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The map label for this gene is hutH [H]

Identifier: 13470444

GI number: 13470444

Start: 106280

End: 107782

Strand: Reverse

Name: hutH [H]

Synonym: mll0151

Alternate gene names: 13470444

Gene position: 107782-106280 (Counterclockwise)

Preceding gene: 13470446

Following gene: 13470442

Centisome position: 1.53

GC content: 63.74

Gene sequence:

>1503_bases
ATGACAATAACGATAGATACAAACGCCAGCTGGCGCGACATCGCGCGGGTGAGCGAAGGCGAATCCCTGGCGCTTAGCCA
GGCAGCATGGGAGAGGATCGCCTTTGCGCACCAGATCGTCGCGGCCATCGTCGAAAAAGGCATCCGCGCCTATGGCGTCA
ATACCGGGGTCGGCGCCTTGGCAAGCAAGGTCGTGGCGCCTGCCCTGCAAAAGAAACTGTCGCGCAATATCATTCGCAGT
CACGCCTGCGGCGTAGGTGACCTCGTGCCGAGACGCGGCGTGCGCGCCATCATTGCCGCTCAAGTGGCTAATTTCGCGCA
TGGCCGTTCGGGCGTTAGCCCTGCGATCGTCCGCAATTTGCTCACCTTTATCGAGCGCGACTGCGTTCCCGACGTGCCCT
CCCGGGGATCGGCCGGGTATTTGACGCACAACGCGCATGTAGCACTGGTCTTGATCGGCGAAGGCAGTGCAACCGTGGCA
GGCCGCCCGATGAGCGGGCTCGAGGCGTTGGCTGAAATGGGTCTGGAGCCATTGGAGCTTGGCGCCAAGGAAGGCTTGAG
CCTGGTCAACGGCACGGCGTGCGCAACCGGCCTGACAAGCATTGCGGTGCTGCGCGCGGAGCGTTTGTTGGGATGGGCTG
ACGCGGCGGCGGCTTTGACGCTCGAAGCCGCGGGCGCGCAAATGCCGGCTTTTGGCGAACAAATCCTGGCGATGAGGCCC
TCACCCGGCATTCAGGACGTGGGCAGATCACTGCGCGGCTGGCTTCATGGCAGCGAACTTATCGCGCTGGCCCATGGCAG
TCGCACGCAGGACGCACTCAGTCTTCGCGCCGTGCCGCATGTTCATGGCGCCGCCCGGGAGGTGCTGGACCGGTCCTCCG
AGCTGGTCGACCGCGAACTGGCTGCCGTCACCGACAATCCCGCGGTATTCGGGTCCTTGAGCGATCCTCAGGTTGTTTCA
GAGGCGCATGCGGTAGCGCCCGCCCTCGGGCAGGCCGCCGACGGCCTGACCATCGCCTTGGCTCAGGTGGCCGGAATGAG
CGAGCGTCGGATCGATCGTCTCGTCAATCCGCTTGTCAACAATTTGCCGGCCTTCCTTGCCGATGAGGACGGAGCCAATT
CCGGCTTCATGATCGCCCAGTACACGGCCACCTCGCTCAGCAACGTCAATCGGCGTCTGGCCGCCCCGGCGGCGACCGAC
GGCGGCGTCACATCCGGCCTGCAAGAGGATTTTCTTGCGCATCCAACCGTCGCAGCCAACAAGCTGCTGGCGGTTATCGA
CAACGCCGAATACATCCTGGCGATCGAACTCATGGCAGCCGCGCAGGCCCATGATTTTCTGGCGCGGCGCGGTGCCCGCG
CGCCTGGTACTGACACCATCTACCAACTGGTCCGGGAAAATATCGCGCACTATTCCGACGATCGGCCTCTGTCCCGGGAT
ATGGAAGCCTTGCGCACCTTCATCCGCGAAATGGACGTGCCGGCCTGTCCGCAGCACAGCTAG

Upstream 100 bases:

>100_bases
CCCGCTGATGTGCGGTAAGGGGCCGAAGCAGCGGTCTCACGCCGCCTTTCGAGCGAGCCAACAGCGCCTGCGCATTCGCA
AAGCTATTTCGGAACGGGCA

Downstream 100 bases:

>100_bases
CAAGGCAATACCCAGCGAGCTTCGAGAGACTAGGCCTTCATCGGGTTCAGCTTCAGATGCTGGATCAGGATAATCGTCTT
GGCATCGACGATGCGACCGT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 500; Mature: 499

Protein sequence:

>500_residues
MTITIDTNASWRDIARVSEGESLALSQAAWERIAFAHQIVAAIVEKGIRAYGVNTGVGALASKVVAPALQKKLSRNIIRS
HACGVGDLVPRRGVRAIIAAQVANFAHGRSGVSPAIVRNLLTFIERDCVPDVPSRGSAGYLTHNAHVALVLIGEGSATVA
GRPMSGLEALAEMGLEPLELGAKEGLSLVNGTACATGLTSIAVLRAERLLGWADAAAALTLEAAGAQMPAFGEQILAMRP
SPGIQDVGRSLRGWLHGSELIALAHGSRTQDALSLRAVPHVHGAAREVLDRSSELVDRELAAVTDNPAVFGSLSDPQVVS
EAHAVAPALGQAADGLTIALAQVAGMSERRIDRLVNPLVNNLPAFLADEDGANSGFMIAQYTATSLSNVNRRLAAPAATD
GGVTSGLQEDFLAHPTVAANKLLAVIDNAEYILAIELMAAAQAHDFLARRGARAPGTDTIYQLVRENIAHYSDDRPLSRD
MEALRTFIREMDVPACPQHS

Sequences:

>Translated_500_residues
MTITIDTNASWRDIARVSEGESLALSQAAWERIAFAHQIVAAIVEKGIRAYGVNTGVGALASKVVAPALQKKLSRNIIRS
HACGVGDLVPRRGVRAIIAAQVANFAHGRSGVSPAIVRNLLTFIERDCVPDVPSRGSAGYLTHNAHVALVLIGEGSATVA
GRPMSGLEALAEMGLEPLELGAKEGLSLVNGTACATGLTSIAVLRAERLLGWADAAAALTLEAAGAQMPAFGEQILAMRP
SPGIQDVGRSLRGWLHGSELIALAHGSRTQDALSLRAVPHVHGAAREVLDRSSELVDRELAAVTDNPAVFGSLSDPQVVS
EAHAVAPALGQAADGLTIALAQVAGMSERRIDRLVNPLVNNLPAFLADEDGANSGFMIAQYTATSLSNVNRRLAAPAATD
GGVTSGLQEDFLAHPTVAANKLLAVIDNAEYILAIELMAAAQAHDFLARRGARAPGTDTIYQLVRENIAHYSDDRPLSRD
MEALRTFIREMDVPACPQHS
>Mature_499_residues
TITIDTNASWRDIARVSEGESLALSQAAWERIAFAHQIVAAIVEKGIRAYGVNTGVGALASKVVAPALQKKLSRNIIRSH
ACGVGDLVPRRGVRAIIAAQVANFAHGRSGVSPAIVRNLLTFIERDCVPDVPSRGSAGYLTHNAHVALVLIGEGSATVAG
RPMSGLEALAEMGLEPLELGAKEGLSLVNGTACATGLTSIAVLRAERLLGWADAAAALTLEAAGAQMPAFGEQILAMRPS
PGIQDVGRSLRGWLHGSELIALAHGSRTQDALSLRAVPHVHGAAREVLDRSSELVDRELAAVTDNPAVFGSLSDPQVVSE
AHAVAPALGQAADGLTIALAQVAGMSERRIDRLVNPLVNNLPAFLADEDGANSGFMIAQYTATSLSNVNRRLAAPAATDG
GVTSGLQEDFLAHPTVAANKLLAVIDNAEYILAIELMAAAQAHDFLARRGARAPGTDTIYQLVRENIAHYSDDRPLSRDM
EALRTFIREMDVPACPQHS

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=496, Percent_Identity=36.2903225806452, Blast_Score=263, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17567831, Length=491, Percent_Identity=37.2708757637475, Blast_Score=250, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 52478; Mature: 52347

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITIDTNASWRDIARVSEGESLALSQAAWERIAFAHQIVAAIVEKGIRAYGVNTGVGAL
CEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHH
ASKVVAPALQKKLSRNIIRSHACGVGDLVPRRGVRAIIAAQVANFAHGRSGVSPAIVRNL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LTFIERDCVPDVPSRGSAGYLTHNAHVALVLIGEGSATVAGRPMSGLEALAEMGLEPLEL
HHHHHHCCCCCCCCCCCCCEEEECCEEEEEEEECCCCEECCCCHHHHHHHHHCCCCHHHC
GAKEGLSLVNGTACATGLTSIAVLRAERLLGWADAAAALTLEAAGAQMPAFGEQILAMRP
CHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECC
SPGIQDVGRSLRGWLHGSELIALAHGSRTQDALSLRAVPHVHGAAREVLDRSSELVDREL
CCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AAVTDNPAVFGSLSDPQVVSEAHAVAPALGQAADGLTIALAQVAGMSERRIDRLVNPLVN
HHHCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
NLPAFLADEDGANSGFMIAQYTATSLSNVNRRLAAPAATDGGVTSGLQEDFLAHPTVAAN
CCCHHEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHCCCCHHHH
KLLAVIDNAEYILAIELMAAAQAHDFLARRGARAPGTDTIYQLVRENIAHYSDDRPLSRD
HHHHEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
MEALRTFIREMDVPACPQHS
HHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TITIDTNASWRDIARVSEGESLALSQAAWERIAFAHQIVAAIVEKGIRAYGVNTGVGAL
EEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHH
ASKVVAPALQKKLSRNIIRSHACGVGDLVPRRGVRAIIAAQVANFAHGRSGVSPAIVRNL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LTFIERDCVPDVPSRGSAGYLTHNAHVALVLIGEGSATVAGRPMSGLEALAEMGLEPLEL
HHHHHHCCCCCCCCCCCCCEEEECCEEEEEEEECCCCEECCCCHHHHHHHHHCCCCHHHC
GAKEGLSLVNGTACATGLTSIAVLRAERLLGWADAAAALTLEAAGAQMPAFGEQILAMRP
CHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHEEECC
SPGIQDVGRSLRGWLHGSELIALAHGSRTQDALSLRAVPHVHGAAREVLDRSSELVDREL
CCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
AAVTDNPAVFGSLSDPQVVSEAHAVAPALGQAADGLTIALAQVAGMSERRIDRLVNPLVN
HHHCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
NLPAFLADEDGANSGFMIAQYTATSLSNVNRRLAAPAATDGGVTSGLQEDFLAHPTVAAN
CCCHHEECCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCHHCCHHHHHHCCCCHHHH
KLLAVIDNAEYILAIELMAAAQAHDFLARRGARAPGTDTIYQLVRENIAHYSDDRPLSRD
HHHHEECCCCEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
MEALRTFIREMDVPACPQHS
HHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]