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The map label for this gene is dapA1 [H]

Identifier: 126700843

GI number: 126700843

Start: 3772094

End: 3772975

Strand: Direct

Name: dapA1 [H]

Synonym: CD3223

Alternate gene names: 126700843

Gene position: 3772094-3772975 (Clockwise)

Preceding gene: 126700830

Following gene: 126700844

Centisome position: 87.92

GC content: 32.09

Gene sequence:

>882_bases
ATGTTATTTAAAGGTTCTGCTGTTGCTTTAGTTACCCCATTTACAGAGGATAATAATGTCAACTTTGAAAAATTAGGTGA
ATTAATCGAATATCACATTGAGAATGGCACAGATGCACTAGTTGTTTGTGGAACAACAGGTGAGGCGACTACTATGAGTG
AATCTGAAATTTTTGCTGTAATAAAATATACAGTTGAAAAAGTTAATAAGAGAATACCTGTTATAGCAGGTACTGGTTCA
AACAATACTATGTTGTCTGTTCATATGAGTCAAGAAGCTGAAAAATTAGGGGTGGATGGTCTTTTAATAATAACTCCTTA
CTATAATAAGACTAATGAGAAAGGTCTTAAACTTCACTTTGAAACAATAGCAAATAGCGTTAAGTTGCCAATTATTTTAT
ACAACGTACCAGGAAGAACTAAAGTGAATATAAAGCCATCTGTTGTGGCTGAACTTGCTAAAATAGATAATATAGTTGCT
GTGAAGGAAGCAAGTGGAGACTTAGCTCAAGTTGCAGAAATAGCTAAATTAGTACCTAAAGACTTTGCTATATACTCCGG
TAATGATGATACTATACTACCACTATTATCATTAGGTGGAAGTGGTGTTATCTCTGTACTTGCTAACATATGTCCTAAAG
AAACACATGATTTAGTAACTAAATTCTTTGAAGGTGATATTGAAGGCTCAAAAAAATTACAACTTGATATGGATGCTTTA
ATTGCTGCTTTATTTATAGAAGTAAATCCAGTTCCTGTTAAAACTGCCATGAACATTTTAGGTTTTAATGTTGGTGATTT
AAGACTTCCTCTAGCTGAAATGGAAGAAACTAATCTTAATGTGTTAAAACAAGAATTGACAAATTTTGGATTTAAATTTT
AG

Upstream 100 bases:

>100_bases
GTTAAGATATTAACTATACCTATTAAAATTAATTAATTTGTACTATAATTATTATTGTACTTAAAAAATTAAATTTAGAT
AAAAAAGGAGATTTGATTAT

Downstream 100 bases:

>100_bases
CAATATTTATATAAATAAGTTGATTTTTTCTTAAATATGTATTATTATTAGAATAATCAAATTTTAATATCCTATTAACC
TAGGGTAGAGGTAGCTGTAA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCGTTGEATTMSESEIFAVIKYTVEKVNKRIPVIAGTGS
NNTMLSVHMSQEAEKLGVDGLLIITPYYNKTNEKGLKLHFETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVA
VKEASGDLAQVAEIAKLVPKDFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDLVTKFFEGDIEGSKKLQLDMDAL
IAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEETNLNVLKQELTNFGFKF

Sequences:

>Translated_293_residues
MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCGTTGEATTMSESEIFAVIKYTVEKVNKRIPVIAGTGS
NNTMLSVHMSQEAEKLGVDGLLIITPYYNKTNEKGLKLHFETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVA
VKEASGDLAQVAEIAKLVPKDFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDLVTKFFEGDIEGSKKLQLDMDAL
IAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEETNLNVLKQELTNFGFKF
>Mature_293_residues
MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCGTTGEATTMSESEIFAVIKYTVEKVNKRIPVIAGTGS
NNTMLSVHMSQEAEKLGVDGLLIITPYYNKTNEKGLKLHFETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVA
VKEASGDLAQVAEIAKLVPKDFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDLVTKFFEGDIEGSKKLQLDMDAL
IAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEETNLNVLKQELTNFGFKF

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=285, Percent_Identity=26.3157894736842, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI13540533, Length=297, Percent_Identity=26.2626262626263, Blast_Score=95, Evalue=8e-20,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=40.5498281786942, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI1786463, Length=230, Percent_Identity=33.0434782608696, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI87082415, Length=273, Percent_Identity=31.8681318681319, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789620, Length=283, Percent_Identity=29.3286219081272, Blast_Score=122, Evalue=3e-29,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31785; Mature: 31785

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00583 PFKB_KINASES_1 ; PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCGTTGEATTMSESEIFAV
CEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
IKYTVEKVNKRIPVIAGTGSNNTMLSVHMSQEAEKLGVDGLLIITPYYNKTNEKGLKLHF
HHHHHHHHCCCCCEEEECCCCCEEEEEEECCHHHHHCCCEEEEEECCCCCCCCCCEEEEH
ETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVAVKEASGDLAQVAEIAKLVPK
HHHHCCCEEEEEEEECCCCEEEEECHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCC
DFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDLVTKFFEGDIEGSKKLQLDMDAL
CEEEEECCCCEEEHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECHHHH
IAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEETNLNVLKQELTNFGFKF
HHHHHHCCCCCCHHHHHHHHCCCCCCEECCHHHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLFKGSAVALVTPFTEDNNVNFEKLGELIEYHIENGTDALVVCGTTGEATTMSESEIFAV
CEECCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHH
IKYTVEKVNKRIPVIAGTGSNNTMLSVHMSQEAEKLGVDGLLIITPYYNKTNEKGLKLHF
HHHHHHHHCCCCCEEEECCCCCEEEEEEECCHHHHHCCCEEEEEECCCCCCCCCCEEEEH
ETIANSVKLPIILYNVPGRTKVNIKPSVVAELAKIDNIVAVKEASGDLAQVAEIAKLVPK
HHHHCCCEEEEEEEECCCCEEEEECHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCC
DFAIYSGNDDTILPLLSLGGSGVISVLANICPKETHDLVTKFFEGDIEGSKKLQLDMDAL
CEEEEECCCCEEEHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEECHHHH
IAALFIEVNPVPVKTAMNILGFNVGDLRLPLAEMEETNLNVLKQELTNFGFKF
HHHHHHCCCCCCHHHHHHHHCCCCCCEECCHHHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA