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The map label for this gene is hemC [H]

Identifier: 134302637

GI number: 134302637

Start: 1709904

End: 1710806

Strand: Direct

Name: hemC [H]

Synonym: FTW_1818

Alternate gene names: 134302637

Gene position: 1709904-1710806 (Clockwise)

Preceding gene: 134302636

Following gene: 134302638

Centisome position: 90.07

GC content: 34.44

Gene sequence:

>903_bases
ATGAAACAAATAACTATAGCTAGTCGAGAAAGTAAACTAGCATTATGGCAGACAAATTTTATCAAAAATCGTATCCAATC
AGAGCTAAACATTCCTTGTGAAATAAGTACTATGAAAACACAGGGAGATATTATTTTGGATCAACCACTAAACAAAATTG
GTGGTAAAGCACTATTTATGAAAGAGCTAGAAGTAGCAATGCTTAGTAATAAGGCTGATATTGCTGTACATTCTCTTAAA
GATGTTCCTTACCAATTACCGCAAGGTTTTTGTTTAGCAGGTTTTATGCCAAGAGAAGATCCTCGAGATGCTTTTGTATC
AAATAAATATAATTCTATTGATGATTTACCTAAAGGAGCTGTTGTTGGAACATCTAGTCTACGGCGAAAAGCGCAGCTTT
TGCACTATAGAGATGATCTTGAGATTAGAGATTTAAGAGGCAATATTCAAACTAGACTGTCTAAGCTTGATAATGGTGAT
TATGATGCGATTATTTTAGCTAGTGCTGGACTTATTCGCTTAGAGTTAGTTGAGAGAATAACTCAGTTTATCCCTGTAGA
AATATCTTTACCAGCGGTAGGTCAAGGTATAGTAGTTATAGAGGCATTAGAGAGAGATAATGACCTTTTAGAAAAAATAC
AAAAATTAAATTGTAGAGAAAGTTCTCGTGTAGCAACAGCTGAGAGAGCTTTTAATCAAGAATTAAAAGGTGGCTGTCAT
GTTGCAATAGGTGCTTATGCAGAATTAGATAATAATCAGATAACCTTGATGGCAATGGTTGCAAGTAGTGATGGTAAGAA
AATTCTCAAGCGAAAGATGATTGGGGATGATCCTACTAAACTTGGTAAATTGTTAGCTCAAGAGATGATAGCACTAGGTG
CATATAAAATATTGGAGAGTTAA

Upstream 100 bases:

>100_bases
GTTTTGCTAATGAATATAAACACTACGTAGGTATGCAGCATTCTGTATGTATGGAAGAAATAAAAGATATCTCAAACTTT
ATTGCAAAGACATTTAAAAT

Downstream 100 bases:

>100_bases
ATGGGACTTTTATTATTATTATTGGTAGGTATTGGTGGTGGTTTTGGTGCAATGGCAAGATTTGCATTGACTCAAGCAAC
CGCAAGTATTTCTAAGCAAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MKQITIASRESKLALWQTNFIKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLK
DVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGD
YDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES

Sequences:

>Translated_300_residues
MKQITIASRESKLALWQTNFIKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLK
DVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGD
YDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
>Mature_300_residues
MKQITIASRESKLALWQTNFIKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFMKELEVAMLSNKADIAVHSLK
DVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGAVVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGD
YDAIILASAGLIRLELVERITQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=278, Percent_Identity=41.3669064748201, Blast_Score=194, Evalue=8e-50,
Organism=Homo sapiens, GI20149500, Length=278, Percent_Identity=41.3669064748201, Blast_Score=194, Evalue=9e-50,
Organism=Escherichia coli, GI48994974, Length=298, Percent_Identity=54.6979865771812, Blast_Score=309, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6319996, Length=314, Percent_Identity=40.1273885350318, Blast_Score=199, Evalue=3e-52,
Organism=Drosophila melanogaster, GI20130425, Length=279, Percent_Identity=41.5770609318996, Blast_Score=186, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33321; Mature: 33321

Theoretical pI: Translated: 7.94; Mature: 7.94

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQITIASRESKLALWQTNFIKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFM
CCCEEEECCCCCEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHCCCEEHH
KELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGA
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCHHCCCCCC
VVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERI
EECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
TQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
HHHCCEEEECCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEE
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
EEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQITIASRESKLALWQTNFIKNRIQSELNIPCEISTMKTQGDIILDQPLNKIGGKALFM
CCCEEEECCCCCEEEHHHHHHHHHHHHHCCCCEEEEEECCCCCEEECCCHHHHCCCEEHH
KELEVAMLSNKADIAVHSLKDVPYQLPQGFCLAGFMPREDPRDAFVSNKYNSIDDLPKGA
HHHHHHHHCCCCHHHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHCCCCCCHHCCCCCC
VVGTSSLRRKAQLLHYRDDLEIRDLRGNIQTRLSKLDNGDYDAIILASAGLIRLELVERI
EECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHH
TQFIPVEISLPAVGQGIVVIEALERDNDLLEKIQKLNCRESSRVATAERAFNQELKGGCH
HHHCCEEEECCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEE
VAIGAYAELDNNQITLMAMVASSDGKKILKRKMIGDDPTKLGKLLAQEMIALGAYKILES
EEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA