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The map label for this gene is tktA [H]

Identifier: 134301589

GI number: 134301589

Start: 508178

End: 510169

Strand: Direct

Name: tktA [H]

Synonym: FTW_0522

Alternate gene names: 134301589

Gene position: 508178-510169 (Clockwise)

Preceding gene: 134301579

Following gene: 134301590

Centisome position: 26.77

GC content: 37.15

Gene sequence:

>1992_bases
ATGTCTTTATCTATTCCACGCGAGTTTTCAAACGCTATAAGATTTTTATCTATTGATGCAACACTTAAAGCTAAATCAGG
ACATCCTGGAATGCCTATGGGGATGGCTGATATTGCCACAGTGTTATGGACAAAGTTTCTTAAGCACAATCCAAATAATC
CACATTGGATAAATAGAGATAGATTTGTTCTTTCAAATGGGCATGGCTCAATGCTTTTATATTCTCTGTTACATCTGACA
GGTTATGATCTATCTATTGAGGATATTAAAAATTTTAGGCAGTTACACTCAAAAACTCCAGGGCACCCTGAGTATGGCTA
TACGCCAGGAGTTGAGACAACAACTGGTCCATTAGGGCAAGGAGTAGCAAATGCTGTGGGTATGGCTTTAGGTGAAAAGC
TATTATCAGATAGGTATAATACACCTGATTTAAAAGTTATAGATCATCACACTTACGTGTTTTTAGGTGATGGATGTTTG
ATGGAGGGTGTTTCTCATGAAGCATGCTCATTAGCAGGGACTCTAGGTTTAAACAAATTAGTAGCATTTTGGGATGATAA
TAATATTTCGATAGATGGCGATACTAAGGGTTGGTTTAGTGATAATACACCTGAGAGATTTAGGGCGTATGGTTGGCATG
TTATAGAAAATGTTGATGGTCATGATTTTGTTGCGATTGAAAAAGCTATAAATGAAGCCCATTCTCAGCAGCAAAAACCA
ACTTTAATCTGTTGTAAAACTGTAATTGGTTTTGGCTCACCTGAGAAAGCTGGAACTGCCTCTGTGCATGGTTCGCCTTT
AAGTGATCAAGAAAGAGCCTCAGCTGCTAAAGAGCTTAACTGGGATTATCAAGCTTTTGAAATACCTCAAGATGTTTATA
AATACTGGGATGCTAGGGAAAAAGGACAAGCTTTAGAAGCAAATTGGCAAGGGCAATGGAATTTATTTAAAGACAGTCCT
AAGTTTGACGAATTTGAACGAGTTTTAAGTAAAGAGTTGCCAGTTGGATTAGAAAGCGCTATTAATGACTATATAGCTTC
GCAATTGAGTAATCCTGTCAAAGTGGCAACACGTAAAGCTTCACAAATGGTGCTTGAAGTCTTGTGTAAGAATATGCCTG
AGATGTTTGGTGGATCAGCAGATTTGACAGGATCAAATAATACTAATTGGAGTGGTTCAGTTTGGCTAAATAATACTCAA
GAAGGCGCAAATTATCTTTCTTATGGTGTTAGAGAGTTTGGTATGGCTGCAATAATGAATGGTCTAAGCCTTTATGGTGG
TATCAAACCTTATGGTGGTACATTCTTGGTATTTAGCGATTATTCAAGAAACGCGATAAGAATGTCAGCGTTGATGAAAC
AGCCTGTAGTTCATGTTATGTCGCATGACTCAATTGGTTTGGGAGAAGATGGATCAACTCATCAACCTATAGAACATGTT
CCGAGTTTAAGACTTATACCTAACTTAAGTGTTTGGCGACCTGCTGATACAATTGAAACAATGATAGCATGGAAAGAGGC
TGTAAAATCTAAAGATACGCCAAGTGTAATGGTACTTACACGTCAAAACTTAATGCCAGTAGTGCAAACACAGCATCAGG
TAGCAAATATTGCTAGAGGTGGTTATCTAGTTAAAGATAATCCTGATGCTAAATTAACTATTGTTGCTACTGGCTCTGAA
GTTGAGCTTGCTGTCAAAGTTGCTAATGAATTTGAAAAGAAAGGTATAAAATTAAATGTTGCTTCTATACCGTGTGTAGA
AGTTTTTGCTACTCAAGCTCACGAGTATAAAAAAACAGTAATAAAAGATGATATCCCGGCAGTTTTTGTTGAGATGGCGC
AACCTGATATGTGGTATAAATATATGCCAAAAGCTGGAGGGGAAGTAAAAGGAATCTATAGCTTTGGTGAGTCAGCACCG
GCTGAAGATTTATTTAAACGTTTTGGATTTACTGTAGAAAATATTAGCAATATTGTTGCTAAATATGTTTAA

Upstream 100 bases:

>100_bases
TATATAGATTTCTTGTTTTATGAAAGTCTCTACTGTATCATCATACTAGTTATTTTTTAAAATTGTCAATCATATAATCA
AATATAAGGGTCAAATACTA

Downstream 100 bases:

>100_bases
TAAACTTTCGCAAGATAATATCTTAAGGAGATTAAAAATGAGAGTTGCAATTAATGGTTTCGGTAGAATTGGTCGTTTAG
CATTTCGTCAAATGTTTGGT

Product: transketolase

Products: NA

Alternate protein names: TK 1 [H]

Number of amino acids: Translated: 663; Mature: 662

Protein sequence:

>663_residues
MSLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRDRFVLSNGHGSMLLYSLLHLT
GYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQGVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCL
MEGVSHEACSLAGTLGLNKLVAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHDFVAIEKAINEAHSQQQKP
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDAREKGQALEANWQGQWNLFKDSP
KFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKASQMVLEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQ
EGANYLSYGVREFGMAAIMNGLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGSTHQPIEHV
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARGGYLVKDNPDAKLTIVATGSE
VELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTVIKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAP
AEDLFKRFGFTVENISNIVAKYV

Sequences:

>Translated_663_residues
MSLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRDRFVLSNGHGSMLLYSLLHLT
GYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQGVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCL
MEGVSHEACSLAGTLGLNKLVAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHDFVAIEKAINEAHSQQQKP
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDAREKGQALEANWQGQWNLFKDSP
KFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKASQMVLEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQ
EGANYLSYGVREFGMAAIMNGLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGSTHQPIEHV
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARGGYLVKDNPDAKLTIVATGSE
VELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTVIKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAP
AEDLFKRFGFTVENISNIVAKYV
>Mature_662_residues
SLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRDRFVLSNGHGSMLLYSLLHLTG
YDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQGVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCLM
EGVSHEACSLAGTLGLNKLVAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHDFVAIEKAINEAHSQQQKPT
LICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDAREKGQALEANWQGQWNLFKDSPK
FDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKASQMVLEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQE
GANYLSYGVREFGMAAIMNGLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGSTHQPIEHVP
SLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARGGYLVKDNPDAKLTIVATGSEV
ELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTVIKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAPA
EDLFKRFGFTVENISNIVAKYV

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=580, Percent_Identity=26.551724137931, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI4507521, Length=580, Percent_Identity=26.551724137931, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI133778974, Length=586, Percent_Identity=26.4505119453925, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI225637459, Length=669, Percent_Identity=23.3183856502242, Blast_Score=126, Evalue=6e-29,
Organism=Homo sapiens, GI225637461, Length=669, Percent_Identity=22.8699551569507, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI225637463, Length=560, Percent_Identity=24.1071428571429, Blast_Score=110, Evalue=5e-24,
Organism=Escherichia coli, GI48994911, Length=657, Percent_Identity=56.468797564688, Blast_Score=784, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=655, Percent_Identity=55.5725190839695, Blast_Score=755, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=577, Percent_Identity=27.7296360485269, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6325331, Length=671, Percent_Identity=46.9448584202683, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319593, Length=666, Percent_Identity=44.5945945945946, Blast_Score=539, Evalue=1e-154,
Organism=Drosophila melanogaster, GI45551847, Length=586, Percent_Identity=26.4505119453925, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI45550715, Length=586, Percent_Identity=26.4505119453925, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24645119, Length=553, Percent_Identity=25.8589511754069, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24666278, Length=278, Percent_Identity=32.7338129496403, Blast_Score=123, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73312; Mature: 73181

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRD
CCCCCCHHHHHCEEEEEECEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCC
RFVLSNGHGSMLLYSLLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
GVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCLMEGVSHEACSLAGTLGLNKL
HHHHHHHHHHHHHHHHCCCCCCCCEEEECEEEEEECCCHHHCCCCHHHHHHHHHCCCCCE
VAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHDFVAIEKAINEAHSQQQKP
EEEECCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDARE
CEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCHHHHHHHCCHH
KGQALEANWQGQWNLFKDSPKFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKA
CCCEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHH
SQMVLEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQEGANYLSYGVREFGMAAIMN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGSTHQPIEHV
HHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHC
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARG
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
GYLVKDNPDAKLTIVATGSEVELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTV
CEEEECCCCCEEEEEEECCCEEEEHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
IKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAPAEDLFKRFGFTVENISNIVA
HHCCCHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
KYV
HCC
>Mature Secondary Structure 
SLSIPREFSNAIRFLSIDATLKAKSGHPGMPMGMADIATVLWTKFLKHNPNNPHWINRD
CCCCCHHHHHCEEEEEECEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEECCC
RFVLSNGHGSMLLYSLLHLTGYDLSIEDIKNFRQLHSKTPGHPEYGYTPGVETTTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHH
GVANAVGMALGEKLLSDRYNTPDLKVIDHHTYVFLGDGCLMEGVSHEACSLAGTLGLNKL
HHHHHHHHHHHHHHHHCCCCCCCCEEEECEEEEEECCCHHHCCCCHHHHHHHHHCCCCCE
VAFWDDNNISIDGDTKGWFSDNTPERFRAYGWHVIENVDGHDFVAIEKAINEAHSQQQKP
EEEECCCEEEECCCCCCCCCCCCHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCC
TLICCKTVIGFGSPEKAGTASVHGSPLSDQERASAAKELNWDYQAFEIPQDVYKYWDARE
CEEEHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHCCCCHHHHHHHCCHH
KGQALEANWQGQWNLFKDSPKFDEFERVLSKELPVGLESAINDYIASQLSNPVKVATRKA
CCCEEECCCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHH
SQMVLEVLCKNMPEMFGGSADLTGSNNTNWSGSVWLNNTQEGANYLSYGVREFGMAAIMN
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
GLSLYGGIKPYGGTFLVFSDYSRNAIRMSALMKQPVVHVMSHDSIGLGEDGSTHQPIEHV
HHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHC
PSLRLIPNLSVWRPADTIETMIAWKEAVKSKDTPSVMVLTRQNLMPVVQTQHQVANIARG
CCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCC
GYLVKDNPDAKLTIVATGSEVELAVKVANEFEKKGIKLNVASIPCVEVFATQAHEYKKTV
CEEEECCCCCEEEEEEECCCEEEEHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHH
IKDDIPAVFVEMAQPDMWYKYMPKAGGEVKGIYSFGESAPAEDLFKRFGFTVENISNIVA
HHCCCHHHHHHHCCCCHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHH
KYV
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]