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The map label for this gene is trxA1 [H]

Identifier: 126699296

GI number: 126699296

Start: 1963250

End: 1963567

Strand: Direct

Name: trxA1 [H]

Synonym: CD1690

Alternate gene names: 126699296

Gene position: 1963250-1963567 (Clockwise)

Preceding gene: 126699295

Following gene: 126699297

Centisome position: 45.76

GC content: 31.13

Gene sequence:

>318_bases
ATGGCAAAAGTTATAAATACATCTGAATTTAGAAGTAGTGTTGAAGGTAGTAAGGGAATAGTTGTAGTTGATTTCTTTGC
AACTTGGTGTGGACCTTGTAACATGTTGGGACCTGTATTTGCAGAATTAGGTGAAGAGATGAAGGATAAAGCTAGATTTG
TAAAAGTTGATATAGATGAGAGCTTAGAAATAGCTCAACAATTCAATGTATCTACAGTACCAACTATGATTATATTTAAA
GATGGAAAACCAGTAGAAACTTTAATTGGATTCATGCCAAAGAACAAAATTGAAATGCAAGTAAAATCATATTTATAA

Upstream 100 bases:

>100_bases
AGTATAAAATATAAAAAGACCTTATAAAAGTAAATTTATATTTATAAATTTCATAGTATAATTATATAGGGATAATAAAG
TTTAATAGGAGGATTTAAAA

Downstream 100 bases:

>100_bases
AAAATGGGTGAGTATTATGAGATATGATATAGCTATAATCGGCAGTGGTCCAGCTGGATTGTCTGCTGCTATAAATGCAA
AAATAAGAAATAAAACAATT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 105; Mature: 104

Protein sequence:

>105_residues
MAKVINTSEFRSSVEGSKGIVVVDFFATWCGPCNMLGPVFAELGEEMKDKARFVKVDIDESLEIAQQFNVSTVPTMIIFK
DGKPVETLIGFMPKNKIEMQVKSYL

Sequences:

>Translated_105_residues
MAKVINTSEFRSSVEGSKGIVVVDFFATWCGPCNMLGPVFAELGEEMKDKARFVKVDIDESLEIAQQFNVSTVPTMIIFK
DGKPVETLIGFMPKNKIEMQVKSYL
>Mature_104_residues
AKVINTSEFRSSVEGSKGIVVVDFFATWCGPCNMLGPVFAELGEEMKDKARFVKVDIDESLEIAQQFNVSTVPTMIIFKD
GKPVETLIGFMPKNKIEMQVKSYL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=36.0824742268041, Blast_Score=75, Evalue=8e-15,
Organism=Homo sapiens, GI50592994, Length=82, Percent_Identity=40.2439024390244, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=38.8235294117647, Blast_Score=80, Evalue=3e-17,
Organism=Escherichia coli, GI87082331, Length=98, Percent_Identity=31.6326530612245, Blast_Score=77, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=71, Percent_Identity=39.4366197183099, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71980565, Length=89, Percent_Identity=34.8314606741573, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980562, Length=84, Percent_Identity=36.9047619047619, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=80, Percent_Identity=38.75, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=78, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=101, Percent_Identity=32.6732673267327, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17510299, Length=103, Percent_Identity=36.8932038834951, Blast_Score=62, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=44.3181818181818, Blast_Score=89, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323072, Length=87, Percent_Identity=44.8275862068966, Blast_Score=84, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319925, Length=93, Percent_Identity=40.8602150537634, Blast_Score=82, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17648013, Length=76, Percent_Identity=44.7368421052632, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24583090, Length=76, Percent_Identity=44.7368421052632, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28573567, Length=83, Percent_Identity=38.5542168674699, Blast_Score=75, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24639826, Length=71, Percent_Identity=38.0281690140845, Blast_Score=73, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21358065, Length=99, Percent_Identity=37.3737373737374, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24664269, Length=80, Percent_Identity=40, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17530795, Length=91, Percent_Identity=27.4725274725275, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24639068, Length=90, Percent_Identity=34.4444444444444, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 11727; Mature: 11596

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVINTSEFRSSVEGSKGIVVVDFFATWCGPCNMLGPVFAELGEEMKDKARFVKVDIDE
CCCCCCHHHHHHHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEECCCC
SLEIAQQFNVSTVPTMIIFKDGKPVETLIGFMPKNKIEMQVKSYL
HHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHEEECCC
>Mature Secondary Structure 
AKVINTSEFRSSVEGSKGIVVVDFFATWCGPCNMLGPVFAELGEEMKDKARFVKVDIDE
CCCCCHHHHHHHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEECCCC
SLEIAQQFNVSTVPTMIIFKDGKPVETLIGFMPKNKIEMQVKSYL
HHHHHHHCCCCCCCEEEEEECCCCHHHHHHHCCCCCHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2559145; 8969504; 9384377; 8755892 [H]