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The map label for this gene is guaA [H]

Identifier: 134301919

GI number: 134301919

Start: 890244

End: 891794

Strand: Reverse

Name: guaA [H]

Synonym: FTW_0926

Alternate gene names: 134301919

Gene position: 891794-890244 (Counterclockwise)

Preceding gene: 134301920

Following gene: 134301918

Centisome position: 46.97

GC content: 34.75

Gene sequence:

>1551_bases
ATGACAGATATACATAATCATAAGATTTTGATTTTAGATTTTGGCTCGCAATATACACAACTTATTGCTCGTAGAGTAAG
AGAATTAGGTGTTTTTTGTGAAATTTTCCCTCATGATGTAGCAGCTGATTTTATCAAAAATTATCAAGCAAAAGGAATAA
TTTTATCAGGTGGTCCTGAGTCAGTTTATGATTCTGATGTCAAAGCTCCTGAGATAGTTTTTGAGCTTGGAGTACCTGTT
TTGGGTATTTGTTATGGCATGCAAACAATGGTAATGCAGCATGGTGGCGAAGTAAAAGGAGCTGATCAAAGTGAATTTGG
TAAGGCAATTATAAATATCCTAAATTCAACAAATAACATATTTTCAAATATGGAGCATGAGCAGCTAGTTTGGATGAGTC
ATAGTGACAAAGTCACTCAAACTGGTGAGCATTTTGAGATAATTGCTTCTTCAACAAATGCTCCAGTTGCGGCAGTTGCA
CATAAAAATAAGCCTTTTTTTGGTGTGCAGTTTCACCCAGAAACTACTCATACAGAAAATGGTAAGCAAATTATTGAGAA
TTTTGTCGTTAATATCTGCGGATGTGATACTCTGTGGAATATCGAAAACATTATCGAAAATGATATAAAAGAAATTAAAC
AAAAAGTTGGTACTGATAAAGTAATTTTAGGGCTATCTGGAGGTGTTGATTCATCTGTTGTAGCTGCGATATTACATCAA
GCTATCGGCGATCAGCTAACTTGTATATTTGTAGATACTGGTTTACTGCGCCTTAATGAGGGTGATCAAGTTATGCAAGT
ATTTGCAGAGCATATGGATATTAATGTTATTCGTATCAATGCAAAAAATAGATTCTTAGATGCCCTAAGGGGTATCTGTG
ATCCAGAACAAAAACGTAAAATTATCGGTAAGCTATTTGTTGATATTTTTGATGAAGAGGCTGCTAAGATAGAGAATGCT
AAATGGCTTGCGCAGGGCACTATCTACAGTGATGTAATTGAATCAGCTGGCAATAATCAGTCTAAAGCACATGTAATTAA
ATCACATCATAATGTTGGTGGCTTACCAAAAGAAATGAAACTTAAGCTTTTAGAACCATTAAGAGAGCTTTTCAAAGATG
AGGTTCGTAAATTAGGCTTAGGTTTAGGATTACCTTATAATATGCTTTATAGACATCCATTTCCTGGTCCTGGTCTTGGA
GTACGTATATTAGGTGAAATAAAGAAAGAGTATGTAGAAACGTTACAAAAAGCTGATGCTATATTTACAGAAGAGCTCTA
TAAACATAATTTATACCATGATGTTTCTCAAGCTTTTGGGGTGTTTTTACCTGTCAAATCGGTAGGTGTAGTTGGTGATC
AGCGTAGATATGAGTATGTAATAGCTCTAAGAGCTGTCGTTAGTATCGATTTTATGACTGCAACGTGGGCTAATTTACCT
TATGATTTTCTGTCACTAGTTTCAAATAGAATTGTAAATGAAGTAAAACAAGTATCAAGAGTTGTGTATGATGTGACAGG
AAAACCACCTGGAACAATTGAATGGGAATAA

Upstream 100 bases:

>100_bases
TAAAAGTATTTAAATATCATTTTTATTATTAAAAGCTAATTACAATCAACTTCATTTAGGATAAAATAACCTTTTAAGAA
AATGTTTATTTTTATAAAAA

Downstream 100 bases:

>100_bases
CGCATCTCTGTGTTATAACATAAATGTTTAATTATAAAAGTATTTTTTATTTACTTTTAAGTTAGATGAAGATTTTAAGC
TATGTCAAAATATACTATTT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 516; Mature: 515

Protein sequence:

>516_residues
MTDIHNHKILILDFGSQYTQLIARRVRELGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPV
LGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNSTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVA
HKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENA
KWLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLG
VRILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPVKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE

Sequences:

>Translated_516_residues
MTDIHNHKILILDFGSQYTQLIARRVRELGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPV
LGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNSTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVA
HKNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENA
KWLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLG
VRILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPVKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
>Mature_515_residues
TDIHNHKILILDFGSQYTQLIARRVRELGVFCEIFPHDVAADFIKNYQAKGIILSGGPESVYDSDVKAPEIVFELGVPVL
GICYGMQTMVMQHGGEVKGADQSEFGKAIINILNSTNNIFSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAH
KNKPFFGVQFHPETTHTENGKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQA
IGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRKIIGKLFVDIFDEEAAKIENAK
WLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMKLKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGV
RILGEIKKEYVETLQKADAIFTEELYKHNLYHDVSQAFGVFLPVKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLPY
DFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=570, Percent_Identity=37.3684210526316, Blast_Score=312, Evalue=5e-85,
Organism=Escherichia coli, GI1788854, Length=522, Percent_Identity=61.3026819923372, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1789760, Length=186, Percent_Identity=27.9569892473118, Blast_Score=62, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71992717, Length=569, Percent_Identity=35.5008787346221, Blast_Score=289, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI133901714, Length=569, Percent_Identity=35.5008787346221, Blast_Score=288, Evalue=3e-78,
Organism=Caenorhabditis elegans, GI71992710, Length=569, Percent_Identity=35.5008787346221, Blast_Score=288, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6323873, Length=517, Percent_Identity=48.936170212766, Blast_Score=520, Evalue=1e-148,
Organism=Saccharomyces cerevisiae, GI6322638, Length=196, Percent_Identity=30.1020408163265, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365319, Length=557, Percent_Identity=37.5224416517056, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57643; Mature: 57512

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDIHNHKILILDFGSQYTQLIARRVRELGVFCEIFPHDVAADFIKNYQAKGIILSGGPE
CCCCCCCEEEEEECCCHHHHHHHHHHHHHCHHHEECCHHHHHHHHHCCCCCEEEEECCCC
SVYDSDVKAPEIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNSTNNI
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHH
FSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTEN
HHCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCCC
GKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRK
HHCCCEEEEEEECCEEEECCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHHH
IIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMK
HHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHH
LKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFTEELYKHNLYHDVSQAFGVFLPVKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
HHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TDIHNHKILILDFGSQYTQLIARRVRELGVFCEIFPHDVAADFIKNYQAKGIILSGGPE
CCCCCCEEEEEECCCHHHHHHHHHHHHHCHHHEECCHHHHHHHHHCCCCCEEEEECCCC
SVYDSDVKAPEIVFELGVPVLGICYGMQTMVMQHGGEVKGADQSEFGKAIINILNSTNNI
CCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHH
FSNMEHEQLVWMSHSDKVTQTGEHFEIIASSTNAPVAAVAHKNKPFFGVQFHPETTHTEN
HHCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCEEEEEECCCCCCCCC
GKQIIENFVVNICGCDTLWNIENIIENDIKEIKQKVGTDKVILGLSGGVDSSVVAAILHQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHH
AIGDQLTCIFVDTGLLRLNEGDQVMQVFAEHMDINVIRINAKNRFLDALRGICDPEQKRK
HHCCCEEEEEEECCEEEECCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHHH
IIGKLFVDIFDEEAAKIENAKWLAQGTIYSDVIESAGNNQSKAHVIKSHHNVGGLPKEMK
HHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHCCCCCCHHHHHHCCCCCCCCCHHHH
LKLLEPLRELFKDEVRKLGLGLGLPYNMLYRHPFPGPGLGVRILGEIKKEYVETLQKADA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
IFTEELYKHNLYHDVSQAFGVFLPVKSVGVVGDQRRYEYVIALRAVVSIDFMTATWANLP
HHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
YDFLSLVSNRIVNEVKQVSRVVYDVTGKPPGTIEWE
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA