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The map label for this gene is uvrB [H]

Identifier: 134302179

GI number: 134302179

Start: 1175813

End: 1177819

Strand: Reverse

Name: uvrB [H]

Synonym: FTW_1246

Alternate gene names: 134302179

Gene position: 1177819-1175813 (Counterclockwise)

Preceding gene: 134302180

Following gene: 134302178

Centisome position: 62.04

GC content: 35.92

Gene sequence:

>2007_bases
ATGAATAAATTCAACCTAGTAACAAAGTATGCTCCAGCTGGCGATCAGCCTCAAGCAATACAAAGCCTTGTTAATGGTAT
AAATACTGGGTTACAACACCAAGTATTGCTTGGTGTGACAGGCTCTGGTAAAACATATACTATGGCAAATGTTATTCAAC
AGACTCAAAAACCATGCTTGATATTAGCGCATAATAAAACTCTAGCTGCACAACTGTATTCTGAGTTTAAACAATACTTT
CCGGATAATGCAGTTGAGTATTTTGTGTCATATTATGATTATTATCAACCAGAAGCGTATGTTGCCGCATCAGATACCTA
TATAGAAAAAGATTCTTCTGTAAATGAGCATATTGAACAAATGCGGTTGTCAGCAACCAAGGCAATACTTGAGCGAAATG
ATGTAATAATTGTTGCAACTGTATCAGCTATATATGGTCTAGGTGATCCTGAGCAGTATATGCAAATGCTTTTGCACCTA
AAGGTAGGCGAAGAGTTAGGACTAAAAAAGGCGCAAACTAAGCTAGTAGAGATGCAATATTCACGTAATGATATGGATTT
TAGTCGTGGAAGCTTTCGCGTACGTGGAGAGGTTTTAGATATTTTCCCTGCTGACTCTGAGAAAGATGCTATTCGAGTAG
AATTTTTTGATGATGAAATAGAAGCAATAAGTGTAATTGATTCATTAACCTCAAAAAAACTCAAATCATTACATCGAGCA
ACAATTTTCCCTAGTACTCATTATGTGGCATCTAAAGAACGTAAAGAGATAGTTATTGAGGATATCAAAAAAGAACTTAA
AGAAAGAGTTAAGTATTTTGAAAAAGAGGGAAAACTTCTTGAAGCTCAAAGAATAGAACAACGTACTAAGTATGATATTG
AAATGATTCAGGAACTTGGCTACTGTACAGGAATCGAAAATTACTCAAGGTTACTTTCTGGAAGAGCTCCTGGTGATCCA
CCACCTACTTTGATTGATTATCTCCCAGAGAATGCCTTAGTGATAGTTGACGAGTCACACGTGACATTACCGCAGTTTGG
AGGAATGTATAAGGGTGATTTATCACGTAAATCAAACCTTGTAAACTATGGTTTCCGTCTTCCTTCTGCTTTAGATAATA
GGCCTTTGAAATTTAATGAGTTTGAGAGTCTGTTGCCTCAGACAATCTATGTATCGGCTACACCTGCTAATTATGAGCTA
GAAAAGTCTCAAAATACTGTACAGCAAGTGATTAGACCAACTGGCTTATTAGATCCGGAAGTTTTTGTAAGACCAGTAGC
GATACAGGTAGAAGATGCTTTATCTGAGATAAATAAAGCAATTGCTAAAGAAGAAAGAGTTTTGATAACGACTTTAACCA
AAAAAATGGTAGAAAACCTTACAGAGTATTTATCTGAGCATGGAGTTAATGTCAGATACTTACATTCAGATATTGATACT
GTCGAAAGGGTGCAGATTATTCATGATTTACGCCATGGTGTTTTTGATGTGCTTGTCGGGATTAACCTTCTTAGGGAAGG
TCTTGATATGCCAGAGGTTGGTGTTTTATTAATTTTTGATGCGGATAAAGAAGGTTTCTTACGTTCTGAAAAATCTTTAA
TTCAGACGATTGGACGTGTAGCAAGAAATCAAAATGGTCGAGCTATTTTATATGCTGATGTAGTGACAAAATCTATGCAA
AAAGCTATGGATGAGACTTTGCGCCGTCGTAAACTCCAAGATGAATATAATCAAAAACACAATATAGTCCCAAAAACTAT
TATTAAGAATATTGATGATATGCTAGACAGCTCTCCAGAGATGCAAAAGCGCGCTTATAAAAATAATTTGCGCTTAAAGG
TTGATGATGTTGATGTTTCGGCTATACTAGGTATGACTGAAGCTACGAAGGTTATCAAAGCTCTCGAAAAGCGTATGCGA
GCTTATGCAAAAGAGCTCGAATTTGAAAAAGCTACAACTATTAGAGACAAGATAACTGAAATAAAGCAGAAGTTTATTAA
CTTATAA

Upstream 100 bases:

>100_bases
GAAGATATTTATCAGGAAATAGAAGATTTACGTATGAATTACGATCTAACAGAAGAGCAACAAGCTTTGTTGTATGAGTT
AGAGGAGTATTTGTTTTAAG

Downstream 100 bases:

>100_bases
TTTTTGTTAGATTTTTTTAAAGAAGTATTATTAATTATGGCAATAGAAAGTAGACTAAAAAAGAATAGGCTTTTTTTGCG
CTTTACTTGGGCAAGGTTGC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MNKFNLVTKYAPAGDQPQAIQSLVNGINTGLQHQVLLGVTGSGKTYTMANVIQQTQKPCLILAHNKTLAAQLYSEFKQYF
PDNAVEYFVSYYDYYQPEAYVAASDTYIEKDSSVNEHIEQMRLSATKAILERNDVIIVATVSAIYGLGDPEQYMQMLLHL
KVGEELGLKKAQTKLVEMQYSRNDMDFSRGSFRVRGEVLDIFPADSEKDAIRVEFFDDEIEAISVIDSLTSKKLKSLHRA
TIFPSTHYVASKERKEIVIEDIKKELKERVKYFEKEGKLLEAQRIEQRTKYDIEMIQELGYCTGIENYSRLLSGRAPGDP
PPTLIDYLPENALVIVDESHVTLPQFGGMYKGDLSRKSNLVNYGFRLPSALDNRPLKFNEFESLLPQTIYVSATPANYEL
EKSQNTVQQVIRPTGLLDPEVFVRPVAIQVEDALSEINKAIAKEERVLITTLTKKMVENLTEYLSEHGVNVRYLHSDIDT
VERVQIIHDLRHGVFDVLVGINLLREGLDMPEVGVLLIFDADKEGFLRSEKSLIQTIGRVARNQNGRAILYADVVTKSMQ
KAMDETLRRRKLQDEYNQKHNIVPKTIIKNIDDMLDSSPEMQKRAYKNNLRLKVDDVDVSAILGMTEATKVIKALEKRMR
AYAKELEFEKATTIRDKITEIKQKFINL

Sequences:

>Translated_668_residues
MNKFNLVTKYAPAGDQPQAIQSLVNGINTGLQHQVLLGVTGSGKTYTMANVIQQTQKPCLILAHNKTLAAQLYSEFKQYF
PDNAVEYFVSYYDYYQPEAYVAASDTYIEKDSSVNEHIEQMRLSATKAILERNDVIIVATVSAIYGLGDPEQYMQMLLHL
KVGEELGLKKAQTKLVEMQYSRNDMDFSRGSFRVRGEVLDIFPADSEKDAIRVEFFDDEIEAISVIDSLTSKKLKSLHRA
TIFPSTHYVASKERKEIVIEDIKKELKERVKYFEKEGKLLEAQRIEQRTKYDIEMIQELGYCTGIENYSRLLSGRAPGDP
PPTLIDYLPENALVIVDESHVTLPQFGGMYKGDLSRKSNLVNYGFRLPSALDNRPLKFNEFESLLPQTIYVSATPANYEL
EKSQNTVQQVIRPTGLLDPEVFVRPVAIQVEDALSEINKAIAKEERVLITTLTKKMVENLTEYLSEHGVNVRYLHSDIDT
VERVQIIHDLRHGVFDVLVGINLLREGLDMPEVGVLLIFDADKEGFLRSEKSLIQTIGRVARNQNGRAILYADVVTKSMQ
KAMDETLRRRKLQDEYNQKHNIVPKTIIKNIDDMLDSSPEMQKRAYKNNLRLKVDDVDVSAILGMTEATKVIKALEKRMR
AYAKELEFEKATTIRDKITEIKQKFINL
>Mature_668_residues
MNKFNLVTKYAPAGDQPQAIQSLVNGINTGLQHQVLLGVTGSGKTYTMANVIQQTQKPCLILAHNKTLAAQLYSEFKQYF
PDNAVEYFVSYYDYYQPEAYVAASDTYIEKDSSVNEHIEQMRLSATKAILERNDVIIVATVSAIYGLGDPEQYMQMLLHL
KVGEELGLKKAQTKLVEMQYSRNDMDFSRGSFRVRGEVLDIFPADSEKDAIRVEFFDDEIEAISVIDSLTSKKLKSLHRA
TIFPSTHYVASKERKEIVIEDIKKELKERVKYFEKEGKLLEAQRIEQRTKYDIEMIQELGYCTGIENYSRLLSGRAPGDP
PPTLIDYLPENALVIVDESHVTLPQFGGMYKGDLSRKSNLVNYGFRLPSALDNRPLKFNEFESLLPQTIYVSATPANYEL
EKSQNTVQQVIRPTGLLDPEVFVRPVAIQVEDALSEINKAIAKEERVLITTLTKKMVENLTEYLSEHGVNVRYLHSDIDT
VERVQIIHDLRHGVFDVLVGINLLREGLDMPEVGVLLIFDADKEGFLRSEKSLIQTIGRVARNQNGRAILYADVVTKSMQ
KAMDETLRRRKLQDEYNQKHNIVPKTIIKNIDDMLDSSPEMQKRAYKNNLRLKVDDVDVSAILGMTEATKVIKALEKRMR
AYAKELEFEKATTIRDKITEIKQKFINL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=666, Percent_Identity=61.5615615615616, Blast_Score=825, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=308, Percent_Identity=22.4025974025974, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76175; Mature: 76175

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKFNLVTKYAPAGDQPQAIQSLVNGINTGLQHQVLLGVTGSGKTYTMANVIQQTQKPCL
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEE
ILAHNKTLAAQLYSEFKQYFPDNAVEYFVSYYDYYQPEAYVAASDTYIEKDSSVNEHIEQ
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCEECCCCCHHHHHHH
MRLSATKAILERNDVIIVATVSAIYGLGDPEQYMQMLLHLKVGEELGLKKAQTKLVEMQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHH
SRNDMDFSRGSFRVRGEVLDIFPADSEKDAIRVEFFDDEIEAISVIDSLTSKKLKSLHRA
CCCCCCCCCCCEEEECEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
TIFPSTHYVASKERKEIVIEDIKKELKERVKYFEKEGKLLEAQRIEQRTKYDIEMIQELG
HCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YCTGIENYSRLLSGRAPGDPPPTLIDYLPENALVIVDESHVTLPQFGGMYKGDLSRKSNL
HHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCCHHHCCH
VNYGFRLPSALDNRPLKFNEFESLLPQTIYVSATPANYELEKSQNTVQQVIRPTGLLDPE
HHCCCCCCHHHCCCCCCCHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCH
VFVRPVAIQVEDALSEINKAIAKEERVLITTLTKKMVENLTEYLSEHGVNVRYLHSDIDT
HHHEEHEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
VERVQIIHDLRHGVFDVLVGINLLREGLDMPEVGVLLIFDADKEGFLRSEKSLIQTIGRV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
ARNQNGRAILYADVVTKSMQKAMDETLRRRKLQDEYNQKHNIVPKTIIKNIDDMLDSSPE
HHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
MQKRAYKNNLRLKVDDVDVSAILGMTEATKVIKALEKRMRAYAKELEFEKATTIRDKITE
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKQKFINL
HHHHHCCC
>Mature Secondary Structure
MNKFNLVTKYAPAGDQPQAIQSLVNGINTGLQHQVLLGVTGSGKTYTMANVIQQTQKPCL
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCEE
ILAHNKTLAAQLYSEFKQYFPDNAVEYFVSYYDYYQPEAYVAASDTYIEKDSSVNEHIEQ
EEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEECCCEECCCCCHHHHHHH
MRLSATKAILERNDVIIVATVSAIYGLGDPEQYMQMLLHLKVGEELGLKKAQTKLVEMQY
HHHHHHHHHHHCCCEEEEEEHHHHHCCCCHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHH
SRNDMDFSRGSFRVRGEVLDIFPADSEKDAIRVEFFDDEIEAISVIDSLTSKKLKSLHRA
CCCCCCCCCCCEEEECEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
TIFPSTHYVASKERKEIVIEDIKKELKERVKYFEKEGKLLEAQRIEQRTKYDIEMIQELG
HCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
YCTGIENYSRLLSGRAPGDPPPTLIDYLPENALVIVDESHVTLPQFGGMYKGDLSRKSNL
HHCCHHHHHHHHCCCCCCCCCCHHHHHCCCCCEEEEECCCCCCHHHCCCCCCCCHHHCCH
VNYGFRLPSALDNRPLKFNEFESLLPQTIYVSATPANYELEKSQNTVQQVIRPTGLLDPE
HHCCCCCCHHHCCCCCCCHHHHHHCCCEEEEEECCCCCEEHHHHHHHHHHHHHCCCCCCH
VFVRPVAIQVEDALSEINKAIAKEERVLITTLTKKMVENLTEYLSEHGVNVRYLHSDIDT
HHHEEHEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHH
VERVQIIHDLRHGVFDVLVGINLLREGLDMPEVGVLLIFDADKEGFLRSEKSLIQTIGRV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHH
ARNQNGRAILYADVVTKSMQKAMDETLRRRKLQDEYNQKHNIVPKTIIKNIDDMLDSSPE
HHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHH
MQKRAYKNNLRLKVDDVDVSAILGMTEATKVIKALEKRMRAYAKELEFEKATTIRDKITE
HHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKQKFINL
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA