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The map label for this gene is gmr [H]

Identifier: 126700985

GI number: 126700985

Start: 3930326

End: 3931282

Strand: Direct

Name: gmr [H]

Synonym: CD3365

Alternate gene names: 126700985

Gene position: 3930326-3931282 (Clockwise)

Preceding gene: 126700979

Following gene: 126700990

Centisome position: 91.61

GC content: 27.9

Gene sequence:

>957_bases
ATGGAAAATAATACAATACAAAAACAATTAAGAGATTTATCAAAAAAAATTTGGCATATTTATATTTTAAATCCAGAAGA
AGAAAACCTTAAATTTATTATTTCCTTATTAGATGACAACCTTGCATTAATTGGAACAGGAAAACATGAATTTTACGAAA
CATTAGAAGAATTTATTATAGGTCTTGAAAAAGACCAAACAGAATCAGAGCAAATAGACTTTGAGATTATAGATGAGTGG
TATTCATGTACCAAAGTCACAGACGAAGCTTTTATAGTATATGGTACTCTTTGGGTAATAGAAAAAGATTACCTAGAAAA
AGATATCTATGTAGAAATGGATACTCGATTTACTATGGTATACAGAGTTACAGATGATATGATTAAACTTATCCATGTTC
ACCATTCTATTCCAAACTTTGACCAAATGAAAGATGAGTATTACCCTAAAACAATAACTGAAAAAGCACAAGAAGCACTA
GCAATGGCAAATGAATTTAAACTAAAATCAGAAAAAGACCTTATGACTGGACTATACAATAGACATTTTTTTGAAGTACA
CATAAAAGAAATGCTTAAAACTGTTTCACATGGATACTTTTACATCTTTGATTTAGATAATTTTAAACAGGTAAATGATA
TCTTTGGTCATGTTCGAGGAGATGAAATACTAATACATTTTTCAAATATTTTGACTAAAGTATTCGTAAATGATGCTATT
ATTGGAAGACTTGGTGGAGATGAATTTGCTGTTTTTGAATATAGTAATCAATCAAAAGAGAATGTTGAAAATAAGGCAAA
GAAGGTTTTAGAATTATGCCTAGAGAGTAATTCTTGTTCTATAGGTATATCTAAATTAGAAAATAACTCTGATACTTTCC
AGTCTTTATACAAACAATCGGATTATGCTTTGTATTATTCAAAACGAAATAATAAAGGAAACTTTAGTTGGTTTTAG

Upstream 100 bases:

>100_bases
AGGATGTAATTTCTTTAGTTCTATATTATAATAATATTGTAATAAGAGTTCAACTTATAATACATTAAAATATAAACTGT
AAATCTTAAGGGGGTAATCT

Downstream 100 bases:

>100_bases
TACAAAAGATATTAAAATAGGCAAATTTATTAGAGTATCTTGTCCTATATACTAATAAGTAAAGTAAACAACAAGCTATC
TTTGCATATATTTATATAAA

Product: signaling protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALIGTGKHEFYETLEEFIIGLEKDQTESEQIDFEIIDEW
YSCTKVTDEAFIVYGTLWVIEKDYLEKDIYVEMDTRFTMVYRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEAL
AMANEFKLKSEKDLMTGLYNRHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHVRGDEILIHFSNILTKVFVNDAI
IGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLESNSCSIGISKLENNSDTFQSLYKQSDYALYYSKRNNKGNFSWF

Sequences:

>Translated_318_residues
MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALIGTGKHEFYETLEEFIIGLEKDQTESEQIDFEIIDEW
YSCTKVTDEAFIVYGTLWVIEKDYLEKDIYVEMDTRFTMVYRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEAL
AMANEFKLKSEKDLMTGLYNRHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHVRGDEILIHFSNILTKVFVNDAI
IGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLESNSCSIGISKLENNSDTFQSLYKQSDYALYYSKRNNKGNFSWF
>Mature_318_residues
MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALIGTGKHEFYETLEEFIIGLEKDQTESEQIDFEIIDEW
YSCTKVTDEAFIVYGTLWVIEKDYLEKDIYVEMDTRFTMVYRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEAL
AMANEFKLKSEKDLMTGLYNRHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHVRGDEILIHFSNILTKVFVNDAI
IGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLESNSCSIGISKLENNSDTFQSLYKQSDYALYYSKRNNKGNFSWF

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=182, Percent_Identity=33.5164835164835, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787056, Length=153, Percent_Identity=34.640522875817, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786584, Length=162, Percent_Identity=29.0123456790123, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788381, Length=202, Percent_Identity=25.7425742574257, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082007, Length=166, Percent_Identity=29.5180722891566, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081977, Length=157, Percent_Identity=31.8471337579618, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081881, Length=154, Percent_Identity=29.8701298701299, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787262, Length=156, Percent_Identity=27.5641025641026, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081974, Length=148, Percent_Identity=30.4054054054054, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787802, Length=170, Percent_Identity=27.0588235294118, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 37549; Mature: 37549

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALIGTGKHEFYETLEEFII
CCCCHHHHHHHHHHHCEEEEEEECCCCCCHHHHEEECCCCEEEEECCHHHHHHHHHHHHH
GLEKDQTESEQIDFEIIDEWYSCTKVTDEAFIVYGTLWVIEKDYLEKDIYVEMDTRFTMV
CCCCCCCCHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEHHHCCCCEEEEECCEEEEE
YRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEALAMANEFKLKSEKDLMTGLYN
EEEHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHVRGDEILIHFSNILTKVFVNDAI
CHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
IGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLESNSCSIGISKLENNSDTFQSLYKQS
EEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCHHHHHHHHHCC
DYALYYSKRNNKGNFSWF
CEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MENNTIQKQLRDLSKKIWHIYILNPEEENLKFIISLLDDNLALIGTGKHEFYETLEEFII
CCCCHHHHHHHHHHHCEEEEEEECCCCCCHHHHEEECCCCEEEEECCHHHHHHHHHHHHH
GLEKDQTESEQIDFEIIDEWYSCTKVTDEAFIVYGTLWVIEKDYLEKDIYVEMDTRFTMV
CCCCCCCCHHHCCHHHHHHHHHHHCCCCCEEEEEEEEEEEEHHHCCCCEEEEECCEEEEE
YRVTDDMIKLIHVHHSIPNFDQMKDEYYPKTITEKAQEALAMANEFKLKSEKDLMTGLYN
EEEHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RHFFEVHIKEMLKTVSHGYFYIFDLDNFKQVNDIFGHVRGDEILIHFSNILTKVFVNDAI
CHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHH
IGRLGGDEFAVFEYSNQSKENVENKAKKVLELCLESNSCSIGISKLENNSDTFQSLYKQS
EEECCCCEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCHHHHHHHHHCC
DYALYYSKRNNKGNFSWF
CEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]