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The map label for this gene is fkpB [H]

Identifier: 134302266

GI number: 134302266

Start: 1271384

End: 1271848

Strand: Reverse

Name: fkpB [H]

Synonym: FTW_1354

Alternate gene names: 134302266

Gene position: 1271848-1271384 (Counterclockwise)

Preceding gene: 134302274

Following gene: 134302265

Centisome position: 66.99

GC content: 34.19

Gene sequence:

>465_bases
ATGAAAATCGCATCAGATAGTTTTGTAAAAATGCACTTTAAATTTAGACTTAAAGATGGCTCAATTGCTGAAGATACAGA
AAATTATAATAGACCTTTTGTATTTCAGATGGGTCAGGGTTGTTTTACTGAGAAAGTCGAGAATGAGCTTGTTGGGACAA
CGATTGGTGAAACTAAAAGGGTAGTTTTAATGCCAGAAGAGGCTTTTGGCGAGAAACATCCTGCAAGTATCTATTCAGTG
CCTAAATATAGATTTCCTAAAGATATGCACTTAGAAGAAGGACTTATAGTTTCTTTTAGTCAAAAAGATGGCTCTAAGTT
GCCAGGATTGATTACAGAAATTAATGAGCAAGATGTTACCGTAGATTTTAATCATCCATTATCAGGACAGATAATCGTAT
TTGAAGCTAAAATTTTAGATGTGGCTGAGAAAGAGGAGGATTTAGGTGAAGATATTACTAGCTAA

Upstream 100 bases:

>100_bases
TAATCTGTTAATATAAAAAATCGATGGCGATGCAAACAAAAGATGACTAAAACTTCTAAATATGGTATCTTGGACTCCAA
AAACTATATAAGTAAATAGC

Downstream 100 bases:

>100_bases
TCCCAGGGGCTTTTGTGCCGGTGTAAGTCGTGCTGTTGAGACTGTAGAGAAAGTTTTAGAAGTTGAGAAGTCGCCTGTAT
ATGTGCGTCATGAGGTCGTA

Product: peptidyl-prolyl cis-trans isomerase, FKBP-type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MKIASDSFVKMHFKFRLKDGSIAEDTENYNRPFVFQMGQGCFTEKVENELVGTTIGETKRVVLMPEEAFGEKHPASIYSV
PKYRFPKDMHLEEGLIVSFSQKDGSKLPGLITEINEQDVTVDFNHPLSGQIIVFEAKILDVAEKEEDLGEDITS

Sequences:

>Translated_154_residues
MKIASDSFVKMHFKFRLKDGSIAEDTENYNRPFVFQMGQGCFTEKVENELVGTTIGETKRVVLMPEEAFGEKHPASIYSV
PKYRFPKDMHLEEGLIVSFSQKDGSKLPGLITEINEQDVTVDFNHPLSGQIIVFEAKILDVAEKEEDLGEDITS
>Mature_154_residues
MKIASDSFVKMHFKFRLKDGSIAEDTENYNRPFVFQMGQGCFTEKVENELVGTTIGETKRVVLMPEEAFGEKHPASIYSV
PKYRFPKDMHLEEGLIVSFSQKDGSKLPGLITEINEQDVTVDFNHPLSGQIIVFEAKILDVAEKEEDLGEDITS

Specific function: PPIases accelerate the folding of proteins. Substrate specificity carried out with 'Suc-Ala-Xaa-Pro-Phe-4-nitroanilide', where Xaa is the amino acid tested, was found to be Phe > Leu >> Ile > Lys = Ala > Trp > His >> Gln [H]

COG id: COG1047

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI1786211, Length=140, Percent_Identity=37.8571428571429, Blast_Score=109, Evalue=8e-26,
Organism=Escherichia coli, GI1789748, Length=147, Percent_Identity=26.530612244898, Blast_Score=60, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179 [H]

Pfam domain/function: PF00254 FKBP_C [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17391; Mature: 17391

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIASDSFVKMHFKFRLKDGSIAEDTENYNRPFVFQMGQGCFTEKVENELVGTTIGETKR
CCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEE
VVLMPEEAFGEKHPASIYSVPKYRFPKDMHLEEGLIVSFSQKDGSKLPGLITEINEQDVT
EEEECHHHCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCEE
VDFNHPLSGQIIVFEAKILDVAEKEEDLGEDITS
EEECCCCCCEEEEEEEEEHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKIASDSFVKMHFKFRLKDGSIAEDTENYNRPFVFQMGQGCFTEKVENELVGTTIGETKR
CCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCCEE
VVLMPEEAFGEKHPASIYSVPKYRFPKDMHLEEGLIVSFSQKDGSKLPGLITEINEQDVT
EEEECHHHCCCCCCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCEEECCCCCEE
VDFNHPLSGQIIVFEAKILDVAEKEEDLGEDITS
EEECCCCCCEEEEEEEEEHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]