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The map label for this gene is trpA [H]

Identifier: 134301179

GI number: 134301179

Start: 10220

End: 11029

Strand: Direct

Name: trpA [H]

Synonym: FTW_0013

Alternate gene names: 134301179

Gene position: 10220-11029 (Clockwise)

Preceding gene: 134301178

Following gene: 134301181

Centisome position: 0.54

GC content: 35.43

Gene sequence:

>810_bases
ATGACAAATAGATACACAACCCTTTTTGCAAATTTAGAGAAAAGAAATGAAGGAGCTTTTATACCTTTTGTAACAATTGG
TGATCCTAATAAAGCGCTATCCTTTGAAATTATCGATACTTTGGTTAGTTCAGGTGCTGATGCTCTTGAGTTGGGTATAC
CTTTTTCAGATCCCTTAGCAGATGGGCCAACAATTCAAGAAGCAAATATTCGCGCTCTGGAGAGTGGAATAACCCCTAAA
GATTGTTTCGATATTCTAACTAAAATAAGAGCAAAATACCCTCATATCCCTATTGGTTTACTACTTTATGCTAATTTAGT
CTATGCAAACGGTATAGAGAACTTTTATCAAAAATGTTTAGATGCAGGTGTTGATTCTATACTTATAGCTGATGTACCCG
CTCACGAATCTAAAGAGTTTCGTGATATTGCTAAAAAAGTTAGTATAGCACAAATATTTATCGCTCCTCCTGATGCTAGT
GAGTCAACTCTTAAGCAAATTTCTGAACTTGGTAGTGGTTATACGTATTTACTATCGAGAGTAGGTGTAACAGGGACAGA
AACTGCTGCAAATATGCCCGTCGAGGATGTATTGACTAAACTTAGAGAATATAATGCTCCTAAACCAGTTTTAGGCTTTG
GTATCTCTAAACCTGAGCAAGTACAACAAGCTATCAAAGCTGGTGCTGCTGGTGCAATTTCAGGCTCAGCAACAGTGAAA
ATTATTCAAAATAATATCTCTAATAAACAAAAAATGCTTAATGAGCTTACATATTTTGTTAAAGAGATGAAAGCAGCTAC
ATTAAACTAA

Upstream 100 bases:

>100_bases
ATCCTAATAAAGAGCAACTTTTGGTTGTTAATCTATCTGGGCGTGGTGATAAGGATATTTTTACAGTGCATGATATTTTA
AAAGAAAAGGGAGAGATTTA

Downstream 100 bases:

>100_bases
CTAAGCATATTTCAGAGAAAATAATAAATCCTATACAAAACAAACTAACAGAACTTATTTACTACTTTTTTGTAGTTTCT
TTGCGAGTTTATTTCCTAAA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MTNRYTTLFANLEKRNEGAFIPFVTIGDPNKALSFEIIDTLVSSGADALELGIPFSDPLADGPTIQEANIRALESGITPK
DCFDILTKIRAKYPHIPIGLLLYANLVYANGIENFYQKCLDAGVDSILIADVPAHESKEFRDIAKKVSIAQIFIAPPDAS
ESTLKQISELGSGYTYLLSRVGVTGTETAANMPVEDVLTKLREYNAPKPVLGFGISKPEQVQQAIKAGAAGAISGSATVK
IIQNNISNKQKMLNELTYFVKEMKAATLN

Sequences:

>Translated_269_residues
MTNRYTTLFANLEKRNEGAFIPFVTIGDPNKALSFEIIDTLVSSGADALELGIPFSDPLADGPTIQEANIRALESGITPK
DCFDILTKIRAKYPHIPIGLLLYANLVYANGIENFYQKCLDAGVDSILIADVPAHESKEFRDIAKKVSIAQIFIAPPDAS
ESTLKQISELGSGYTYLLSRVGVTGTETAANMPVEDVLTKLREYNAPKPVLGFGISKPEQVQQAIKAGAAGAISGSATVK
IIQNNISNKQKMLNELTYFVKEMKAATLN
>Mature_268_residues
TNRYTTLFANLEKRNEGAFIPFVTIGDPNKALSFEIIDTLVSSGADALELGIPFSDPLADGPTIQEANIRALESGITPKD
CFDILTKIRAKYPHIPIGLLLYANLVYANGIENFYQKCLDAGVDSILIADVPAHESKEFRDIAKKVSIAQIFIAPPDASE
STLKQISELGSGYTYLLSRVGVTGTETAANMPVEDVLTKLREYNAPKPVLGFGISKPEQVQQAIKAGAAGAISGSATVKI
IQNNISNKQKMLNELTYFVKEMKAATLN

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=264, Percent_Identity=60.2272727272727, Blast_Score=314, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6321412, Length=251, Percent_Identity=30.2788844621514, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29099; Mature: 28967

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNRYTTLFANLEKRNEGAFIPFVTIGDPNKALSFEIIDTLVSSGADALELGIPFSDPLA
CCCCEEEHEEEHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DGPTIQEANIRALESGITPKDCFDILTKIRAKYPHIPIGLLLYANLVYANGIENFYQKCL
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DAGVDSILIADVPAHESKEFRDIAKKVSIAQIFIAPPDASESTLKQISELGSGYTYLLSR
HCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
VGVTGTETAANMPVEDVLTKLREYNAPKPVLGFGISKPEQVQQAIKAGAAGAISGSATVK
CCCCCCCHHCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCEEE
IIQNNISNKQKMLNELTYFVKEMKAATLN
EEHHCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNRYTTLFANLEKRNEGAFIPFVTIGDPNKALSFEIIDTLVSSGADALELGIPFSDPLA
CCCEEEHEEEHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCC
DGPTIQEANIRALESGITPKDCFDILTKIRAKYPHIPIGLLLYANLVYANGIENFYQKCL
CCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DAGVDSILIADVPAHESKEFRDIAKKVSIAQIFIAPPDASESTLKQISELGSGYTYLLSR
HCCCCEEEEECCCCCCHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHCCCHHHHHHH
VGVTGTETAANMPVEDVLTKLREYNAPKPVLGFGISKPEQVQQAIKAGAAGAISGSATVK
CCCCCCCHHCCCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCCCEEE
IIQNNISNKQKMLNELTYFVKEMKAATLN
EEHHCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA