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The map label for this gene is mtaD

Identifier: 134299907

GI number: 134299907

Start: 2257009

End: 2258310

Strand: Reverse

Name: mtaD

Synonym: Dred_2061

Alternate gene names: 134299907

Gene position: 2258310-2257009 (Counterclockwise)

Preceding gene: 134299908

Following gene: 134299906

Centisome position: 62.59

GC content: 48.0

Gene sequence:

>1302_bases
TTGAATAGACTACTTATCCGCGGGGCAACAATTCTAACCATGGAAGGTCCAGAAGCCATTATAGAGACCGGAGAGCTTTT
AATTGAGGACGGCTGGATTACTCACGTAGGATTGCCAGGATCTGCATCCGGTTCCTTTGATATGGATGAGGTCATAGAAG
CAGATGGTCAGGTGGCGATGCCGGGCTTTATTAACTGCCATACCCATGCTGCCATGACGCTACTCAGAGGATATGCCGAT
GACCTCCCATTGATGACCTGGCTATCTGAAAAGATATGGCCCTTTGAGGGTAGAATGACCAATGAGGATATTTACTGGGG
AACCATGCTGGCCTGTCTGGAAATGATTAAGTCCGGAACCACCTGTTTTGGTGACATGTACGACTGTATGCATGATGTTG
CCAGAGCAGTGGAAAAGACGGGCATGAGGGCAATGTTGTCCCGGGGAATGATCGGTATAGCACCCACTGCTGACAAAGCC
CTGATTGAAGCAGAGGAACTGGCAAGGAACTGGAACGGCAAAGCAGATGGCAGGATTACGGTGATGGTAGCTCCCCATGC
ACCCTATACATGCCCACCGGATTACCTGGACAAGGCTATGAATTTAGCGGCCAAGCACAAGCTTGGCATCAATATCCATC
TGGCGGAAACATTGACAGAATTTGAGGACATTAAAAAGCAGTATGGCAAGACCCCAGTGAAACATTTAGACCAATTGGGA
TTATTTAAATTACCCGTATTAGCTGCCCATTGTGTCCATTTAGATGAGGAAGATATGGATATTTTAGCCCAAAAGGCCAT
GGGTGTTGCCTATAACCCCCAAAGTAATATGAAGTTAGCCAGTGGCATCGCGCCGGTAGCCAAGTTACTGGAATTGGGTG
CCACAGTTGGTATTGGTACGGATGGAACAGCCAGTAACAATAACCTGGATATGTTGGAAGAATTAAGGGCAGGCTCTTTT
CTGCAAAAGGTTAGTACTATGAATCCAGAAGTGATACCAGCTTATCGTGCCCTACAGATGGCGACCATTGACGGTGCCCT
GTGCATGGGGCTGGGAGACAGAGTGGGCCTGATAAAGGAAGGCATGCGGGGGGACGTTATTTTGCTGGATACCCAACAGC
CCCATATGTGTCCCCGTCATAATTTGGTGGCAAATATAGCCTATGCCGCCAATTCTTCGGATGTACGCACCGTTGTGATT
GATGGTAAGGTTGTCATGTTGGACAGGGTTGTTAAAACCATTGATGAGGAAAGGGTAATGTACGAAGTTAGGGAGCGAGC
AGCACGTTTAGCCGGTAAATAG

Upstream 100 bases:

>100_bases
AGATGTGTCCGAGCTATCTAGGATTTACCGTAGCTCTTATGGCCAGCCCCAAAAATAGAGAGCACCCCCAAAAGGGGAGC
AGTTTTAGGAGAGATGAATT

Downstream 100 bases:

>100_bases
AATTGTTAGCCCGGAGGAGGAAGTGGGATACTTTATGCTCACTTCCATTTTTATATTAGCGCATAAATCATGTGGTGATA
CTATTAAGAATTGGGTGAAT

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MNRLLIRGATILTMEGPEAIIETGELLIEDGWITHVGLPGSASGSFDMDEVIEADGQVAMPGFINCHTHAAMTLLRGYAD
DLPLMTWLSEKIWPFEGRMTNEDIYWGTMLACLEMIKSGTTCFGDMYDCMHDVARAVEKTGMRAMLSRGMIGIAPTADKA
LIEAEELARNWNGKADGRITVMVAPHAPYTCPPDYLDKAMNLAAKHKLGINIHLAETLTEFEDIKKQYGKTPVKHLDQLG
LFKLPVLAAHCVHLDEEDMDILAQKAMGVAYNPQSNMKLASGIAPVAKLLELGATVGIGTDGTASNNNLDMLEELRAGSF
LQKVSTMNPEVIPAYRALQMATIDGALCMGLGDRVGLIKEGMRGDVILLDTQQPHMCPRHNLVANIAYAANSSDVRTVVI
DGKVVMLDRVVKTIDEERVMYEVRERAARLAGK

Sequences:

>Translated_433_residues
MNRLLIRGATILTMEGPEAIIETGELLIEDGWITHVGLPGSASGSFDMDEVIEADGQVAMPGFINCHTHAAMTLLRGYAD
DLPLMTWLSEKIWPFEGRMTNEDIYWGTMLACLEMIKSGTTCFGDMYDCMHDVARAVEKTGMRAMLSRGMIGIAPTADKA
LIEAEELARNWNGKADGRITVMVAPHAPYTCPPDYLDKAMNLAAKHKLGINIHLAETLTEFEDIKKQYGKTPVKHLDQLG
LFKLPVLAAHCVHLDEEDMDILAQKAMGVAYNPQSNMKLASGIAPVAKLLELGATVGIGTDGTASNNNLDMLEELRAGSF
LQKVSTMNPEVIPAYRALQMATIDGALCMGLGDRVGLIKEGMRGDVILLDTQQPHMCPRHNLVANIAYAANSSDVRTVVI
DGKVVMLDRVVKTIDEERVMYEVRERAARLAGK
>Mature_433_residues
MNRLLIRGATILTMEGPEAIIETGELLIEDGWITHVGLPGSASGSFDMDEVIEADGQVAMPGFINCHTHAAMTLLRGYAD
DLPLMTWLSEKIWPFEGRMTNEDIYWGTMLACLEMIKSGTTCFGDMYDCMHDVARAVEKTGMRAMLSRGMIGIAPTADKA
LIEAEELARNWNGKADGRITVMVAPHAPYTCPPDYLDKAMNLAAKHKLGINIHLAETLTEFEDIKKQYGKTPVKHLDQLG
LFKLPVLAAHCVHLDEEDMDILAQKAMGVAYNPQSNMKLASGIAPVAKLLELGATVGIGTDGTASNNNLDMLEELRAGSF
LQKVSTMNPEVIPAYRALQMATIDGALCMGLGDRVGLIKEGMRGDVILLDTQQPHMCPRHNLVANIAYAANSSDVRTVVI
DGKVVMLDRVVKTIDEERVMYEVRERAARLAGK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family

Homologues:

Organism=Homo sapiens, GI4758426, Length=337, Percent_Identity=24.9258160237389, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1789249, Length=450, Percent_Identity=26.6666666666667, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI87082177, Length=446, Percent_Identity=23.0941704035874, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17540282, Length=400, Percent_Identity=23.75, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=341, Percent_Identity=21.1143695014663, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24643849, Length=402, Percent_Identity=26.6169154228856, Blast_Score=127, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTAD_DESRM (A4J675)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113403.1
- ProteinModelPortal:   A4J675
- SMR:   A4J675
- STRING:   A4J675
- GeneID:   4958575
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_2061
- eggNOG:   COG0402
- HOGENOM:   HBG668170
- OMA:   MYLIEDA
- PhylomeDB:   A4J675
- BioCyc:   DRED349161:DRED_2061-MONOMER
- HAMAP:   MF_01281
- InterPro:   IPR006680
- InterPro:   IPR011059

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.4.28

Molecular weight: Translated: 47328; Mature: 47328

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: BINDING 96-96 BINDING 148-148 BINDING 186-186 BINDING 216-216 BINDING 301-301

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
8.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
8.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLLIRGATILTMEGPEAIIETGELLIEDGWITHVGLPGSASGSFDMDEVIEADGQVAM
CCCEEEECEEEEEECCCHHHHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHCCCCCEEC
PGFINCHTHAAMTLLRGYADDLPLMTWLSEKIWPFEGRMTNEDIYWGTMLACLEMIKSGT
CCCEEHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TCFGDMYDCMHDVARAVEKTGMRAMLSRGMIGIAPTADKALIEAEELARNWNGKADGRIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
VMVAPHAPYTCPPDYLDKAMNLAAKHKLGINIHLAETLTEFEDIKKQYGKTPVKHLDQLG
EEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCC
LFKLPVLAAHCVHLDEEDMDILAQKAMGVAYNPQSNMKLASGIAPVAKLLELGATVGIGT
CHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHCCCCEECCC
DGTASNNNLDMLEELRAGSFLQKVSTMNPEVIPAYRALQMATIDGALCMGLGDRVGLIKE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHHHC
GMRGDVILLDTQQPHMCPRHNLVANIAYAANSSDVRTVVIDGKVVMLDRVVKTIDEERVM
CCCCCEEEEECCCCCCCCCCHHHEEEEEECCCCCCEEEEECCEEHHHHHHHHHHHHHHHH
YEVRERAARLAGK
HHHHHHHHHHCCC
>Mature Secondary Structure
MNRLLIRGATILTMEGPEAIIETGELLIEDGWITHVGLPGSASGSFDMDEVIEADGQVAM
CCCEEEECEEEEEECCCHHHHHCCCEEEECCCEEEECCCCCCCCCCCHHHHHCCCCCEEC
PGFINCHTHAAMTLLRGYADDLPLMTWLSEKIWPFEGRMTNEDIYWGTMLACLEMIKSGT
CCCEEHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TCFGDMYDCMHDVARAVEKTGMRAMLSRGMIGIAPTADKALIEAEELARNWNGKADGRIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
VMVAPHAPYTCPPDYLDKAMNLAAKHKLGINIHLAETLTEFEDIKKQYGKTPVKHLDQLG
EEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHCC
LFKLPVLAAHCVHLDEEDMDILAQKAMGVAYNPQSNMKLASGIAPVAKLLELGATVGIGT
CHHHHHHHHHHHCCCCHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHHHHHCCCCEECCC
DGTASNNNLDMLEELRAGSFLQKVSTMNPEVIPAYRALQMATIDGALCMGLGDRVGLIKE
CCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHHHC
GMRGDVILLDTQQPHMCPRHNLVANIAYAANSSDVRTVVIDGKVVMLDRVVKTIDEERVM
CCCCCEEEEECCCCCCCCCCHHHEEEEEECCCCCCEEEEECCEEHHHHHHHHHHHHHHHH
YEVRERAARLAGK
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA