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The map label for this gene is cbh [H]

Identifier: 134302314

GI number: 134302314

Start: 1327731

End: 1328699

Strand: Direct

Name: cbh [H]

Synonym: FTW_1419

Alternate gene names: 134302314

Gene position: 1327731-1328699 (Clockwise)

Preceding gene: 134302313

Following gene: 134302315

Centisome position: 69.94

GC content: 32.71

Gene sequence:

>969_bases
ATGCTTAAGAAAATACTAATAACTCCTTTAATTATACTATCATTTCTACAGTTTAGCTTTGGATGTACTTGGTTTAGCTT
TGAAAATGATAAGGGACATTATTTTATTGGCAGAACTATGGAATGGCCTGGCGATTTAAATACTAAAATCACCTTAGTAC
CAAGAGGATATAAGTTTGGAAACTTTACAACTCACTATGGCTTTGTAGGTATGAGTCATAATGGTAATTTTAGTGATGGT
ATGAATGAATATAGTCTAGCAGTAAGCGCTCTTTGGCTTAGTGGTAGTAAATATCCTGATAAAAAAGATGCTGACTATAA
TATTACTATGCTATTGCCATATGTTTTAGGTAATACCACAACAGTTACGCAAGCTGTAGAATTCATCAAGAAACACAAGT
TCTACACTTCTGTATTACCAGAGATCTCAGATAAAGTTGAAATTACAGTACATTTTGCGATTAGTGATGCTCAGGGTAAT
TCTGTAGTAGTTGAGTTTATAAATGGTAAAACCAAAATTTATGATAATAAAATTAAAGTTCTTACCAATGATCCTGCTTA
TGACGAACAGCTTAAATTACTCAAAAAATATCAAGATCGTGAAATTAAAGAAGATAAATTTATCGCTTTTGATTATTCAC
CTCAAGGTCGCTTTGCAAAAATGGTAGCTTTTAATACTACTAAAGCAAATACACCAGATGATTTAACAGCTGTAAATCAT
GCTTGGTCAATGATCAATACTGTAGATATACCACAGGGTTCTCTATATTGGCGATGGGTAAGCTCTAAGCCACAGTTTAC
CTCATACTCTGTAGTTGATGACCTTAGCAATCGTATTTACTATTTCCGTACTTGGGATAATTATGATATCCGTAAAGTTG
ATCTTAGTAAGATAGATTTTGCCAAAGCCAAATATCAAGCAGATACAATCTTTGGACAAGCCGACTATCAAGAGTTTAAA
TTCAAATAG

Upstream 100 bases:

>100_bases
TCGATAAGATAACTTTTTAAAAAAATCAAAACATGGCTATATAAATTACTCTATCTATATGTATAATAATCAATAATTAT
CATTTAAAAAAATATTTAAA

Downstream 100 bases:

>100_bases
TTTTCTATATCAATTTGTCAAATAGTACATTTCTCTACTTTTTGTATATAGTTTTAGTTATATAAAATTTGTCTATTTTG
CTAAGTTACAAATCATCGTA

Product: linear amide C-N hydrolase, choloylglycine hydrolase family protein

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDG
MNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTTTVTQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGN
SVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQDREIKEDKFIAFDYSPQGRFAKMVAFNTTKANTPDDLTAVNH
AWSMINTVDIPQGSLYWRWVSSKPQFTSYSVVDDLSNRIYYFRTWDNYDIRKVDLSKIDFAKAKYQADTIFGQADYQEFK
FK

Sequences:

>Translated_322_residues
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDG
MNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTTTVTQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGN
SVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQDREIKEDKFIAFDYSPQGRFAKMVAFNTTKANTPDDLTAVNH
AWSMINTVDIPQGSLYWRWVSSKPQFTSYSVVDDLSNRIYYFRTWDNYDIRKVDLSKIDFAKAKYQADTIFGQADYQEFK
FK
>Mature_322_residues
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFGNFTTHYGFVGMSHNGNFSDG
MNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTTTVTQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGN
SVVVEFINGKTKIYDNKIKVLTNDPAYDEQLKLLKKYQDREIKEDKFIAFDYSPQGRFAKMVAFNTTKANTPDDLTAVNH
AWSMINTVDIPQGSLYWRWVSSKPQFTSYSVVDDLSNRIYYFRTWDNYDIRKVDLSKIDFAKAKYQADTIFGQADYQEFK
FK

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 37205; Mature: 37205

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFG
CCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCC
NFTTHYGFVGMSHNGNFSDGMNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTT
CEEEEEEEEEECCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCEEEEEEEEEHHCCCH
TVTQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGNSVVVEFINGKTKIYDNKIKV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEECCCEEEECCEEEE
LTNDPAYDEQLKLLKKYQDREIKEDKFIAFDYSPQGRFAKMVAFNTTKANTPDDLTAVNH
EECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHH
AWSMINTVDIPQGSLYWRWVSSKPQFTSYSVVDDLSNRIYYFRTWDNYDIRKVDLSKIDF
HHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECCHHHH
AKAKYQADTIFGQADYQEFKFK
HHHHEEHHEEECCCCCHHCCCC
>Mature Secondary Structure
MLKKILITPLIILSFLQFSFGCTWFSFENDKGHYFIGRTMEWPGDLNTKITLVPRGYKFG
CCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCEEEEEEEECCCCCCCEEEEEECCCCCC
NFTTHYGFVGMSHNGNFSDGMNEYSLAVSALWLSGSKYPDKKDADYNITMLLPYVLGNTT
CEEEEEEEEEECCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCEEEEEEEEEHHCCCH
TVTQAVEFIKKHKFYTSVLPEISDKVEITVHFAISDAQGNSVVVEFINGKTKIYDNKIKV
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCCCCEEEEEEECCCEEEECCEEEE
LTNDPAYDEQLKLLKKYQDREIKEDKFIAFDYSPQGRFAKMVAFNTTKANTPDDLTAVNH
EECCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCEEEEEEEECCCCCCCCHHHHHHH
AWSMINTVDIPQGSLYWRWVSSKPQFTSYSVVDDLSNRIYYFRTWDNYDIRKVDLSKIDF
HHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHCCEEEEEECCCCCEEEEECCHHHH
AKAKYQADTIFGQADYQEFKFK
HHHHEEHHEEECCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]