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The map label for this gene is nupC [H]

Identifier: 134301326

GI number: 134301326

Start: 208412

End: 209611

Strand: Direct

Name: nupC [H]

Synonym: FTW_0200

Alternate gene names: 134301326

Gene position: 208412-209611 (Clockwise)

Preceding gene: 134301325

Following gene: 134301327

Centisome position: 10.98

GC content: 30.5

Gene sequence:

>1200_bases
ATGATTATTAAATCGCTATATTTTATATTAGGTCTTATAGTCATTTATTTTTTAGCTTATATTTGGAGTAATAATCGTAG
AAATATCAGATATAAGAATCTTATAATTATTTTAATAGTTCAACTTATCTTAGCTAAATTTATGCTAAGTACTTCAATAG
GTATAAATATTATCAACTACGTTAATAAATGTTTTGAAGTATTGCTTGATAGTACACATATCGGTGTTGAATTTGTTTTT
GGTAATTTAGCAAACACAAAAGAGTTTATATTCTTTTTTAATGCTGCTATGCCTATTGTAGTAATGTCGGCAGTGATAGG
GATTTTGCAATATTTTAGGATATTACAGTTTCTAGTAGTTGCTATAGGTAGTATCTTATCTAAAGTAACAGGTATGGGTA
AGCTAGAATCATTTAATGCAGTAAGTTCCTTGAGCGTTGGTCAGTCTGAGAATTTTCTATACTACAAAAAAATAATCAAG
TACCTGCCTTCAAATGTCTTGTATACAATGGTTGCAACAGCTATGTCAACTGTTTCGATAGGCACTGCAGCAGCGTATAT
GACAATTATAGATCCAAGCTATGTCTGTGTTGCTATTGTGATGAATATGTTTGGCGCATTTTTTGTACTAAATATTATTA
ATCCTTATGAAAAAACTAAGGAAGTCACATATGAATTTTTGACTGATCAAGTTGAGGATTATGAGAGACAAAGATTTTTT
GAAATGCTATCTGAATATATCTTAGATGGTTTTAAGGTTGCGATTATTGTATGTGTTATGATAATGGGCTATATTGCGTT
TCTTAATTTAGCTGATGGTATTTTCTCAAGTTTGGTAGGGATATCATTACGAGATATCCTGGGATATATTTTTTATCCGA
TTGCTTGGATTCTAAATATTCATGGCAATGAGATATTTTTATCAAGTCAAATAATGGGCACAAAGATTGTTACTAATGAA
TTTGTAGCAATGCAAGAGTTAGCCAACCATTCAACACAGCTTTCTCAGCATACAAAAGCCGTAGTCTCAGTATTTTTAGT
ATCGTTTGCAAATTTTTCATCAATTGGAATTATTATTGGAGCTATTCAAGCTTTGAGTAGAGAGGCATCAGTAAAAGTTG
CGAGATTTAGTTTAAAGATCCTTTATGGAGCAGTTTTAGTGAGCTTTTTGTCCGCTAATATTGTTGGTTTTATTTTATAA

Upstream 100 bases:

>100_bases
GCTAATATACTTGCTAATAATTTTATAAATCCGCAAACCTTTAGGTTTGGTGTAAGTGGTCTTTTAGATAACTTGCTTAA
CGAACAACAAGAGCAGATAG

Downstream 100 bases:

>100_bases
ATATTTGGGAAAGTAGGTGTGTTTGTAAAGATTTTATATTTGTTGTTAGGTTTAGTAACGGTTTTTATATTAGCTTTTAT
TTGGAGTAGTGATAGAAAAA

Product: nucleoside permease, NupC family protein

Products: uridine [Cytoplasm]; thymidine [Cytoplasm]; inosine [Cytoplasm]; Deoxyuridine [Cytoplasm]; deoxyinosine [Cytoplasm]; deoxycytidine [Cytoplasm]; deoxyadenosine [Cytoplasm]; cytidine [Cytoplasm]; Proton [Cytoplasm]; adenosine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MIIKSLYFILGLIVIYFLAYIWSNNRRNIRYKNLIIILIVQLILAKFMLSTSIGINIINYVNKCFEVLLDSTHIGVEFVF
GNLANTKEFIFFFNAAMPIVVMSAVIGILQYFRILQFLVVAIGSILSKVTGMGKLESFNAVSSLSVGQSENFLYYKKIIK
YLPSNVLYTMVATAMSTVSIGTAAAYMTIIDPSYVCVAIVMNMFGAFFVLNIINPYEKTKEVTYEFLTDQVEDYERQRFF
EMLSEYILDGFKVAIIVCVMIMGYIAFLNLADGIFSSLVGISLRDILGYIFYPIAWILNIHGNEIFLSSQIMGTKIVTNE
FVAMQELANHSTQLSQHTKAVVSVFLVSFANFSSIGIIIGAIQALSREASVKVARFSLKILYGAVLVSFLSANIVGFIL

Sequences:

>Translated_399_residues
MIIKSLYFILGLIVIYFLAYIWSNNRRNIRYKNLIIILIVQLILAKFMLSTSIGINIINYVNKCFEVLLDSTHIGVEFVF
GNLANTKEFIFFFNAAMPIVVMSAVIGILQYFRILQFLVVAIGSILSKVTGMGKLESFNAVSSLSVGQSENFLYYKKIIK
YLPSNVLYTMVATAMSTVSIGTAAAYMTIIDPSYVCVAIVMNMFGAFFVLNIINPYEKTKEVTYEFLTDQVEDYERQRFF
EMLSEYILDGFKVAIIVCVMIMGYIAFLNLADGIFSSLVGISLRDILGYIFYPIAWILNIHGNEIFLSSQIMGTKIVTNE
FVAMQELANHSTQLSQHTKAVVSVFLVSFANFSSIGIIIGAIQALSREASVKVARFSLKILYGAVLVSFLSANIVGFIL
>Mature_399_residues
MIIKSLYFILGLIVIYFLAYIWSNNRRNIRYKNLIIILIVQLILAKFMLSTSIGINIINYVNKCFEVLLDSTHIGVEFVF
GNLANTKEFIFFFNAAMPIVVMSAVIGILQYFRILQFLVVAIGSILSKVTGMGKLESFNAVSSLSVGQSENFLYYKKIIK
YLPSNVLYTMVATAMSTVSIGTAAAYMTIIDPSYVCVAIVMNMFGAFFVLNIINPYEKTKEVTYEFLTDQVEDYERQRFF
EMLSEYILDGFKVAIIVCVMIMGYIAFLNLADGIFSSLVGISLRDILGYIFYPIAWILNIHGNEIFLSSQIMGTKIVTNE
FVAMQELANHSTQLSQHTKAVVSVFLVSFANFSSIGIIIGAIQALSREASVKVARFSLKILYGAVLVSFLSANIVGFIL

Specific function: Transports Nucleosides With A High Affinity Except Guanosine And Deoxyguanosine. Driven By A Proton Motive Force. [C]

COG id: COG1972

COG function: function code F; Nucleoside permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family [H]

Homologues:

Organism=Homo sapiens, GI11545853, Length=411, Percent_Identity=23.1143552311436, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI42542381, Length=411, Percent_Identity=22.1411192214112, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI227116277, Length=411, Percent_Identity=20.6812652068127, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788737, Length=408, Percent_Identity=47.0588235294118, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788485, Length=407, Percent_Identity=27.2727272727273, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788488, Length=407, Percent_Identity=27.027027027027, Blast_Score=158, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17560276, Length=402, Percent_Identity=25.1243781094527, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71991794, Length=397, Percent_Identity=23.4256926952141, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45552519, Length=409, Percent_Identity=22.9828850855746, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552517, Length=409, Percent_Identity=22.9828850855746, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19921868, Length=409, Percent_Identity=22.9828850855746, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI281360430, Length=358, Percent_Identity=23.1843575418994, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008276
- InterPro:   IPR018270
- InterPro:   IPR011657
- InterPro:   IPR002668 [H]

Pfam domain/function: PF07662 Nucleos_tra2_C; PF01773 Nucleos_tra2_N [H]

EC number: NA

Molecular weight: Translated: 44691; Mature: 44691

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: uridine [Periplasm]; thymidine [Periplasm]; inosine [Periplasm]; Deoxyuridine [Periplasm]; deoxyinosine [Periplasm]; deoxycytidine [Periplasm]; deoxyadenosine [Periplasm]; cytidine [Periplasm]; Proton [Periplasm]; adenosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uridine [Periplasm] = Proton [Cytoplasm] + uridine [Cytoplasm] Proton [Periplasm] + thymidine [Periplasm] = Proton [Cytoplasm] + thymidine [Cytoplasm] Proton [Periplasm] + inosine [Periplasm] = Proton [Cytoplasm] + inosine [Cytoplasm]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8550462; 8867804; 9384377 [H]