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The map label for this gene is ksgA [H]

Identifier: 134302453

GI number: 134302453

Start: 1503864

End: 1504652

Strand: Reverse

Name: ksgA [H]

Synonym: FTW_1601

Alternate gene names: 134302453

Gene position: 1504652-1503864 (Counterclockwise)

Preceding gene: 134302454

Following gene: 134302452

Centisome position: 79.26

GC content: 31.18

Gene sequence:

>789_bases
ATGCAATATAAGACAAAAGCAAAGAAATCGCTAGGGCAGAATTTTCTTCAAGATGAGAATATAATTCGTAAGATTGTTCA
GCTAGCTAATATAAAAAAGCACGATATAGTTGTCGAGATCGGACCAGGATTAGGTGCTCTGACAAGATATTTGCTTTCTA
GTAGTAATAATGTCAGTGTTGTTGAGTTTGATGCGAGCGTTATCGATACGCTAATAGCAAATTGCCAAAAATATGGAACT
CCACATATATATAATCAAGACTTTTTAAAATTTGATATTTCTTCTCTAGAGAATTCATCAAATCAAAAAATAAAATTAAT
AGGTAATCTCCCTTATAACATATCTTCACCAATTCTTTTTAAGGTAATCAAAGACAGTGATAAAATTGTTGATGCACATT
TTATGCTACAAAAAGAAGTTGTTGAAAGAATAGTTTCTTTACCTAACAGTAAATCATACGGAAGGTTGTCAGTGATATTA
CAGTATCATTTTGATTGTAGTATGATTTTAAAGATTCCTCCCGAAGTTTTTTACCCACAGCCTAAAGTTGACTCGGCTAT
TTTACGTCTTAAACCTAAAAATAGTAAAGAATTGTTAAAAAACTACAATTTTTTTGAAGAAATTGTCAAACAAAGCTTTG
CGCAACGCAGAAAAACTTTGCATAATAACTTAAAGAGTATATTAAAAGAGCGAAAGATTGATCCTAGCACACTGCCGGTA
GATACTAATCTTAGAGCAGAGAATTTAAGTGTTGGAGATTTTGTCAGCTTAGCAAACTTTTTAAGTTAA

Upstream 100 bases:

>100_bases
AAAGCTCAAGAGATTTATAAAACTTGGTTAACGTCGATGAAAGATGATGCGTATATTGAAATACTTGAAGATGATTTAAA
AACACCTGAACTTTACTAAA

Downstream 100 bases:

>100_bases
GGCATAACAAAATGGCTACATATGTTATCGGCGACGTACAGGGCTGTTACGATGAACTGCAATTATTACTACAAAAGATA
AATTTTGATATACAAAAAGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MQYKTKAKKSLGQNFLQDENIIRKIVQLANIKKHDIVVEIGPGLGALTRYLLSSSNNVSVVEFDASVIDTLIANCQKYGT
PHIYNQDFLKFDISSLENSSNQKIKLIGNLPYNISSPILFKVIKDSDKIVDAHFMLQKEVVERIVSLPNSKSYGRLSVIL
QYHFDCSMILKIPPEVFYPQPKVDSAILRLKPKNSKELLKNYNFFEEIVKQSFAQRRKTLHNNLKSILKERKIDPSTLPV
DTNLRAENLSVGDFVSLANFLS

Sequences:

>Translated_262_residues
MQYKTKAKKSLGQNFLQDENIIRKIVQLANIKKHDIVVEIGPGLGALTRYLLSSSNNVSVVEFDASVIDTLIANCQKYGT
PHIYNQDFLKFDISSLENSSNQKIKLIGNLPYNISSPILFKVIKDSDKIVDAHFMLQKEVVERIVSLPNSKSYGRLSVIL
QYHFDCSMILKIPPEVFYPQPKVDSAILRLKPKNSKELLKNYNFFEEIVKQSFAQRRKTLHNNLKSILKERKIDPSTLPV
DTNLRAENLSVGDFVSLANFLS
>Mature_262_residues
MQYKTKAKKSLGQNFLQDENIIRKIVQLANIKKHDIVVEIGPGLGALTRYLLSSSNNVSVVEFDASVIDTLIANCQKYGT
PHIYNQDFLKFDISSLENSSNQKIKLIGNLPYNISSPILFKVIKDSDKIVDAHFMLQKEVVERIVSLPNSKSYGRLSVIL
QYHFDCSMILKIPPEVFYPQPKVDSAILRLKPKNSKELLKNYNFFEEIVKQSFAQRRKTLHNNLKSILKERKIDPSTLPV
DTNLRAENLSVGDFVSLANFLS

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=281, Percent_Identity=30.2491103202847, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI7657198, Length=222, Percent_Identity=31.981981981982, Blast_Score=111, Evalue=7e-25,
Organism=Escherichia coli, GI1786236, Length=259, Percent_Identity=40.5405405405405, Blast_Score=203, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI25141369, Length=296, Percent_Identity=29.3918918918919, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI25146882, Length=216, Percent_Identity=32.8703703703704, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324989, Length=221, Percent_Identity=31.2217194570136, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21357273, Length=243, Percent_Identity=32.0987654320988, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI21358017, Length=222, Percent_Identity=31.5315315315315, Blast_Score=112, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 29831; Mature: 29831

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQYKTKAKKSLGQNFLQDENIIRKIVQLANIKKHDIVVEIGPGLGALTRYLLSSSNNVSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCEEE
VEFDASVIDTLIANCQKYGTPHIYNQDFLKFDISSLENSSNQKIKLIGNLPYNISSPILF
EEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHH
KVIKDSDKIVDAHFMLQKEVVERIVSLPNSKSYGRLSVILQYHFDCSMILKIPPEVFYPQ
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCHHHCCCC
PKVDSAILRLKPKNSKELLKNYNFFEEIVKQSFAQRRKTLHNNLKSILKERKIDPSTLPV
CCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DTNLRAENLSVGDFVSLANFLS
CCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MQYKTKAKKSLGQNFLQDENIIRKIVQLANIKKHDIVVEIGPGLGALTRYLLSSSNNVSV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCCCCEEE
VEFDASVIDTLIANCQKYGTPHIYNQDFLKFDISSLENSSNQKIKLIGNLPYNISSPILF
EEECHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHH
KVIKDSDKIVDAHFMLQKEVVERIVSLPNSKSYGRLSVILQYHFDCSMILKIPPEVFYPQ
EEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEEEEECCHHHCCCC
PKVDSAILRLKPKNSKELLKNYNFFEEIVKQSFAQRRKTLHNNLKSILKERKIDPSTLPV
CCCCCCEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
DTNLRAENLSVGDFVSLANFLS
CCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA