGSFAATASALGISPQMVAKHVTYLEARLGARLLNRTTRKQSLTVIGKSYYDRCKVALAEVDWAD
AIADEARGKPRGLLRVNAAVSFGAHCVTPVVARYLSSHPSVDVDLVLNDRFVDLIDDGFEAVFRIGPLGESNLGAIELAP
FQTIACGSPAYLKERGMPSIVSDLVNHECLLFGNWPEPTFSDWLFVRDGLTSKASVHGRLKVNNPASLLEAALAGFGLAL
IGEEAVRTHLATGRLVRVLPNYETPPRPIHLLFHPDRRQTPKLKTFIEMVVDQLGRNGQDGRRRQQGE
>Mature_308_residues
MDRLASMTAFVKAAESGSFAATASALGISPQMVAKHVTYLEARLGARLLNRTTRKQSLTVIGKSYYDRCKVALAEVDWAD
AIADEARGKPRGLLRVNAAVSFGAHCVTPVVARYLSSHPSVDVDLVLNDRFVDLIDDGFEAVFRIGPLGESNLGAIELAP
FQTIACGSPAYLKERGMPSIVSDLVNHECLLFGNWPEPTFSDWLFVRDGLTSKASVHGRLKVNNPASLLEAALAGFGLAL
IGEEAVRTHLATGRLVRVLPNYETPPRPIHLLFHPDRRQTPKLKTFIEMVVDQLGRNGQDGRRRQQGE

Specific function: Activates transcription of the aaeXAB operon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789639, Length=299, Percent_Identity=30.4347826086957, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI145693193, Length=287, Percent_Identity=32.7526132404181, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786401, Length=291, Percent_Identity=31.6151202749141, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1787128, Length=305, Percent_Identity=28.8524590163934, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1787589, Length=298, Percent_Identity=28.5234899328859, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI87081978, Length=263, Percent_Identity=32.319391634981, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789440, Length=256, Percent_Identity=29.296875, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786448, Length=294, Percent_Identity=24.8299319727891, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789173, Length=304, Percent_Identity=23.0263157894737, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788706, Length=296, Percent_Identity=22.972972972973, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33642; Mature: 33642

Theoretical pI: Translated: 8.62; Mature: 8.62

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRLASMTAFVKAAESGSFAATASALGISPQMVAKHVTYLEARLGARLLNRTTRKQSLTV
CCHHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKSYYDRCKVALAEVDWADAIADEARGKPRGLLRVNAAVSFGAHCVTPVVARYLSSHPS
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCC
VDVDLVLNDRFVDLIDDGFEAVFRIGPLGESNLGAIELAPFQTIACGSPAYLKERGMPSI
CEEEEEECCCHHHHHHHHHHHHEEECCCCCCCCCEEEECCCCEEECCCCHHHHHCCCHHH
VSDLVNHECLLFGNWPEPTFSDWLFVRDGLTSKASVHGRLKVNNPASLLEAALAGFGLAL
HHHHHCCCEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHCCHHH
IGEEAVRTHLATGRLVRVLPNYETPPRPIHLLFHPDRRQTPKLKTFIEMVVDQLGRNGQD
HHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCC
GRRRQQGE
CCCCCCCC
>Mature Secondary Structure
MDRLASMTAFVKAAESGSFAATASALGISPQMVAKHVTYLEARLGARLLNRTTRKQSLTV
CCHHHHHHHHHHHHCCCCCEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGKSYYDRCKVALAEVDWADAIADEARGKPRGLLRVNAAVSFGAHCVTPVVARYLSSHPS
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEHHHHCCHHHHHHHHHHHHHCCCC
VDVDLVLNDRFVDLIDDGFEAVFRIGPLGESNLGAIELAPFQTIACGSPAYLKERGMPSI
CEEEEEECCCHHHHHHHHHHHHEEECCCCCCCCCEEEECCCCEEECCCCHHHHHCCCHHH
VSDLVNHECLLFGNWPEPTFSDWLFVRDGLTSKASVHGRLKVNNPASLLEAALAGFGLAL
HHHHHCCCEEEECCCCCCCCCCEEEEECCCCCCCEEEEEEEECCHHHHHHHHHHHCCHHH
IGEEAVRTHLATGRLVRVLPNYETPPRPIHLLFHPDRRQTPKLKTFIEMVVDQLGRNGQD
HHHHHHHHHHHCCCEEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCC
GRRRQQGE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]