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The map label for this gene is sdhA [H]

Identifier: 134299722

GI number: 134299722

Start: 2054648

End: 2056405

Strand: Reverse

Name: sdhA [H]

Synonym: Dred_1869

Alternate gene names: 134299722

Gene position: 2056405-2054648 (Counterclockwise)

Preceding gene: 134299723

Following gene: 134299721

Centisome position: 56.99

GC content: 43.91

Gene sequence:

>1758_bases
ATGCAAAATAAAATCATTGTGGTTGGCGGTGGTCTGGCTGGTTTAATGGCAACCATAAAAGCTGCGGAGATGGGTGTGAA
GGTTCGGCTGTTTTCTTTGGTTCCGGTTAAAAGATCCCACTCGGTGTGTGCCCAGGGTGGAATCAACGGAGCTGTAAACA
CCAAAGGCGAAGGCGATTCTCCCTGGATACATTTTGATGACACAATTTACGGCGGGGACTTTCTGGCCAACCAACTCCAA
GTAAAAAATATGTGTGAGGCAGCCCCGGCAATTATTAATTTAATGGATCGGATGGGTGTTATGTTTAATCGAACTCCCGA
AGGTTTATTAGATTTTAGAAGGTTTGGTGGCAGTAAACATCACAGGACAGCCTTTGCTGGGGCTACTACTGGACAACAAT
TATTATATGCCCTTGATGAACAGGTTCGACATTGGGAAGTGGCTGGCTTTGTAGAAAAATATGAAGGCTGGGATCTTTTA
TCCATCGTTATGGATAGTGAAAACATTTGCCGAGGCATAGTAGCCCAAGATCTAAAAAGCATGAAAGTCCAGTCTTTTTC
AGGTGATGCTGTGATTCTGGCCACTGGTGGTTGTGGCATTGTGTATGGTAAGAGTACCAATTCCACCATTAATACAGGGG
CTGCTGCCAGTGCAGTTTATCAGCAGGGGGTCTACTATGCCAATGGCGAAATGATCCAAATTCACCCCACCGCTATCCCT
GGGGATGACAAACTGAGATTAATGAGTGAATCGGCCCGGGGCGAAGGGGGGCGTCTGTGGACCATTAAGGATGGCAAGCC
GTGGTACTTCCTGGAGGAATGGTACCCTGCCTATGGCAACTTGGTTCCGCGGGATATTGCAACCCGGGCAATTTATAGGG
TATGCTATGAGTTGAAACTTGGTATTGAAGGAAAAAACATGGTTTATCTGGATGTTTCACACGTTGAGCGAGAAATATTG
GATAAAAAACTAGCAGGTATTCTGGAGATTTATGAACGTTTTGTGGGGGATGACCCACGAAAAGTTCCTATGAGAATCTT
TCCAGCGGTTCATTACTCCATGGGCGGTCTTTGGGTGGACTATGATCAAATGACAAATATTACCGGTTTGTTTGCCTGTG
GTGAGTGTGAATATCAGTACCATGGTGCAAACCGCCTTGGCGCTAATTCATTATTATCAGCAATTTATGGCGGAATGGTT
GCCGGACCCAATGCAGTAAAGTACCTTCATTCTCTGAAAAGGACAGCACAGGATGTTAGCCAAAGTATATTTACACAAGA
AGAAAAGCGTCAACAAGCTTGGGTAGAGAAAACTTATAAAATGGATGGTACAGAGAATGTTTATAAACTGCATGAAGAGT
TAGGGGAATGGATGACAGAAAACGTTACAGTGGTACGATACAATAAAAAGCTTCAAGAAACAGATCAAAAAATACAGGAA
CTCATTGCAAGATGGCATCGAATAAAATTAACGGATAAGAGCATCTGGGCGAATCAAGAAGTGACTTTTGTTCGGCATTT
GTGGCATATGCTGCAGTTGTCCAGGGTTATTACGCTGGGGGCGCTGGCTCGCAATGAAAGCAGGGGAGCCCATTATAAAC
CGGAATTTCCAGATCGTGATGACCAAAACTGGTTAAAAACAACCAAGGCAAAATATACTTTCAATGGTCCAGAATTAACC
TATGAAGATATAGATACTTCGCTTATTAAGCCAAGGCCGCGGAGATATGATGTTGATAAAGGGGCGTTGAATAAATGA

Upstream 100 bases:

>100_bases
AATTTTTTATGGAAGTTGTGTATGCTATTCTTTATCTTTTCTTCTATCCTAGGTATCGCAGCAATTCGGGCCTTTATCCA
GTAATTCAGGAGGTTTCATG

Downstream 100 bases:

>100_bases
GTAAAATGGTGTCCTTAAAGATTAAACGTCAGTCTGATGTATCCACAGCGGCTTATTGGGAAGAATTTATGATTCCATAT
AAAGAAAAAATGAATGTTAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MQNKIIVVGGGLAGLMATIKAAEMGVKVRLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQLQ
VKNMCEAAPAIINLMDRMGVMFNRTPEGLLDFRRFGGSKHHRTAFAGATTGQQLLYALDEQVRHWEVAGFVEKYEGWDLL
SIVMDSENICRGIVAQDLKSMKVQSFSGDAVILATGGCGIVYGKSTNSTINTGAAASAVYQQGVYYANGEMIQIHPTAIP
GDDKLRLMSESARGEGGRLWTIKDGKPWYFLEEWYPAYGNLVPRDIATRAIYRVCYELKLGIEGKNMVYLDVSHVEREIL
DKKLAGILEIYERFVGDDPRKVPMRIFPAVHYSMGGLWVDYDQMTNITGLFACGECEYQYHGANRLGANSLLSAIYGGMV
AGPNAVKYLHSLKRTAQDVSQSIFTQEEKRQQAWVEKTYKMDGTENVYKLHEELGEWMTENVTVVRYNKKLQETDQKIQE
LIARWHRIKLTDKSIWANQEVTFVRHLWHMLQLSRVITLGALARNESRGAHYKPEFPDRDDQNWLKTTKAKYTFNGPELT
YEDIDTSLIKPRPRRYDVDKGALNK

Sequences:

>Translated_585_residues
MQNKIIVVGGGLAGLMATIKAAEMGVKVRLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQLQ
VKNMCEAAPAIINLMDRMGVMFNRTPEGLLDFRRFGGSKHHRTAFAGATTGQQLLYALDEQVRHWEVAGFVEKYEGWDLL
SIVMDSENICRGIVAQDLKSMKVQSFSGDAVILATGGCGIVYGKSTNSTINTGAAASAVYQQGVYYANGEMIQIHPTAIP
GDDKLRLMSESARGEGGRLWTIKDGKPWYFLEEWYPAYGNLVPRDIATRAIYRVCYELKLGIEGKNMVYLDVSHVEREIL
DKKLAGILEIYERFVGDDPRKVPMRIFPAVHYSMGGLWVDYDQMTNITGLFACGECEYQYHGANRLGANSLLSAIYGGMV
AGPNAVKYLHSLKRTAQDVSQSIFTQEEKRQQAWVEKTYKMDGTENVYKLHEELGEWMTENVTVVRYNKKLQETDQKIQE
LIARWHRIKLTDKSIWANQEVTFVRHLWHMLQLSRVITLGALARNESRGAHYKPEFPDRDDQNWLKTTKAKYTFNGPELT
YEDIDTSLIKPRPRRYDVDKGALNK
>Mature_585_residues
MQNKIIVVGGGLAGLMATIKAAEMGVKVRLFSLVPVKRSHSVCAQGGINGAVNTKGEGDSPWIHFDDTIYGGDFLANQLQ
VKNMCEAAPAIINLMDRMGVMFNRTPEGLLDFRRFGGSKHHRTAFAGATTGQQLLYALDEQVRHWEVAGFVEKYEGWDLL
SIVMDSENICRGIVAQDLKSMKVQSFSGDAVILATGGCGIVYGKSTNSTINTGAAASAVYQQGVYYANGEMIQIHPTAIP
GDDKLRLMSESARGEGGRLWTIKDGKPWYFLEEWYPAYGNLVPRDIATRAIYRVCYELKLGIEGKNMVYLDVSHVEREIL
DKKLAGILEIYERFVGDDPRKVPMRIFPAVHYSMGGLWVDYDQMTNITGLFACGECEYQYHGANRLGANSLLSAIYGGMV
AGPNAVKYLHSLKRTAQDVSQSIFTQEEKRQQAWVEKTYKMDGTENVYKLHEELGEWMTENVTVVRYNKKLQETDQKIQE
LIARWHRIKLTDKSIWANQEVTFVRHLWHMLQLSRVITLGALARNESRGAHYKPEFPDRDDQNWLKTTKAKYTFNGPELT
YEDIDTSLIKPRPRRYDVDKGALNK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=541, Percent_Identity=30.3142329020333, Blast_Score=220, Evalue=4e-57,
Organism=Escherichia coli, GI1790597, Length=567, Percent_Identity=33.5097001763668, Blast_Score=268, Evalue=8e-73,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=31.1270125223614, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1788928, Length=555, Percent_Identity=28.2882882882883, Blast_Score=168, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17550100, Length=541, Percent_Identity=30.3142329020333, Blast_Score=223, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17505833, Length=542, Percent_Identity=29.8892988929889, Blast_Score=217, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322701, Length=550, Percent_Identity=32.3636363636364, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6322416, Length=554, Percent_Identity=31.2274368231047, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17137288, Length=540, Percent_Identity=31.2962962962963, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655642, Length=540, Percent_Identity=31.2962962962963, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655647, Length=540, Percent_Identity=31.2962962962963, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24663005, Length=541, Percent_Identity=29.7597042513863, Blast_Score=217, Evalue=2e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65914; Mature: 65914

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNKIIVVGGGLAGLMATIKAAEMGVKVRLFSLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLANQLQVKNMCEAAPAIINLMDRMGVMFNRTPEGLLDFRRFGGSKH
CEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHCCCCCC
HRTAFAGATTGQQLLYALDEQVRHWEVAGFVEKYEGWDLLSIVMDSENICRGIVAQDLKS
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHH
MKVQSFSGDAVILATGGCGIVYGKSTNSTINTGAAASAVYQQGVYYANGEMIQIHPTAIP
HHHCCCCCCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCEEEEECCCCC
GDDKLRLMSESARGEGGRLWTIKDGKPWYFLEEWYPAYGNLVPRDIATRAIYRVCYELKL
CCCCEEEEECCCCCCCCEEEEEECCCCEEEHHHHCCHHCCCCCHHHHHHHHHHHHHHHHC
GIEGKNMVYLDVSHVEREILDKKLAGILEIYERFVGDDPRKVPMRIFPAVHYSMGGLWVD
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHCCCCEEEE
YDQMTNITGLFACGECEYQYHGANRLGANSLLSAIYGGMVAGPNAVKYLHSLKRTAQDVS
HHHHCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QSIFTQEEKRQQAWVEKTYKMDGTENVYKLHEELGEWMTENVTVVRYNKKLQETDQKIQE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHH
LIARWHRIKLTDKSIWANQEVTFVRHLWHMLQLSRVITLGALARNESRGAHYKPEFPDRD
HHHHHHEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DQNWLKTTKAKYTFNGPELTYEDIDTSLIKPRPRRYDVDKGALNK
CCHHHHHCCCEEEECCCCEEHHHCCHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQNKIIVVGGGLAGLMATIKAAEMGVKVRLFSLVPVKRSHSVCAQGGINGAVNTKGEGDS
CCCCEEEEECCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHCCCCCCCCCCCCCCCC
PWIHFDDTIYGGDFLANQLQVKNMCEAAPAIINLMDRMGVMFNRTPEGLLDFRRFGGSKH
CEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCCHHHHHHHHHCCCCCC
HRTAFAGATTGQQLLYALDEQVRHWEVAGFVEKYEGWDLLSIVMDSENICRGIVAQDLKS
CCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHH
MKVQSFSGDAVILATGGCGIVYGKSTNSTINTGAAASAVYQQGVYYANGEMIQIHPTAIP
HHHCCCCCCEEEEEECCCEEEEECCCCCCCCCCHHHHHHHHCCEEEECCCEEEEECCCCC
GDDKLRLMSESARGEGGRLWTIKDGKPWYFLEEWYPAYGNLVPRDIATRAIYRVCYELKL
CCCCEEEEECCCCCCCCEEEEEECCCCEEEHHHHCCHHCCCCCHHHHHHHHHHHHHHHHC
GIEGKNMVYLDVSHVEREILDKKLAGILEIYERFVGDDPRKVPMRIFPAVHYSMGGLWVD
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHCCCCEEEE
YDQMTNITGLFACGECEYQYHGANRLGANSLLSAIYGGMVAGPNAVKYLHSLKRTAQDVS
HHHHCCCEEEEEECCCEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
QSIFTQEEKRQQAWVEKTYKMDGTENVYKLHEELGEWMTENVTVVRYNKKLQETDQKIQE
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHH
LIARWHRIKLTDKSIWANQEVTFVRHLWHMLQLSRVITLGALARNESRGAHYKPEFPDRD
HHHHHHEEEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
DQNWLKTTKAKYTFNGPELTYEDIDTSLIKPRPRRYDVDKGALNK
CCHHHHHCCCEEEECCCCEEHHHCCHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]