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The map label for this gene is putP2 [H]

Identifier: 126699819

GI number: 126699819

Start: 2551237

End: 2552601

Strand: Direct

Name: putP2 [H]

Synonym: CD2202

Alternate gene names: 126699819

Gene position: 2551237-2552601 (Clockwise)

Preceding gene: 126699811

Following gene: 126699820

Centisome position: 59.47

GC content: 30.99

Gene sequence:

>1365_bases
ATGTTACTTTTAATTGTTACGTGTGCAATATACATATGGATTGGTTTTTATTTTTCAAAAAAAGTTAAAACAGCATCCGA
TTTCCTAATCGCAGGTAGAAATCTGCCTTTGCCTATACTAGCTGCAACCATTGCTGCTACATCTTTTGGAGGAGGGTGCT
TAGTTGGTGGAGTTCAATGGGGAGCTGAAAGAGGACTTTGGGTTGGAATGTATTCTACTATAGGTGCAGCTTTAGCTTGC
TTTATAAATGCATTTTTCGCAGGAAAATTAAGAAGCTTATCTTGTGATATAACACCTGCTGATTATATTGAAACTAGATA
TGGTCATAGTGTATTTTTAAGAGCTTATCAAAGTCTTGTAACACCAATATCTATACTAGCTATTATGGGTAGTCAATTAA
TTTCTTTTGGTTCTGTATCTACTGCATTTGGTATTCCTTATGATATAGCTGTAATTATAGGAGTTATAGTTATAATTATA
TATACTTATACATCAGGAATGTGGGGAGTTGCAGTATCAGCATTTATTCAACTTGCTATTTGTATAGTGTTTTTGCCAAT
AGTAGCTTATATAAGCTTAAAATTAGTTGGCGACAACCCTTTACTTATGTTACAATCAATGGTAAAAGAACCATTCTTTC
CAGGAAATAAATCGATTAGTGATTTTATGTATACAGTTTTACCATTAGTTTTAGGCTCAATATTTTCTTATGAAAGTTTT
TTAAGATATCAATGTGCTGATAATGCTAAAAATGCAGTTAAAAGTAGTGTAATTGCAGGATTTATACTATTATTTCTTGC
TTTCCCTATAGGAATAATTGGAGCTATTGGTGGTAGTTTATTTCCAAATATATCATCTGTTCAGGTTTTACCTCAAATGA
TATCGACTACTTTGCCACCTTTAATATCTGTATTATTCTTAGCTGCTATATTGGCTGCCATAATGTCTACTGCCGATTCA
TTAATGACCTCAATGAGTGCTATTATATCAAGAGATATTTATAACAAATTATTACATCCTAATATAGAATTTAATGATTT
AAAAAATACTCTAAAGTATTCTCAAATTGCATCAGCTTTGACAGCTATAATAGGTGCAATCATAGCACTTAAATTTGATA
GTTTATTAGAATTATTGTTTTGGCCAGCTCCATTATGTACAGGTGTAATATTTGCACCATTTGTAATTGGTCTTTGCTGG
AAAGGTGCTACAAAAAAAGGAGCTATCTATGCTGTTATAGTAAGTGTTATATTGGCATTATTAAATATGATTGGTATTCT
TACTGTATTTGACAGAATTTTGGTTCCTATAATAGGTGGTTCTATTACAATATTTATAGTTAGCAAATTTTCAAAAAAAG
ATTGA

Upstream 100 bases:

>100_bases
CTAAAACCAATAAAACAAATATCGTACTACTTTTATATAAAATATATTTTAAATATATTTTGTATATTTTATTAAAATAT
TTTATAAAGGAGAAAAGACT

Downstream 100 bases:

>100_bases
AAAGAGAGGTATATACAGTAAATATGTCAAAATCAGAAAAGGGCAAAGAAACAAAAGCTAGTATTATAAGTGCTGCTAGA
GAATTATTTTTTGAGCAAGG

Product: sodium/solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Proline permease 2 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATIAATSFGGGCLVGGVQWGAERGLWVGMYSTIGAALAC
FINAFFAGKLRSLSCDITPADYIETRYGHSVFLRAYQSLVTPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIII
YTYTSGMWGVAVSAFIQLAICIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKSISDFMYTVLPLVLGSIFSYESF
LRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAIGGSLFPNISSVQVLPQMISTTLPPLISVLFLAAILAAIMSTADS
LMTSMSAIISRDIYNKLLHPNIEFNDLKNTLKYSQIASALTAIIGAIIALKFDSLLELLFWPAPLCTGVIFAPFVIGLCW
KGATKKGAIYAVIVSVILALLNMIGILTVFDRILVPIIGGSITIFIVSKFSKKD

Sequences:

>Translated_454_residues
MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATIAATSFGGGCLVGGVQWGAERGLWVGMYSTIGAALAC
FINAFFAGKLRSLSCDITPADYIETRYGHSVFLRAYQSLVTPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIII
YTYTSGMWGVAVSAFIQLAICIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKSISDFMYTVLPLVLGSIFSYESF
LRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAIGGSLFPNISSVQVLPQMISTTLPPLISVLFLAAILAAIMSTADS
LMTSMSAIISRDIYNKLLHPNIEFNDLKNTLKYSQIASALTAIIGAIIALKFDSLLELLFWPAPLCTGVIFAPFVIGLCW
KGATKKGAIYAVIVSVILALLNMIGILTVFDRILVPIIGGSITIFIVSKFSKKD
>Mature_454_residues
MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATIAATSFGGGCLVGGVQWGAERGLWVGMYSTIGAALAC
FINAFFAGKLRSLSCDITPADYIETRYGHSVFLRAYQSLVTPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIII
YTYTSGMWGVAVSAFIQLAICIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKSISDFMYTVLPLVLGSIFSYESF
LRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAIGGSLFPNISSVQVLPQMISTTLPPLISVLFLAAILAAIMSTADS
LMTSMSAIISRDIYNKLLHPNIEFNDLKNTLKYSQIASALTAIIGAIIALKFDSLLELLFWPAPLCTGVIFAPFVIGLCW
KGATKKGAIYAVIVSVILALLNMIGILTVFDRILVPIIGGSITIFIVSKFSKKD

Specific function: Catalyzes the sodium-dependent uptake of extracellular L-proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI11141885, Length=420, Percent_Identity=24.047619047619, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI87082237, Length=440, Percent_Identity=26.1363636363636, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1787251, Length=373, Percent_Identity=24.1286863270777, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17539284, Length=417, Percent_Identity=24.220623501199, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 48771; Mature: 48771

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATIAATSFGGGCLVGGVQW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCCEECCHHH
GAERGLWVGMYSTIGAALACFINAFFAGKLRSLSCDITPADYIETRYGHSVFLRAYQSLV
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHH
TPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIIIYTYTSGMWGVAVSAFIQLAI
HHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
CIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKSISDFMYTVLPLVLGSIFSYESF
HHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAIGGSLFPNISSVQVLPQMISTTLPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LISVLFLAAILAAIMSTADSLMTSMSAIISRDIYNKLLHPNIEFNDLKNTLKYSQIASAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TAIIGAIIALKFDSLLELLFWPAPLCTGVIFAPFVIGLCWKGATKKGAIYAVIVSVILAL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LNMIGILTVFDRILVPIIGGSITIFIVSKFSKKD
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
>Mature Secondary Structure
MLLLIVTCAIYIWIGFYFSKKVKTASDFLIAGRNLPLPILAATIAATSFGGGCLVGGVQW
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHCCCCCCEECCHHH
GAERGLWVGMYSTIGAALACFINAFFAGKLRSLSCDITPADYIETRYGHSVFLRAYQSLV
CCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHH
TPISILAIMGSQLISFGSVSTAFGIPYDIAVIIGVIVIIIYTYTSGMWGVAVSAFIQLAI
HHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
CIVFLPIVAYISLKLVGDNPLLMLQSMVKEPFFPGNKSISDFMYTVLPLVLGSIFSYESF
HHHHHHHHHHHHHHEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LRYQCADNAKNAVKSSVIAGFILLFLAFPIGIIGAIGGSLFPNISSVQVLPQMISTTLPP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
LISVLFLAAILAAIMSTADSLMTSMSAIISRDIYNKLLHPNIEFNDLKNTLKYSQIASAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
TAIIGAIIALKFDSLLELLFWPAPLCTGVIFAPFVIGLCWKGATKKGAIYAVIVSVILAL
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
LNMIGILTVFDRILVPIIGGSITIFIVSKFSKKD
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA