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The map label for this gene is dapA2 [H]

Identifier: 126700845

GI number: 126700845

Start: 3774518

End: 3775405

Strand: Direct

Name: dapA2 [H]

Synonym: CD3225

Alternate gene names: 126700845

Gene position: 3774518-3775405 (Clockwise)

Preceding gene: 126700844

Following gene: 126700846

Centisome position: 87.98

GC content: 32.88

Gene sequence:

>888_bases
ATGATATTTAAAGGTTCTGCTGTTGCTCTAGTTACACCATTTACAAAGGATAACAAAGTTGATTTTGACAAATTAGGTGA
ATTAGTTGAATACCAAATAGCTAATGGTACTGATGCTATAGTATCTTGTGGTACTACTGGTGAAGCTAATACTATGACTG
ATGAAGAACAACTTGCTACTATTAAGTATGTTGTTGAAAAAGTTAATAAAAGAGTTCCTGTTATAGCTGGAAGTGGTTCT
AATGATACTATGCACTCAGTTAACTTAAGTCAAGAAGCTGAAAAATTAGGAGTAGATGCTCTATTAATAATAACACCTTA
TTACAATAAAGCTAATAAAGCTGGACTTAAGCGTCATTTTGAAACAATAGCTAACAGTGTTAAACTTCCAATTATACTTT
ACAATGTCCCTGGAAGAACTTGTGTAAATATAAGTCCTAGCCTTATAGTTGAACTTGCTAAAATTGATAACATAGTTGCT
GTAAAAGAAGCTAGTGGAGACCTAGGACAGGTTGCAGAAATAGCTAGTTTAGTTCCAGATGACTTTGCTATCTACTCTGG
TAATGATGATACTATACTTCCTTTATTATCTTTAGGAGGTCAAGGAGTTATATCAGTACTTGCTAATGTTTGCCCTCAAG
AAACTCACGATTTAGTAGCTAAATTCTTTGAAGGCGATATTGAAGGTTCTAGAAAATTACAACTTGGTATGGATGCTCTA
ATCGCAGCTTTATTTATAGAAGTAAATCCTATACCAGTTAAGACTGCAATGAATTTATTGGGATTCAATGTTGGAGATTT
AAGATTACCTCTAGCAGAAATGGACCCAGCAAATTTAGAAGTATTAAAGAAAGAATTAGTTAACTTTGGACTAAAAGTTA
ATGCATAG

Upstream 100 bases:

>100_bases
AATATATAATTTTGTAAAATATTAATAGTAACTCAAAAACAAGCATTAGAAGTAACTGTAATATAAAACACAAAAATAAA
AAAGAGGGGATTGATTTTAT

Downstream 100 bases:

>100_bases
TAAAGATTAATGCATGGTAAAAAGTAAGTTTGGTCAAAAGTTAGCCCTTAATCATAGGAGGAAATTATGTTAAAAGTTAT
AGCAACTGGTTATGATGGAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCGTTGEANTMTDEEQLATIKYVVEKVNKRVPVIAGSGS
NDTMHSVNLSQEAEKLGVDALLIITPYYNKANKAGLKRHFETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVA
VKEASGDLGQVAEIASLVPDDFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDLVAKFFEGDIEGSRKLQLGMDAL
IAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDPANLEVLKKELVNFGLKVNA

Sequences:

>Translated_295_residues
MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCGTTGEANTMTDEEQLATIKYVVEKVNKRVPVIAGSGS
NDTMHSVNLSQEAEKLGVDALLIITPYYNKANKAGLKRHFETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVA
VKEASGDLGQVAEIASLVPDDFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDLVAKFFEGDIEGSRKLQLGMDAL
IAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDPANLEVLKKELVNFGLKVNA
>Mature_295_residues
MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCGTTGEANTMTDEEQLATIKYVVEKVNKRVPVIAGSGS
NDTMHSVNLSQEAEKLGVDALLIITPYYNKANKAGLKRHFETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVA
VKEASGDLGQVAEIASLVPDDFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDLVAKFFEGDIEGSRKLQLGMDAL
IAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDPANLEVLKKELVNFGLKVNA

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=285, Percent_Identity=28.0701754385965, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI13540533, Length=281, Percent_Identity=25.6227758007117, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=40.5498281786942, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1786463, Length=233, Percent_Identity=33.0472103004292, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI87082415, Length=273, Percent_Identity=30.7692307692308, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789620, Length=283, Percent_Identity=28.9752650176678, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31596; Mature: 31596

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCGTTGEANTMTDEEQLAT
CEECCCEEEEEECCCCCCCCCHHHHHHHHEEEECCCCCEEEECCCCCCCCCCCCHHHHHH
IKYVVEKVNKRVPVIAGSGSNDTMHSVNLSQEAEKLGVDALLIITPYYNKANKAGLKRHF
HHHHHHHHCCCCCEEECCCCCCCEEECCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH
ETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVAVKEASGDLGQVAEIASLVPD
HHHHCCCCCEEEEEECCCCEEEECCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCC
DFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDLVAKFFEGDIEGSRKLQLGMDAL
CEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEHHHHHHH
IAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDPANLEVLKKELVNFGLKVNA
HHHHHHCCCCCCHHHHHHHHCCCCCCEECCHHHCCCCHHHHHHHHHHHCCCEECC
>Mature Secondary Structure
MIFKGSAVALVTPFTKDNKVDFDKLGELVEYQIANGTDAIVSCGTTGEANTMTDEEQLAT
CEECCCEEEEEECCCCCCCCCHHHHHHHHEEEECCCCCEEEECCCCCCCCCCCCHHHHHH
IKYVVEKVNKRVPVIAGSGSNDTMHSVNLSQEAEKLGVDALLIITPYYNKANKAGLKRHF
HHHHHHHHCCCCCEEECCCCCCCEEECCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHH
ETIANSVKLPIILYNVPGRTCVNISPSLIVELAKIDNIVAVKEASGDLGQVAEIASLVPD
HHHHCCCCCEEEEEECCCCEEEECCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCC
DFAIYSGNDDTILPLLSLGGQGVISVLANVCPQETHDLVAKFFEGDIEGSRKLQLGMDAL
CEEEEECCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEHHHHHHH
IAALFIEVNPIPVKTAMNLLGFNVGDLRLPLAEMDPANLEVLKKELVNFGLKVNA
HHHHHHCCCCCCHHHHHHHHCCCCCCEECCHHHCCCCHHHHHHHHHHHCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA