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The map label for this gene is cheA [H]

Identifier: 134300279

GI number: 134300279

Start: 2655946

End: 2658036

Strand: Reverse

Name: cheA [H]

Synonym: Dred_2440

Alternate gene names: 134300279

Gene position: 2658036-2655946 (Counterclockwise)

Preceding gene: 134300280

Following gene: 134300278

Centisome position: 73.67

GC content: 47.25

Gene sequence:

>2091_bases
ATGTTTTCAGATCTGGAAATTGGTGTATTTATAGATGAGCTTGAAGAGAAAATTCAAGTGATTAACGATGGTTTGCTGGC
TTTGGAGCGGGATGAGAGTAATCCTGACATTATCCAAGAGATTTTTCGAGCTGCCCACACCGTAAAGGGTTCTTCGGGTA
TTATGGGTTACCAGAACATGGCCAGCCTTACCCACGAAATGGAAAACCTCTTTGATAAAATCCGTCATGGAGAAATTCAT
GTAACCTCGGAGATGATCAATGTACTCTTCGAAGCCCTGGATACCCTAAAGGCATTAAAGGAGGAAGTAACAGGGGAAGG
TCCCGCTGTGGATACTTCTGTAGTGGTAGAGAAAATTAAAGCCTTTGTAACCGGGGGCGATGCAGCGCCCGAGATACCCG
AACCACCGAAGGAAAACCCTGTAGCTTCTGTTAAAGCAGCCGCCACTGTACGACAATGGCTGGAAATTGGTGATGTGGAA
GAAAATGTAATTAGAGAAGCCGAGTTAAGGGGCTTCCAATGCTATCGCATTGCCATCGATATTGATCGGGACTGTCAAAT
GAAAAATGTTAGGGCCTTTTTGGTCTTTGAAACCCTGCAGCAGGTGGGTGAAATCATTAAAAGTGAGCCCTCTGCCGAGG
ATATTCAGGAGGGTAAGTACGACATCAGTTTCCAGGTGTTGCTAATTACTAAGGAAGATCAAGACCAAATTAAAAATCTT
ATGGTTACCATCTCCGAGGTTACCGAAGCAGAGGTTCAACCTGTGCTGCTGAACAGTATCGAAGCAGTGATTGAGCAACC
GAAAGCTCAGACAACCACCACGATAAACCGCCCGGTGGAACAGGAGAACAATGCAGTCAAGCTGGAGACCACCGAGAGAA
AGACCGTTAAAACCGTTCGGGTGGATGTTACCAAACTGGATAATCTAATGAATTTGGTGGGGGAGTTGGTCATCGACCGT
ACCCGACTCAATCGTTTTGCAGAAATCTTTGAGTCCCGTTTTGGTTCCGATGAAATGGTGGAAGCCATTAATGAAATTTC
CAACCACCTGGGTCAGGTAACCGGCGATCTGCAGGAACAAATTATGAAAGCCCGCATGCTGCCAGTGGCACAGCTATTTA
ACCGTTTTCCCCGCATGGTACGGGACACCGCCCAAAAACTGGGCAAAGAAATCGACTTTGTGGTGGAAGGTAAGGAAACC
GAACTGGACCGTAATGTAATTGAAGTTATTGGTGATCCCATCATCCACCTAATTCGAAATTCCATTGACCACGGCATAGA
ATTACCGGCAGAACGTCAGGCTGCAGGAAAGAATAGAGTGGGAACTCTATTGCTAAAGGCTTCCTATGCAGAAAGCCATA
TTGTTATCACCGTAAAAGACGATGGTCGGGGCATGGATGCCAATAAGATCCGCAACAAGGCTGTGGAAATGGGCTTTGTG
GATCGGGAAACCGCTGACCGTATGAGTGATCGAGATGCCCTGCAATTGATCTTCAAGGCGGGTTTTTCCACCAAGAATAA
TGAAGTCAGCGACTTGTCTGGTCGAGGCGTGGGCATGGATGTGGTAAACACTGCCATTGAGCAAATTAATGGTACGGTGG
AATTGGATACCAAACTGGGTGCCGGTACCACCATCACCATTCGTTTACCCTTAACCCTAGCCATTATCCGGGCCCTCATG
GTAACCCTGGGCAACCAGGTATATGCTTTCCCCTTAACCAACGTATCCGAAACCATTCGTATCACCGATCAAGAAATTCG
CCGCATTGGCAACAACGAAGTGATTGTGGTGCGAGATAAAATTCTACCACTGGCTCGCATGGGTCGTCTGTTCAATTGTG
CTGAGTGTGAAGAATCCAGCAAGATGTATGTGGTAATTCTGGGTTCCGGTGACAAAAAGATTGCGGTGGTTGTTGATAAA
TTGTTGGGAGAACAGGAAATTGTCATTAAGTCCCTGGGCGATTACCTGGGGCAAGTACAGGGTCTCTCCGGTGCCTGCAT
CCTAGGTGATGGCAAAGTGGCCCTCATTGTGGATGTGAGAGGTCTGGTAAAGGATCTCGGGGCTGAGGAGGTAGCCTATG
CTGCCGGTTAA

Upstream 100 bases:

>100_bases
TGATTATTCTTCTGGATCAAAATAGGATTCTGCTGGATGAAGAAAAGGATCAATTACTGCAGGCAAATATGGGTGCTGCC
CAGGCCTAGGAGGTATAAAC

Downstream 100 bases:

>100_bases
AGTCCTGGTGGTGGACGATTCCTCCCTGATGAGGCGGCTGATTAGCCGCCTATTGGAGGAAGACAAAGGAATAAAAGTCA
TTGGCACCGCTGCGGATGGA

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 696; Mature: 696

Protein sequence:

>696_residues
MFSDLEIGVFIDELEEKIQVINDGLLALERDESNPDIIQEIFRAAHTVKGSSGIMGYQNMASLTHEMENLFDKIRHGEIH
VTSEMINVLFEALDTLKALKEEVTGEGPAVDTSVVVEKIKAFVTGGDAAPEIPEPPKENPVASVKAAATVRQWLEIGDVE
ENVIREAELRGFQCYRIAIDIDRDCQMKNVRAFLVFETLQQVGEIIKSEPSAEDIQEGKYDISFQVLLITKEDQDQIKNL
MVTISEVTEAEVQPVLLNSIEAVIEQPKAQTTTTINRPVEQENNAVKLETTERKTVKTVRVDVTKLDNLMNLVGELVIDR
TRLNRFAEIFESRFGSDEMVEAINEISNHLGQVTGDLQEQIMKARMLPVAQLFNRFPRMVRDTAQKLGKEIDFVVEGKET
ELDRNVIEVIGDPIIHLIRNSIDHGIELPAERQAAGKNRVGTLLLKASYAESHIVITVKDDGRGMDANKIRNKAVEMGFV
DRETADRMSDRDALQLIFKAGFSTKNNEVSDLSGRGVGMDVVNTAIEQINGTVELDTKLGAGTTITIRLPLTLAIIRALM
VTLGNQVYAFPLTNVSETIRITDQEIRRIGNNEVIVVRDKILPLARMGRLFNCAECEESSKMYVVILGSGDKKIAVVVDK
LLGEQEIVIKSLGDYLGQVQGLSGACILGDGKVALIVDVRGLVKDLGAEEVAYAAG

Sequences:

>Translated_696_residues
MFSDLEIGVFIDELEEKIQVINDGLLALERDESNPDIIQEIFRAAHTVKGSSGIMGYQNMASLTHEMENLFDKIRHGEIH
VTSEMINVLFEALDTLKALKEEVTGEGPAVDTSVVVEKIKAFVTGGDAAPEIPEPPKENPVASVKAAATVRQWLEIGDVE
ENVIREAELRGFQCYRIAIDIDRDCQMKNVRAFLVFETLQQVGEIIKSEPSAEDIQEGKYDISFQVLLITKEDQDQIKNL
MVTISEVTEAEVQPVLLNSIEAVIEQPKAQTTTTINRPVEQENNAVKLETTERKTVKTVRVDVTKLDNLMNLVGELVIDR
TRLNRFAEIFESRFGSDEMVEAINEISNHLGQVTGDLQEQIMKARMLPVAQLFNRFPRMVRDTAQKLGKEIDFVVEGKET
ELDRNVIEVIGDPIIHLIRNSIDHGIELPAERQAAGKNRVGTLLLKASYAESHIVITVKDDGRGMDANKIRNKAVEMGFV
DRETADRMSDRDALQLIFKAGFSTKNNEVSDLSGRGVGMDVVNTAIEQINGTVELDTKLGAGTTITIRLPLTLAIIRALM
VTLGNQVYAFPLTNVSETIRITDQEIRRIGNNEVIVVRDKILPLARMGRLFNCAECEESSKMYVVILGSGDKKIAVVVDK
LLGEQEIVIKSLGDYLGQVQGLSGACILGDGKVALIVDVRGLVKDLGAEEVAYAAG
>Mature_696_residues
MFSDLEIGVFIDELEEKIQVINDGLLALERDESNPDIIQEIFRAAHTVKGSSGIMGYQNMASLTHEMENLFDKIRHGEIH
VTSEMINVLFEALDTLKALKEEVTGEGPAVDTSVVVEKIKAFVTGGDAAPEIPEPPKENPVASVKAAATVRQWLEIGDVE
ENVIREAELRGFQCYRIAIDIDRDCQMKNVRAFLVFETLQQVGEIIKSEPSAEDIQEGKYDISFQVLLITKEDQDQIKNL
MVTISEVTEAEVQPVLLNSIEAVIEQPKAQTTTTINRPVEQENNAVKLETTERKTVKTVRVDVTKLDNLMNLVGELVIDR
TRLNRFAEIFESRFGSDEMVEAINEISNHLGQVTGDLQEQIMKARMLPVAQLFNRFPRMVRDTAQKLGKEIDFVVEGKET
ELDRNVIEVIGDPIIHLIRNSIDHGIELPAERQAAGKNRVGTLLLKASYAESHIVITVKDDGRGMDANKIRNKAVEMGFV
DRETADRMSDRDALQLIFKAGFSTKNNEVSDLSGRGVGMDVVNTAIEQINGTVELDTKLGAGTTITIRLPLTLAIIRALM
VTLGNQVYAFPLTNVSETIRITDQEIRRIGNNEVIVVRDKILPLARMGRLFNCAECEESSKMYVVILGSGDKKIAVVVDK
LLGEQEIVIKSLGDYLGQVQGLSGACILGDGKVALIVDVRGLVKDLGAEEVAYAAG

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=429, Percent_Identity=42.1911421911422, Blast_Score=312, Evalue=4e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76976; Mature: 76976

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSDLEIGVFIDELEEKIQVINDGLLALERDESNPDIIQEIFRAAHTVKGSSGIMGYQNM
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
ASLTHEMENLFDKIRHGEIHVTSEMINVLFEALDTLKALKEEVTGEGPAVDTSVVVEKIK
HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AFVTGGDAAPEIPEPPKENPVASVKAAATVRQWLEIGDVEENVIREAELRGFQCYRIAID
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEE
IDRDCQMKNVRAFLVFETLQQVGEIIKSEPSAEDIQEGKYDISFQVLLITKEDQDQIKNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEEEEEECCCHHHHHHH
MVTISEVTEAEVQPVLLNSIEAVIEQPKAQTTTTINRPVEQENNAVKLETTERKTVKTVR
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHE
VDVTKLDNLMNLVGELVIDRTRLNRFAEIFESRFGSDEMVEAINEISNHLGQVTGDLQEQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IMKARMLPVAQLFNRFPRMVRDTAQKLGKEIDFVVEGKETELDRNVIEVIGDPIIHLIRN
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
SIDHGIELPAERQAAGKNRVGTLLLKASYAESHIVITVKDDGRGMDANKIRNKAVEMGFV
HHHCCCCCCCHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCC
DRETADRMSDRDALQLIFKAGFSTKNNEVSDLSGRGVGMDVVNTAIEQINGTVELDTKLG
CHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCC
AGTTITIRLPLTLAIIRALMVTLGNQVYAFPLTNVSETIRITDQEIRRIGNNEVIVVRDK
CCCEEEEEECHHHHHHHHHHHHHCCCEEEEECCCCCHHEEECHHHHHHCCCCCEEEEECC
ILPLARMGRLFNCAECEESSKMYVVILGSGDKKIAVVVDKLLGEQEIVIKSLGDYLGQVQ
CCCHHHHCCCCCCHHHCCCCCEEEEEECCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHC
GLSGACILGDGKVALIVDVRGLVKDLGAEEVAYAAG
CCCCEEEECCCCEEEEEEHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure
MFSDLEIGVFIDELEEKIQVINDGLLALERDESNPDIIQEIFRAAHTVKGSSGIMGYQNM
CCCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCHHHH
ASLTHEMENLFDKIRHGEIHVTSEMINVLFEALDTLKALKEEVTGEGPAVDTSVVVEKIK
HHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AFVTGGDAAPEIPEPPKENPVASVKAAATVRQWLEIGDVEENVIREAELRGFQCYRIAID
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEEEEE
IDRDCQMKNVRAFLVFETLQQVGEIIKSEPSAEDIQEGKYDISFQVLLITKEDQDQIKNL
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCEEEEEEEEEEECCCHHHHHHH
MVTISEVTEAEVQPVLLNSIEAVIEQPKAQTTTTINRPVEQENNAVKLETTERKTVKTVR
HHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHE
VDVTKLDNLMNLVGELVIDRTRLNRFAEIFESRFGSDEMVEAINEISNHLGQVTGDLQEQ
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
IMKARMLPVAQLFNRFPRMVRDTAQKLGKEIDFVVEGKETELDRNVIEVIGDPIIHLIRN
HHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHH
SIDHGIELPAERQAAGKNRVGTLLLKASYAESHIVITVKDDGRGMDANKIRNKAVEMGFV
HHHCCCCCCCHHHHCCCCCCEEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHCCCC
DRETADRMSDRDALQLIFKAGFSTKNNEVSDLSGRGVGMDVVNTAIEQINGTVELDTKLG
CHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCC
AGTTITIRLPLTLAIIRALMVTLGNQVYAFPLTNVSETIRITDQEIRRIGNNEVIVVRDK
CCCEEEEEECHHHHHHHHHHHHHCCCEEEEECCCCCHHEEECHHHHHHCCCCCEEEEECC
ILPLARMGRLFNCAECEESSKMYVVILGSGDKKIAVVVDKLLGEQEIVIKSLGDYLGQVQ
CCCHHHHCCCCCCHHHCCCCCEEEEEECCCCCEEHHHHHHHHCCHHHHHHHHHHHHHHHC
GLSGACILGDGKVALIVDVRGLVKDLGAEEVAYAAG
CCCCEEEECCCCEEEEEEHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377 [H]