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The map label for this gene is mscS [H]

Identifier: 134301344

GI number: 134301344

Start: 232119

End: 232616

Strand: Direct

Name: mscS [H]

Synonym: FTW_0225

Alternate gene names: 134301344

Gene position: 232119-232616 (Clockwise)

Preceding gene: 134301343

Following gene: 134301345

Centisome position: 12.23

GC content: 34.54

Gene sequence:

>498_bases
ATGTTCGATCAATTAGGCAATAGTGGAGCATTTCTTATAAATGCTATAGTTGCAGTTGTTATTTTAGTTGTTGGCTTTTG
GGCATCTAAGTATATAAAGTCTCTTGTGTATAGCCTGTTGAAAGAGTATGACAAGACAGTATCGCAATTTTTAGCTAGTC
TAGTTTACACAATTTTTTTAGTGTTAGTGGTTGTAATTGCTTTAGCAAAGTTGGGGGTGCCGATATCTCCTGTGACAGGA
GTTCTAACAGGTGTGGTTTTTGGTATCTCAATGTCATTAAAGACATCTTATAATACTGTTGCCTGTGGTATTATGCTGGC
ATTTAGTAAGCCTTTTGAGGTTGGGGAAAAGGTTGATTTTGGCGGAATCAAAGGTACTGTTAAATCAATTGGTTTTTTGT
ATACTAAGCTTGATGATGAGGATGGTAATGAAATTGTAATCTCAAACAACCTTGTTCTATCTAAGGTAATTACTAGATTT
ACTCAAACAGATAAATAA

Upstream 100 bases:

>100_bases
GTATTTGAAGAGGTATTGTTTGCGACTATATCGATAGTCTTAAGTGCTATAGCTGTGTATATACTTACTAGAGCAAAAAG
AATATATAAGGAAAATAGCG

Downstream 100 bases:

>100_bases
TGCAAAAAACGTTACTTTCTTCAGATGAAATCCTCTATCTGCCTAACGGGCAAAAGATAGTTCTCAATCAACAGCAATTA
GAAGCAGTAAATCAAATCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MFDQLGNSGAFLINAIVAVVILVVGFWASKYIKSLVYSLLKEYDKTVSQFLASLVYTIFLVLVVVIALAKLGVPISPVTG
VLTGVVFGISMSLKTSYNTVACGIMLAFSKPFEVGEKVDFGGIKGTVKSIGFLYTKLDDEDGNEIVISNNLVLSKVITRF
TQTDK

Sequences:

>Translated_165_residues
MFDQLGNSGAFLINAIVAVVILVVGFWASKYIKSLVYSLLKEYDKTVSQFLASLVYTIFLVLVVVIALAKLGVPISPVTG
VLTGVVFGISMSLKTSYNTVACGIMLAFSKPFEVGEKVDFGGIKGTVKSIGFLYTKLDDEDGNEIVISNNLVLSKVITRF
TQTDK
>Mature_165_residues
MFDQLGNSGAFLINAIVAVVILVVGFWASKYIKSLVYSLLKEYDKTVSQFLASLVYTIFLVLVVVIALAKLGVPISPVTG
VLTGVVFGISMSLKTSYNTVACGIMLAFSKPFEVGEKVDFGGIKGTVKSIGFLYTKLDDEDGNEIVISNNLVLSKVITRF
TQTDK

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=155, Percent_Identity=30.9677419354839, Blast_Score=87, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 17816; Mature: 17816

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDQLGNSGAFLINAIVAVVILVVGFWASKYIKSLVYSLLKEYDKTVSQFLASLVYTIFL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVVVIALAKLGVPISPVTGVLTGVVFGISMSLKTSYNTVACGIMLAFSKPFEVGEKVDF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCCC
GGIKGTVKSIGFLYTKLDDEDGNEIVISNNLVLSKVITRFTQTDK
CCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFDQLGNSGAFLINAIVAVVILVVGFWASKYIKSLVYSLLKEYDKTVSQFLASLVYTIFL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLVVVIALAKLGVPISPVTGVLTGVVFGISMSLKTSYNTVACGIMLAFSKPFEVGEKVDF
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHCCCCCCC
GGIKGTVKSIGFLYTKLDDEDGNEIVISNNLVLSKVITRFTQTDK
CCCHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]