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The map label for this gene is sdhA [H]

Identifier: 134301288

GI number: 134301288

Start: 159546

End: 161339

Strand: Direct

Name: sdhA [H]

Synonym: FTW_0150

Alternate gene names: 134301288

Gene position: 159546-161339 (Clockwise)

Preceding gene: 134301287

Following gene: 134301289

Centisome position: 8.4

GC content: 40.02

Gene sequence:

>1794_bases
ATGAGTATAGCTACGCAAGAATTTGATGCTATTGTTATCGGTGCTGGTGGTGCGGGTTTAAGAGCTTCTTTCCAGCTGTC
ACAGTCGGGTTTTAAAACTGCTGTTGTTTCTAAAGTCTTTCCAACAAGATCACATACGGTTGCAGCTCAAGGTGGTATTG
CAGCTGCTTTAGGTAATATTGAATTTGATGATGGCTTGCCATCAGATGATTGGAAGTGGCATATGTATGATACTGTTAAA
GGTTCTGATTATATTGGTGATCAGGATGCTATTGAGTATATGTGTGAGCATGCGCCACAATCAATTATTGAGTTGGAGCA
TATGGGTATGCCTTTCTCAAGACTTAAAAATGGCAAGATATATCAACGAGCGTTTGGTGGGATGTCAAGGAACTATGATC
CTGCTAATCAAGCAGAAAGAACTTGCGCAGCAGCTGATAGGACCGGGCATGCTCTTTTACATACGCTGTATCAGGGTAAC
TTAGCGCACAAAACTGATTTCTATACGGAGTGGTTTGCTGTTGATTTGGTTAAGGCGGATGATGGTAGTATTGCTGGGGT
TATAGCTCTTTGTATAGAAACTGGTGAAACTGTTTTCTTAAAAGCAAAGATTACTATATTAGCTACTGGTGGCGCTGGGC
GTATATACGAGTCAAGTACTAATGCTTATATCAATACTGGTGATGGTATGGGTCTTGCTTTAAGAGCTGGATTACCTCTT
CAAGATATGGAGTTTTGGCAGTTCCATCCTACAGGCATTGCAGGTGCTGGAGTTCTTGTTACTGAAGGTTGTCGCGGTGA
AGGTGGTGTGCTACGCAATAAAGATGGTGAAAGATTTATGGAGCGATATGCTCCTAATGCTAAAGATCTTGCTTGTCGTG
ATGTTGTATCGCGTGCCTCTCAGCAAGAAATTATGGAAGGGCGTGGTGATACTTTCTCTGGGACAAGCTGTGTGTGGTTG
GATTTGACTCACTTGGGTGAAGACGTCATTAATGAGAGATTGCCTACTGTTAGAGAATTAGGTAGAACTTTTGCTGGGAT
TGATCCAGTTGAAAAACCAATACCGGTTGTGCCTACTTGTCATTATCAAATGGGTGGGATACCAACTAATAAACATGGTC
AAGTAATTACTCAGGTTGATGGTAAAGATAAGGTTATAGGTGGATTGTACGCTGTTGGTGAATGCGCCTCTGTGTCAGTT
CATGGTGCAAACAGGCTTGGAAGTAATTCTTTATTAGATTTAGTTGTTTTTGGTAGAGCTGCTGGTATGCATGCGGAACA
AAGCCTAAAAGAAGGTATGCCTATGAAAGAAGTTTCTCAAGAGAATATTGAGAAAGCTACTGCTAGAATCACTAAGTGGG
ATACTTCAGAGCAAAGAGGCTGTAAGGAAAAAATTTCTGAATTAAGAAAAGAATTACAGCGCGTAATGCAGCAGTACTTC
TCTGTATTTAGGCAAGAAAGCACAATGAAAGAAGGGCTTGATAAGTTATTTAATATTAGAGAAAGGTTAGATAATGCTGT
TCTGGAAGATAACTCTAGAATTTTCAATATGATGAGAATAGAAGCGTTAGAGTTAGATAATCTAGTATTAACTGCGATAG
CTACTGCAAAATTAGCACTTGAAAGAAAGGAATCAAGAGGCGCTCATTCAAGAGTAGACTATCCTGAAAGAGATGATAAG
AATTGGATGAAGCATACGCTATACTTCTTAGAAGGAGATAGAACATCTCTGCGTGATGTAAATATGTCTCCTACTAAAGT
AAAAGCTTTTCAACCAGCAGAACGTAAGTACTAA

Upstream 100 bases:

>100_bases
TTGGGCTTCTGCGCTTGTGATGCTGAGCTTTGTTTTGGTGTATATATTCTGCTTTTTTTGGTTATTTGCAGTTTTATTTT
TCTATTAAGAGGTTGTTTTT

Downstream 100 bases:

>100_bases
TACAAGGATTTAATATAATGGAAGTAAGATTTAAAATTTATAGATATAATCCAGAAGTTGATAAAAAACCTTATTACGAT
GAGTATACGGTTGAAGTAGA

Product: succinate dehydrogenase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 596

Protein sequence:

>597_residues
MSIATQEFDAIVIGAGGAGLRASFQLSQSGFKTAVVSKVFPTRSHTVAAQGGIAAALGNIEFDDGLPSDDWKWHMYDTVK
GSDYIGDQDAIEYMCEHAPQSIIELEHMGMPFSRLKNGKIYQRAFGGMSRNYDPANQAERTCAAADRTGHALLHTLYQGN
LAHKTDFYTEWFAVDLVKADDGSIAGVIALCIETGETVFLKAKITILATGGAGRIYESSTNAYINTGDGMGLALRAGLPL
QDMEFWQFHPTGIAGAGVLVTEGCRGEGGVLRNKDGERFMERYAPNAKDLACRDVVSRASQQEIMEGRGDTFSGTSCVWL
DLTHLGEDVINERLPTVRELGRTFAGIDPVEKPIPVVPTCHYQMGGIPTNKHGQVITQVDGKDKVIGGLYAVGECASVSV
HGANRLGSNSLLDLVVFGRAAGMHAEQSLKEGMPMKEVSQENIEKATARITKWDTSEQRGCKEKISELRKELQRVMQQYF
SVFRQESTMKEGLDKLFNIRERLDNAVLEDNSRIFNMMRIEALELDNLVLTAIATAKLALERKESRGAHSRVDYPERDDK
NWMKHTLYFLEGDRTSLRDVNMSPTKVKAFQPAERKY

Sequences:

>Translated_597_residues
MSIATQEFDAIVIGAGGAGLRASFQLSQSGFKTAVVSKVFPTRSHTVAAQGGIAAALGNIEFDDGLPSDDWKWHMYDTVK
GSDYIGDQDAIEYMCEHAPQSIIELEHMGMPFSRLKNGKIYQRAFGGMSRNYDPANQAERTCAAADRTGHALLHTLYQGN
LAHKTDFYTEWFAVDLVKADDGSIAGVIALCIETGETVFLKAKITILATGGAGRIYESSTNAYINTGDGMGLALRAGLPL
QDMEFWQFHPTGIAGAGVLVTEGCRGEGGVLRNKDGERFMERYAPNAKDLACRDVVSRASQQEIMEGRGDTFSGTSCVWL
DLTHLGEDVINERLPTVRELGRTFAGIDPVEKPIPVVPTCHYQMGGIPTNKHGQVITQVDGKDKVIGGLYAVGECASVSV
HGANRLGSNSLLDLVVFGRAAGMHAEQSLKEGMPMKEVSQENIEKATARITKWDTSEQRGCKEKISELRKELQRVMQQYF
SVFRQESTMKEGLDKLFNIRERLDNAVLEDNSRIFNMMRIEALELDNLVLTAIATAKLALERKESRGAHSRVDYPERDDK
NWMKHTLYFLEGDRTSLRDVNMSPTKVKAFQPAERKY
>Mature_596_residues
SIATQEFDAIVIGAGGAGLRASFQLSQSGFKTAVVSKVFPTRSHTVAAQGGIAAALGNIEFDDGLPSDDWKWHMYDTVKG
SDYIGDQDAIEYMCEHAPQSIIELEHMGMPFSRLKNGKIYQRAFGGMSRNYDPANQAERTCAAADRTGHALLHTLYQGNL
AHKTDFYTEWFAVDLVKADDGSIAGVIALCIETGETVFLKAKITILATGGAGRIYESSTNAYINTGDGMGLALRAGLPLQ
DMEFWQFHPTGIAGAGVLVTEGCRGEGGVLRNKDGERFMERYAPNAKDLACRDVVSRASQQEIMEGRGDTFSGTSCVWLD
LTHLGEDVINERLPTVRELGRTFAGIDPVEKPIPVVPTCHYQMGGIPTNKHGQVITQVDGKDKVIGGLYAVGECASVSVH
GANRLGSNSLLDLVVFGRAAGMHAEQSLKEGMPMKEVSQENIEKATARITKWDTSEQRGCKEKISELRKELQRVMQQYFS
VFRQESTMKEGLDKLFNIRERLDNAVLEDNSRIFNMMRIEALELDNLVLTAIATAKLALERKESRGAHSRVDYPERDDKN
WMKHTLYFLEGDRTSLRDVNMSPTKVKAFQPAERKY

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=586, Percent_Identity=52.2184300341297, Blast_Score=564, Evalue=1e-161,
Organism=Escherichia coli, GI1786942, Length=598, Percent_Identity=61.2040133779264, Blast_Score=699, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=582, Percent_Identity=41.4089347079038, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1788928, Length=571, Percent_Identity=32.2241681260946, Blast_Score=235, Evalue=5e-63,
Organism=Caenorhabditis elegans, GI17505833, Length=593, Percent_Identity=49.5784148397976, Blast_Score=545, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17550100, Length=541, Percent_Identity=52.1256931608133, Blast_Score=535, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI71986328, Length=155, Percent_Identity=34.8387096774194, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322701, Length=567, Percent_Identity=55.026455026455, Blast_Score=593, Evalue=1e-170,
Organism=Saccharomyces cerevisiae, GI6322416, Length=578, Percent_Identity=53.6332179930796, Blast_Score=578, Evalue=1e-166,
Organism=Drosophila melanogaster, GI17137288, Length=619, Percent_Identity=50.4038772213247, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655642, Length=619, Percent_Identity=50.4038772213247, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24655647, Length=619, Percent_Identity=50.4038772213247, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24663005, Length=623, Percent_Identity=44.7833065810594, Blast_Score=498, Evalue=1e-141,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65871; Mature: 65740

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIATQEFDAIVIGAGGAGLRASFQLSQSGFKTAVVSKVFPTRSHTVAAQGGIAAALGNI
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEECCCEEEEECCE
EFDDGLPSDDWKWHMYDTVKGSDYIGDQDAIEYMCEHAPQSIIELEHMGMPFSRLKNGKI
EECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCH
YQRAFGGMSRNYDPANQAERTCAAADRTGHALLHTLYQGNLAHKTDFYTEWFAVDLVKAD
HHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC
DGSIAGVIALCIETGETVFLKAKITILATGGAGRIYESSTNAYINTGDGMGLALRAGLPL
CCCHHHHHHEEECCCCEEEEEEEEEEEEECCCCCEEECCCCCEEECCCCCCEEEECCCCC
QDMEFWQFHPTGIAGAGVLVTEGCRGEGGVLRNKDGERFMERYAPNAKDLACRDVVSRAS
CCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
QQEIMEGRGDTFSGTSCVWLDLTHLGEDVINERLPTVRELGRTFAGIDPVEKPIPVVPTC
HHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCC
HYQMGGIPTNKHGQVITQVDGKDKVIGGLYAVGECASVSVHGANRLGSNSLLDLVVFGRA
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
AGMHAEQSLKEGMPMKEVSQENIEKATARITKWDTSEQRGCKEKISELRKELQRVMQQYF
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVFRQESTMKEGLDKLFNIRERLDNAVLEDNSRIFNMMRIEALELDNLVLTAIATAKLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ERKESRGAHSRVDYPERDDKNWMKHTLYFLEGDRTSLRDVNMSPTKVKAFQPAERKY
HHHHHCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCCCCCCEEEECCCHHCCC
>Mature Secondary Structure 
SIATQEFDAIVIGAGGAGLRASFQLSQSGFKTAVVSKVFPTRSHTVAAQGGIAAALGNI
CCCCCCCCEEEEECCCCCCEEEEEECCCCCHHHHHHHHCCCCCCEEEECCCEEEEECCE
EFDDGLPSDDWKWHMYDTVKGSDYIGDQDAIEYMCEHAPQSIIELEHMGMPFSRLKNGKI
EECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCH
YQRAFGGMSRNYDPANQAERTCAAADRTGHALLHTLYQGNLAHKTDFYTEWFAVDLVKAD
HHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECC
DGSIAGVIALCIETGETVFLKAKITILATGGAGRIYESSTNAYINTGDGMGLALRAGLPL
CCCHHHHHHEEECCCCEEEEEEEEEEEEECCCCCEEECCCCCEEECCCCCCEEEECCCCC
QDMEFWQFHPTGIAGAGVLVTEGCRGEGGVLRNKDGERFMERYAPNAKDLACRDVVSRAS
CCCCCEEECCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHH
QQEIMEGRGDTFSGTSCVWLDLTHLGEDVINERLPTVRELGRTFAGIDPVEKPIPVVPTC
HHHHHHCCCCCCCCCEEEEEEHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCC
HYQMGGIPTNKHGQVITQVDGKDKVIGGLYAVGECASVSVHGANRLGSNSLLDLVVFGRA
CCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
AGMHAEQSLKEGMPMKEVSQENIEKATARITKWDTSEQRGCKEKISELRKELQRVMQQYF
CCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SVFRQESTMKEGLDKLFNIRERLDNAVLEDNSRIFNMMRIEALELDNLVLTAIATAKLAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
ERKESRGAHSRVDYPERDDKNWMKHTLYFLEGDRTSLRDVNMSPTKVKAFQPAERKY
HHHHHCCCCCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCCCCCCEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]