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The map label for this gene is 134298338

Identifier: 134298338

GI number: 134298338

Start: 505261

End: 506823

Strand: Reverse

Name: 134298338

Synonym: Dred_0463

Alternate gene names: NA

Gene position: 506823-505261 (Counterclockwise)

Preceding gene: 134298340

Following gene: 134298337

Centisome position: 14.05

GC content: 47.41

Gene sequence:

>1563_bases
ATGCAGAACCAACAAGAGGGTAAAGACAAACAAAAGCAAATTACCAGGCGGGGCTTCCTCAAAATGATGGGAGGTATCGG
TCTTACCGGTATTACTGCTACCATTGCCGGTTGCAGTACTGATCCCGCTGGTGGTAAGGGTTGGATGCCACAGCAGTACC
AGGTTGCCAGCTCCTATCCCATTCAGGTAAAAGGTCGTATTCCAATCGACCCCAACAACCCCTCCATTACTCGGGACGAC
AAAAAGTGTATTTTGTGCGGCCAGTGTATCGAAGTCTGCCAGAGGGTACAAACAGTTTACGGTTATTATGAACTTCCCAT
CAAGAATGACATTACCTGTGTTAACTGCGGTCAATGCACCCTGTGGTGTCCCACTGCAGCTATCACCGAGCGCGACGACA
TTGATAAGGTTGTTAAAGCGTTGGAAAACAAAGACCTACATGTAGTTGTTCAAACCGCACCTGCAACTCGGGTTGGTCTG
GGTGAAGAATTTGGTATGGCACCCGGTACCTTTGTAGAAGGTAAACAGGTAGCCGCCTTAAAGCAACTGGGATTCGATGC
AGTCTTTGATACCAACTTTTCTGCAGACCTAACTATTTTTGAAGAAGGAACCGAGTTAATCAAGAGGATTTCAGGCGACC
TCCACGAACCCCTGCCTCAGTTTACCTCTTGTAGCCCTGGCTGGGTTAAATTCTGTGAATACTACTACCCAGATCTGTTA
CCCCATATGTCTACCTGCAAATCACCTCAGCAAATGCTGGGTGCACTGATTAAAACCTATTATGCCAAGGAAAAGGGTAT
TAAGCCTGAAAAAATCTTCTCTGTTTCCATCATGCCCTGTACCGCTAAGAAATTTGAAGCAGCCCGCCCAGAAATGAATA
GTTCTGGTAAACATGCTGGTAAGCCTCAATTAAAGGATGTTGACGTAGTACTAACAACCCGTGAACTAGCCCGTCTAATA
AAGGCCAAAGGCATGGATTTAAACAACTTACCAGACAAAAAGTATGATTCCCTAATGGGCGAAGGTACCGGTGCCGGTTT
AATATTTGGTGCCACCGGCGGTGTTATGGAAGCAGCCATTCGTTCTGCTTATTTCTTAATTACTAAACAGGATCCACCGG
AAGCTCTTCTGAACCTGACACCCATTCGTGGCCTGCAGGGCTGTAAAGAAGCCTCTGTGGATATTCCCGGTGTGGGTACT
GTAAAAGTAGCGGTTGTACATGGACTTAGCAATGCCCGCCCCATTCTGGAAGCCGTCCGCAAGAAGGAAGCGCCCTGGCA
CTTTATTGAGTTCATGTGTTGTCCCGGCGGTTGCATCAGTGGCGGTGGCCAGCCCCGAACCTCTTTGCCGCCGTCTGACG
AGGTTCGTCAAGCTCGTATTAACAGTATTTACAACGCAGATGCGCACATTTATTCAAAACGTAAGAGCTATGAAAACCAA
GAGGTTCTGGCTCTCTATGAAAAATTCATGGAGAACCCCAACAGTCACCTAGCTCACGAACTGCTGCACACCCACTATAC
CGACCGCAGCAAGCAACTGACTGTGAAAAAGAAAAATGCGTAA

Upstream 100 bases:

>100_bases
ATTAGGCAACTAGCTAGCTAACTCTTAAGTAAAATTATTACTGGCAGAGTTGTTAGCTTGCTAAATAAAAAGAAAGTTTT
TTAGCAAAGGGGGAAAACCT

Downstream 100 bases:

>100_bases
TTCTGCATATTCCGGGAGGTGAAGAACCATGTCAAAAGGCGTACTGGTTGACCTGACTAAATGTGTAGGCTGCGGTAGTT
GTACCGTTGCCTGTAAGTTA

Product: hydrogenase

Products: NA

Alternate protein names: CpI; Fe-only hydrogenase; [Fe] hydrogenase [H]

Number of amino acids: Translated: 520; Mature: 520

Protein sequence:

>520_residues
MQNQQEGKDKQKQITRRGFLKMMGGIGLTGITATIAGCSTDPAGGKGWMPQQYQVASSYPIQVKGRIPIDPNNPSITRDD
KKCILCGQCIEVCQRVQTVYGYYELPIKNDITCVNCGQCTLWCPTAAITERDDIDKVVKALENKDLHVVVQTAPATRVGL
GEEFGMAPGTFVEGKQVAALKQLGFDAVFDTNFSADLTIFEEGTELIKRISGDLHEPLPQFTSCSPGWVKFCEYYYPDLL
PHMSTCKSPQQMLGALIKTYYAKEKGIKPEKIFSVSIMPCTAKKFEAARPEMNSSGKHAGKPQLKDVDVVLTTRELARLI
KAKGMDLNNLPDKKYDSLMGEGTGAGLIFGATGGVMEAAIRSAYFLITKQDPPEALLNLTPIRGLQGCKEASVDIPGVGT
VKVAVVHGLSNARPILEAVRKKEAPWHFIEFMCCPGGCISGGGQPRTSLPPSDEVRQARINSIYNADAHIYSKRKSYENQ
EVLALYEKFMENPNSHLAHELLHTHYTDRSKQLTVKKKNA

Sequences:

>Translated_520_residues
MQNQQEGKDKQKQITRRGFLKMMGGIGLTGITATIAGCSTDPAGGKGWMPQQYQVASSYPIQVKGRIPIDPNNPSITRDD
KKCILCGQCIEVCQRVQTVYGYYELPIKNDITCVNCGQCTLWCPTAAITERDDIDKVVKALENKDLHVVVQTAPATRVGL
GEEFGMAPGTFVEGKQVAALKQLGFDAVFDTNFSADLTIFEEGTELIKRISGDLHEPLPQFTSCSPGWVKFCEYYYPDLL
PHMSTCKSPQQMLGALIKTYYAKEKGIKPEKIFSVSIMPCTAKKFEAARPEMNSSGKHAGKPQLKDVDVVLTTRELARLI
KAKGMDLNNLPDKKYDSLMGEGTGAGLIFGATGGVMEAAIRSAYFLITKQDPPEALLNLTPIRGLQGCKEASVDIPGVGT
VKVAVVHGLSNARPILEAVRKKEAPWHFIEFMCCPGGCISGGGQPRTSLPPSDEVRQARINSIYNADAHIYSKRKSYENQ
EVLALYEKFMENPNSHLAHELLHTHYTDRSKQLTVKKKNA
>Mature_520_residues
MQNQQEGKDKQKQITRRGFLKMMGGIGLTGITATIAGCSTDPAGGKGWMPQQYQVASSYPIQVKGRIPIDPNNPSITRDD
KKCILCGQCIEVCQRVQTVYGYYELPIKNDITCVNCGQCTLWCPTAAITERDDIDKVVKALENKDLHVVVQTAPATRVGL
GEEFGMAPGTFVEGKQVAALKQLGFDAVFDTNFSADLTIFEEGTELIKRISGDLHEPLPQFTSCSPGWVKFCEYYYPDLL
PHMSTCKSPQQMLGALIKTYYAKEKGIKPEKIFSVSIMPCTAKKFEAARPEMNSSGKHAGKPQLKDVDVVLTTRELARLI
KAKGMDLNNLPDKKYDSLMGEGTGAGLIFGATGGVMEAAIRSAYFLITKQDPPEALLNLTPIRGLQGCKEASVDIPGVGT
VKVAVVHGLSNARPILEAVRKKEAPWHFIEFMCCPGGCISGGGQPRTSLPPSDEVRQARINSIYNADAHIYSKRKSYENQ
EVLALYEKFMENPNSHLAHELLHTHYTDRSKQLTVKKKNA

Specific function: Unknown

COG id: COG4624

COG function: function code R; Iron only hydrogenase large subunit, C-terminal domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI11968051, Length=408, Percent_Identity=30.6372549019608, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI6912524, Length=374, Percent_Identity=28.6096256684492, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI134284357, Length=374, Percent_Identity=28.6096256684492, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI84452151, Length=342, Percent_Identity=30.1169590643275, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI14165461, Length=408, Percent_Identity=26.7156862745098, Blast_Score=140, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71995015, Length=366, Percent_Identity=26.5027322404372, Blast_Score=118, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6324089, Length=361, Percent_Identity=23.8227146814404, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI116007468, Length=419, Percent_Identity=26.2529832935561, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI116007470, Length=419, Percent_Identity=26.2529832935561, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI116007466, Length=419, Percent_Identity=26.2529832935561, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI116007464, Length=419, Percent_Identity=26.2529832935561, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI116007462, Length=302, Percent_Identity=27.4834437086093, Blast_Score=119, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR009016
- InterPro:   IPR004108
- InterPro:   IPR003149
- InterPro:   IPR013352
- InterPro:   IPR001041 [H]

Pfam domain/function: PF02906 Fe_hyd_lg_C; PF02256 Fe_hyd_SSU [H]

EC number: =1.12.7.2 [H]

Molecular weight: Translated: 57172; Mature: 57172

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNQQEGKDKQKQITRRGFLKMMGGIGLTGITATIAGCSTDPAGGKGWMPQQYQVASSYP
CCCCHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCCCCCCCCEECCCCCC
IQVKGRIPIDPNNPSITRDDKKCILCGQCIEVCQRVQTVYGYYELPIKNDITCVNCGQCT
EEEECEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCEEECCCCCCCEEEECCCEE
LWCPTAAITERDDIDKVVKALENKDLHVVVQTAPATRVGLGEEFGMAPGTFVEGKQVAAL
EECCCHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCHHHHHH
KQLGFDAVFDTNFSADLTIFEEGTELIKRISGDLHEPLPQFTSCSPGWVKFCEYYYPDLL
HHCCCCEEECCCCCCCEEEEHHHHHHHHHHHCHHHHCCHHHCCCCCHHHHHHHHHHHHHH
PHMSTCKSPQQMLGALIKTYYAKEKGIKPEKIFSVSIMPCTAKKFEAARPEMNSSGKHAG
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCHHHHHCCCCCCCCCCCCCC
KPQLKDVDVVLTTRELARLIKAKGMDLNNLPDKKYDSLMGEGTGAGLIFGATGGVMEAAI
CCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCHHHHHHH
RSAYFLITKQDPPEALLNLTPIRGLQGCKEASVDIPGVGTVKVAVVHGLSNARPILEAVR
HCEEEEEECCCCHHHHHCCCCCHHHCCHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
KKEAPWHFIEFMCCPGGCISGGGQPRTSLPPSDEVRQARINSIYNADAHIYSKRKSYENQ
HCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCH
EVLALYEKFMENPNSHLAHELLHTHYTDRSKQLTVKKKNA
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCC
>Mature Secondary Structure
MQNQQEGKDKQKQITRRGFLKMMGGIGLTGITATIAGCSTDPAGGKGWMPQQYQVASSYP
CCCCHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCCCCCCCCEECCCCCC
IQVKGRIPIDPNNPSITRDDKKCILCGQCIEVCQRVQTVYGYYELPIKNDITCVNCGQCT
EEEECEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHCEEECCCCCCCEEEECCCEE
LWCPTAAITERDDIDKVVKALENKDLHVVVQTAPATRVGLGEEFGMAPGTFVEGKQVAAL
EECCCHHCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHCCCCCCCCCCHHHHHH
KQLGFDAVFDTNFSADLTIFEEGTELIKRISGDLHEPLPQFTSCSPGWVKFCEYYYPDLL
HHCCCCEEECCCCCCCEEEEHHHHHHHHHHHCHHHHCCHHHCCCCCHHHHHHHHHHHHHH
PHMSTCKSPQQMLGALIKTYYAKEKGIKPEKIFSVSIMPCTAKKFEAARPEMNSSGKHAG
HHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEEECCCHHHHHCCCCCCCCCCCCCC
KPQLKDVDVVLTTRELARLIKAKGMDLNNLPDKKYDSLMGEGTGAGLIFGATGGVMEAAI
CCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCHHHHHHH
RSAYFLITKQDPPEALLNLTPIRGLQGCKEASVDIPGVGTVKVAVVHGLSNARPILEAVR
HCEEEEEECCCCHHHHHCCCCCHHHCCHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHH
KKEAPWHFIEFMCCPGGCISGGGQPRTSLPPSDEVRQARINSIYNADAHIYSKRKSYENQ
HCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCCH
EVLALYEKFMENPNSHLAHELLHTHYTDRSKQLTVKKKNA
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1911757; 9836629; 10529166 [H]