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The map label for this gene is yggV [C]

Identifier: 134300518

GI number: 134300518

Start: 2908175

End: 2908780

Strand: Reverse

Name: yggV [C]

Synonym: Dred_2683

Alternate gene names: 134300518

Gene position: 2908780-2908175 (Counterclockwise)

Preceding gene: 134300519

Following gene: 134300517

Centisome position: 80.62

GC content: 46.04

Gene sequence:

>606_bases
TTGAAGTTAGTTTTAGCAACCAACAATAAAGGCAAAGTGAAAGAGTTGGCCGAGCTATTAAAACCCTGCGGGTATCAGGT
AGTTTCCATCGGCGAATTTCCGGGTTTTACAGAGGTAGAGGAAGACGGAAATACCTTTGCAGACAATGCCATTAAAAAAG
CTCTGGCCGCAGCAGAATTTACCGGAGAATTGGCTTTGGCCGATGATTCGGGTTTAGAGGTGGATGCATTAAAGGGTGCG
CCGGGGGTTTACTCAGCCCGTTTTGCTGGGGAACCCAAGGACGATACGGCAAACAATGCTAAATTATTAAGTCTGTTGGA
AGGAGTTCCCCAGGATCATCGGACAGCCAGATTCCGGTGTGTCATAGCCATTGCGGAACCTAATGGTAGGATTCACACAG
CGGAAGGAAGCTGTGAGGGGGTTATTTTAAGAGAATTAAAGGGCGAGGGTGGTTTTGGCTACGATCCCCTGTTTTACGTG
CCGGAATATAAACAAACCTTTGCAGAATTGGATATGGAAAAGAAGAACTCCATTAGTCACCGGGGGAAAGCTCTAAAAAA
AGCAATGGAGATTCTAAACCGCCTTTACATTCACCAGGAGGTTTAA

Upstream 100 bases:

>100_bases
TCAACTTCTGGATTTAGCCGCAGCGGGTATTGAAGAATTAAATAAGGTTCAGCGCCAGGTACTGGGAGATATAGCAGCTA
AGATAGGGTAGGTGTAATTT

Downstream 100 bases:

>100_bases
GGATTGCGTATTTTGGTTTTAGCGGATACCCACGGTAGGCTGGGTCCCATTTATCATATAATGAAACATATAGGGAAGGT
GGACCTCATTCTCCATGCTG

Product: nucleoside-triphosphatase

Products: NA

Alternate protein names: Nucleoside triphosphate phosphohydrolase; NTPase

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MKLVLATNNKGKVKELAELLKPCGYQVVSIGEFPGFTEVEEDGNTFADNAIKKALAAAEFTGELALADDSGLEVDALKGA
PGVYSARFAGEPKDDTANNAKLLSLLEGVPQDHRTARFRCVIAIAEPNGRIHTAEGSCEGVILRELKGEGGFGYDPLFYV
PEYKQTFAELDMEKKNSISHRGKALKKAMEILNRLYIHQEV

Sequences:

>Translated_201_residues
MKLVLATNNKGKVKELAELLKPCGYQVVSIGEFPGFTEVEEDGNTFADNAIKKALAAAEFTGELALADDSGLEVDALKGA
PGVYSARFAGEPKDDTANNAKLLSLLEGVPQDHRTARFRCVIAIAEPNGRIHTAEGSCEGVILRELKGEGGFGYDPLFYV
PEYKQTFAELDMEKKNSISHRGKALKKAMEILNRLYIHQEV
>Mature_201_residues
MKLVLATNNKGKVKELAELLKPCGYQVVSIGEFPGFTEVEEDGNTFADNAIKKALAAAEFTGELALADDSGLEVDALKGA
PGVYSARFAGEPKDDTANNAKLLSLLEGVPQDHRTARFRCVIAIAEPNGRIHTAEGSCEGVILRELKGEGGFGYDPLFYV
PEYKQTFAELDMEKKNSISHRGKALKKAMEILNRLYIHQEV

Specific function: Hydrolyzes non-standard nucleotides such as XTP and dITP/ITP. Might exclude non-standard purines from DNA precursor pool, preventing thus incorporation into DNA and avoiding chromosomal lesions

COG id: COG0127

COG function: function code F; Xanthosine triphosphate pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAM1 NTPase family

Homologues:

Organism=Homo sapiens, GI15626999, Length=201, Percent_Identity=29.3532338308458, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1789324, Length=195, Percent_Identity=50.2564102564103, Blast_Score=172, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17556833, Length=190, Percent_Identity=32.6315789473684, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322529, Length=197, Percent_Identity=28.9340101522843, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19920712, Length=184, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NTPA_DESRM (A4J7Y6)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001114014.1
- ProteinModelPortal:   A4J7Y6
- SMR:   A4J7Y6
- STRING:   A4J7Y6
- GeneID:   4955397
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2683
- eggNOG:   COG0127
- HOGENOM:   HBG697237
- OMA:   TGVTFAE
- PhylomeDB:   A4J7Y6
- ProtClustDB:   PRK14822
- BioCyc:   DRED349161:DRED_2683-MONOMER
- HAMAP:   MF_01405
- InterPro:   IPR002637
- InterPro:   IPR020922
- PANTHER:   PTHR11067
- TIGRFAMs:   TIGR00042

Pfam domain/function: PF01725 Ham1p_like

EC number: =3.6.1.15

Molecular weight: Translated: 21902; Mature: 21902

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVLATNNKGKVKELAELLKPCGYQVVSIGEFPGFTEVEEDGNTFADNAIKKALAAAEF
CEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TGELALADDSGLEVDALKGAPGVYSARFAGEPKDDTANNAKLLSLLEGVPQDHRTARFRC
CCCEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
VIAIAEPNGRIHTAEGSCEGVILRELKGEGGFGYDPLFYVPEYKQTFAELDMEKKNSISH
EEEEECCCCEEEECCCCCCEEEEEEECCCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHH
RGKALKKAMEILNRLYIHQEV
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLVLATNNKGKVKELAELLKPCGYQVVSIGEFPGFTEVEEDGNTFADNAIKKALAAAEF
CEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
TGELALADDSGLEVDALKGAPGVYSARFAGEPKDDTANNAKLLSLLEGVPQDHRTARFRC
CCCEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
VIAIAEPNGRIHTAEGSCEGVILRELKGEGGFGYDPLFYVPEYKQTFAELDMEKKNSISH
EEEEECCCCEEEECCCCCCEEEEEEECCCCCCCCCCEEECCHHHHHHHHHCCHHHHHHHH
RGKALKKAMEILNRLYIHQEV
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA