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The map label for this gene is phoR [H]

Identifier: 134300476

GI number: 134300476

Start: 2859903

End: 2861306

Strand: Reverse

Name: phoR [H]

Synonym: Dred_2640

Alternate gene names: 134300476

Gene position: 2861306-2859903 (Counterclockwise)

Preceding gene: 134300477

Following gene: 134300475

Centisome position: 79.3

GC content: 43.45

Gene sequence:

>1404_bases
ATGAAGGGCATTAAAAGAAGGATGGTCTGGCACTATGTTATCGTTATCTTTCTAACTGTGCTTGTGCTTGAAGGTTTGTT
TATAGGTACCATAAGACAATATTACTTTGGCAGTGCCGAGCAGGCACTGGTGAGCCGTGCCACTGTTTCTGCGAACTTTT
ATAATAAATACCTACGAGATTATAATTTTTATTTAAAAACAAATGCCCAAAAAATATTGGAAACTTTACCCAAGGATGAA
CCAGCTAGAATTGAGATCATAGACTGGCAGGGGAACGTGCTGGTAGATTCTAATGGTTTTCCACGGGCTCAAAGGGTGGA
TTCACCGGACTTTAAGGAAGCCCTGGCAGGGAAAACCGGGGTCTGGAGGGGGAAAAACGACATCACCGGGGAAAGAATTC
TTGCTGTTTCCAACCCATTAAAAGATGGGAACCGATCTGTGGGGGTTCTGCGGTATGTTGTTTCCCTGGAAGCTTTACAT
AACGTGGTGTTGAAGATAACCCTTGTTTCTGTGACCGTGGGTTTATTAGTTGTGCTCCTGGCTGTGGGAGTAAGCTTAGT
CCTAGCCAGAAGCATTGTCATTCCTCTGCAAGAAGTGACCCGGGTTGCCGGGCAAATGGCCAAGGGAGACTTTTCGGTGA
AAGCGACAAAAAGGGAGGATGACGAAGTAGGAAAACTGGCCGATACTCTCAATTATATGTCTGAAGAAATTCTTAAGAGC
GATAAAATGAAAAATGATTTTATATCGTCCATATCCCATGAGTTAAGAACACCCCTTACCTCCATCAAGGGCTGGGGCGA
AACCCTTTTCGGTGAGGAACTGCAGGACAGGGAGGAAGTGAAGGAAGGACTGAACATCATCTGTAAGGAAACAGACCGGA
TGATCGGCTTGGTAGAAGAGCTTTTGGATTTTTCAAGGTTTCAGTCTGGTCGTATTAAATTAAACCTGGAAAAGATAAAT
ATTAACTCCCTTTTAACCGAAGTGATTCAGCAATACGCCATACGGGTTCGTCAGAAAAAAATTGAGATGCCGTACCAATT
TAATGACAGTGTGCCAGAGATAACTGGAGACAGAAACCGTTTGAAACAAGTCTTTATTAACTTATTGGATAATGCCGTTA
AGTTTACTCCATTTTGTGGTAAGGTACAGATTAGCACAGAATATTCAGAGGGAACAATTAAAATAGACTTTGTCAATAGC
GGAGAAGGGATCCGGTCGGAAGACCTTCCCCGTGTAACGGAAAAATTTTACAAGGCCAATGCCAACCGCCCCGGAAGTGG
TCTGGGATTGGCAATTGTTAAGGAGATTATTAATCTTCATCAGGGTGACTTGCATATTGAAAGCATCCCGGGGCAGAATA
CCAGGGTGACCGTAATTCTCCTAGGAGAGCAGAAAAAACTCTAG

Upstream 100 bases:

>100_bases
ATCCGCAGAATCAGGCAAAAAATTGAGAATGACCCATCAAATCCCGCTACGTTAGAAAAAGTATGGGGGTATGGTTATCG
CTGGCGGGGAGGAGTTGAGA

Downstream 100 bases:

>100_bases
GTGCTCTTTTGTAAGAATGTGGATAGTCCATGGTCATTGGGTCTTGGCAGCTTAAATGATAGACTAGTATTGCTGGCAAT
AAGGAAGAATATTTAGATTA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MKGIKRRMVWHYVIVIFLTVLVLEGLFIGTIRQYYFGSAEQALVSRATVSANFYNKYLRDYNFYLKTNAQKILETLPKDE
PARIEIIDWQGNVLVDSNGFPRAQRVDSPDFKEALAGKTGVWRGKNDITGERILAVSNPLKDGNRSVGVLRYVVSLEALH
NVVLKITLVSVTVGLLVVLLAVGVSLVLARSIVIPLQEVTRVAGQMAKGDFSVKATKREDDEVGKLADTLNYMSEEILKS
DKMKNDFISSISHELRTPLTSIKGWGETLFGEELQDREEVKEGLNIICKETDRMIGLVEELLDFSRFQSGRIKLNLEKIN
INSLLTEVIQQYAIRVRQKKIEMPYQFNDSVPEITGDRNRLKQVFINLLDNAVKFTPFCGKVQISTEYSEGTIKIDFVNS
GEGIRSEDLPRVTEKFYKANANRPGSGLGLAIVKEIINLHQGDLHIESIPGQNTRVTVILLGEQKKL

Sequences:

>Translated_467_residues
MKGIKRRMVWHYVIVIFLTVLVLEGLFIGTIRQYYFGSAEQALVSRATVSANFYNKYLRDYNFYLKTNAQKILETLPKDE
PARIEIIDWQGNVLVDSNGFPRAQRVDSPDFKEALAGKTGVWRGKNDITGERILAVSNPLKDGNRSVGVLRYVVSLEALH
NVVLKITLVSVTVGLLVVLLAVGVSLVLARSIVIPLQEVTRVAGQMAKGDFSVKATKREDDEVGKLADTLNYMSEEILKS
DKMKNDFISSISHELRTPLTSIKGWGETLFGEELQDREEVKEGLNIICKETDRMIGLVEELLDFSRFQSGRIKLNLEKIN
INSLLTEVIQQYAIRVRQKKIEMPYQFNDSVPEITGDRNRLKQVFINLLDNAVKFTPFCGKVQISTEYSEGTIKIDFVNS
GEGIRSEDLPRVTEKFYKANANRPGSGLGLAIVKEIINLHQGDLHIESIPGQNTRVTVILLGEQKKL
>Mature_467_residues
MKGIKRRMVWHYVIVIFLTVLVLEGLFIGTIRQYYFGSAEQALVSRATVSANFYNKYLRDYNFYLKTNAQKILETLPKDE
PARIEIIDWQGNVLVDSNGFPRAQRVDSPDFKEALAGKTGVWRGKNDITGERILAVSNPLKDGNRSVGVLRYVVSLEALH
NVVLKITLVSVTVGLLVVLLAVGVSLVLARSIVIPLQEVTRVAGQMAKGDFSVKATKREDDEVGKLADTLNYMSEEILKS
DKMKNDFISSISHELRTPLTSIKGWGETLFGEELQDREEVKEGLNIICKETDRMIGLVEELLDFSRFQSGRIKLNLEKIN
INSLLTEVIQQYAIRVRQKKIEMPYQFNDSVPEITGDRNRLKQVFINLLDNAVKFTPFCGKVQISTEYSEGTIKIDFVNS
GEGIRSEDLPRVTEKFYKANANRPGSGLGLAIVKEIINLHQGDLHIESIPGQNTRVTVILLGEQKKL

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=30.3249097472924, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1786600, Length=222, Percent_Identity=32.8828828828829, Blast_Score=123, Evalue=3e-29,
Organism=Escherichia coli, GI1788713, Length=249, Percent_Identity=31.7269076305221, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790436, Length=237, Percent_Identity=29.1139240506329, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1788549, Length=217, Percent_Identity=30.8755760368664, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1790861, Length=384, Percent_Identity=27.8645833333333, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=29.2035398230088, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI145693157, Length=239, Percent_Identity=28.0334728033473, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=401, Percent_Identity=23.9401496259352, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081816, Length=303, Percent_Identity=25.7425742574257, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI87082128, Length=287, Percent_Identity=24.0418118466899, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=27.5109170305677, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=226, Percent_Identity=28.3185840707965, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=27.536231884058, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1789403, Length=222, Percent_Identity=30.6306306306306, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1789808, Length=299, Percent_Identity=23.7458193979933, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788279, Length=295, Percent_Identity=22.0338983050847, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=24.4755244755245, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790300, Length=248, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52578; Mature: 52578

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIKRRMVWHYVIVIFLTVLVLEGLFIGTIRQYYFGSAEQALVSRATVSANFYNKYLRD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
YNFYLKTNAQKILETLPKDEPARIEIIDWQGNVLVDSNGFPRAQRVDSPDFKEALAGKTG
CCEEEECCHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCHHHHHCCCCC
VWRGKNDITGERILAVSNPLKDGNRSVGVLRYVVSLEALHNVVLKITLVSVTVGLLVVLL
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGVSLVLARSIVIPLQEVTRVAGQMAKGDFSVKATKREDDEVGKLADTLNYMSEEILKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
DKMKNDFISSISHELRTPLTSIKGWGETLFGEELQDREEVKEGLNIICKETDRMIGLVEE
HCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLDFSRFQSGRIKLNLEKININSLLTEVIQQYAIRVRQKKIEMPYQFNDSVPEITGDRNR
HHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
LKQVFINLLDNAVKFTPFCGKVQISTEYSEGTIKIDFVNSGEGIRSEDLPRVTEKFYKAN
HHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCC
ANRPGSGLGLAIVKEIINLHQGDLHIESIPGQNTRVTVILLGEQKKL
CCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCC
>Mature Secondary Structure
MKGIKRRMVWHYVIVIFLTVLVLEGLFIGTIRQYYFGSAEQALVSRATVSANFYNKYLRD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
YNFYLKTNAQKILETLPKDEPARIEIIDWQGNVLVDSNGFPRAQRVDSPDFKEALAGKTG
CCEEEECCHHHHHHHCCCCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCHHHHHCCCCC
VWRGKNDITGERILAVSNPLKDGNRSVGVLRYVVSLEALHNVVLKITLVSVTVGLLVVLL
CCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVGVSLVLARSIVIPLQEVTRVAGQMAKGDFSVKATKREDDEVGKLADTLNYMSEEILKS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
DKMKNDFISSISHELRTPLTSIKGWGETLFGEELQDREEVKEGLNIICKETDRMIGLVEE
HCHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLDFSRFQSGRIKLNLEKININSLLTEVIQQYAIRVRQKKIEMPYQFNDSVPEITGDRNR
HHHHHHCCCCCEEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHH
LKQVFINLLDNAVKFTPFCGKVQISTEYSEGTIKIDFVNSGEGIRSEDLPRVTEKFYKAN
HHHHHHHHHHHHHEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCCCCHHHHHHHHHCC
ANRPGSGLGLAIVKEIINLHQGDLHIESIPGQNTRVTVILLGEQKKL
CCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]