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The map label for this gene is lexA [H]

Identifier: 134299046

GI number: 134299046

Start: 1259977

End: 1260609

Strand: Reverse

Name: lexA [H]

Synonym: Dred_1183

Alternate gene names: 134299046

Gene position: 1260609-1259977 (Counterclockwise)

Preceding gene: 134299093

Following gene: 134299045

Centisome position: 34.94

GC content: 43.44

Gene sequence:

>633_bases
ATGGGAAGGTACTTTGATAAAGGCTTATTTAGTAAGCGGCTGCTAGAGCTTATGGTGGATAACAACGACACGACTTACAG
CCTGGGTGAACATTTGCACTTAAGCAATGCAACGATATCCAGATACACCACTGGTGACATTGCGCCAAAAATACCGACGA
TTGAAAAGATAGCAGAAAAGTACGGCGTTAACCCGGCATGGTTAACCGGAACGGAAGGCGCCAGTAAATACGTTGAAAAA
ACTATGCCCTCCAAGAAAATACCCATTATAGGAGCCATTGCAGCCGGCATCCCAATCCTTGCCCAGGAAAACATAGACGG
CTATGAATACATTCCTGATAACGTGAGTATTGATTTCTGCTTAAGGGTTAAGGGAGATAGCATGATAGGCGCTCGCATTT
TGGACGGCGATATCGTCTACATAAGGAAACAGCCGCAGGTAGAAAACGGGGAAATTGCTGCAGTAATAATCGATAACGAG
GAAGCAACCTTAAAGCGGATTTATGCGTTAAACGGGAGCGTTATTCTCAGGGCTGAAAATCCCAATTACCCGGATAAGGT
ATTCTCAAAAAAGGACATGAAGCAAATCTCAATAATAGGGAAAGCGATATTTTTTAAATCGGAGGTGAGATAA

Upstream 100 bases:

>100_bases
CAATACGTTTTGCAATAAAATTTAAGAATTTCTAAACGGTATTATTGCATTTATTAACATTCCAATATATAATAACAAAA
TGAAATAAGGGGGTTATTGC

Downstream 100 bases:

>100_bases
GAGTGGCTAGTATTGCAAGAAGGCCAAACGGTAAGTGGCAAGCAACTATTTACATGGGCAGAGATGAGAATGGTAAACAG
ATTCGTAGATACGTTACTGG

Product: putative prophage repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MGRYFDKGLFSKRLLELMVDNNDTTYSLGEHLHLSNATISRYTTGDIAPKIPTIEKIAEKYGVNPAWLTGTEGASKYVEK
TMPSKKIPIIGAIAAGIPILAQENIDGYEYIPDNVSIDFCLRVKGDSMIGARILDGDIVYIRKQPQVENGEIAAVIIDNE
EATLKRIYALNGSVILRAENPNYPDKVFSKKDMKQISIIGKAIFFKSEVR

Sequences:

>Translated_210_residues
MGRYFDKGLFSKRLLELMVDNNDTTYSLGEHLHLSNATISRYTTGDIAPKIPTIEKIAEKYGVNPAWLTGTEGASKYVEK
TMPSKKIPIIGAIAAGIPILAQENIDGYEYIPDNVSIDFCLRVKGDSMIGARILDGDIVYIRKQPQVENGEIAAVIIDNE
EATLKRIYALNGSVILRAENPNYPDKVFSKKDMKQISIIGKAIFFKSEVR
>Mature_209_residues
GRYFDKGLFSKRLLELMVDNNDTTYSLGEHLHLSNATISRYTTGDIAPKIPTIEKIAEKYGVNPAWLTGTEGASKYVEKT
MPSKKIPIIGAIAAGIPILAQENIDGYEYIPDNVSIDFCLRVKGDSMIGARILDGDIVYIRKQPQVENGEIAAVIIDNEE
ATLKRIYALNGSVILRAENPNYPDKVFSKKDMKQISIIGKAIFFKSEVR

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=129, Percent_Identity=34.1085271317829, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23344; Mature: 23213

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS50943 HTH_CROC1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRYFDKGLFSKRLLELMVDNNDTTYSLGEHLHLSNATISRYTTGDIAPKIPTIEKIAEK
CCCCHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCEEEEEECCCCCCCCCHHHHHHHH
YGVNPAWLTGTEGASKYVEKTMPSKKIPIIGAIAAGIPILAQENIDGYEYIPDNVSIDFC
HCCCCEEEECCCCHHHHHHHHCCCCCCCEEEEHHCCCEEEEECCCCCCEECCCCCCEEEE
LRVKGDSMIGARILDGDIVYIRKQPQVENGEIAAVIIDNEEATLKRIYALNGSVILRAEN
EEECCCCEEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCHHEEEEEEECCEEEEEECC
PNYPDKVFSKKDMKQISIIGKAIFFKSEVR
CCCCHHHHCHHHHHHHHHHHHHHEEEECCC
>Mature Secondary Structure 
GRYFDKGLFSKRLLELMVDNNDTTYSLGEHLHLSNATISRYTTGDIAPKIPTIEKIAEK
CCCHHHHHHHHHHHHHHCCCCCCEEECCCEEEECCCEEEEEECCCCCCCCCHHHHHHHH
YGVNPAWLTGTEGASKYVEKTMPSKKIPIIGAIAAGIPILAQENIDGYEYIPDNVSIDFC
HCCCCEEEECCCCHHHHHHHHCCCCCCCEEEEHHCCCEEEEECCCCCCEECCCCCCEEEE
LRVKGDSMIGARILDGDIVYIRKQPQVENGEIAAVIIDNEEATLKRIYALNGSVILRAEN
EEECCCCEEEEEEECCCEEEEECCCCCCCCCEEEEEECCCCHHEEEEEEECCEEEEEECC
PNYPDKVFSKKDMKQISIIGKAIFFKSEVR
CCCCHHHHCHHHHHHHHHHHHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA