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The map label for this gene is sufS [H]

Identifier: 13470403

GI number: 13470403

Start: 70772

End: 72049

Strand: Direct

Name: sufS [H]

Synonym: mlr0102

Alternate gene names: 13470403

Gene position: 70772-72049 (Clockwise)

Preceding gene: 13470402

Following gene: 13470410

Centisome position: 1.01

GC content: 62.68

Gene sequence:

>1278_bases
GTGGAGACGATGGTGGATTTTCCGATCGAGGCCGTGCGCGGACAATTTCCAGCGCTTTCCCTGACCGACAAGGGCCGCCG
TCGCATCTATCTTGACAATCCCGCCGGCACGCAGGTGCCGCAGGCCGTCGCCGATGCGGTGTCGCGCTGCTTGCTCACCA
CCAATGCCAATCTCGGTGGCTATTTCGAAACGACGATCGCGGCTCAATCCGTCGTCGATGACGCGCATCGGGCGATGGCC
GATTTCCTCGGTGCGGCGAGCCCGGAGGAAATCATCATCGGCGCCAATATGACGACGCTGACCTACCACATGTCGCGCAC
GCTCGGCCGCACGCTGAAGCCCGGTGACGAGATCATCCTCACCCGCATGGACCATGAGGGCAACGTCTCGCCGTGGCTGC
AACTGGCCGAGGATTTGAGCCTCGTCGTGCGCTGGCTGCCATTCGATGAAAAGAGCTGGCAGGTCGAGGAGGCGGCGCTG
ACCGGGCTGCTGTCCGACAAGACACGGCTGGTCGCGCTGAATTATGCCTCGAACCTGACCGGTTCGATCAACCGGGTTAA
GGCCCTGACCGCCATCGCAAAACGGGCCGGCGCCCTGGTCTATGTCGACGCCGTGCAGTTCGCGCCGCATGGCCTGATCG
ACGTGCAGGACCTCGGCTGCGATCTCCTGATCTGCTCGGCCTACAAATTCTTCGGTCCGCATATGGGCATTTTGTGGGGG
CGGCGCGAAATCATCGATGGCCTGAAGCCCTACAAATGCCGCTGTTCGTCAAATGGCCTGCCGGAGCGGTTCGAGCTTGG
CACACCGCAGATCGAACTGATGGCCGGCCTCATGGCGGCGGTCGACTATTTTGCCGGGCTGGGTGTAGCAGCGGGCGAGG
GTGGTTCGCGCAGGCAGAAGATCGCCAGGGCGTTCGAGGTTTCCATCGCCTACGAGAATCCGCTGGCACAAAGGCTGATC
GATGGCCTGTCCGACATTCCAGGCCTGACTATCCATGGCATCACCGATCGCAAGCGGCTCGCCGATCGCGTGCCGACGGT
GTCCTTCACCGTCGACGGCATCGTACCGGAGACGATCGTTCGACAGATGAATGCCGAAAACATCTTCCTGTGGTCCGGCC
ACAACTACGCCTGGGAGATCGTCCACCAGCTCGGCATTCCGGCCGAGCAGGGCGTTGTGCGCATCGGCATCGCGCACTAC
AACACGGCGGCCGAAATCGACGAGACGCTGGAGAGCGTGCACCGGGTCATCGCCATGCTCAGGCAGCAGCGCTCCTGA

Upstream 100 bases:

>100_bases
GTCTGGACAGAGGAGATGCAGAAGGCGGTGGACGCGATCCACCAGCGGGTCGGCAATCCCTGTCCCTGATCGGCGTGAAT
TATCAAGGAACAACGGAGGG

Downstream 100 bases:

>100_bases
CGTAAGAAGAAACCGTCACCGCACCTTGCCGCCAAAACCTGTGAGGAAGGCGGTGAGATTGTCGCTGAGTGCGTCGCAGA
GATAGCCGCCTTCCTGGACG

Product: aminotransferase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
METMVDFPIEAVRGQFPALSLTDKGRRRIYLDNPAGTQVPQAVADAVSRCLLTTNANLGGYFETTIAAQSVVDDAHRAMA
DFLGAASPEEIIIGANMTTLTYHMSRTLGRTLKPGDEIILTRMDHEGNVSPWLQLAEDLSLVVRWLPFDEKSWQVEEAAL
TGLLSDKTRLVALNYASNLTGSINRVKALTAIAKRAGALVYVDAVQFAPHGLIDVQDLGCDLLICSAYKFFGPHMGILWG
RREIIDGLKPYKCRCSSNGLPERFELGTPQIELMAGLMAAVDYFAGLGVAAGEGGSRRQKIARAFEVSIAYENPLAQRLI
DGLSDIPGLTIHGITDRKRLADRVPTVSFTVDGIVPETIVRQMNAENIFLWSGHNYAWEIVHQLGIPAEQGVVRIGIAHY
NTAAEIDETLESVHRVIAMLRQQRS

Sequences:

>Translated_425_residues
METMVDFPIEAVRGQFPALSLTDKGRRRIYLDNPAGTQVPQAVADAVSRCLLTTNANLGGYFETTIAAQSVVDDAHRAMA
DFLGAASPEEIIIGANMTTLTYHMSRTLGRTLKPGDEIILTRMDHEGNVSPWLQLAEDLSLVVRWLPFDEKSWQVEEAAL
TGLLSDKTRLVALNYASNLTGSINRVKALTAIAKRAGALVYVDAVQFAPHGLIDVQDLGCDLLICSAYKFFGPHMGILWG
RREIIDGLKPYKCRCSSNGLPERFELGTPQIELMAGLMAAVDYFAGLGVAAGEGGSRRQKIARAFEVSIAYENPLAQRLI
DGLSDIPGLTIHGITDRKRLADRVPTVSFTVDGIVPETIVRQMNAENIFLWSGHNYAWEIVHQLGIPAEQGVVRIGIAHY
NTAAEIDETLESVHRVIAMLRQQRS
>Mature_425_residues
METMVDFPIEAVRGQFPALSLTDKGRRRIYLDNPAGTQVPQAVADAVSRCLLTTNANLGGYFETTIAAQSVVDDAHRAMA
DFLGAASPEEIIIGANMTTLTYHMSRTLGRTLKPGDEIILTRMDHEGNVSPWLQLAEDLSLVVRWLPFDEKSWQVEEAAL
TGLLSDKTRLVALNYASNLTGSINRVKALTAIAKRAGALVYVDAVQFAPHGLIDVQDLGCDLLICSAYKFFGPHMGILWG
RREIIDGLKPYKCRCSSNGLPERFELGTPQIELMAGLMAAVDYFAGLGVAAGEGGSRRQKIARAFEVSIAYENPLAQRLI
DGLSDIPGLTIHGITDRKRLADRVPTVSFTVDGIVPETIVRQMNAENIFLWSGHNYAWEIVHQLGIPAEQGVVRIGIAHY
NTAAEIDETLESVHRVIAMLRQQRS

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI156713448, Length=436, Percent_Identity=23.394495412844, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1787970, Length=430, Percent_Identity=27.6744186046512, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1789175, Length=422, Percent_Identity=27.4881516587678, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI48994898, Length=411, Percent_Identity=24.330900243309, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319831, Length=417, Percent_Identity=25.8992805755396, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 46583; Mature: 46583

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METMVDFPIEAVRGQFPALSLTDKGRRRIYLDNPAGTQVPQAVADAVSRCLLTTNANLGG
CCCCCCCCHHHHCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCC
YFETTIAAQSVVDDAHRAMADFLGAASPEEIIIGANMTTLTYHMSRTLGRTLKPGDEIIL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCEEE
TRMDHEGNVSPWLQLAEDLSLVVRWLPFDEKSWQVEEAALTGLLSDKTRLVALNYASNLT
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCC
GSINRVKALTAIAKRAGALVYVDAVQFAPHGLIDVQDLGCDLLICSAYKFFGPHMGILWG
CCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCEEHHHCCCCEEEEHHHHHHCCCCCHHCC
RREIIDGLKPYKCRCSSNGLPERFELGTPQIELMAGLMAAVDYFAGLGVAAGEGGSRRQK
HHHHHCCCCCCEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IARAFEVSIAYENPLAQRLIDGLSDIPGLTIHGITDRKRLADRVPTVSFTVDGIVPETIV
HHHHHHEEEEECCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCEEEEEECCCCHHHHH
RQMNAENIFLWSGHNYAWEIVHQLGIPAEQGVVRIGIAHYNTAAEIDETLESVHRVIAML
HHCCCCEEEEECCCCHHHHHHHHHCCCHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHH
RQQRS
HHHCC
>Mature Secondary Structure
METMVDFPIEAVRGQFPALSLTDKGRRRIYLDNPAGTQVPQAVADAVSRCLLTTNANLGG
CCCCCCCCHHHHCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCC
YFETTIAAQSVVDDAHRAMADFLGAASPEEIIIGANMTTLTYHMSRTLGRTLKPGDEIIL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHCCCCCCCCCEEE
TRMDHEGNVSPWLQLAEDLSLVVRWLPFDEKSWQVEEAALTGLLSDKTRLVALNYASNLT
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCC
GSINRVKALTAIAKRAGALVYVDAVQFAPHGLIDVQDLGCDLLICSAYKFFGPHMGILWG
CCHHHHHHHHHHHHHCCCEEEEEEHHHCCCCCEEHHHCCCCEEEEHHHHHHCCCCCHHCC
RREIIDGLKPYKCRCSSNGLPERFELGTPQIELMAGLMAAVDYFAGLGVAAGEGGSRRQK
HHHHHCCCCCCEEEECCCCCCCHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHH
IARAFEVSIAYENPLAQRLIDGLSDIPGLTIHGITDRKRLADRVPTVSFTVDGIVPETIV
HHHHHHEEEEECCHHHHHHHHHHHHCCCCEEECCCHHHHHHHHCCEEEEEECCCCHHHHH
RQMNAENIFLWSGHNYAWEIVHQLGIPAEQGVVRIGIAHYNTAAEIDETLESVHRVIAML
HHCCCCEEEEECCCCHHHHHHHHHCCCHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHH
RQQRS
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA