Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 134299817

GI number: 134299817

Start: 2165598

End: 2166761

Strand: Reverse

Name: dxr

Synonym: Dred_1970

Alternate gene names: 134299817

Gene position: 2166761-2165598 (Counterclockwise)

Preceding gene: 134299818

Following gene: 134299816

Centisome position: 60.05

GC content: 42.1

Gene sequence:

>1164_bases
ATGATGAAACAGATATCTATTTTAGGAAGTACCGGCTCGATTGGCAGGCAGACCCTGGAAGTTGTAAATAGTTTCCCGGA
AGAACTTAATGTGGTAGCCTTAGCTGCAGGCAGAAACCGTGAGTTGTTTTTGGAACAATGTAAAGCCTATAAACCCCTTT
TAGTTTCCCTTCAGTTAGAAGAAGATGCTCTTTGGCTTAAAGAGCATCTGATAAAGGAGAAGTTAAGGCCTGAAATTCGT
TATGGTTTAGATGGTCTGGTGGCGGTGGCCACTTGTCATGAAGCAGTTGTAGTTGTAACCGCGCTAAGTGGGGCCATTGG
TTTAGTTCCCACCTGTGCTGCCATCAAAGCAAGTAAGAAAATTGCACTGGCAAACAAAGAAACTCTGGTGGCAGCGGGAC
AATATGTTACTAAACTGGCAGAAGAATATAAGGTTGAAATTTTACCTGTGGATAGTGAACATTCCGCTATTTGGCAGTGC
TTACATGGGGAAAATAGATCAGCGATAAGAAAAATCCAACTGACAGCCTCTGGTGGTCCTTTTCGCCAATTAAACAGACA
AGAACTTGAAAATGTCACGCCAGAGATGGCCCTGAAACATCCCAATTGGTCCATGGGACAAAAAATCACCATCGACTCCG
CTACTTTAATGAACAAAGGATTAGAAGTTATAGAAGCCAAATGGCTTTTTGGTGTTGACTACGACGATATTAATGTAGTG
GTTCATCCCCAGAGTGTTATTCATTCCATGGTTGAATATGGCGATGGTTCATTGCTTGCTCACCTTGGCATGCCAGATAT
GAGAATACCCATTCAATATGCCCTTAGTTACCCAGAACGTTGGTTTAACCATTTACCTAAGTTAAATCTAACAGAACTTA
AGGGGCTAACCTTCGAAGAACCAGATACAAATAGGTTTCCTTCCCTGTCATTGGCTTATCAGGCTGGGAAAATAGGAGGT
ACAGCACCGGCAGTTTTAAACGCTGCCAACGAAGTAGCTGTTCATGCATTTCTGGCGGGACAAATAAAATTTATGCAAAT
TCCCTCCATTGTTAAACGAACTTTAAACGAACATCAATTTCAGGGGTCTCCTGTCCTAGAGGAGATTCTTGAAATTGATG
GTTGGGCAAGGGAAGAGGCAAACAAAATCATTAGAAATTGTTAG

Upstream 100 bases:

>100_bases
AGGAATGATCGTTGGCCCAATTTTGTTAATTGCCATCCAAGCAATAGTAAAAGCAGGAATTCAAAGCCCAAGGGTGAAAT
AAGATTAACTGAGGTGCCAA

Downstream 100 bases:

>100_bases
AGGTGAAGTTATGCAAACATTTATCGCTTCGGTTGCTGTCTTTGGATTATTAATATTTTTCCATGAGCTAGGCCATTTCC
TGGTAGCAAAGAAGGTAGGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MMKQISILGSTGSIGRQTLEVVNSFPEELNVVALAAGRNRELFLEQCKAYKPLLVSLQLEEDALWLKEHLIKEKLRPEIR
YGLDGLVAVATCHEAVVVVTALSGAIGLVPTCAAIKASKKIALANKETLVAAGQYVTKLAEEYKVEILPVDSEHSAIWQC
LHGENRSAIRKIQLTASGGPFRQLNRQELENVTPEMALKHPNWSMGQKITIDSATLMNKGLEVIEAKWLFGVDYDDINVV
VHPQSVIHSMVEYGDGSLLAHLGMPDMRIPIQYALSYPERWFNHLPKLNLTELKGLTFEEPDTNRFPSLSLAYQAGKIGG
TAPAVLNAANEVAVHAFLAGQIKFMQIPSIVKRTLNEHQFQGSPVLEEILEIDGWAREEANKIIRNC

Sequences:

>Translated_387_residues
MMKQISILGSTGSIGRQTLEVVNSFPEELNVVALAAGRNRELFLEQCKAYKPLLVSLQLEEDALWLKEHLIKEKLRPEIR
YGLDGLVAVATCHEAVVVVTALSGAIGLVPTCAAIKASKKIALANKETLVAAGQYVTKLAEEYKVEILPVDSEHSAIWQC
LHGENRSAIRKIQLTASGGPFRQLNRQELENVTPEMALKHPNWSMGQKITIDSATLMNKGLEVIEAKWLFGVDYDDINVV
VHPQSVIHSMVEYGDGSLLAHLGMPDMRIPIQYALSYPERWFNHLPKLNLTELKGLTFEEPDTNRFPSLSLAYQAGKIGG
TAPAVLNAANEVAVHAFLAGQIKFMQIPSIVKRTLNEHQFQGSPVLEEILEIDGWAREEANKIIRNC
>Mature_387_residues
MMKQISILGSTGSIGRQTLEVVNSFPEELNVVALAAGRNRELFLEQCKAYKPLLVSLQLEEDALWLKEHLIKEKLRPEIR
YGLDGLVAVATCHEAVVVVTALSGAIGLVPTCAAIKASKKIALANKETLVAAGQYVTKLAEEYKVEILPVDSEHSAIWQC
LHGENRSAIRKIQLTASGGPFRQLNRQELENVTPEMALKHPNWSMGQKITIDSATLMNKGLEVIEAKWLFGVDYDDINVV
VHPQSVIHSMVEYGDGSLLAHLGMPDMRIPIQYALSYPERWFNHLPKLNLTELKGLTFEEPDTNRFPSLSLAYQAGKIGG
TAPAVLNAANEVAVHAFLAGQIKFMQIPSIVKRTLNEHQFQGSPVLEEILEIDGWAREEANKIIRNC

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=44.7570332480818, Blast_Score=321, Evalue=7e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_DESRM (A4J5Y5)

Other databases:

- EMBL:   CP000612
- RefSeq:   YP_001113313.1
- ProteinModelPortal:   A4J5Y5
- SMR:   A4J5Y5
- STRING:   A4J5Y5
- GeneID:   4957343
- GenomeReviews:   CP000612_GR
- KEGG:   drm:Dred_1970
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   A4J5Y5
- ProtClustDB:   PRK05447
- BioCyc:   DRED349161:DRED_1970-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42846; Mature: 42846

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 153-153 BINDING 177-177 BINDING 200-200 BINDING 222-222

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKQISILGSTGSIGRQTLEVVNSFPEELNVVALAAGRNRELFLEQCKAYKPLLVSLQLE
CCCEEEEECCCCCHHHHHHHHHHHCCHHCCEEEEECCCCHHHHHHHHHCCCCEEEEEEEC
EDALWLKEHLIKEKLRPEIRYGLDGLVAVATCHEAVVVVTALSGAIGLVPTCAAIKASKK
CHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
IALANKETLVAAGQYVTKLAEEYKVEILPVDSEHSAIWQCLHGENRSAIRKIQLTASGGP
EEECCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCC
FRQLNRQELENVTPEMALKHPNWSMGQKITIDSATLMNKGLEVIEAKWLFGVDYDDINVV
HHHCCHHHHHCCCHHHEECCCCCCCCCEEEECHHHHHHCCHHHEEEEEEEECCCCCCEEE
VHPQSVIHSMVEYGDGSLLAHLGMPDMRIPIQYALSYPERWFNHLPKLNLTELKGLTFEE
ECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHCCHHHHHHHCCCCCHHHHCCCCCCC
PDTNRFPSLSLAYQAGKIGGTAPAVLNAANEVAVHAFLAGQIKFMQIPSIVKRTLNEHQF
CCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCC
QGSPVLEEILEIDGWAREEANKIIRNC
CCCHHHHHHHHCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MMKQISILGSTGSIGRQTLEVVNSFPEELNVVALAAGRNRELFLEQCKAYKPLLVSLQLE
CCCEEEEECCCCCHHHHHHHHHHHCCHHCCEEEEECCCCHHHHHHHHHCCCCEEEEEEEC
EDALWLKEHLIKEKLRPEIRYGLDGLVAVATCHEAVVVVTALSGAIGLVPTCAAIKASKK
CHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
IALANKETLVAAGQYVTKLAEEYKVEILPVDSEHSAIWQCLHGENRSAIRKIQLTASGGP
EEECCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCCCCCCEEEEEEEECCCC
FRQLNRQELENVTPEMALKHPNWSMGQKITIDSATLMNKGLEVIEAKWLFGVDYDDINVV
HHHCCHHHHHCCCHHHEECCCCCCCCCEEEECHHHHHHCCHHHEEEEEEEECCCCCCEEE
VHPQSVIHSMVEYGDGSLLAHLGMPDMRIPIQYALSYPERWFNHLPKLNLTELKGLTFEE
ECCHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHCCHHHHHHHCCCCCHHHHCCCCCCC
PDTNRFPSLSLAYQAGKIGGTAPAVLNAANEVAVHAFLAGQIKFMQIPSIVKRTLNEHQF
CCCCCCCCEEEEEECCCCCCCCHHHHHCHHHHHHHHHHHCCEEEEECHHHHHHHHHHHCC
QGSPVLEEILEIDGWAREEANKIIRNC
CCCHHHHHHHHCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA