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The map label for this gene is nadC [H]

Identifier: 134301689

GI number: 134301689

Start: 622032

End: 622895

Strand: Direct

Name: nadC [H]

Synonym: FTW_0630

Alternate gene names: 134301689

Gene position: 622032-622895 (Clockwise)

Preceding gene: 134301688

Following gene: 134301690

Centisome position: 32.76

GC content: 34.26

Gene sequence:

>864_bases
ATGGCTGATGTGATGTTGAATACTGACCAAATTAACAAAGTTCCCAATGATATTGTTACAAGACTAGTTAGAGAGTCTTT
GGCAGAAGATATAGCAACTGGAGATATCACAGCACAGCTAGCTGAAGATATTGATACTACAGCGTTTTGTATCACTAGAG
AAGAGATGATCTTATGTGGGCAAGATTTTGCTAATGAAGTGATTAATCAGCTAGATAAAAATATACAGATAACTTGGTTA
TATAGCGATGCTCAAAAAGTACCAGCAAATGCTAGAATTTTTGAGCTTAAAGGTAATGCGCGAAGTATCTTAACAGCGGA
AAGAACGATATTAAACTTTATTCAAATGCTTTCTGGTACAGCTACAGTGACAAATAAGCAAGTCAAATTGATTTCTCAAT
ATAAGACAAAATTACTTGATACACGTAAGACTATTCCAGGGTTTCGTTTAGCACAAAAATATGCAGTTAGGTGTGGTGGT
GGTTTTAACCATCGTATTGGTTTATTTGATGCTTATTTAATTAAAGAAAACCATATTCGTTCAGCTGGTGGTATTGCCAA
AGCTGTCACCAAAGCAAAAAAATTAGACAGCAATAAAGTTGTTGAAGTTGAAGTTACAAACTTAGATGAATTAAATCAAG
CAATAGCGGCTAAAGCAGATATTGTAATGCTCGATAATTTTAGCGGTGAAGATATTGATATAGCTGTGAGTATTGCTAGG
GGTAAAGTAGCTCTTGAAGTATCTGGGAATATCGATCGTAATTCTATAGTTGCTATAGCTAAAACTGGAGTTGATTTTAT
TTCTGTTGGGGCGATTACAAAACATATCAAAGCAATAGATTTATCATTGCAGGTTCAGTTATAA

Upstream 100 bases:

>100_bases
ATTGTTTAATTAATCAGACTAACGAAATATTTATTGATGAAGAAGTAAGACAAAAGGCGCTTATCCCATTAAATAGGATG
ATAAATTTCTAGGAAATAGT

Downstream 100 bases:

>100_bases
ATATGATTATAAAAAAGCATGATGTAGCTATAATAGGTGGTGGTTTAGCAGGTGTAGTTGCTGCTATTGAGTTAGCTGAG
AATAATTTAGATGTTGCAAT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MADVMLNTDQINKVPNDIVTRLVRESLAEDIATGDITAQLAEDIDTTAFCITREEMILCGQDFANEVINQLDKNIQITWL
YSDAQKVPANARIFELKGNARSILTAERTILNFIQMLSGTATVTNKQVKLISQYKTKLLDTRKTIPGFRLAQKYAVRCGG
GFNHRIGLFDAYLIKENHIRSAGGIAKAVTKAKKLDSNKVVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIAR
GKVALEVSGNIDRNSIVAIAKTGVDFISVGAITKHIKAIDLSLQVQL

Sequences:

>Translated_287_residues
MADVMLNTDQINKVPNDIVTRLVRESLAEDIATGDITAQLAEDIDTTAFCITREEMILCGQDFANEVINQLDKNIQITWL
YSDAQKVPANARIFELKGNARSILTAERTILNFIQMLSGTATVTNKQVKLISQYKTKLLDTRKTIPGFRLAQKYAVRCGG
GFNHRIGLFDAYLIKENHIRSAGGIAKAVTKAKKLDSNKVVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIAR
GKVALEVSGNIDRNSIVAIAKTGVDFISVGAITKHIKAIDLSLQVQL
>Mature_286_residues
ADVMLNTDQINKVPNDIVTRLVRESLAEDIATGDITAQLAEDIDTTAFCITREEMILCGQDFANEVINQLDKNIQITWLY
SDAQKVPANARIFELKGNARSILTAERTILNFIQMLSGTATVTNKQVKLISQYKTKLLDTRKTIPGFRLAQKYAVRCGGG
FNHRIGLFDAYLIKENHIRSAGGIAKAVTKAKKLDSNKVVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIARG
KVALEVSGNIDRNSIVAIAKTGVDFISVGAITKHIKAIDLSLQVQL

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=278, Percent_Identity=32.3741007194245, Blast_Score=147, Evalue=2e-35,
Organism=Escherichia coli, GI1786299, Length=271, Percent_Identity=49.8154981549816, Blast_Score=232, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6321162, Length=278, Percent_Identity=31.6546762589928, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31418; Mature: 31286

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVMLNTDQINKVPNDIVTRLVRESLAEDIATGDITAQLAEDIDTTAFCITREEMILCG
CCCEEECHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEHHHHEEEC
QDFANEVINQLDKNIQITWLYSDAQKVPANARIFELKGNARSILTAERTILNFIQMLSGT
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCC
ATVTNKQVKLISQYKTKLLDTRKTIPGFRLAQKYAVRCGGGFNHRIGLFDAYLIKENHIR
CEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEHEEEEEEECCCCC
SAGGIAKAVTKAKKLDSNKVVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIAR
CCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEC
GKVALEVSGNIDRNSIVAIAKTGVDFISVGAITKHIKAIDLSLQVQL
CEEEEEECCCCCCCCEEEEEECCCCEEEHHHHHHHHEEEEEEEEEEC
>Mature Secondary Structure 
ADVMLNTDQINKVPNDIVTRLVRESLAEDIATGDITAQLAEDIDTTAFCITREEMILCG
CCEEECHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEEEEEHHHHEEEC
QDFANEVINQLDKNIQITWLYSDAQKVPANARIFELKGNARSILTAERTILNFIQMLSGT
HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCC
ATVTNKQVKLISQYKTKLLDTRKTIPGFRLAQKYAVRCGGGFNHRIGLFDAYLIKENHIR
CEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEHEEEEEEECCCCC
SAGGIAKAVTKAKKLDSNKVVEVEVTNLDELNQAIAAKADIVMLDNFSGEDIDIAVSIAR
CCCHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHCCCCEEEEECCCCCCEEEEEEEEC
GKVALEVSGNIDRNSIVAIAKTGVDFISVGAITKHIKAIDLSLQVQL
CEEEEEECCCCCCCCEEEEEECCCCEEEHHHHHHHHEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]