Click here to switch to the map view.

The map label for this gene is dapL [H]

Identifier: 134299763

GI number: 134299763

Start: 2102069

End: 2103238

Strand: Reverse

Name: dapL [H]

Synonym: Dred_1913

Alternate gene names: 134299763

Gene position: 2103238-2102069 (Counterclockwise)

Preceding gene: 134299764

Following gene: 134299762

Centisome position: 58.29

GC content: 42.39

Gene sequence:

>1170_bases
ATGAAATTGGCAAGAAGAATGGAAGCACTGGTTTCTGGAATATTCACAGAATTAGCCAATGCCAGAGCTGAAAAAGAAAA
TTTGGGAATTAAGGTGATTGATTTAAGTATAGGAAGTCCGGACCTTCCTCCGGCTCCTCATATCATCGAAACCCTTAGTA
AGGCTGTACAAAAGCCAACGAATTATACGTATCCCATAGGCGGTAAATATGAGCTTCATAAAGCCTTGGCAAATTGGTAT
AAGAAGAGGTTTAATGTTGATTTGGACCCTGTCACCGAGATTTTGACACTAATGGGGTCTCAGGATGGATTAGCCCATGT
GGCACAAGCTTTTATTAACCCTGGTGATATAGCCCTAGTACCTGACCCGGGATATCCCATCTATTCTGCATCCATCCTGC
TGGCCGAAGGCCAGTTATATCCAATGCCTCTTCTGGAGAAGAATCAGTACCTGCCGGATCTTAGCAATATACCCACAGAC
ATTGCTAAAAAAGCTAAAATGATGACAATTAATTATCCTAATAATCCAGTGGCAGCTTCAGCCAATGAAGAATTTTTTAA
ACGGGTTGTTGCTTTTGCTAAGGAACATAATATTGTGGTATGTCACGATGTTGCCTATGCTGAGTTAGCCTTTGATGGCT
TTAAGCCTATGAGTTTTCTAGAAGTACCAGGTGCCAAGGAAGTTGGGATTGAATTTTACTCATTATCAAAAACCTATAAC
ATGGCGGGTTGCCGTATTGGCTTTGCTGTAGGAAATCCAGATGTATTAAGTGCGCTAGGGCGGATTAAATCAAACATTGA
CTATGGTGTTTTTTCAGCAGTGCAAGAAGCTGGGATAGCGGCCTTAACAGGAGACCAGACCTGTGTAGCGAAAACTGCGG
CAACTTATCAAAGACGACGGGATCTTCTTGTTGAGGGATTTGGCGAGTTGGGTTGGCTGATGCCTAAGCCCCAAGCCTCT
ATGTTTATCTGGGCACCACTACCCGCTGGTTTTCAATCTTCTATGGATTTTTGTCTGGAATTTTTAGATAAAACAGGTGT
TTTAATGGTGCCAGGAAATGCTTTTGGAGAACTGGGTCAGGGTTATGTTCGAATTGCCTTGGTTCAAAGGGAAGAAGTGT
TGTTGGAGGCTTTAGAAAGAGTTCGCAATAACTTTACCTTCGCTAGTTAA

Upstream 100 bases:

>100_bases
TTGGGTGGTGCAGTGGCCCCATTTGATTCGGTGCAATTATTAAAAAATGCTCACCAGAAACTATTTTAAATATAGGACTT
ACTGAACGGAGTTGATTTCA

Downstream 100 bases:

>100_bases
ATGTCTATGGTACCACTCCTATGCATATACTAATTTAAGTGAATTGAAGGAGTGGTGCAGTTTTGAACAGTAGCGCGGAT
GTTCAGTATCTGCAGAGCCG

Product: class I and II aminotransferase

Products: NA

Alternate protein names: DAP-AT; DAP-aminotransferase; LL-DAP-aminotransferase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKLARRMEALVSGIFTELANARAEKENLGIKVIDLSIGSPDLPPAPHIIETLSKAVQKPTNYTYPIGGKYELHKALANWY
KKRFNVDLDPVTEILTLMGSQDGLAHVAQAFINPGDIALVPDPGYPIYSASILLAEGQLYPMPLLEKNQYLPDLSNIPTD
IAKKAKMMTINYPNNPVAASANEEFFKRVVAFAKEHNIVVCHDVAYAELAFDGFKPMSFLEVPGAKEVGIEFYSLSKTYN
MAGCRIGFAVGNPDVLSALGRIKSNIDYGVFSAVQEAGIAALTGDQTCVAKTAATYQRRRDLLVEGFGELGWLMPKPQAS
MFIWAPLPAGFQSSMDFCLEFLDKTGVLMVPGNAFGELGQGYVRIALVQREEVLLEALERVRNNFTFAS

Sequences:

>Translated_389_residues
MKLARRMEALVSGIFTELANARAEKENLGIKVIDLSIGSPDLPPAPHIIETLSKAVQKPTNYTYPIGGKYELHKALANWY
KKRFNVDLDPVTEILTLMGSQDGLAHVAQAFINPGDIALVPDPGYPIYSASILLAEGQLYPMPLLEKNQYLPDLSNIPTD
IAKKAKMMTINYPNNPVAASANEEFFKRVVAFAKEHNIVVCHDVAYAELAFDGFKPMSFLEVPGAKEVGIEFYSLSKTYN
MAGCRIGFAVGNPDVLSALGRIKSNIDYGVFSAVQEAGIAALTGDQTCVAKTAATYQRRRDLLVEGFGELGWLMPKPQAS
MFIWAPLPAGFQSSMDFCLEFLDKTGVLMVPGNAFGELGQGYVRIALVQREEVLLEALERVRNNFTFAS
>Mature_389_residues
MKLARRMEALVSGIFTELANARAEKENLGIKVIDLSIGSPDLPPAPHIIETLSKAVQKPTNYTYPIGGKYELHKALANWY
KKRFNVDLDPVTEILTLMGSQDGLAHVAQAFINPGDIALVPDPGYPIYSASILLAEGQLYPMPLLEKNQYLPDLSNIPTD
IAKKAKMMTINYPNNPVAASANEEFFKRVVAFAKEHNIVVCHDVAYAELAFDGFKPMSFLEVPGAKEVGIEFYSLSKTYN
MAGCRIGFAVGNPDVLSALGRIKSNIDYGVFSAVQEAGIAALTGDQTCVAKTAATYQRRRDLLVEGFGELGWLMPKPQAS
MFIWAPLPAGFQSSMDFCLEFLDKTGVLMVPGNAFGELGQGYVRIALVQREEVLLEALERVRNNFTFAS

Specific function: Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=423, Percent_Identity=22.4586288416076, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI169881279, Length=423, Percent_Identity=22.4586288416076, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI56713254, Length=293, Percent_Identity=26.2798634812287, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI56713256, Length=293, Percent_Identity=26.2798634812287, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI169881281, Length=404, Percent_Identity=20.2970297029703, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1788722, Length=383, Percent_Identity=40.4699738903394, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1786816, Length=381, Percent_Identity=23.0971128608924, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788627, Length=369, Percent_Identity=28.4552845528455, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71994472, Length=297, Percent_Identity=28.2828282828283, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI71994476, Length=297, Percent_Identity=28.2828282828283, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17567369, Length=268, Percent_Identity=24.6268656716418, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17567663, Length=387, Percent_Identity=24.5478036175711, Blast_Score=84, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6322401, Length=388, Percent_Identity=22.680412371134, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573069, Length=383, Percent_Identity=23.2375979112272, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24646114, Length=383, Percent_Identity=23.2375979112272, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573067, Length=383, Percent_Identity=23.2375979112272, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28573065, Length=383, Percent_Identity=23.2375979112272, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR019881
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.83 [H]

Molecular weight: Translated: 42653; Mature: 42653

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLARRMEALVSGIFTELANARAEKENLGIKVIDLSIGSPDLPPAPHIIETLSKAVQKPT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
NYTYPIGGKYELHKALANWYKKRFNVDLDPVTEILTLMGSQDGLAHVAQAFINPGDIALV
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
PDPGYPIYSASILLAEGQLYPMPLLEKNQYLPDLSNIPTDIAKKAKMMTINYPNNPVAAS
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHHCCCEEEEEECCCCCCCCC
ANEEFFKRVVAFAKEHNIVVCHDVAYAELAFDGFKPMSFLEVPGAKEVGIEFYSLSKTYN
CCHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCCCCEEECCCCHHHCEEEEEECCCCC
MAGCRIGFAVGNPDVLSALGRIKSNIDYGVFSAVQEAGIAALTGDQTCVAKTAATYQRRR
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHH
DLLVEGFGELGWLMPKPQASMFIWAPLPAGFQSSMDFCLEFLDKTGVLMVPGNAFGELGQ
HHHHHCHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHCC
GYVRIALVQREEVLLEALERVRNNFTFAS
CEEEEEEEHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKLARRMEALVSGIFTELANARAEKENLGIKVIDLSIGSPDLPPAPHIIETLSKAVQKPT
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
NYTYPIGGKYELHKALANWYKKRFNVDLDPVTEILTLMGSQDGLAHVAQAFINPGDIALV
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEE
PDPGYPIYSASILLAEGQLYPMPLLEKNQYLPDLSNIPTDIAKKAKMMTINYPNNPVAAS
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCHHCCCHHHHCCCEEEEEECCCCCCCCC
ANEEFFKRVVAFAKEHNIVVCHDVAYAELAFDGFKPMSFLEVPGAKEVGIEFYSLSKTYN
CCHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCCCCEEECCCCHHHCEEEEEECCCCC
MAGCRIGFAVGNPDVLSALGRIKSNIDYGVFSAVQEAGIAALTGDQTCVAKTAATYQRRR
CCCEEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHH
DLLVEGFGELGWLMPKPQASMFIWAPLPAGFQSSMDFCLEFLDKTGVLMVPGNAFGELGQ
HHHHHCHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCEEEECCCHHHHHCC
GYVRIALVQREEVLLEALERVRNNFTFAS
CEEEEEEEHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA