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The map label for this gene is patB [H]

Identifier: 126700348

GI number: 126700348

Start: 3169431

End: 3170597

Strand: Direct

Name: patB [H]

Synonym: CD2733

Alternate gene names: 126700348

Gene position: 3169431-3170597 (Clockwise)

Preceding gene: 126700347

Following gene: 126700349

Centisome position: 73.88

GC content: 28.45

Gene sequence:

>1167_bases
ATGAATTATAATTTTAATGAGATTGTTGATAGAAGCAATAATTTTTCATCTAAATGGTCAGAAATGGAAAAAAAGTATGG
AACTAATGATTTACTTCCTATGTGGGTGGCTGACATGGATTTTAAGGCTGCACCTTGTATAATTGATTCCTTAAAAAATA
GACTAGAACAAGAGATTTATGGCTACACAACAAGACCAGATTCTTACAATGAATCTATAGTAAACTGGCTATATAGGAGA
CATAACTGGAAAATAAAAAGTGAGTGGTTAATTTATAGTCCAGGTGTTATCCCAGCTATAAGTCTTTTAATAAATGAACT
CACAAAAGCAAATGATAAAATAATGATACAAGAACCAGTTTACAGCCCTTTTAATAGTGTTGTAAAAAATAACAATAGAG
AACTAATTATAAGCCCATTACAAAAACTAGAAAATGGAAACTACATAATGGATTATGAAGATATTGAAAACAAGATTAAA
GATGTAAAATTATTCATACTTTGTAATCCTCATAATCCAGTTGGTAGAGTATGGACAAAAGATGAATTAAAAAAACTAGG
AGATATTTGTCTTAAGCATAATGTAAAAATTATATCTGATGAAATACATAGTGACATTATATTAAAAAAACATAAGCATA
TTCCTATGGCATCTATTTCTAAAGAATTTGAAAAAAATACAATTACTTGTATGGCTCCAACTAAAACTTTTAATATAGCT
GGTCTTCAATCATCATATGTAGTACTACCTGATGAAAAAGACTATAAATTGTTAGATGATGCCTTTACCAGAATTGATAT
AAAGAGAAATAATTGCTTTAGCTTAGTTGCAACTGAAGCTTCATATAATAATGGTGAATCTTGGCTAGAATCATTTTTAG
AATATTTAGAATCTAATATAGATTTTGCTATAAAATATATAAATGAAAATATGCCAAAACTTAAAGTTAGAAAACCAGAA
GGTACTTATTTATTATGGGTAGACTTTAGTGCACTTGGATTAAGTGATGAGGAACTAGAAAGTATACTTGTACAAAAAGG
TAAAGTTGCTCTAAATCAAGGAAACAGCTTTGGCATTGGAGGAAGTGGGTATCAAAGAATAAACTTAGCTTGTCCAAGAA
GTATGCTTGAAGAAGCTCTTATAAGAATAAAAAATGCAATTAACTAA

Upstream 100 bases:

>100_bases
TAAATATTAACTTGTGAATAAATATTTTTTATTATCAATATTGGCACGTTGTTTGCTTAATATTATTAACATAAAATTAA
AATTACTGGAGGTATTTACA

Downstream 100 bases:

>100_bases
AAATATTTAAGGAGAATTTGCACTATGAAAATGAATACAGAAAGAAAAATACCTTCATTTAGATATTCCTTGTTAGTAAT
GCTTGCAATAATAGCTCTAA

Product: aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAAPCIIDSLKNRLEQEIYGYTTRPDSYNESIVNWLYRR
HNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIK
DVKLFILCNPHNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIA
GLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPE
GTYLLWVDFSALGLSDEELESILVQKGKVALNQGNSFGIGGSGYQRINLACPRSMLEEALIRIKNAIN

Sequences:

>Translated_388_residues
MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAAPCIIDSLKNRLEQEIYGYTTRPDSYNESIVNWLYRR
HNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIK
DVKLFILCNPHNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIA
GLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPE
GTYLLWVDFSALGLSDEELESILVQKGKVALNQGNSFGIGGSGYQRINLACPRSMLEEALIRIKNAIN
>Mature_388_residues
MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAAPCIIDSLKNRLEQEIYGYTTRPDSYNESIVNWLYRR
HNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPVYSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIK
DVKLFILCNPHNPVGRVWTKDELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIA
GLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGESWLESFLEYLESNIDFAIKYINENMPKLKVRKPE
GTYLLWVDFSALGLSDEELESILVQKGKVALNQGNSFGIGGSGYQRINLACPRSMLEEALIRIKNAIN

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=254, Percent_Identity=24.4094488188976, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI56713254, Length=254, Percent_Identity=24.4094488188976, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI95147551, Length=253, Percent_Identity=24.901185770751, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI169881279, Length=253, Percent_Identity=24.901185770751, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI169881281, Length=250, Percent_Identity=25.2, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4507369, Length=354, Percent_Identity=22.0338983050847, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1787909, Length=389, Percent_Identity=32.133676092545, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1786816, Length=309, Percent_Identity=21.0355987055016, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788627, Length=321, Percent_Identity=22.4299065420561, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17567663, Length=335, Percent_Identity=23.8805970149254, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994476, Length=148, Percent_Identity=29.0540540540541, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=148, Percent_Identity=29.0540540540541, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17567369, Length=147, Percent_Identity=25.1700680272109, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322401, Length=287, Percent_Identity=26.8292682926829, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573069, Length=256, Percent_Identity=23.4375, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646114, Length=256, Percent_Identity=23.4375, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573067, Length=256, Percent_Identity=23.4375, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573065, Length=256, Percent_Identity=23.4375, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18859735, Length=376, Percent_Identity=22.3404255319149, Blast_Score=86, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44761; Mature: 44761

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAAPCIIDSLKNRLEQEIY
CCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHC
GYTTRPDSYNESIVNWLYRRHNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPV
CCCCCCCCCHHHHHHHHHHHCCCEEECCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCC
YSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIKDVKLFILCNPHNPVGRVWTK
CCHHHHHHHCCCCEEEEEHHHHHCCCCEEEEHHHHHHHHCEEEEEEEECCCCCCCCCCCH
DELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCEEEEE
GLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGESWLESFLEYLESNI
CCCCCEEECCCCCCCHHHHHHHHEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCH
DFAIKYINENMPKLKVRKPEGTYLLWVDFSALGLSDEELESILVQKGKVALNQGNSFGIG
HEEEEECCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCCCC
GSGYQRINLACPRSMLEEALIRIKNAIN
CCCCEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNYNFNEIVDRSNNFSSKWSEMEKKYGTNDLLPMWVADMDFKAAPCIIDSLKNRLEQEIY
CCCCHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHC
GYTTRPDSYNESIVNWLYRRHNWKIKSEWLIYSPGVIPAISLLINELTKANDKIMIQEPV
CCCCCCCCCHHHHHHHHHHHCCCEEECCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCC
YSPFNSVVKNNNRELIISPLQKLENGNYIMDYEDIENKIKDVKLFILCNPHNPVGRVWTK
CCHHHHHHHCCCCEEEEEHHHHHCCCCEEEEHHHHHHHHCEEEEEEEECCCCCCCCCCCH
DELKKLGDICLKHNVKIISDEIHSDIILKKHKHIPMASISKEFEKNTITCMAPTKTFNIA
HHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEECCCEEEEE
GLQSSYVVLPDEKDYKLLDDAFTRIDIKRNNCFSLVATEASYNNGESWLESFLEYLESNI
CCCCCEEECCCCCCCHHHHHHHHEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHCCH
DFAIKYINENMPKLKVRKPEGTYLLWVDFSALGLSDEELESILVQKGKVALNQGNSFGIG
HEEEEECCCCCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEECCCCCCCC
GSGYQRINLACPRSMLEEALIRIKNAIN
CCCCEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]