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The map label for this gene is purL

Identifier: 13470370

GI number: 13470370

Start: 42089

End: 44320

Strand: Reverse

Name: purL

Synonym: mll0057

Alternate gene names: 13470370

Gene position: 44320-42089 (Counterclockwise)

Preceding gene: 13470372

Following gene: 13470369

Centisome position: 0.63

GC content: 65.59

Gene sequence:

>2232_bases
ATGACCATTTCCAATTCCGTGCCGATCACCCCCGAGCTCATTGCCGCGCATGGGCTGAAGCCAGACGAGTATCAGCGCAT
CCTCGATCTCGTTGGGCGCGAACCGAGTTTTACCGAGCTCGGCATTTTCTCGGCGATGTGGAACGAGCACTGCTCCTACA
AATCCTCGAAGAAGTGGCTGCGCACACTGCCCACGACGGGGCCACAAGTTATCCAGGGGCCGGGCGAGAATGCCGGCGTG
GTCGACATCGGCGACGGCGATTGCGTCGTCTTCAAGATGGAAAGCCACAACCACCCCTCTTTCATCGAGCCCTACCAGGG
CGCGGCGACCGGCGTCGGCGGCATTTTGCGCGACGTCTTCACCATGGGCGCACGGCCGATCGCGGCGATGAATGCGCTGC
GCTTCGGCGCGCCTGACCACCCCAAGACCAGGCATCTCGTCGCCGGTGTGGTTTCAGGCGTCGGCGGTTACGGCAATTCC
TTCGGCGTGCCGACGGTAGGCGGTGAGGTCAACTTCGACGCCCGCTACAACGGCAACATCCTGGTCAACGCCTTCGCCGC
CGGCCTCGCCAAGACCAATGCCATCTTCCTGTCGGAAGCCAAGGGCGTCGGCCTGCCGGTCGTCTATCTCGGCGCCAAGA
CTGGCCGCGACGGCGTCGGCGGCGCCACCATGGCGTCGGCCGAGTTCGACGACAAGATCGACGAGAAGCGCCCGACCGTG
CAGGTCGGCGACCCTTTCACCGAAAAGTGCCTGCTCGAGGCCTGCCTCGAGCTGATGGCATCGGGCGCCGTCATCGCCAT
CCAGGACATGGGTGCGGCCGGCCTCACCTGCTCGGCGGTCGAGATGGGCGCCAAGGGCGATCTCGGCATCGAGCTCGACC
TCGACAAGGTGCCGGTGCGCGAGGAGCGCATGAGCGCCTATGAGATGATGCTGTCGGAAAGCCAGGAGCGCATGCTGATG
GTGCTGCGCCCCGAGAAGGAAAAGGAAGCCGAGGCGATCTTCCACAAATGGGGCCTCGACTTCGCCATTGTCGGCAAGAC
CACCGACGATCTGCGTTTTCGCGTGCTGCATCAGGGCGACCAGGTCGCCGATCTGCCGATCAAGGATCTCGGCGACAAGG
CGCCGGAATATGACCGCCCCTGGATCGAGCCGAAGAAGCCGGCACCGCTTGCCGCCAACGACATTCCGCAGGCCGATGTC
GCGGACGCGCTGCTGAAACTACTCGGCGGACCGGACCTGTCGTCGCGCCGCTGGGTCTGGGAGCAGTATGACACGCTGAT
TCAGGGCAATTCGCTGCAGCTTCCCGGCGGCGATGCCGGCGTGGTGCGGGTGGAAGGCCATGCGACCAAAGCGCTCGCCT
TCTCCTCGGATGTGACGCCGCGTTATTGCGAAGCCGATCCCTATGAAGGCGGCAAGCAGGCCGTGGCCGAATGCTGGCGC
AATCTCACCGCCACCGGCGCGCTGCCGCTGGCCGCGACCGACAACCTCAATTTCGGCAATCCGGAACGGCCCGAGATCAT
GGGCCAGCTGGTCGGCGCGGTGAAAGGCATCGGCGACGCCTGCCGCGCGCTCGGCTTCCCGATCGTGTCTGGCAATGTCT
CGCTCTACAACGAGACCAACGGCCAGGGCATCCTGCCGACACCGACCATCGGCGGCGTCGGGCTGATCGCCGACTGGTCG
AAGATGGTGCGCACCGGTTTTGCCGCGCAAGACCAGATGATCCTGCTGGTCGGCGCGCCCGCCTCCTGGGGCACGCATCT
TGGCCAGTCCGTCTATTTCAGGGACATCCATGGCCGCACCGACGGTCCGCCGCCGCCGGTCGACCTCGCGCATGAGAAGC
GCGTCGGCGACCACGTGCGCTCGCTGATCGCCTCCGGCATCGTCACCGCGGCGCATGACGTTTCAGATGGCGGTATCGCC
GTGGCGCTGGCCGAAATGGCGATGGCGTCGGGCATCGGCGCGACCGTTCCCGGCCTTGTCGGCACCGATCCCATCCCGGT
CTGGTTCGGCGAGGATCAGGGCCGCTATCTGCTGACACTGTCGATCGACCCGCATGGCGATGAATGGGACGCCATCCGCA
AGCAGCAGGGCGAACTCGGCATCTTCGCGCCGTGGATCGGCTCGACCGGAGGCGATGCGCTGAAGCTCGGCGATGCCAAG
GCGATCCCGGTCGGCGATCTGAAGGCCGCCCATGAAGGCTGGTTCCCCCGCTTCATGGACCAGGCCAGTTGA

Upstream 100 bases:

>100_bases
CTTTCTGTCTTTTTTCGCTCATCGACGGGTGTATCGGCCGCAAAGCTTGCGATAAGAGGGGACTCAAAATCCCCGCTCCC
ATGGACATAAATCGCCGCCC

Downstream 100 bases:

>100_bases
GCACACTGGCGGCCCGGGCGCTGCTTGCAGTCGTTTTCTGGCCGTCGCTGTTCTTCTTCTGGTTCCTCGGGCCGTTCGTC
TTTTTCCTGTTGTCGACGAC

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 743; Mature: 742

Protein sequence:

>743_residues
MTISNSVPITPELIAAHGLKPDEYQRILDLVGREPSFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVIQGPGENAGV
VDIGDGDCVVFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTRHLVAGVVSGVGGYGNS
FGVPTVGGEVNFDARYNGNILVNAFAAGLAKTNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDDKIDEKRPTV
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLM
VLRPEKEKEAEAIFHKWGLDFAIVGKTTDDLRFRVLHQGDQVADLPIKDLGDKAPEYDRPWIEPKKPAPLAANDIPQADV
ADALLKLLGGPDLSSRRWVWEQYDTLIQGNSLQLPGGDAGVVRVEGHATKALAFSSDVTPRYCEADPYEGGKQAVAECWR
NLTATGALPLAATDNLNFGNPERPEIMGQLVGAVKGIGDACRALGFPIVSGNVSLYNETNGQGILPTPTIGGVGLIADWS
KMVRTGFAAQDQMILLVGAPASWGTHLGQSVYFRDIHGRTDGPPPPVDLAHEKRVGDHVRSLIASGIVTAAHDVSDGGIA
VALAEMAMASGIGATVPGLVGTDPIPVWFGEDQGRYLLTLSIDPHGDEWDAIRKQQGELGIFAPWIGSTGGDALKLGDAK
AIPVGDLKAAHEGWFPRFMDQAS

Sequences:

>Translated_743_residues
MTISNSVPITPELIAAHGLKPDEYQRILDLVGREPSFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVIQGPGENAGV
VDIGDGDCVVFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTRHLVAGVVSGVGGYGNS
FGVPTVGGEVNFDARYNGNILVNAFAAGLAKTNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDDKIDEKRPTV
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLM
VLRPEKEKEAEAIFHKWGLDFAIVGKTTDDLRFRVLHQGDQVADLPIKDLGDKAPEYDRPWIEPKKPAPLAANDIPQADV
ADALLKLLGGPDLSSRRWVWEQYDTLIQGNSLQLPGGDAGVVRVEGHATKALAFSSDVTPRYCEADPYEGGKQAVAECWR
NLTATGALPLAATDNLNFGNPERPEIMGQLVGAVKGIGDACRALGFPIVSGNVSLYNETNGQGILPTPTIGGVGLIADWS
KMVRTGFAAQDQMILLVGAPASWGTHLGQSVYFRDIHGRTDGPPPPVDLAHEKRVGDHVRSLIASGIVTAAHDVSDGGIA
VALAEMAMASGIGATVPGLVGTDPIPVWFGEDQGRYLLTLSIDPHGDEWDAIRKQQGELGIFAPWIGSTGGDALKLGDAK
AIPVGDLKAAHEGWFPRFMDQAS
>Mature_742_residues
TISNSVPITPELIAAHGLKPDEYQRILDLVGREPSFTELGIFSAMWNEHCSYKSSKKWLRTLPTTGPQVIQGPGENAGVV
DIGDGDCVVFKMESHNHPSFIEPYQGAATGVGGILRDVFTMGARPIAAMNALRFGAPDHPKTRHLVAGVVSGVGGYGNSF
GVPTVGGEVNFDARYNGNILVNAFAAGLAKTNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDDKIDEKRPTVQ
VGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVREERMSAYEMMLSESQERMLMV
LRPEKEKEAEAIFHKWGLDFAIVGKTTDDLRFRVLHQGDQVADLPIKDLGDKAPEYDRPWIEPKKPAPLAANDIPQADVA
DALLKLLGGPDLSSRRWVWEQYDTLIQGNSLQLPGGDAGVVRVEGHATKALAFSSDVTPRYCEADPYEGGKQAVAECWRN
LTATGALPLAATDNLNFGNPERPEIMGQLVGAVKGIGDACRALGFPIVSGNVSLYNETNGQGILPTPTIGGVGLIADWSK
MVRTGFAAQDQMILLVGAPASWGTHLGQSVYFRDIHGRTDGPPPPVDLAHEKRVGDHVRSLIASGIVTAAHDVSDGGIAV
ALAEMAMASGIGATVPGLVGTDPIPVWFGEDQGRYLLTLSIDPHGDEWDAIRKQQGELGIFAPWIGSTGGDALKLGDAKA
IPVGDLKAAHEGWFPRFMDQAS

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Homo sapiens, GI31657129, Length=635, Percent_Identity=24.8818897637795, Blast_Score=100, Evalue=4e-21,
Organism=Escherichia coli, GI48994899, Length=763, Percent_Identity=25.9501965923984, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17553022, Length=674, Percent_Identity=22.4035608308605, Blast_Score=98, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=733, Percent_Identity=24.5566166439291, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24582111, Length=461, Percent_Identity=25.3796095444685, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24582109, Length=461, Percent_Identity=25.3796095444685, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137292, Length=461, Percent_Identity=25.3796095444685, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_RHILO (Q98NN7)

Other databases:

- EMBL:   BA000012
- RefSeq:   NP_101938.1
- ProteinModelPortal:   Q98NN7
- SMR:   Q98NN7
- GeneID:   1224601
- GenomeReviews:   BA000012_GR
- KEGG:   mlo:mll0057
- NMPDR:   fig|266835.1.peg.43
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- ProtClustDB:   PRK01213
- BRENDA:   6.3.5.3
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 78927; Mature: 78796

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTISNSVPITPELIAAHGLKPDEYQRILDLVGREPSFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
RTLPTTGPQVIQGPGENAGVVDIGDGDCVVFKMESHNHPSFIEPYQGAATGVGGILRDVF
HHCCCCCCCEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGAPDHPKTRHLVAGVVSGVGGYGNSFGVPTVGGEVNFDARYNGNI
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECEEECCCE
LVNAFAAGLAKTNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDDKIDEKRPTV
EEEEHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEECCCCCHHHHCCCCEE
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHHCCCCCCCEEEEECCCCCCH
EERMSAYEMMLSESQERMLMVLRPEKEKEAEAIFHKWGLDFAIVGKTTDDLRFRVLHQGD
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCC
QVADLPIKDLGDKAPEYDRPWIEPKKPAPLAANDIPQADVADALLKLLGGPDLSSRRWVW
CEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHH
EQYDTLIQGNSLQLPGGDAGVVRVEGHATKALAFSSDVTPRYCEADPYEGGKQAVAECWR
HHHHHHHCCCEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
NLTATGALPLAATDNLNFGNPERPEIMGQLVGAVKGIGDACRALGFPIVSGNVSLYNETN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCC
GQGILPTPTIGGVGLIADWSKMVRTGFAAQDQMILLVGAPASWGTHLGQSVYFRDIHGRT
CCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCCEEEEEEECCCC
DGPPPPVDLAHEKRVGDHVRSLIASGIVTAAHDVSDGGIAVALAEMAMASGIGATVPGLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GTDPIPVWFGEDQGRYLLTLSIDPHGDEWDAIRKQQGELGIFAPWIGSTGGDALKLGDAK
CCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCC
AIPVGDLKAAHEGWFPRFMDQAS
CCCCCCCHHHHCCCCHHHHHCCC
>Mature Secondary Structure 
TISNSVPITPELIAAHGLKPDEYQRILDLVGREPSFTELGIFSAMWNEHCSYKSSKKWL
CCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHH
RTLPTTGPQVIQGPGENAGVVDIGDGDCVVFKMESHNHPSFIEPYQGAATGVGGILRDVF
HHCCCCCCCEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHH
TMGARPIAAMNALRFGAPDHPKTRHLVAGVVSGVGGYGNSFGVPTVGGEVNFDARYNGNI
HHCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECEEECCCE
LVNAFAAGLAKTNAIFLSEAKGVGLPVVYLGAKTGRDGVGGATMASAEFDDKIDEKRPTV
EEEEHHHHHHHCCEEEEECCCCCCCEEEEEECCCCCCCCCCCEEECCCCCHHHHCCCCEE
QVGDPFTEKCLLEACLELMASGAVIAIQDMGAAGLTCSAVEMGAKGDLGIELDLDKVPVR
EECCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCEEHHHHCCCCCCCEEEEECCCCCCH
EERMSAYEMMLSESQERMLMVLRPEKEKEAEAIFHKWGLDFAIVGKTTDDLRFRVLHQGD
HHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEECCC
QVADLPIKDLGDKAPEYDRPWIEPKKPAPLAANDIPQADVADALLKLLGGPDLSSRRWVW
CEECCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHH
EQYDTLIQGNSLQLPGGDAGVVRVEGHATKALAFSSDVTPRYCEADPYEGGKQAVAECWR
HHHHHHHCCCEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHH
NLTATGALPLAATDNLNFGNPERPEIMGQLVGAVKGIGDACRALGFPIVSGNVSLYNETN
CCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEECCEEEEECCC
GQGILPTPTIGGVGLIADWSKMVRTGFAAQDQMILLVGAPASWGTHLGQSVYFRDIHGRT
CCEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHCCCEEEEEEECCCC
DGPPPPVDLAHEKRVGDHVRSLIASGIVTAAHDVSDGGIAVALAEMAMASGIGATVPGLV
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCC
GTDPIPVWFGEDQGRYLLTLSIDPHGDEWDAIRKQQGELGIFAPWIGSTGGDALKLGDAK
CCCCCEEEECCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEECCCCCCCCCEEEECCCC
AIPVGDLKAAHEGWFPRFMDQAS
CCCCCCCHHHHCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968