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The map label for this gene is tyrP [H]

Identifier: 134301216

GI number: 134301216

Start: 72482

End: 73678

Strand: Direct

Name: tyrP [H]

Synonym: FTW_0065

Alternate gene names: 134301216

Gene position: 72482-73678 (Clockwise)

Preceding gene: 134301215

Following gene: 134301217

Centisome position: 3.82

GC content: 32.0

Gene sequence:

>1197_bases
ATGAATTCTAGATCTATTGGTTCAGTTTTTTTGATAATAGGTACTACAATTGGTGCAGGGATGCTATCACTACCTTTGAT
AGTTGCATCGTGTGGCTTTAGTATGGCAATAATTCTTTTAATTTTATCTTGGAGTGTAATGTATATAACAGCACTTAAGA
TACTTAGAGTTTGTGCTAAGTATCCTTTAGGTGTCAATTTTACATCGATGATGCAATCACAAGTATCAAGAAGATATTTG
CTATTTTTTAGTATCATTTATTTGTTGTTATTGTATTCTTTAATGTCCGCATACACTACACAAGGTTCATCTCTTGTAAG
TGCTATAACTAGCCTAGATAATTCTAATAAAGCTCAAGTGGGGCTATCAGCTATTGTCTTTACTATAATTTTTGGTGCGC
TAATGTTTAGCTACAGAATTAGTGACTATGCAAATAGATTTTTTGTGATAGTTAAGTTTTTATTTTTTGCGATTGCTGTA
GTTATTATGTTGTTTTACATAGATCCAAGTTATTTAAGCAGAGCGCCTCTTAGCTTATCAGCATTTATCTTTGCTTGGCC
GACTTTGTTACCTTCATTTGGATTTCATAATATAATTCCGGTTATCTATGAATATCAAAAAGGTGATATTAATAAGATTA
AAAAAAGTATTCTTATTGGTAGTCTAAGTGTCCTAGTGATTTATATTATTTGGATATTTTTAGCCTTAGCACTTATTCCA
CAGCAGGGCTTACATAGCTATCAAACATTATTTAGCTTTGGTAATAATACCCCTGCAGGGCTAGCAGCGGAGATTAGAGA
AGTATCTGGTTCGGGACTCCTAGAGATAGGGTTAAATACATTTATTCATATAGCAATTATTACATCTTTTATTGGAGTGG
GTATTTCGTTAATGCATTATATTCGCGATTTGTTTACGCGTTATCATAGACAAATAGGTAATCTAGCTCTAGGTCTGATA
TGTTTTATCCCGCCATTGATTTTTACCATTTTTTATCCGCGTGGTTTTATTTTAGCTTTACAATATGCGGCAATATTTGC
AGTGATAATATTTGTTTACACGCCATCATTCCTAAGTAGGAAAGCTGACCTTAAAGTCTACTATTTAAATCTTTATGTGA
TATCTATGGGTAGTGTTGTGATACTTTTCCAAATTTTTAACTTGTGTTTTAATATTAATCCTTTTAGTGGCTTTTAA

Upstream 100 bases:

>100_bases
TTTATTATAAGAAAATTTTGTCATGGGAGTCAGCATTATTTGCTTAGTTATTAAAATAGCGTTATTATTCATAGCGTTTA
ACAAAAAATATAGTTGATAT

Downstream 100 bases:

>100_bases
ATAGTCGATGATAATTTGAGCTAGAACATATATAATGTATGATTAGCATTTTTGTAAGTATAAGATTTTGATATTATGAG
ATTTGTAGATGAAGTAGTGA

Product: tryptophan/tyrosine permease family protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNSRSIGSVFLIIGTTIGAGMLSLPLIVASCGFSMAIILLILSWSVMYITALKILRVCAKYPLGVNFTSMMQSQVSRRYL
LFFSIIYLLLLYSLMSAYTTQGSSLVSAITSLDNSNKAQVGLSAIVFTIIFGALMFSYRISDYANRFFVIVKFLFFAIAV
VIMLFYIDPSYLSRAPLSLSAFIFAWPTLLPSFGFHNIIPVIYEYQKGDINKIKKSILIGSLSVLVIYIIWIFLALALIP
QQGLHSYQTLFSFGNNTPAGLAAEIREVSGSGLLEIGLNTFIHIAIITSFIGVGISLMHYIRDLFTRYHRQIGNLALGLI
CFIPPLIFTIFYPRGFILALQYAAIFAVIIFVYTPSFLSRKADLKVYYLNLYVISMGSVVILFQIFNLCFNINPFSGF

Sequences:

>Translated_398_residues
MNSRSIGSVFLIIGTTIGAGMLSLPLIVASCGFSMAIILLILSWSVMYITALKILRVCAKYPLGVNFTSMMQSQVSRRYL
LFFSIIYLLLLYSLMSAYTTQGSSLVSAITSLDNSNKAQVGLSAIVFTIIFGALMFSYRISDYANRFFVIVKFLFFAIAV
VIMLFYIDPSYLSRAPLSLSAFIFAWPTLLPSFGFHNIIPVIYEYQKGDINKIKKSILIGSLSVLVIYIIWIFLALALIP
QQGLHSYQTLFSFGNNTPAGLAAEIREVSGSGLLEIGLNTFIHIAIITSFIGVGISLMHYIRDLFTRYHRQIGNLALGLI
CFIPPLIFTIFYPRGFILALQYAAIFAVIIFVYTPSFLSRKADLKVYYLNLYVISMGSVVILFQIFNLCFNINPFSGF
>Mature_398_residues
MNSRSIGSVFLIIGTTIGAGMLSLPLIVASCGFSMAIILLILSWSVMYITALKILRVCAKYPLGVNFTSMMQSQVSRRYL
LFFSIIYLLLLYSLMSAYTTQGSSLVSAITSLDNSNKAQVGLSAIVFTIIFGALMFSYRISDYANRFFVIVKFLFFAIAV
VIMLFYIDPSYLSRAPLSLSAFIFAWPTLLPSFGFHNIIPVIYEYQKGDINKIKKSILIGSLSVLVIYIIWIFLALALIP
QQGLHSYQTLFSFGNNTPAGLAAEIREVSGSGLLEIGLNTFIHIAIITSFIGVGISLMHYIRDLFTRYHRQIGNLALGLI
CFIPPLIFTIFYPRGFILALQYAAIFAVIIFVYTPSFLSRKADLKVYYLNLYVISMGSVVILFQIFNLCFNINPFSGF

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=376, Percent_Identity=35.3723404255319, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1790145, Length=409, Percent_Identity=29.3398533007335, Blast_Score=141, Evalue=8e-35,
Organism=Escherichia coli, GI1789552, Length=356, Percent_Identity=26.123595505618, Blast_Score=107, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44438; Mature: 44438

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure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CCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]