Click here to switch to the map view.

The map label for this gene is purE [H]

Identifier: 134300210

GI number: 134300210

Start: 2595853

End: 2596368

Strand: Reverse

Name: purE [H]

Synonym: Dred_2371

Alternate gene names: 134300210

Gene position: 2596368-2595853 (Counterclockwise)

Preceding gene: 134300211

Following gene: 134300209

Centisome position: 71.96

GC content: 49.42

Gene sequence:

>516_bases
ATGACTGCTTTGGTCGGTATTGTCTTGGGCAGTGACTCGGATCTGCCGCTGATGAAAGATGCAGTTAAAATATTGGATAC
ACTTGAAATTTCTTATGAGGTAACCATTTCCTCAGCTCACCGGGCACCGGAAAAAACTGCTGAGTATGCCCGGTCTGCGG
AGGCCAGAGGAATTAAAGTAATTATAGCCGCTGCTGGATTGGCAGCCCACCTGCCAGGGGTCATAGCAGCTCATAGTATT
TTACCTGTCATCGGGGTGCCGGTAAAATCCGGTGCTTTGGAGGGTGTGGATGCCCTTTACTCCATCGCCCAAATGCCTCC
GGGTATCCCAGTGGCATCTGTGGCCATTAACGGGGCGAAAAACGCAGCCATCTTAGCAGCCCAAATGATTGCCTTAGCCG
ATGCATCACTGGGGAAAAAATTGCATGACTTTAAAGAAGATCTAGCCAGGGAAGTGGAAGCCAAGGACAGCAAGCTAAAA
GAGCTGGGTGTAGAGGGTTACCTGAATAACAAATAG

Upstream 100 bases:

>100_bases
GCCAAAGAAGTTCATTGGATGATGTATCTGCTGTTTGTTATTATTGTTGCCCGCTACCTCTTCCTGGGTGGCGAGTAAAC
CCTAAAAGGAGGGGCTGTTG

Downstream 100 bases:

>100_bases
GTTTATAGACGAAACGGAGGAACCTTATCGATGATTGAACGTTATACCTTGCCCGAAATGAAGCACATCTGGTCTGACAC
AAACAAATTCCAAAAATGGC

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MTALVGIVLGSDSDLPLMKDAVKILDTLEISYEVTISSAHRAPEKTAEYARSAEARGIKVIIAAAGLAAHLPGVIAAHSI
LPVIGVPVKSGALEGVDALYSIAQMPPGIPVASVAINGAKNAAILAAQMIALADASLGKKLHDFKEDLAREVEAKDSKLK
ELGVEGYLNNK

Sequences:

>Translated_171_residues
MTALVGIVLGSDSDLPLMKDAVKILDTLEISYEVTISSAHRAPEKTAEYARSAEARGIKVIIAAAGLAAHLPGVIAAHSI
LPVIGVPVKSGALEGVDALYSIAQMPPGIPVASVAINGAKNAAILAAQMIALADASLGKKLHDFKEDLAREVEAKDSKLK
ELGVEGYLNNK
>Mature_170_residues
TALVGIVLGSDSDLPLMKDAVKILDTLEISYEVTISSAHRAPEKTAEYARSAEARGIKVIIAAAGLAAHLPGVIAAHSIL
PVIGVPVKSGALEGVDALYSIAQMPPGIPVASVAINGAKNAAILAAQMIALADASLGKKLHDFKEDLAREVEAKDSKLKE
LGVEGYLNNK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=152, Percent_Identity=48.6842105263158, Blast_Score=125, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324702, Length=168, Percent_Identity=54.1666666666667, Blast_Score=178, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17687; Mature: 17556

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALVGIVLGSDSDLPLMKDAVKILDTLEISYEVTISSAHRAPEKTAEYARSAEARGIKV
CCEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
IIAAAGLAAHLPGVIAAHSILPVIGVPVKSGALEGVDALYSIAQMPPGIPVASVAINGAK
EEEECCHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEECCCC
NAAILAAQMIALADASLGKKLHDFKEDLAREVEAKDSKLKELGVEGYLNNK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TALVGIVLGSDSDLPLMKDAVKILDTLEISYEVTISSAHRAPEKTAEYARSAEARGIKV
CEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCCCCEEE
IIAAAGLAAHLPGVIAAHSILPVIGVPVKSGALEGVDALYSIAQMPPGIPVASVAINGAK
EEEECCHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHEEECCCC
NAAILAAQMIALADASLGKKLHDFKEDLAREVEAKDSKLKELGVEGYLNNK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]