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The map label for this gene is apt [H]

Identifier: 134301292

GI number: 134301292

Start: 166436

End: 166963

Strand: Direct

Name: apt [H]

Synonym: FTW_0154

Alternate gene names: 134301292

Gene position: 166436-166963 (Clockwise)

Preceding gene: 134301291

Following gene: 134301293

Centisome position: 8.77

GC content: 38.83

Gene sequence:

>528_bases
ATGAACTTAGATTTTATTAAGAGTAAGATTGCAGCTGTGCCTGATTTTCCAAAACCAGGAATTATGTTTCGCGACATTAC
TCCTTTGCTTGCAGATCCACAAGGACTCAGAAAAACTGCTGAGGCAATGGCACAAGAGTTAAAAAACAAAGGTATCCAAC
CAACTATTGTTGCTGGTACAGAAAGTAGAGGTTTTATCTTTGGTGTTGCTCTTGCTGAAGTATTAGGTCTGGGCTTTGTA
CCTGTCAGAAAGCCTGGCAAGCTACCAAGAGCAACTTATAGCGTTAAGTATGACCTAGAATATGGCAGTGATAGTCTTGA
AATACATCAAGATGCCTTTAAAGTTACAGATGAGGTATTGGTGGTTGATGATTTATTGGCAACTGGTGGTACTGCAAAAG
CAACAGTAGATCTTATAGAAAAAACCCAAGCAAAAGTCGCAGGACTTATATTTGTGATGGAGCTTGATGGTTTGAGTGGT
AGAGAAGTACTTGCTGGATACAATGTTTCAGCATTAATAAAATTCTAG

Upstream 100 bases:

>100_bases
ATTCTTGAAGATGATCAAAGAGCTAATTGAAGATCCAAATAGAATTCTTCTACAAGTATAGTTATTATTCTTTTTTAAAT
TATCCTAAAGGTACTTTTTT

Downstream 100 bases:

>100_bases
AGGATAAATTATGGCAAAGTATTTTGGAACTGATGGTATCCGTGGTGAAGTCGCTAACTCAACAATAACAGTAGAGTTTA
CGCAAAAATTAGGTAATGCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQELKNKGIQPTIVAGTESRGFIFGVALAEVLGLGFV
PVRKPGKLPRATYSVKYDLEYGSDSLEIHQDAFKVTDEVLVVDDLLATGGTAKATVDLIEKTQAKVAGLIFVMELDGLSG
REVLAGYNVSALIKF

Sequences:

>Translated_175_residues
MNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQELKNKGIQPTIVAGTESRGFIFGVALAEVLGLGFV
PVRKPGKLPRATYSVKYDLEYGSDSLEIHQDAFKVTDEVLVVDDLLATGGTAKATVDLIEKTQAKVAGLIFVMELDGLSG
REVLAGYNVSALIKF
>Mature_175_residues
MNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQELKNKGIQPTIVAGTESRGFIFGVALAEVLGLGFV
PVRKPGKLPRATYSVKYDLEYGSDSLEIHQDAFKVTDEVLVVDDLLATGGTAKATVDLIEKTQAKVAGLIFVMELDGLSG
REVLAGYNVSALIKF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=175, Percent_Identity=45.1428571428571, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=48.8372093023256, Blast_Score=122, Evalue=2e-28,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=52.3529411764706, Blast_Score=172, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=44.7058823529412, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=161, Percent_Identity=42.8571428571429, Blast_Score=118, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=38.2716049382716, Blast_Score=92, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17136334, Length=174, Percent_Identity=44.2528735632184, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 18825; Mature: 18825

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQELKNKGIQPTIVAGT
CCHHHHHHHHHCCCCCCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECC
ESRGFIFGVALAEVLGLGFVPVRKPGKLPRATYSVKYDLEYGSDSLEIHQDAFKVTDEVL
CCCCEEHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEEECCCCCCEEEHHHHHHHHHHHH
VVDDLLATGGTAKATVDLIEKTQAKVAGLIFVMELDGLSGREVLAGYNVSALIKF
EEHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEECCCEEEEEEC
>Mature Secondary Structure
MNLDFIKSKIAAVPDFPKPGIMFRDITPLLADPQGLRKTAEAMAQELKNKGIQPTIVAGT
CCHHHHHHHHHCCCCCCCCCEEEECCCHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECC
ESRGFIFGVALAEVLGLGFVPVRKPGKLPRATYSVKYDLEYGSDSLEIHQDAFKVTDEVL
CCCCEEHHHHHHHHHCCCCEECCCCCCCCCEEEEEEEEECCCCCCEEEHHHHHHHHHHHH
VVDDLLATGGTAKATVDLIEKTQAKVAGLIFVMELDGLSGREVLAGYNVSALIKF
EEHHHHHCCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCCCEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA