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The map label for this gene is aas [H]

Identifier: 134302413

GI number: 134302413

Start: 1454192

End: 1456291

Strand: Reverse

Name: aas [H]

Synonym: FTW_1549

Alternate gene names: 134302413

Gene position: 1456291-1454192 (Counterclockwise)

Preceding gene: 134302416

Following gene: 134302412

Centisome position: 76.71

GC content: 33.0

Gene sequence:

>2100_bases
ATGCGTTTAAAAAAGCTTAAATCTTCAATACATAAAAGACTAAATCAGCGTTATATATATGATTGTAATAAAAACATAAA
TTTTGCAAACTTTAAAAATGGCTCAATAATTGTTGCTAATGATACCACTATAGTTACAGTATTAGCATTAAAAACTTACC
TTGAAGATAAGTATATTACCGTTTTAGGGGCTTTTGATGATAGGGCTAAAGGTCTAGAGAAGGTTATGGGTAGGATTGGT
ATTAAGTATATCGATCATATTAGCTTTTGGGATCATCAGGGCGTACTACTAGTCAATAAAAATTTAACATCTCAAGTTGA
GCAGAGCGAAAATAGGTTTATATTATTTATATGTGGACCAGAAATGCCATACTTTTCACAACGAAGAAATTTAGACAGAC
AAATCTATTTTGATATTGCTAAGCTAGAAAACCTTAGGTGCTTGAATGAAGAGATGGAGAATCTTTCTGTTAAAACATGG
GAAGGATATCTAAATGAACTCAAAGCGCCTGCAGAAATATGGTTTAGGCAGATGCTTAATGCTAAAAATAATTTAGTGTT
GACAGATACAACGGGTGTTGTATTAGATGGCTATAAGTTTGTTACCGGTGCGGTATTGATGTCTAAAAAACTTCAAGAAA
TTACCCAGCAAGAGGATAATGTCGGTGTATGTTTACCAACAAGCGGTGGCGGTTATTTAGCAATTTTAGCACTGATGATG
AGTGCTAAAGCAATAGTTAATCTAAATTACACTGCTTCTGAAGAGGCGTTAAGACATTCTATTAACAATGCTGGAATAAA
AACTATTATTACCTCAAAAGCATTTGTGGAGAAGTTAACACATAAAGGTTTCTTTGTTGAAGAAGTTTTTTCGATGTGTA
AGATTGTTTATCTTGAGGATATAAGGGCTAAGATTACTAAGTCAGAAGGTATAAAAACATTTTTAGAAATTAAAATTTTA
CCTGCTTCATGGTTAGTCAAAAAGTATCTCAAACCAACTAAGCTAGATGATGTTTCATTTATAATATTTAGTAGTGGTAG
CGAGGCTGTGCCTAAGGGTATAGTTATAAAAAATAAAAACCTCTTAGCAAATGTATATCAAAGTACAAATGTTATTGAAT
GTAAGGAAAATGATTCTGTAGCAGGGATATTGCCAATATTTCATGCGTTTGGACTTACTATTTCATTGGTATCATTATTT
CAAGGTGGTTATATTGCGTGTCATCCAGATCCAACTGATGCAAAGGGTGTTGCAAACTTGATTAGAAAAAATAAAAATAC
AGTACTATGTGCTACACCAACATTTTTACGAATTTACACTAAGAATAAGTCGGTTAACAAAGAAGACTTTGCTACTCTTA
GGCTAATTATTACAGGCGCTGAGAAGCTTTCAAGAGAAGTCCGTACAATGTTTGAAGATAAATTTGATAAAGTTATTAAC
GAAGGCTATGGTACTACTGAGCTTTCACCTGTTGCTGCAGTTAATAGACCAACTAAATCACCAAATAAAATAGGTACTGT
TGGGCTAACGGTACCGGGTGGACAGTTTAAGATCATTCATCCTGAATCGCATGAAGAGCTTCCAGTCGGGGTTGAGGGTA
TGATTATATACAGGGGTGTTAATAAGATGGATTATTACCTTAATGATCTTAAAAAGACTAATGAAGTGATGATACAAAAA
TATGGTCATACATGGTACATAACTGGAGATAAGGGTAAAATTGATGGAGAAGGTTATTTAACAGTTGTTGATAGGTATTC
TAGATTTGCTAAAGTTGCTGGTGAGATGGTAAGTTTAGGTTTACTTGAGCAAAAAGTTTATGATGCTTTAAGAGAAAAGG
GTTATGATTCTAACAAGATAGATTTTGAGGTTTTAGCAGTAGCTACTTCAGATACCAAAAGAGGCGAGATAATTAGTTTA
CTTTATACCCTAGAAGTACTTGAACCATCTGACCTTAAAGAGATTGTAAGACATTCTGGTATAGAGAATTTGTATAAGCC
AACAAACTATTTTAAAGTTATATCTATACCTAAACTTGGTTCTGGTAAAACTGATTTTTCAAAAGCTAAGAAGTTAACTA
ATGAATTAGTTAAGGCATAG

Upstream 100 bases:

>100_bases
CAGGCATAAAATGATTTTATTATAAAAATTAAAGTGAGTATATGATAACATAGTATCTTATCTATAAGCTTACTATTTAT
GATTTGATACTGGTAGGAAA

Downstream 100 bases:

>100_bases
TTTAGATGCATTATTCAGTATTGTTGCAAGAGTCTATTAATGATTTAAATATTAATCCTCAAGGTATTTATATCGATGCA
ACCTTTGGTAGAGGTGGACA

Product: AMP binding protein

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 699; Mature: 699

Protein sequence:

>699_residues
MRLKKLKSSIHKRLNQRYIYDCNKNINFANFKNGSIIVANDTTIVTVLALKTYLEDKYITVLGAFDDRAKGLEKVMGRIG
IKYIDHISFWDHQGVLLVNKNLTSQVEQSENRFILFICGPEMPYFSQRRNLDRQIYFDIAKLENLRCLNEEMENLSVKTW
EGYLNELKAPAEIWFRQMLNAKNNLVLTDTTGVVLDGYKFVTGAVLMSKKLQEITQQEDNVGVCLPTSGGGYLAILALMM
SAKAIVNLNYTASEEALRHSINNAGIKTIITSKAFVEKLTHKGFFVEEVFSMCKIVYLEDIRAKITKSEGIKTFLEIKIL
PASWLVKKYLKPTKLDDVSFIIFSSGSEAVPKGIVIKNKNLLANVYQSTNVIECKENDSVAGILPIFHAFGLTISLVSLF
QGGYIACHPDPTDAKGVANLIRKNKNTVLCATPTFLRIYTKNKSVNKEDFATLRLIITGAEKLSREVRTMFEDKFDKVIN
EGYGTTELSPVAAVNRPTKSPNKIGTVGLTVPGGQFKIIHPESHEELPVGVEGMIIYRGVNKMDYYLNDLKKTNEVMIQK
YGHTWYITGDKGKIDGEGYLTVVDRYSRFAKVAGEMVSLGLLEQKVYDALREKGYDSNKIDFEVLAVATSDTKRGEIISL
LYTLEVLEPSDLKEIVRHSGIENLYKPTNYFKVISIPKLGSGKTDFSKAKKLTNELVKA

Sequences:

>Translated_699_residues
MRLKKLKSSIHKRLNQRYIYDCNKNINFANFKNGSIIVANDTTIVTVLALKTYLEDKYITVLGAFDDRAKGLEKVMGRIG
IKYIDHISFWDHQGVLLVNKNLTSQVEQSENRFILFICGPEMPYFSQRRNLDRQIYFDIAKLENLRCLNEEMENLSVKTW
EGYLNELKAPAEIWFRQMLNAKNNLVLTDTTGVVLDGYKFVTGAVLMSKKLQEITQQEDNVGVCLPTSGGGYLAILALMM
SAKAIVNLNYTASEEALRHSINNAGIKTIITSKAFVEKLTHKGFFVEEVFSMCKIVYLEDIRAKITKSEGIKTFLEIKIL
PASWLVKKYLKPTKLDDVSFIIFSSGSEAVPKGIVIKNKNLLANVYQSTNVIECKENDSVAGILPIFHAFGLTISLVSLF
QGGYIACHPDPTDAKGVANLIRKNKNTVLCATPTFLRIYTKNKSVNKEDFATLRLIITGAEKLSREVRTMFEDKFDKVIN
EGYGTTELSPVAAVNRPTKSPNKIGTVGLTVPGGQFKIIHPESHEELPVGVEGMIIYRGVNKMDYYLNDLKKTNEVMIQK
YGHTWYITGDKGKIDGEGYLTVVDRYSRFAKVAGEMVSLGLLEQKVYDALREKGYDSNKIDFEVLAVATSDTKRGEIISL
LYTLEVLEPSDLKEIVRHSGIENLYKPTNYFKVISIPKLGSGKTDFSKAKKLTNELVKA
>Mature_699_residues
MRLKKLKSSIHKRLNQRYIYDCNKNINFANFKNGSIIVANDTTIVTVLALKTYLEDKYITVLGAFDDRAKGLEKVMGRIG
IKYIDHISFWDHQGVLLVNKNLTSQVEQSENRFILFICGPEMPYFSQRRNLDRQIYFDIAKLENLRCLNEEMENLSVKTW
EGYLNELKAPAEIWFRQMLNAKNNLVLTDTTGVVLDGYKFVTGAVLMSKKLQEITQQEDNVGVCLPTSGGGYLAILALMM
SAKAIVNLNYTASEEALRHSINNAGIKTIITSKAFVEKLTHKGFFVEEVFSMCKIVYLEDIRAKITKSEGIKTFLEIKIL
PASWLVKKYLKPTKLDDVSFIIFSSGSEAVPKGIVIKNKNLLANVYQSTNVIECKENDSVAGILPIFHAFGLTISLVSLF
QGGYIACHPDPTDAKGVANLIRKNKNTVLCATPTFLRIYTKNKSVNKEDFATLRLIITGAEKLSREVRTMFEDKFDKVIN
EGYGTTELSPVAAVNRPTKSPNKIGTVGLTVPGGQFKIIHPESHEELPVGVEGMIIYRGVNKMDYYLNDLKKTNEVMIQK
YGHTWYITGDKGKIDGEGYLTVVDRYSRFAKVAGEMVSLGLLEQKVYDALREKGYDSNKIDFEVLAVATSDTKRGEIISL
LYTLEVLEPSDLKEIVRHSGIENLYKPTNYFKVISIPKLGSGKTDFSKAKKLTNELVKA

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI57165412, Length=413, Percent_Identity=25.4237288135593, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI38505220, Length=502, Percent_Identity=23.5059760956175, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI156151445, Length=470, Percent_Identity=22.7659574468085, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI42544132, Length=494, Percent_Identity=22.8744939271255, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789201, Length=508, Percent_Identity=32.6771653543307, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI1788107, Length=448, Percent_Identity=24.7767857142857, Blast_Score=116, Evalue=5e-27,
Organism=Escherichia coli, GI145693145, Length=355, Percent_Identity=23.943661971831, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI221142682, Length=388, Percent_Identity=25, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17558820, Length=262, Percent_Identity=31.2977099236641, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=422, Percent_Identity=23.9336492890995, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994690, Length=422, Percent_Identity=23.9336492890995, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71994703, Length=422, Percent_Identity=23.9336492890995, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25147511, Length=466, Percent_Identity=25.1072961373391, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=283, Percent_Identity=25.4416961130742, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=251, Percent_Identity=30.2788844621514, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=330, Percent_Identity=24.8484848484848, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=501, Percent_Identity=24.1516966067864, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=506, Percent_Identity=24.3083003952569, Blast_Score=73, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17560140, Length=284, Percent_Identity=23.943661971831, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6319699, Length=487, Percent_Identity=24.0246406570842, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI21355181, Length=409, Percent_Identity=27.1393643031785, Blast_Score=108, Evalue=2e-23,
Organism=Drosophila melanogaster, GI18859661, Length=407, Percent_Identity=24.8157248157248, Blast_Score=105, Evalue=1e-22,
Organism=Drosophila melanogaster, GI62471681, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI62471687, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24586634, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI22026970, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI62471689, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI62471679, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI62471683, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI62471685, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24586636, Length=469, Percent_Identity=24.0938166311301, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24648260, Length=549, Percent_Identity=22.4043715846995, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21356441, Length=270, Percent_Identity=24.4444444444444, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24581924, Length=453, Percent_Identity=21.8543046357616, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281365686, Length=267, Percent_Identity=25.0936329588015, Blast_Score=69, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21358303, Length=270, Percent_Identity=24.8148148148148, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 78616; Mature: 78616

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLKKLKSSIHKRLNQRYIYDCNKNINFANFKNGSIIVANDTTIVTVLALKTYLEDKYIT
CCHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCEEEEECCCCEEHHHHHHHHHCCCEEE
VLGAFDDRAKGLEKVMGRIGIKYIDHISFWDHQGVLLVNKNLTSQVEQSENRFILFICGP
EEECCCHHHHHHHHHHHHHCHHHHHHCCEECCCCEEEECCCCHHHHHCCCCCEEEEEECC
EMPYFSQRRNLDRQIYFDIAKLENLRCLNEEMENLSVKTWEGYLNELKAPAEIWFRQMLN
CCCCHHHHCCCCHHEEEEHHHHHHHHHHHHHHHCCEEEHHHHHHHHCCCHHHHHHHHHHC
AKNNLVLTDTTGVVLDGYKFVTGAVLMSKKLQEITQQEDNVGVCLPTSGGGYLAILALMM
CCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
SAKAIVNLNYTASEEALRHSINNAGIKTIITSKAFVEKLTHKGFFVEEVFSMCKIVYLED
CCHHEEEECCCCHHHHHHHHHCCCCHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IRAKITKSEGIKTFLEIKILPASWLVKKYLKPTKLDDVSFIIFSSGSEAVPKGIVIKNKN
HHHHHHHCCCCEEEEEEEEECHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEECCC
LLANVYQSTNVIECKENDSVAGILPIFHAFGLTISLVSLFQGGYIACHPDPTDAKGVANL
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
IRKNKNTVLCATPTFLRIYTKNKSVNKEDFATLRLIITGAEKLSREVRTMFEDKFDKVIN
HHCCCCEEEEECCCEEEEEECCCCCCHHHHHEEEEEEECHHHHHHHHHHHHHHHHHHHHH
EGYGTTELSPVAAVNRPTKSPNKIGTVGLTVPGGQFKIIHPESHEELPVGVEGMIIYRGV
CCCCCCCCCCHHHCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEECC
NKMDYYLNDLKKTNEVMIQKYGHTWYITGDKGKIDGEGYLTVVDRYSRFAKVAGEMVSLG
CHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
LLEQKVYDALREKGYDSNKIDFEVLAVATSDTKRGEIISLLYTLEVLEPSDLKEIVRHSG
HHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCHHEEEEHHHHHCCCCHHHHHHHHCC
IENLYKPTNYFKVISIPKLGSGKTDFSKAKKLTNELVKA
HHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRLKKLKSSIHKRLNQRYIYDCNKNINFANFKNGSIIVANDTTIVTVLALKTYLEDKYIT
CCHHHHHHHHHHHHCCCEEEECCCCCCEEEECCCEEEEECCCCEEHHHHHHHHHCCCEEE
VLGAFDDRAKGLEKVMGRIGIKYIDHISFWDHQGVLLVNKNLTSQVEQSENRFILFICGP
EEECCCHHHHHHHHHHHHHCHHHHHHCCEECCCCEEEECCCCHHHHHCCCCCEEEEEECC
EMPYFSQRRNLDRQIYFDIAKLENLRCLNEEMENLSVKTWEGYLNELKAPAEIWFRQMLN
CCCCHHHHCCCCHHEEEEHHHHHHHHHHHHHHHCCEEEHHHHHHHHCCCHHHHHHHHHHC
AKNNLVLTDTTGVVLDGYKFVTGAVLMSKKLQEITQQEDNVGVCLPTSGGGYLAILALMM
CCCCEEEEECCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
SAKAIVNLNYTASEEALRHSINNAGIKTIITSKAFVEKLTHKGFFVEEVFSMCKIVYLED
CCHHEEEECCCCHHHHHHHHHCCCCHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
IRAKITKSEGIKTFLEIKILPASWLVKKYLKPTKLDDVSFIIFSSGSEAVPKGIVIKNKN
HHHHHHHCCCCEEEEEEEEECHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEECCC
LLANVYQSTNVIECKENDSVAGILPIFHAFGLTISLVSLFQGGYIACHPDPTDAKGVANL
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
IRKNKNTVLCATPTFLRIYTKNKSVNKEDFATLRLIITGAEKLSREVRTMFEDKFDKVIN
HHCCCCEEEEECCCEEEEEECCCCCCHHHHHEEEEEEECHHHHHHHHHHHHHHHHHHHHH
EGYGTTELSPVAAVNRPTKSPNKIGTVGLTVPGGQFKIIHPESHEELPVGVEGMIIYRGV
CCCCCCCCCCHHHCCCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCCCCCCEEEEECC
NKMDYYLNDLKKTNEVMIQKYGHTWYITGDKGKIDGEGYLTVVDRYSRFAKVAGEMVSLG
CHHHHHHHHHHHHHHHHHEECCCEEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHH
LLEQKVYDALREKGYDSNKIDFEVLAVATSDTKRGEIISLLYTLEVLEPSDLKEIVRHSG
HHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCHHEEEEHHHHHCCCCHHHHHHHHCC
IENLYKPTNYFKVISIPKLGSGKTDFSKAKKLTNELVKA
HHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA