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The map label for this gene is treA [H]

Identifier: 126700708

GI number: 126700708

Start: 3592313

End: 3593980

Strand: Direct

Name: treA [H]

Synonym: CD3091

Alternate gene names: 126700708

Gene position: 3592313-3593980 (Clockwise)

Preceding gene: 126700707

Following gene: 126700723

Centisome position: 83.73

GC content: 29.74

Gene sequence:

>1668_bases
ATGAAAAATTGGTGGAAAAAAGCAACTGTCTATCAAATATATCCAAAAAGTTTCAAAGATAGCAACAATGATGGTATAGG
TGATATAAATGGTATTATAGAAAAATTAGATTATCTGTATTCTTTAGGTGTTGATTTATTATGGTTGACTCCTATGTACG
TTTCTCCTCAAAGAGATAATGGATATGATATAGAAGATTATTATAATATAGACCCAAAATATGGGACAATGAGTGACTTT
GAAAAACTCTTAAAAGAAGCTCATAAAAGAGACATAAAAATAATGATGGATATGGTCCTAAACCATACATCTACTGAACA
CAAATGGTTTAAAGAATCTAAAAAAAGCAAAGACAATCCATATCGTGATTATTATTTCTGGAAAGATGCTAAACCTGATG
GTTCTGTTCCTAATAACTGGATATCCAGATTTAGTGGAACTGCTTGGAAATATGATGAAACCACTAACCAATATTATTTA
CATTTATTTGAAGAAACTCAAGCTGATTTAAATTGGGAAAATGAAAAGGTTCGTGAAGAATGTTACAAAATACTAGAATT
TTGGGCTGATAAAGGTATTGATGGTTTTCGTTTAGATGTAGTCAACCTACTCTCCAAAACACCTGGATTACCTGATGACC
CTATAACAGGACCAAAAGGAGATGGAAGAACTCACTACGCTGATGGTCCTCGTATACACGAATATTTACATAATATGAAT
CAAAAAGTTTTCAAACCTAAAAATATAGTTACTGTAGGTGAAATGTCATCTACTACACCTGAAGAGTGTATCAACTATAC
TAGAGAAAATCGAGAAGAACTATCTATGGTTTTTAGCTTCCATCATATGAAAACAGATTATAAAGGAGGCGCAAAATGGA
CTAATGAAATGTTCTCTCTGGATAAATTAAAAAAAGCACAATCTGACTTTCAATATAAAATGTATGAAGGAAAAGGATGG
AATGCTCTATTTTACTCTAATCACGACCAACCTAGAGCTTTATCTCGATTTGGAGATGATAGATTTTTTCGTCAAGAAAG
TGCTAAGATGTTAGCCATAACATTATTTGGTCTACAGGGTACTACATACATATATCAAGGTGAAGAAATAGGTATGACAA
ATGCCTACTTTACTAAAATAGATGAATATGATGATGCTGAAAGCAAGAATGCATACTATCATATGATTAAATCTGGTATT
GATGAAAAGGAGGCATTGCTTATACTTCAACAAAAATCCAGAGATAATGCCCGTACTCCTATGCAATGGGATAATACTAT
TTATAAGGGGTTTTCTAATCATAAACCGTGGTTAAAAGTTAATAATGACAATATTAGTGTAGAAAATGAGCTTAATGATT
CTCGTTCAGTATTTTATACTTATCAAAGATTAATCAAATATCGTAAACAATATGATATTTTTACAGAAGGTACTTATAGA
TTGTTAGATGAAAATCATAAAAATCTATTTGTTTATGAAAGAGAGTATAAAAACCAAAATCTTCTTGTTATAAGTAATTT
TACTCATGATAATGTAGTATATAAATTACCTGAAACTTATTTGAATAAATTAAACTACACAATACTTGAAACCAATTACA
CTAGAGATATAATTGAAAATAAAATGGAAATAAAACCTTACGAAAGTATAATGATATATTATAAATAA

Upstream 100 bases:

>100_bases
TAATTATTTATTGTATATTTTAGCTTTAATATTAGTTTAATGCTTGACAATTTGTTTGAACATATTATAATTAACTTATA
AATTACAGGAGGTATCAAGT

Downstream 100 bases:

>100_bases
AGTTATTTATGTAAAAATCGGTATAACACCCTGGTGTTATACCAATTTTACTAAATTCAAAGTAATATTTATAGAATATC
TATAGATTACAATAATTATT

Product: trehalose-6-phosphate hydrolase

Products: NA

Alternate protein names: Alpha,alpha-phosphotrehalase [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGVDLLWLTPMYVSPQRDNGYDIEDYYNIDPKYGTMSDF
EKLLKEAHKRDIKIMMDMVLNHTSTEHKWFKESKKSKDNPYRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYL
HLFEETQADLNWENEKVREECYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGPKGDGRTHYADGPRIHEYLHNMN
QKVFKPKNIVTVGEMSSTTPEECINYTRENREELSMVFSFHHMKTDYKGGAKWTNEMFSLDKLKKAQSDFQYKMYEGKGW
NALFYSNHDQPRALSRFGDDRFFRQESAKMLAITLFGLQGTTYIYQGEEIGMTNAYFTKIDEYDDAESKNAYYHMIKSGI
DEKEALLILQQKSRDNARTPMQWDNTIYKGFSNHKPWLKVNNDNISVENELNDSRSVFYTYQRLIKYRKQYDIFTEGTYR
LLDENHKNLFVYEREYKNQNLLVISNFTHDNVVYKLPETYLNKLNYTILETNYTRDIIENKMEIKPYESIMIYYK

Sequences:

>Translated_555_residues
MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGVDLLWLTPMYVSPQRDNGYDIEDYYNIDPKYGTMSDF
EKLLKEAHKRDIKIMMDMVLNHTSTEHKWFKESKKSKDNPYRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYL
HLFEETQADLNWENEKVREECYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGPKGDGRTHYADGPRIHEYLHNMN
QKVFKPKNIVTVGEMSSTTPEECINYTRENREELSMVFSFHHMKTDYKGGAKWTNEMFSLDKLKKAQSDFQYKMYEGKGW
NALFYSNHDQPRALSRFGDDRFFRQESAKMLAITLFGLQGTTYIYQGEEIGMTNAYFTKIDEYDDAESKNAYYHMIKSGI
DEKEALLILQQKSRDNARTPMQWDNTIYKGFSNHKPWLKVNNDNISVENELNDSRSVFYTYQRLIKYRKQYDIFTEGTYR
LLDENHKNLFVYEREYKNQNLLVISNFTHDNVVYKLPETYLNKLNYTILETNYTRDIIENKMEIKPYESIMIYYK
>Mature_555_residues
MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGVDLLWLTPMYVSPQRDNGYDIEDYYNIDPKYGTMSDF
EKLLKEAHKRDIKIMMDMVLNHTSTEHKWFKESKKSKDNPYRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYL
HLFEETQADLNWENEKVREECYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGPKGDGRTHYADGPRIHEYLHNMN
QKVFKPKNIVTVGEMSSTTPEECINYTRENREELSMVFSFHHMKTDYKGGAKWTNEMFSLDKLKKAQSDFQYKMYEGKGW
NALFYSNHDQPRALSRFGDDRFFRQESAKMLAITLFGLQGTTYIYQGEEIGMTNAYFTKIDEYDDAESKNAYYHMIKSGI
DEKEALLILQQKSRDNARTPMQWDNTIYKGFSNHKPWLKVNNDNISVENELNDSRSVFYTYQRLIKYRKQYDIFTEGTYR
LLDENHKNLFVYEREYKNQNLLVISNFTHDNVVYKLPETYLNKLNYTILETNYTRDIIENKMEIKPYESIMIYYK

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=530, Percent_Identity=30.377358490566, Blast_Score=236, Evalue=6e-62,
Organism=Homo sapiens, GI61744475, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI65506891, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI61744477, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI61744479, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI61744481, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI61744483, Length=134, Percent_Identity=31.3432835820896, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1790687, Length=553, Percent_Identity=50.4520795660036, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI1786604, Length=196, Percent_Identity=29.0816326530612, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789995, Length=136, Percent_Identity=30.1470588235294, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147709, Length=595, Percent_Identity=26.5546218487395, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI32565753, Length=391, Percent_Identity=24.0409207161125, Blast_Score=105, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6322245, Length=580, Percent_Identity=40.3448275862069, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321726, Length=542, Percent_Identity=41.3284132841328, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6324416, Length=574, Percent_Identity=40.418118466899, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322241, Length=574, Percent_Identity=40.418118466899, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322021, Length=574, Percent_Identity=40.418118466899, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321731, Length=579, Percent_Identity=40.0690846286701, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6319776, Length=579, Percent_Identity=40.0690846286701, Blast_Score=382, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24583747, Length=556, Percent_Identity=33.273381294964, Blast_Score=279, Evalue=4e-75,
Organism=Drosophila melanogaster, GI24583749, Length=556, Percent_Identity=33.273381294964, Blast_Score=278, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24586599, Length=538, Percent_Identity=33.6431226765799, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24586593, Length=494, Percent_Identity=35.2226720647773, Blast_Score=275, Evalue=7e-74,
Organism=Drosophila melanogaster, GI221330053, Length=524, Percent_Identity=33.3969465648855, Blast_Score=273, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24586597, Length=546, Percent_Identity=32.967032967033, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24583745, Length=529, Percent_Identity=32.5141776937618, Blast_Score=258, Evalue=6e-69,
Organism=Drosophila melanogaster, GI24586589, Length=493, Percent_Identity=33.8742393509128, Blast_Score=256, Evalue=2e-68,
Organism=Drosophila melanogaster, GI45549022, Length=534, Percent_Identity=33.7078651685393, Blast_Score=256, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24586591, Length=499, Percent_Identity=34.0681362725451, Blast_Score=254, Evalue=1e-67,
Organism=Drosophila melanogaster, GI24586587, Length=590, Percent_Identity=29.4915254237288, Blast_Score=232, Evalue=5e-61,
Organism=Drosophila melanogaster, GI281360393, Length=439, Percent_Identity=32.1184510250569, Blast_Score=199, Evalue=5e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781
- InterPro:   IPR012769 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.93 [H]

Molecular weight: Translated: 66123; Mature: 66123

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGVDLLWLTPMYVSPQRDN
CCCHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCEEECCCCCC
GYDIEDYYNIDPKYGTMSDFEKLLKEAHKRDIKIMMDMVLNHTSTEHKWFKESKKSKDNP
CCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
YRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYLHLFEETQADLNWENEKVREE
CCCEEEEECCCCCCCCCHHHHHHCCCCCEECCCCCCEEEEEEEEHHCCCCCCCHHHHHHH
CYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGPKGDGRTHYADGPRIHEYLHNMN
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
QKVFKPKNIVTVGEMSSTTPEECINYTRENREELSMVFSFHHMKTDYKGGAKWTNEMFSL
HHHCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
DKLKKAQSDFQYKMYEGKGWNALFYSNHDQPRALSRFGDDRFFRQESAKMLAITLFGLQG
HHHHHHHCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCHHHHHHHCCCEEEEEEEECCC
TTYIYQGEEIGMTNAYFTKIDEYDDAESKNAYYHMIKSGIDEKEALLILQQKSRDNARTP
CEEEEECCCCCCCCHHHEECCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
MQWDNTIYKGFSNHKPWLKVNNDNISVENELNDSRSVFYTYQRLIKYRKQYDIFTEGTYR
CCCCCHHHCCCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCE
LLDENHKNLFVYEREYKNQNLLVISNFTHDNVVYKLPETYLNKLNYTILETNYTRDIIEN
EECCCCCEEEEEECCCCCCCEEEEECCCCCCEEEECCHHHHHHCCEEEEECCCHHHHHCC
KMEIKPYESIMIYYK
CCCCCCCEEEEEEEC
>Mature Secondary Structure
MKNWWKKATVYQIYPKSFKDSNNDGIGDINGIIEKLDYLYSLGVDLLWLTPMYVSPQRDN
CCCHHHCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCEEECCCCCC
GYDIEDYYNIDPKYGTMSDFEKLLKEAHKRDIKIMMDMVLNHTSTEHKWFKESKKSKDNP
CCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCC
YRDYYFWKDAKPDGSVPNNWISRFSGTAWKYDETTNQYYLHLFEETQADLNWENEKVREE
CCCEEEEECCCCCCCCCHHHHHHCCCCCEECCCCCCEEEEEEEEHHCCCCCCCHHHHHHH
CYKILEFWADKGIDGFRLDVVNLLSKTPGLPDDPITGPKGDGRTHYADGPRIHEYLHNMN
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
QKVFKPKNIVTVGEMSSTTPEECINYTRENREELSMVFSFHHMKTDYKGGAKWTNEMFSL
HHHCCCCCEEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
DKLKKAQSDFQYKMYEGKGWNALFYSNHDQPRALSRFGDDRFFRQESAKMLAITLFGLQG
HHHHHHHCCCEEEEEECCCCEEEEECCCCCCHHHHHCCCHHHHHHHCCCEEEEEEEECCC
TTYIYQGEEIGMTNAYFTKIDEYDDAESKNAYYHMIKSGIDEKEALLILQQKSRDNARTP
CEEEEECCCCCCCCHHHEECCCCCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCCCCCC
MQWDNTIYKGFSNHKPWLKVNNDNISVENELNDSRSVFYTYQRLIKYRKQYDIFTEGTYR
CCCCCHHHCCCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCE
LLDENHKNLFVYEREYKNQNLLVISNFTHDNVVYKLPETYLNKLNYTILETNYTRDIIEN
EECCCCCEEEEEECCCCCCCEEEEECCCCCCEEEECCHHHHHHCCEEEEECCCHHHHHCC
KMEIKPYESIMIYYK
CCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7651129; 8969503; 9384377; 7751281 [H]