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The map label for this gene is phoP [H]

Identifier: 134300477

GI number: 134300477

Start: 2861293

End: 2862012

Strand: Reverse

Name: phoP [H]

Synonym: Dred_2641

Alternate gene names: 134300477

Gene position: 2862012-2861293 (Counterclockwise)

Preceding gene: 134300478

Following gene: 134300476

Centisome position: 79.32

GC content: 43.33

Gene sequence:

>720_bases
ATGCAAAAAATATTGGTGCTGGAAGATGAGGAGTCAATCCGTAGTTTTATTAGGGTTAACTTAAAAAGAAACGGATTTCA
GGCGGTGGAGGCCTGCAGCGGAGAAGAAGCTTTGGAGAAAGTAGAGCAAGCGGGTCCCATTACCGTAGCTCTCTTAGATG
TAATGCTGCCAGGTATTGACGGTTTTGAGGTTTGTCGGATATTAAAGGAACGCTATCCCGGCTTAGGCATCATTATGCTT
ACTGCCAAGGGGCAGGAAGCGGATAAAGTATCTGGACTGGTACTGGGCGCCGATGATTATGTGGTAAAGCCCTTTAGTCC
AAAGGAATTGATTGCCAGGATCAATGCACTAATAAGACGGTTGCAGCCCTTTAACACTCAGCTAGGAGGGGAAGCTGAGA
ACAGGCTATGCTCCGGTATTTATTGTATCTGCCTGGACAAGAAGAAGTTTTACAAAGGGGAGAAAGAAATTGATCTTACG
CCTAAGGAATTTGAAATTATCAAGTTGTTTTTACACAATGTAGATAAAGCCATTAGCCGGGATGATATTTTAAACCAGAT
TTGGGGACGTCATTATATTGGCGATTTAAAAATTGTGGATGTGAACATCCGCAGAATCAGGCAAAAAATTGAGAATGACC
CATCAAATCCCGCTACGTTAGAAAAAGTATGGGGGTATGGTTATCGCTGGCGGGGAGGAGTTGAGAATGAAGGGCATTAA

Upstream 100 bases:

>100_bases
AGAATTGCTATTAAAACAGGAGCAAGTGAAGGAACAATTTGAATTTATATCGTCTCCGTACTAGAGAATGTTGATAACAG
ATTCAATTGGGGATGGTGCT

Downstream 100 bases:

>100_bases
AAGAAGGATGGTCTGGCACTATGTTATCGTTATCTTTCTAACTGTGCTTGTGCTTGAAGGTTTGTTTATAGGTACCATAA
GACAATATTACTTTGGCAGT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQKILVLEDEESIRSFIRVNLKRNGFQAVEACSGEEALEKVEQAGPITVALLDVMLPGIDGFEVCRILKERYPGLGIIML
TAKGQEADKVSGLVLGADDYVVKPFSPKELIARINALIRRLQPFNTQLGGEAENRLCSGIYCICLDKKKFYKGEKEIDLT
PKEFEIIKLFLHNVDKAISRDDILNQIWGRHYIGDLKIVDVNIRRIRQKIENDPSNPATLEKVWGYGYRWRGGVENEGH

Sequences:

>Translated_239_residues
MQKILVLEDEESIRSFIRVNLKRNGFQAVEACSGEEALEKVEQAGPITVALLDVMLPGIDGFEVCRILKERYPGLGIIML
TAKGQEADKVSGLVLGADDYVVKPFSPKELIARINALIRRLQPFNTQLGGEAENRLCSGIYCICLDKKKFYKGEKEIDLT
PKEFEIIKLFLHNVDKAISRDDILNQIWGRHYIGDLKIVDVNIRRIRQKIENDPSNPATLEKVWGYGYRWRGGVENEGH
>Mature_239_residues
MQKILVLEDEESIRSFIRVNLKRNGFQAVEACSGEEALEKVEQAGPITVALLDVMLPGIDGFEVCRILKERYPGLGIIML
TAKGQEADKVSGLVLGADDYVVKPFSPKELIARINALIRRLQPFNTQLGGEAENRLCSGIYCICLDKKKFYKGEKEIDLT
PKEFEIIKLFLHNVDKAISRDDILNQIWGRHYIGDLKIVDVNIRRIRQKIENDPSNPATLEKVWGYGYRWRGGVENEGH

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=35.3982300884956, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=36.9098712446352, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=33.4763948497854, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786911, Length=231, Percent_Identity=32.4675324675325, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=33.0434782608696, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790860, Length=237, Percent_Identity=32.4894514767932, Blast_Score=117, Evalue=6e-28,
Organism=Escherichia coli, GI1790863, Length=239, Percent_Identity=31.3807531380753, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=32.0175438596491, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=29.9145299145299, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=213, Percent_Identity=30.0469483568075, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=30.9734513274336, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI2367329, Length=235, Percent_Identity=30.2127659574468, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787375, Length=230, Percent_Identity=29.5652173913043, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=28.2051282051282, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790299, Length=136, Percent_Identity=33.8235294117647, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1788191, Length=122, Percent_Identity=32.7868852459016, Blast_Score=62, Evalue=2e-11,
Organism=Escherichia coli, GI1788550, Length=110, Percent_Identity=30, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27100; Mature: 27100

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVLEDEESIRSFIRVNLKRNGFQAVEACSGEEALEKVEQAGPITVALLDVMLPGID
CCCEEEEECHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCC
GFEVCRILKERYPGLGIIMLTAKGQEADKVSGLVLGADDYVVKPFSPKELIARINALIRR
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHCEEEECCCCCEECCCCHHHHHHHHHHHHHH
LQPFNTQLGGEAENRLCSGIYCICLDKKKFYKGEKEIDLTPKEFEIIKLFLHNVDKAISR
HCCCCCCCCCCHHHHHHCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
DDILNQIWGRHYIGDLKIVDVNIRRIRQKIENDPSNPATLEKVWGYGYRWRGGVENEGH
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCCCC
>Mature Secondary Structure
MQKILVLEDEESIRSFIRVNLKRNGFQAVEACSGEEALEKVEQAGPITVALLDVMLPGID
CCCEEEEECHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHCCCC
GFEVCRILKERYPGLGIIMLTAKGQEADKVSGLVLGADDYVVKPFSPKELIARINALIRR
HHHHHHHHHHHCCCCEEEEEEECCCCCHHHCEEEECCCCCEECCCCHHHHHHHHHHHHHH
LQPFNTQLGGEAENRLCSGIYCICLDKKKFYKGEKEIDLTPKEFEIIKLFLHNVDKAISR
HCCCCCCCCCCHHHHHHCCEEEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
DDILNQIWGRHYIGDLKIVDVNIRRIRQKIENDPSNPATLEKVWGYGYRWRGGVENEGH
HHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]