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The map label for this gene is lutP [H]

Identifier: 134300033

GI number: 134300033

Start: 2391941

End: 2393701

Strand: Reverse

Name: lutP [H]

Synonym: Dred_2189

Alternate gene names: 134300033

Gene position: 2393701-2391941 (Counterclockwise)

Preceding gene: 134300034

Following gene: 134300032

Centisome position: 66.34

GC content: 37.08

Gene sequence:

>1761_bases
ATGATGTGGGAGCAGATAATCACTCCTTTTGAAAACCAATATTTATCAGCATTTGTGGCGTCCATACCGATATCCTTTCT
TTTTTTTACACTTTACTCAAGGGTTAGAATACACATTGCTGGGTTTTTGACATTACTTGTTACAACGGGAGTTGCTATTT
TTGTATATGGTATGCCTTTTAAGTTGGCAGCATGGTCTTCGTTTTACGGCGGGATGACGGGGATGTTTTCCATTGGTTGG
ATTATGCTTTCGTCACTTTTCTTATACAAACTAACGGTCAAGACGGGTCAGATTCACATCATTACCTGGTCAATCCAATC
TATAACAAGGGATCACCGTCTTCAATGCTTATTAGTTGCCCTTTGTTTAGGAGCTTTTTTAGAGAACCTTGCAGGTTACA
GCACTTCAGTGGCTATAACCTCTGGGATACTGGTTGCTCTGGGATTTCGCCCCATCTATGCGGCAGTTCTTTGTTTAATT
ACTTCAATATCCTTTGGTTTTATGGGAGTTCCTATTATTACTGCAGGGCTTACTTCTGATATCGATATGATGGCTGTTTC
CCAAATGGTAGGCCGCCAGTTGCCGATTCTTTCATTTTTGCTTCCCTTCTGGTTAGTTTTTATCTTAGCAGGTTGGAAAG
GGACTAAGGAAGTTTGGCTGCCAATTCTAGTATGTGGTATTTCCTTTGCTGGGGTTCAATGGTTTGCGGCAAATTATATA
TTTCTGAGCATTGTTAATACTTTAGCAGCAGTTACAACCATGATCATTATGGTATTTTTTCTTCGTAATTGGCAACCCAA
AGATGTTTGGCACTCACAGAAAACTAGTTCCTTTTACCCGAATGAGAAAATTTCATTTAGTACGGTTTTGAGCGCTTGGT
TGCCCTATATAATCATGACTATTTTTATTATAAACTGGTCATTTAAACCCGTTCAGGATTTTCTTAATACTTTTACGGTT
TATGTAGCAGTAAGCACTCTGAATAATACCATTATTGCTAGTGGGAAACCAATTGAAGTTTATTTAAGCTTGTCCCTTTT
ATCATCTGTAGGAACGGTAATTTTTATATCAGCAATTATTAATGCATATATATATAAAGTTTGTCACAAGGAATTAATTA
CCTTGTTAGGACAAGCAGTAAGAAATTTATTTCTGCCCTTGGTTGGAATATCACTTATTATTGGAGTATCATATTTAATG
AATTGGTCCGGGATGATCGCTTCCATGGCCAATGTTATTGCTTCTGCCAATGGCTTATTGCCAATGTTTGCACCAATTTT
AGGTTGGTTGGGTGTATTTATTACTGGTTCAGATGTTTCTTCCAATACTTTAATGGCAAAACTTCAGGCCAATACTGCCC
AAATAGTTGGTTTTGATCCTGTTCTTACGGTAGCTGCCAATCATTCCGGTGGCGCAGTGGCAAAAATGATTTCTCCCGAG
GCCATCGGTGCTGCTGCTTCAGCAACGGGATTAAACGGAAGGGAAGATGATATTTTTAGTTATACATTAACCCATAGTCT
GTTTTTTCTATCATTCCTATGTTTTTTAACATATCTTCAAGCTTATACCTTTAAATGGTTAATTCCTTCCTATCATAAAG
TGTTGGGGATTACGGCTGAAATGGTAAATTATAAAATTGAAGGATATAAGTTAATGATACTTATGTTAGGATTAGTTCTA
GTATTAGCTTTATTCTCCAGTAAATTAAAGGGGAAAGATAACAAGCAAAATGAACATACTAACAGGGTGAAAACTTTATG
A

Upstream 100 bases:

>100_bases
GATATATAAAGGTCAGACCACTCTTCCACAAAACCAGAAAGGAGAATGTATTTTACAAAGTAGCTAATAAATGACCCAAC
CAAATAGGAGGCGATTCATA

Downstream 100 bases:

>100_bases
CATGATCAGATAGAAATATATCTTTTAATATTTAATAAAGTTGCTTTGCAAAAATAAAATATATTATATGGAGTGCAAAA
GATGGAGTTTAAGCCTATAA

Product: L-lactate transport

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MMWEQIITPFENQYLSAFVASIPISFLFFTLYSRVRIHIAGFLTLLVTTGVAIFVYGMPFKLAAWSSFYGGMTGMFSIGW
IMLSSLFLYKLTVKTGQIHIITWSIQSITRDHRLQCLLVALCLGAFLENLAGYSTSVAITSGILVALGFRPIYAAVLCLI
TSISFGFMGVPIITAGLTSDIDMMAVSQMVGRQLPILSFLLPFWLVFILAGWKGTKEVWLPILVCGISFAGVQWFAANYI
FLSIVNTLAAVTTMIIMVFFLRNWQPKDVWHSQKTSSFYPNEKISFSTVLSAWLPYIIMTIFIINWSFKPVQDFLNTFTV
YVAVSTLNNTIIASGKPIEVYLSLSLLSSVGTVIFISAIINAYIYKVCHKELITLLGQAVRNLFLPLVGISLIIGVSYLM
NWSGMIASMANVIASANGLLPMFAPILGWLGVFITGSDVSSNTLMAKLQANTAQIVGFDPVLTVAANHSGGAVAKMISPE
AIGAAASATGLNGREDDIFSYTLTHSLFFLSFLCFLTYLQAYTFKWLIPSYHKVLGITAEMVNYKIEGYKLMILMLGLVL
VLALFSSKLKGKDNKQNEHTNRVKTL

Sequences:

>Translated_586_residues
MMWEQIITPFENQYLSAFVASIPISFLFFTLYSRVRIHIAGFLTLLVTTGVAIFVYGMPFKLAAWSSFYGGMTGMFSIGW
IMLSSLFLYKLTVKTGQIHIITWSIQSITRDHRLQCLLVALCLGAFLENLAGYSTSVAITSGILVALGFRPIYAAVLCLI
TSISFGFMGVPIITAGLTSDIDMMAVSQMVGRQLPILSFLLPFWLVFILAGWKGTKEVWLPILVCGISFAGVQWFAANYI
FLSIVNTLAAVTTMIIMVFFLRNWQPKDVWHSQKTSSFYPNEKISFSTVLSAWLPYIIMTIFIINWSFKPVQDFLNTFTV
YVAVSTLNNTIIASGKPIEVYLSLSLLSSVGTVIFISAIINAYIYKVCHKELITLLGQAVRNLFLPLVGISLIIGVSYLM
NWSGMIASMANVIASANGLLPMFAPILGWLGVFITGSDVSSNTLMAKLQANTAQIVGFDPVLTVAANHSGGAVAKMISPE
AIGAAASATGLNGREDDIFSYTLTHSLFFLSFLCFLTYLQAYTFKWLIPSYHKVLGITAEMVNYKIEGYKLMILMLGLVL
VLALFSSKLKGKDNKQNEHTNRVKTL
>Mature_586_residues
MMWEQIITPFENQYLSAFVASIPISFLFFTLYSRVRIHIAGFLTLLVTTGVAIFVYGMPFKLAAWSSFYGGMTGMFSIGW
IMLSSLFLYKLTVKTGQIHIITWSIQSITRDHRLQCLLVALCLGAFLENLAGYSTSVAITSGILVALGFRPIYAAVLCLI
TSISFGFMGVPIITAGLTSDIDMMAVSQMVGRQLPILSFLLPFWLVFILAGWKGTKEVWLPILVCGISFAGVQWFAANYI
FLSIVNTLAAVTTMIIMVFFLRNWQPKDVWHSQKTSSFYPNEKISFSTVLSAWLPYIIMTIFIINWSFKPVQDFLNTFTV
YVAVSTLNNTIIASGKPIEVYLSLSLLSSVGTVIFISAIINAYIYKVCHKELITLLGQAVRNLFLPLVGISLIIGVSYLM
NWSGMIASMANVIASANGLLPMFAPILGWLGVFITGSDVSSNTLMAKLQANTAQIVGFDPVLTVAANHSGGAVAKMISPE
AIGAAASATGLNGREDDIFSYTLTHSLFFLSFLCFLTYLQAYTFKWLIPSYHKVLGITAEMVNYKIEGYKLMILMLGLVL
VLALFSSKLKGKDNKQNEHTNRVKTL

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=557, Percent_Identity=40.2154398563734, Blast_Score=382, Evalue=1e-107,
Organism=Escherichia coli, GI1790031, Length=549, Percent_Identity=36.976320582878, Blast_Score=360, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 64675; Mature: 64675

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMWEQIITPFENQYLSAFVASIPISFLFFTLYSRVRIHIAGFLTLLVTTGVAIFVYGMPF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KLAAWSSFYGGMTGMFSIGWIMLSSLFLYKLTVKTGQIHIITWSIQSITRDHRLQCLLVA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEEHHHHHHHHHHHHHHHH
LCLGAFLENLAGYSTSVAITSGILVALGFRPIYAAVLCLITSISFGFMGVPIITAGLTSD
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHCHHHHCCCCCCC
IDMMAVSQMVGRQLPILSFLLPFWLVFILAGWKGTKEVWLPILVCGISFAGVQWFAANYI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLSIVNTLAAVTTMIIMVFFLRNWQPKDVWHSQKTSSFYPNEKISFSTVLSAWLPYIIMT
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IFIINWSFKPVQDFLNTFTVYVAVSTLNNTIIASGKPIEVYLSLSLLSSVGTVIFISAII
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
NAYIYKVCHKELITLLGQAVRNLFLPLVGISLIIGVSYLMNWSGMIASMANVIASANGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PMFAPILGWLGVFITGSDVSSNTLMAKLQANTAQIVGFDPVLTVAANHSGGAVAKMISPE
HHHHHHHHHHHHEEECCCCCCCCEEEEEECCCEEEEECCCEEEEEECCCCCCHHHHCCCH
AIGAAASATGLNGREDDIFSYTLTHSLFFLSFLCFLTYLQAYTFKWLIPSYHKVLGITAE
HHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVNYKIEGYKLMILMLGLVLVLALFSSKLKGKDNKQNEHTNRVKTL
HHCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC
>Mature Secondary Structure
MMWEQIITPFENQYLSAFVASIPISFLFFTLYSRVRIHIAGFLTLLVTTGVAIFVYGMPF
CCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KLAAWSSFYGGMTGMFSIGWIMLSSLFLYKLTVKTGQIHIITWSIQSITRDHRLQCLLVA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHEEEECCEEEEEEEEHHHHHHHHHHHHHHHH
LCLGAFLENLAGYSTSVAITSGILVALGFRPIYAAVLCLITSISFGFMGVPIITAGLTSD
HHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCHHCHHHHCCCCCCC
IDMMAVSQMVGRQLPILSFLLPFWLVFILAGWKGTKEVWLPILVCGISFAGVQWFAANYI
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
FLSIVNTLAAVTTMIIMVFFLRNWQPKDVWHSQKTSSFYPNEKISFSTVLSAWLPYIIMT
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IFIINWSFKPVQDFLNTFTVYVAVSTLNNTIIASGKPIEVYLSLSLLSSVGTVIFISAII
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHH
NAYIYKVCHKELITLLGQAVRNLFLPLVGISLIIGVSYLMNWSGMIASMANVIASANGLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
PMFAPILGWLGVFITGSDVSSNTLMAKLQANTAQIVGFDPVLTVAANHSGGAVAKMISPE
HHHHHHHHHHHHEEECCCCCCCCEEEEEECCCEEEEECCCEEEEEECCCCCCHHHHCCCH
AIGAAASATGLNGREDDIFSYTLTHSLFFLSFLCFLTYLQAYTFKWLIPSYHKVLGITAE
HHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MVNYKIEGYKLMILMLGLVLVLALFSSKLKGKDNKQNEHTNRVKTL
HHCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]