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The map label for this gene is uppS [H]

Identifier: 134299309

GI number: 134299309

Start: 1573246

End: 1573905

Strand: Reverse

Name: uppS [H]

Synonym: Dred_1450

Alternate gene names: 134299309

Gene position: 1573905-1573246 (Counterclockwise)

Preceding gene: 134299310

Following gene: 134299308

Centisome position: 43.62

GC content: 39.85

Gene sequence:

>660_bases
ATGATACCAAAATTCAAACGTCTCCCAAAGCATATTGGCATTATTCCGGACGGCAATAGAAGATGGGCTCAAAACCAGGG
CCTGGCAAAGGAAGCTGGTTATGACCATGGCATTACCCCTGGGTTTGATCTATATCAAATATGTTTGGAATTAGGTATAC
CAGAAATAACCTTTTATGGTTTTACCGTTGATAATACCAAGCGACCCCCAGTGCAAAAAAAAGCCTTTCAGAAAGCCTGT
GTGGATGCAGTTAACATATTGGCTAACCGAGATGCCTCATTGCTGGTGATTGGCAATCATGAATCTGCTCAGTTTCCAAA
GGAATTACTTCCCTATACCACCCGCAAAATCTTTGGCAGTAATCGGATTAAGATTAACTTTTTGGTAAATTATGGTTGGA
AATGGGATTTGAATCAGGCATTTAACAACAATTCAATGGATTCTTCTTACTTTCACGAAAAAATTGCTTCCAAGGATATT
TCTAGAATTGACTTAATCATACGCTGGGGTGGACGTAGAAGGTTAAGTGGTTTTCTCCCTGTCCAATCCATTTACGCAGA
TTTTTATGTAGTTGAAGACCTTTGGCCAAATTTTCGTTCTGAACAATTCTACGAAGCTCTTATGTGGTATCAAGATCAGG
ACATTACTCTGGGGGGATGA

Upstream 100 bases:

>100_bases
AACAATACTTAAGATAATCCACTGGTTTATGTATAGAATAGCTAAATTCTGCTCATATTAACCTCGAACTAATATTGCCT
AAATGGTTATGAGGTGTAAT

Downstream 100 bases:

>100_bases
AGCTATTTATGCCTAAATAATTAAAAACTTTAATATATTCTCAATAATATTGAAAAGATTCCTAAATCATGCTAATATGA
ACTATAAGCATAGCGAAATA

Product: di-trans,poly-cis-decaprenylcistransferase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MIPKFKRLPKHIGIIPDGNRRWAQNQGLAKEAGYDHGITPGFDLYQICLELGIPEITFYGFTVDNTKRPPVQKKAFQKAC
VDAVNILANRDASLLVIGNHESAQFPKELLPYTTRKIFGSNRIKINFLVNYGWKWDLNQAFNNNSMDSSYFHEKIASKDI
SRIDLIIRWGGRRRLSGFLPVQSIYADFYVVEDLWPNFRSEQFYEALMWYQDQDITLGG

Sequences:

>Translated_219_residues
MIPKFKRLPKHIGIIPDGNRRWAQNQGLAKEAGYDHGITPGFDLYQICLELGIPEITFYGFTVDNTKRPPVQKKAFQKAC
VDAVNILANRDASLLVIGNHESAQFPKELLPYTTRKIFGSNRIKINFLVNYGWKWDLNQAFNNNSMDSSYFHEKIASKDI
SRIDLIIRWGGRRRLSGFLPVQSIYADFYVVEDLWPNFRSEQFYEALMWYQDQDITLGG
>Mature_219_residues
MIPKFKRLPKHIGIIPDGNRRWAQNQGLAKEAGYDHGITPGFDLYQICLELGIPEITFYGFTVDNTKRPPVQKKAFQKAC
VDAVNILANRDASLLVIGNHESAQFPKELLPYTTRKIFGSNRIKINFLVNYGWKWDLNQAFNNNSMDSSYFHEKIASKDI
SRIDLIIRWGGRRRLSGFLPVQSIYADFYVVEDLWPNFRSEQFYEALMWYQDQDITLGG

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=225, Percent_Identity=24.8888888888889, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI45580742, Length=225, Percent_Identity=24.8888888888889, Blast_Score=75, Evalue=3e-14,
Organism=Escherichia coli, GI1786371, Length=240, Percent_Identity=27.0833333333333, Blast_Score=100, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=26.7241379310345, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319474, Length=209, Percent_Identity=21.5311004784689, Blast_Score=66, Evalue=4e-12,
Organism=Drosophila melanogaster, GI18857969, Length=233, Percent_Identity=25.7510729613734, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 25344; Mature: 25344

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPKFKRLPKHIGIIPDGNRRWAQNQGLAKEAGYDHGITPGFDLYQICLELGIPEITFYG
CCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEE
FTVDNTKRPPVQKKAFQKACVDAVNILANRDASLLVIGNHESAQFPKELLPYTTRKIFGS
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHCCHHHHCHHHHHHHCC
NRIKINFLVNYGWKWDLNQAFNNNSMDSSYFHEKIASKDISRIDLIIRWGGRRRLSGFLP
CEEEEEEEEECCCEEECHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCC
VQSIYADFYVVEDLWPNFRSEQFYEALMWYQDQDITLGG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MIPKFKRLPKHIGIIPDGNRRWAQNQGLAKEAGYDHGITPGFDLYQICLELGIPEITFYG
CCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEE
FTVDNTKRPPVQKKAFQKACVDAVNILANRDASLLVIGNHESAQFPKELLPYTTRKIFGS
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHCCHHHHCHHHHHHHCC
NRIKINFLVNYGWKWDLNQAFNNNSMDSSYFHEKIASKDISRIDLIIRWGGRRRLSGFLP
CEEEEEEEEECCCEEECHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCC
VQSIYADFYVVEDLWPNFRSEQFYEALMWYQDQDITLGG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12446909 [H]