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The map label for this gene is fadD [H]

Identifier: 134301730

GI number: 134301730

Start: 668886

End: 670577

Strand: Reverse

Name: fadD [H]

Synonym: FTW_0690

Alternate gene names: 134301730

Gene position: 670577-668886 (Counterclockwise)

Preceding gene: 134301731

Following gene: 134301728

Centisome position: 35.32

GC content: 32.33

Gene sequence:

>1692_bases
ATGAGTACATTTTCCAATAAAACATGGATAGCTAATTATCCTGATTATACTCCTGAGAATATTACGGAAAACCACGCTAC
AATTTTAGATCTATATGAAAAAACAATTATACAATTTCCTTACAGAGAGGCTGTATCATGTCACGATGTAAATCTAACTT
TTATTGAACTTGACAAGCTTGCTACTAAAATGGCTAGTTTTCTACAAAACAACCTTGGAATCAACAAGGGAGATAGAGTC
GCAATTGTACTACCTAACTGCTTACAATTTACTGTTAGCTTATTTGCATGTGTTAAGATTGGTGCTGTATTTGTCAACAC
CAACCCTCTTTATACTGCAGATGAGATTGAAGCAATATTTAATAATTGTAATGTCAAAGCTGCGATTGTAATGGATATGT
TTGCCCATCATATACAAAAAGCTCGTGTAAACATCGACTCTTTAGAGAATGTAATAGTTACAAATATTGCTGATTTATAC
CCATTTCCTAAAAAACAGATTATTGGTTTTGTCTCTAAATATTTAATTGAAAATAAACCAAAGTATACAAAAAGTAATTT
TATTGCGTTTAGTAAAGTCATTAAAGCTGACATAAGTTTATATAAAAAACCTGTTTTAACAAAACAAGATATACTATGTT
TGCAATACTCAAGTGGAACAACTGGAAGACCTAAAGGAGCAATACTAACGCATGATAATCTTGCTTCAAATATTCAGCAA
GTTTGGGCATGGATCAAACATGACATGGATATGTCTGATCAAGTAATTATAACTGCACTACCTCTTTACCATATATTCTC
ACTAAGTGCTAATTTACTTTGCTTCTTTTTTGCTGGTGCAAAAAATGTCTTAATTCCCAATGCTAGAGATATAAAAAACC
TCATTAAGACTATGTCAAAAAATGAATTCACTATTTTTAATGGTCTTAACACCCTCTATATGGCAATGCTTGAGCATCCT
GATTTTGAGAAAATTAACAAAACAAGATATCTATATTCTTTAAGCGGGGGCATGCCAATTTCACGTAAAATATATTTAGA
GTGGTTAGATAGAACTGGTGTAGAACTAAAAGAGGGTTATGGTATGACTGAAATGTCTCCGGCAATCGCTCTAAATAAAT
TCAACGAGTCTGAGGATGATTATTTTGGTACTTGTGGCTACCCTATTCCGAGCACAGAGCTCAGTATTCGTGATATCCAT
ACTCACCAAGAAATAACTGAGTGTTTCAAAGAAGGTGAAATCTGGCTTAAAGGTCCACAAAGATGTCAAGGTTTCTGGAA
TGATAAAGAGAATAATGAACTTCACTTTACTGCAGATGGTTGGCTAAAAACTGGAGATATTGGCTATATAGACAAAAAAG
GTCGTCTAACTATATCCGATAGAATTAAAAATATGATAATTGTCTCCGGTTTTAATGTTTATCCGAGAGAAATTGAGTTA
TGCATACTTAAGTTAGACTATGTAAGAGAGGTAGCTGTCACTGGAATTAAGTCAAAAACATCTGGTGAAAGACCTATAGC
TTTTATCTCATTGGAAAAAGACTCAAATGCAACTGAGGAAGATATTATCAAACATTGCAAAGATAAATTAGCAAGCTATA
AAGTCCCTAGATCATGTATATTTGTAGAAACTCTACCAAAAAATAATACTAGTAAAATAGATATTAAGAAACTAAAAAAT
CAGTTCTTATAA

Upstream 100 bases:

>100_bases
TAATTTAACACCTTCTAATAAAGAAATAATCTTGCAAATTTATTTCAATACTTTGTTTTTTTGCTAGAATTAGTTCTAGT
AATTAACAATCTTATTTATT

Downstream 100 bases:

>100_bases
ATATTTTTTATCTGTACTCTTTCACTAGAGAAATACTGTTTTGGTGTTTTACCAAATGCCTTGCGAAACATTGCTATAAA
ATTACTTGGTGAAGCATATC

Product: amino acid adenylase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; Acyl-CoA synthetase [H]

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MSTFSNKTWIANYPDYTPENITENHATILDLYEKTIIQFPYREAVSCHDVNLTFIELDKLATKMASFLQNNLGINKGDRV
AIVLPNCLQFTVSLFACVKIGAVFVNTNPLYTADEIEAIFNNCNVKAAIVMDMFAHHIQKARVNIDSLENVIVTNIADLY
PFPKKQIIGFVSKYLIENKPKYTKSNFIAFSKVIKADISLYKKPVLTKQDILCLQYSSGTTGRPKGAILTHDNLASNIQQ
VWAWIKHDMDMSDQVIITALPLYHIFSLSANLLCFFFAGAKNVLIPNARDIKNLIKTMSKNEFTIFNGLNTLYMAMLEHP
DFEKINKTRYLYSLSGGMPISRKIYLEWLDRTGVELKEGYGMTEMSPAIALNKFNESEDDYFGTCGYPIPSTELSIRDIH
THQEITECFKEGEIWLKGPQRCQGFWNDKENNELHFTADGWLKTGDIGYIDKKGRLTISDRIKNMIIVSGFNVYPREIEL
CILKLDYVREVAVTGIKSKTSGERPIAFISLEKDSNATEEDIIKHCKDKLASYKVPRSCIFVETLPKNNTSKIDIKKLKN
QFL

Sequences:

>Translated_563_residues
MSTFSNKTWIANYPDYTPENITENHATILDLYEKTIIQFPYREAVSCHDVNLTFIELDKLATKMASFLQNNLGINKGDRV
AIVLPNCLQFTVSLFACVKIGAVFVNTNPLYTADEIEAIFNNCNVKAAIVMDMFAHHIQKARVNIDSLENVIVTNIADLY
PFPKKQIIGFVSKYLIENKPKYTKSNFIAFSKVIKADISLYKKPVLTKQDILCLQYSSGTTGRPKGAILTHDNLASNIQQ
VWAWIKHDMDMSDQVIITALPLYHIFSLSANLLCFFFAGAKNVLIPNARDIKNLIKTMSKNEFTIFNGLNTLYMAMLEHP
DFEKINKTRYLYSLSGGMPISRKIYLEWLDRTGVELKEGYGMTEMSPAIALNKFNESEDDYFGTCGYPIPSTELSIRDIH
THQEITECFKEGEIWLKGPQRCQGFWNDKENNELHFTADGWLKTGDIGYIDKKGRLTISDRIKNMIIVSGFNVYPREIEL
CILKLDYVREVAVTGIKSKTSGERPIAFISLEKDSNATEEDIIKHCKDKLASYKVPRSCIFVETLPKNNTSKIDIKKLKN
QFL
>Mature_562_residues
STFSNKTWIANYPDYTPENITENHATILDLYEKTIIQFPYREAVSCHDVNLTFIELDKLATKMASFLQNNLGINKGDRVA
IVLPNCLQFTVSLFACVKIGAVFVNTNPLYTADEIEAIFNNCNVKAAIVMDMFAHHIQKARVNIDSLENVIVTNIADLYP
FPKKQIIGFVSKYLIENKPKYTKSNFIAFSKVIKADISLYKKPVLTKQDILCLQYSSGTTGRPKGAILTHDNLASNIQQV
WAWIKHDMDMSDQVIITALPLYHIFSLSANLLCFFFAGAKNVLIPNARDIKNLIKTMSKNEFTIFNGLNTLYMAMLEHPD
FEKINKTRYLYSLSGGMPISRKIYLEWLDRTGVELKEGYGMTEMSPAIALNKFNESEDDYFGTCGYPIPSTELSIRDIHT
HQEITECFKEGEIWLKGPQRCQGFWNDKENNELHFTADGWLKTGDIGYIDKKGRLTISDRIKNMIIVSGFNVYPREIELC
ILKLDYVREVAVTGIKSKTSGERPIAFISLEKDSNATEEDIIKHCKDKLASYKVPRSCIFVETLPKNNTSKIDIKKLKNQ
FL

Specific function: Catalyzes the esterification, concomitant with transport, of exogenous long-chain fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids [H]

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Membrane; Peripheral membrane protein (Potential). Note=Partially membrane-associated (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=552, Percent_Identity=27.3550724637681, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI187761345, Length=384, Percent_Identity=30.2083333333333, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI187761343, Length=384, Percent_Identity=30.2083333333333, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI122937307, Length=530, Percent_Identity=24.5283018867925, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI38505220, Length=532, Percent_Identity=24.2481203007519, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI42544132, Length=532, Percent_Identity=23.4962406015038, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI115511026, Length=530, Percent_Identity=24.1509433962264, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI157311624, Length=520, Percent_Identity=23.0769230769231, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI157311622, Length=520, Percent_Identity=23.0769230769231, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI58082049, Length=520, Percent_Identity=22.5, Blast_Score=109, Evalue=8e-24,
Organism=Homo sapiens, GI42794756, Length=465, Percent_Identity=26.2365591397849, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI13375727, Length=548, Percent_Identity=25, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI42794760, Length=465, Percent_Identity=26.2365591397849, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI42794758, Length=465, Percent_Identity=26.2365591397849, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI40807491, Length=490, Percent_Identity=24.2857142857143, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI57165412, Length=340, Percent_Identity=26.4705882352941, Blast_Score=93, Evalue=8e-19,
Organism=Homo sapiens, GI57165410, Length=346, Percent_Identity=26.3005780346821, Blast_Score=91, Evalue=4e-18,
Organism=Escherichia coli, GI1788107, Length=557, Percent_Identity=37.1633752244165, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI145693145, Length=535, Percent_Identity=25.981308411215, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI221142682, Length=514, Percent_Identity=27.431906614786, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1789201, Length=535, Percent_Identity=24.1121495327103, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1786810, Length=519, Percent_Identity=22.1579961464355, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1788595, Length=354, Percent_Identity=25.7062146892655, Blast_Score=90, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=513, Percent_Identity=28.8499025341131, Blast_Score=195, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI32563687, Length=520, Percent_Identity=28.6538461538462, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17560308, Length=564, Percent_Identity=25.886524822695, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17559526, Length=564, Percent_Identity=27.3049645390071, Blast_Score=175, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI71994694, Length=545, Percent_Identity=25.5045871559633, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71994703, Length=545, Percent_Identity=25.5045871559633, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71994690, Length=545, Percent_Identity=25.5045871559633, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17557194, Length=502, Percent_Identity=27.6892430278884, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17531443, Length=369, Percent_Identity=30.8943089430894, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17538037, Length=502, Percent_Identity=26.2948207171315, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI71996755, Length=567, Percent_Identity=26.1022927689594, Blast_Score=145, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI17560140, Length=345, Percent_Identity=29.5652173913043, Blast_Score=138, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI71985884, Length=576, Percent_Identity=22.3958333333333, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17556552, Length=532, Percent_Identity=26.3157894736842, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17510401, Length=336, Percent_Identity=27.0833333333333, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534440, Length=539, Percent_Identity=23.0055658627087, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17564090, Length=537, Percent_Identity=24.3947858472998, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193204819, Length=150, Percent_Identity=32, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=533, Percent_Identity=23.827392120075, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320852, Length=344, Percent_Identity=25.2906976744186, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6324893, Length=352, Percent_Identity=26.4204545454545, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6319264, Length=590, Percent_Identity=23.3898305084746, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI18859661, Length=527, Percent_Identity=28.2732447817837, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI21355181, Length=532, Percent_Identity=27.8195488721804, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24581924, Length=531, Percent_Identity=25.4237288135593, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI19921316, Length=496, Percent_Identity=24.3951612903226, Blast_Score=105, Evalue=9e-23,
Organism=Drosophila melanogaster, GI21356441, Length=522, Percent_Identity=24.904214559387, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI19922652, Length=520, Percent_Identity=22.8846153846154, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648253, Length=519, Percent_Identity=24.8554913294798, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648255, Length=519, Percent_Identity=24.4701348747592, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356947, Length=520, Percent_Identity=23.8461538461538, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656500, Length=384, Percent_Identity=26.5625, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358303, Length=527, Percent_Identity=22.3908918406072, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281365686, Length=536, Percent_Identity=22.9477611940299, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24653035, Length=363, Percent_Identity=24.5179063360882, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24648260, Length=535, Percent_Identity=20.7476635514019, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648257, Length=370, Percent_Identity=23.7837837837838, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI20130357, Length=353, Percent_Identity=24.0793201133144, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161076582, Length=359, Percent_Identity=23.3983286908078, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 64127; Mature: 63996

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFSNKTWIANYPDYTPENITENHATILDLYEKTIIQFPYREAVSCHDVNLTFIELDKL
CCCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCEECCEEEEEEHHHH
ATKMASFLQNNLGINKGDRVAIVLPNCLQFTVSLFACVKIGAVFVNTNPLYTADEIEAIF
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHH
NNCNVKAAIVMDMFAHHIQKARVNIDSLENVIVTNIADLYPFPKKQIIGFVSKYLIENKP
HCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
KYTKSNFIAFSKVIKADISLYKKPVLTKQDILCLQYSSGTTGRPKGAILTHDNLASNIQQ
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHHH
VWAWIKHDMDMSDQVIITALPLYHIFSLSANLLCFFFAGAKNVLIPNARDIKNLIKTMSK
HHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHEEEEEEECCCCEECCCHHHHHHHHHHHCC
NEFTIFNGLNTLYMAMLEHPDFEKINKTRYLYSLSGGMPISRKIYLEWLDRTGVELKEGY
CCEEEECCHHHHHHHHHCCCCHHHHCCEEEEEEECCCCCCCHHHHEEEHHCCCCCHHHCC
GMTEMSPAIALNKFNESEDDYFGTCGYPIPSTELSIRDIHTHQEITECFKEGEIWLKGPQ
CCCCCCHHHEEECCCCCCCCCEEECCCCCCCCCEEEHHHHHHHHHHHHHHCCCEEECCCH
RCQGFWNDKENNELHFTADGWLKTGDIGYIDKKGRLTISDRIKNMIIVSGFNVYPREIEL
HHCCCCCCCCCCEEEEEECCCEEECCEEEECCCCCEEHHHHHCCEEEEECCCCCCCEEEE
CILKLDYVREVAVTGIKSKTSGERPIAFISLEKDSNATEEDIIKHCKDKLASYKVPRSCI
EEEEHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
FVETLPKNNTSKIDIKKLKNQFL
EEEECCCCCCCEEHHHHHHHHCC
>Mature Secondary Structure 
STFSNKTWIANYPDYTPENITENHATILDLYEKTIIQFPYREAVSCHDVNLTFIELDKL
CCCCCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHCCCEECCEEEEEEHHHH
ATKMASFLQNNLGINKGDRVAIVLPNCLQFTVSLFACVKIGAVFVNTNPLYTADEIEAIF
HHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHH
NNCNVKAAIVMDMFAHHIQKARVNIDSLENVIVTNIADLYPFPKKQIIGFVSKYLIENKP
HCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCC
KYTKSNFIAFSKVIKADISLYKKPVLTKQDILCLQYSSGTTGRPKGAILTHDNLASNIQQ
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHHHHHH
VWAWIKHDMDMSDQVIITALPLYHIFSLSANLLCFFFAGAKNVLIPNARDIKNLIKTMSK
HHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHEEEEEEECCCCEECCCHHHHHHHHHHHCC
NEFTIFNGLNTLYMAMLEHPDFEKINKTRYLYSLSGGMPISRKIYLEWLDRTGVELKEGY
CCEEEECCHHHHHHHHHCCCCHHHHCCEEEEEEECCCCCCCHHHHEEEHHCCCCCHHHCC
GMTEMSPAIALNKFNESEDDYFGTCGYPIPSTELSIRDIHTHQEITECFKEGEIWLKGPQ
CCCCCCHHHEEECCCCCCCCCEEECCCCCCCCCEEEHHHHHHHHHHHHHHCCCEEECCCH
RCQGFWNDKENNELHFTADGWLKTGDIGYIDKKGRLTISDRIKNMIIVSGFNVYPREIEL
HHCCCCCCCCCCEEEEEECCCEEECCEEEECCCCCEEHHHHHCCEEEEECCCCCCCEEEE
CILKLDYVREVAVTGIKSKTSGERPIAFISLEKDSNATEEDIIKHCKDKLASYKVPRSCI
EEEEHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEE
FVETLPKNNTSKIDIKKLKNQFL
EEEECCCCCCCEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]