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The map label for this gene is msrB [H]

Identifier: 134302228

GI number: 134302228

Start: 1234364

End: 1234756

Strand: Direct

Name: msrB [H]

Synonym: FTW_1302

Alternate gene names: 134302228

Gene position: 1234364-1234756 (Clockwise)

Preceding gene: 134302225

Following gene: 134302229

Centisome position: 65.02

GC content: 36.9

Gene sequence:

>393_bases
GTGACTCAAAAAGGCGGTACTGAAAGAGCGTTCAATAATAAATACTGGAATAATCATAGGCAAGGCATCTATGTCGACGT
TGTCTCTGGAGAGCCACTTTTTAGTTCTACTGATAAATACGATTCTGGCACAGGTTGGCCAAGTTTTACTAAACCTATTG
ATAACTCATTTATAAAAACAAAAACTGATAATAGCTGGTTTATGACTCGTACAGAAGTTCTCTCACGCTATGCTAATTCG
CACTTAGGCCATGTCTTCGATGATGGTCCTCAACCTACTGGCAAGAGATACTGTATGAATTCTGCGGCTCTTAAATTTAT
CCCTAAAGAAGACATGCAGAAAGATGGTTATGGTAAGTATCTATATTTATTTACTAACAAAAACTTACAATAG

Upstream 100 bases:

>100_bases
ATTAGCATTTATACCGATTATCACTTTAGCTGATACGCAAAACTGGCAAAGCTTTGATAAGACACAAGCATTAGCTAAAC
TAACTAGGCTGCAATATTAT

Downstream 100 bases:

>100_bases
TTGTCAAAAAACTAATACATGATATTATTAAATCAATTTATCAGAAGCTGGAGCTGTACTATTAATACTCATTTTTTTGG
ACAAATAGCACTTAATGCTT

Product: methionine sulfoxide reductase B

Products: NA

Alternate protein names: Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 130; Mature: 129

Protein sequence:

>130_residues
MTQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANS
HLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKYLYLFTNKNLQ

Sequences:

>Translated_130_residues
MTQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANS
HLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKYLYLFTNKNLQ
>Mature_129_residues
TQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKTKTDNSWFMTRTEVLSRYANSH
LGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKYLYLFTNKNLQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0229

COG function: function code O; Conserved domain frequently associated with peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the msrB Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=110, Percent_Identity=51.8181818181818, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI301336162, Length=110, Percent_Identity=51.8181818181818, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI73089054, Length=110, Percent_Identity=51.8181818181818, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI37620216, Length=110, Percent_Identity=51.8181818181818, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI117606353, Length=117, Percent_Identity=46.1538461538462, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1788077, Length=114, Percent_Identity=46.4912280701754, Blast_Score=115, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17553450, Length=112, Percent_Identity=37.5, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115532676, Length=112, Percent_Identity=37.5, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319816, Length=107, Percent_Identity=33.6448598130841, Blast_Score=67, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45553335, Length=108, Percent_Identity=46.2962962962963, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI21356369, Length=108, Percent_Identity=46.2962962962963, Blast_Score=108, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24645799, Length=108, Percent_Identity=46.2962962962963, Blast_Score=108, Evalue=9e-25,
Organism=Drosophila melanogaster, GI221378664, Length=108, Percent_Identity=44.4444444444444, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645804, Length=119, Percent_Identity=42.0168067226891, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645801, Length=119, Percent_Identity=42.0168067226891, Blast_Score=104, Evalue=2e-23,
Organism=Drosophila melanogaster, GI221378662, Length=115, Percent_Identity=41.7391304347826, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 14970; Mature: 14839

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKT
CCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
KTDNSWFMTRTEVLSRYANSHLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKY
CCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEECCCHHCCCCCCCCE
LYLFTNKNLQ
EEEEECCCCC
>Mature Secondary Structure 
TQKGGTERAFNNKYWNNHRQGIYVDVVSGEPLFSSTDKYDSGTGWPSFTKPIDNSFIKT
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
KTDNSWFMTRTEVLSRYANSHLGHVFDDGPQPTGKRYCMNSAALKFIPKEDMQKDGYGKY
CCCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCEEECCCHHCCCCCCCCE
LYLFTNKNLQ
EEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]