| Definition | Clostridium difficile 630 chromosome, complete genome. |
|---|---|
| Accession | NC_009089 |
| Length | 4,290,252 |
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The map label for this gene is vanTG [H]
Identifier: 126699232
GI number: 126699232
Start: 1885924
End: 1888062
Strand: Direct
Name: vanTG [H]
Synonym: CD1628
Alternate gene names: 126699232
Gene position: 1885924-1888062 (Clockwise)
Preceding gene: 126699231
Following gene: 126699233
Centisome position: 43.96
GC content: 28.66
Gene sequence:
>2139_bases ATGATTAGGAATAAATCTTATGCAGGGCTTGATTATTTTAGGATTATAGCTGCATTACTTATAATTGCAATTCATACATC TCCATTATTATCATATAGTAAAATGGCTGACTTTGTGTTAACTAGTATAATTGCTCGTATTGCTGTGCCATTCTTTTTTA TGCTATCAGGCTTTTTTCTAATTTCAACATATAATTATAATTGTAATAAACTGAAATCTTTTCTAAAAAATGTATTATTT ATTTACGGGATAGCTATTGTAATTTATATTCCCTTAAATATTTACACTGGATATTTTTCCATGAATAATTTAGTGCCCAA TATTATTAAGGACATTGTATTTGATGGGACTTTATATCATTTATGGTATCTACCTGCATCAATTATTGGTGCAAGTATTG CATACTTTCTTGTAAAAAAACTAGGTTTAAAGTACTCATTAGTAATCACTATTGTTATTTATGTAATTGGTATGTTTGGT GATAGTTATTATGGTTTTTTAGAAAAAATACCACTATTAAAGAATTTATATGGGTATATTTTTGAAGTATCAGATTATAC ACGAAATGGTATATTTTTTGCACCTGTATTTTTCATACTTGGTGGAATAATATCTAATAAATCTAATTATATGTCAACTA AAAATAGCTTGATTGGATTTCTTATATCATTCTTACTTATGTTATGTGAGGGAATGTTTTTACATAAACTAGGGGTACAG CGTCATGATAGCATGTATATTATGTTATTGCCATGTATGTATTTCTTATTTACAGCCTTAACATTTTTGAAAGGTTCTCG AGCTAGGTTATTGCGAACATCATCATTAATTATTTATATTATACATCCTATGATGATTGTTGTTATTCGTATGTTTTCTA AAATATTCGGAATACAAACTGTCTTGGTTGACAATAGCCTTATTCATTATATAGTGGTAAGTATAGCATCTTTTATAGCT TCTATAATTATTATATTGATTCTTAAACCTCTAAAAAAAGACTTGAAAGGAGAACATAAGGTAAATACCAATAGAGCTTG GATTGAAATTGATTTAAATAATTTGGAACATAATGTAAAGATGATACAAAAAGCTATGCCAGAAGATTGTGAATTGATGG CAGTTGTAAAAGCTAATGCCTATGGTCATAGTGCTTTTGAAGTAGCGACTTGTGCAAACCAAATAGGTGTAAAAGCATTT GCAGTAGCAACAATAGATGAGGGGATTGATTTACGTCGATATGGAATACTAGGAGAAATATTGATTCTTGGATATACTAA CCCAATAAGGGCAAAGGAACTTCATAAATACAATCTTACACAGAGTGTTATTGACCTTAATCATGCTATCTCTTTAAACA AACAGAAATACAACATAAAATCACACATTAAAATTGATACAGGTATGCACAGACTGGGTTTTGATGTTAATGATGTGAGG TCAATTTTAAAGGCATTTAAATTAAAATACTTAGATATATGTGGCATATTTACACACTTGTGTGTTTCAGATAGTCTGAA AGATGAAGATGTAGACTTTACAAATAAACAAATTGAATGTTTTTATAAGTTAATTGATTTTCTGTTAAAAAAAGGTATAA AAATTCCTAAAGTACATATTCAAAGTAGTTATGGTTTTTTTAATTATCCCAATCTTAAGTGTAATTATGTAAGAATTGGA ATTGCATTATACGGGATATTAAGTTCTCCAAATGATACGACTAAATTGCAACTTGATTTACGACCTGTTTTATCCTTAAA ATCACAAGTAATTCTTATTAGAAAAATACAAAAAGATGATAGTTTTGGATATGGAAGAGTCTTTATTGCAAGCAGAGATA GCGTAATTGCTATATTATCTATTGGCTATGCCGATGGTATACCTAGAAATTTATCCTGTGGAAAAAGTTACGTAATAATA AATGGTTGTAGAGCAGCAATAGTGGGTCGAATTTGCATGGACCAACTTGCTGTTGATATTACAGATATACCTAATGTAGA AGTTGGTAATACGGCAATAATAATAGGAAGAGATAATTTATCTGAATTATCTGCTTCTGAAGTTGCAAATAACTCATGTA GTATATCAAATGAATTATTGAGCAGAGTAGGAAGAAGGTTAAATGTTATAAAGAAGTAA
Upstream 100 bases:
>100_bases TACCTGAACAATGTGTATATCAAATATCGGGTAACAATAAGGATGGTTTTATTGTGACATTTTGGAGAAATAGAAAGGAC TAAGAAATGGAGGAACAAGA
Downstream 100 bases:
>100_bases CTCAATTAAATAGTAATATTTGTTGTACTGTGTAATTTATTTTACTCTGACTAGACATTTTTAGTAATATTATGTCTAAT ATATATTTTTTATAACTTAC
Product: serine/alanine racemase
Products: D-alanine
Alternate protein names: Vancomycin G-type resistance protein VanT [H]
Number of amino acids: Translated: 712; Mature: 712
Protein sequence:
>712_residues MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSIIARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLF IYGIAIVIYIPLNIYTGYFSMNNLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLIGFLISFLLMLCEGMFLHKLGVQ RHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSLIIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIA SIIIILILKPLKKDLKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCANQIGVKAF AVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAISLNKQKYNIKSHIKIDTGMHRLGFDVNDVR SILKAFKLKYLDICGIFTHLCVSDSLKDEDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIG IALYGILSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYADGIPRNLSCGKSYVII NGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSELSASEVANNSCSISNELLSRVGRRLNVIKK
Sequences:
>Translated_712_residues MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSIIARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLF IYGIAIVIYIPLNIYTGYFSMNNLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLIGFLISFLLMLCEGMFLHKLGVQ RHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSLIIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIA SIIIILILKPLKKDLKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCANQIGVKAF AVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAISLNKQKYNIKSHIKIDTGMHRLGFDVNDVR SILKAFKLKYLDICGIFTHLCVSDSLKDEDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIG IALYGILSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYADGIPRNLSCGKSYVII NGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSELSASEVANNSCSISNELLSRVGRRLNVIKK >Mature_712_residues MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSIIARIAVPFFFMLSGFFLISTYNYNCNKLKSFLKNVLF IYGIAIVIYIPLNIYTGYFSMNNLVPNIIKDIVFDGTLYHLWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFG DSYYGFLEKIPLLKNLYGYIFEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLIGFLISFLLMLCEGMFLHKLGVQ RHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSLIIYIIHPMMIVVIRMFSKIFGIQTVLVDNSLIHYIVVSIASFIA SIIIILILKPLKKDLKGEHKVNTNRAWIEIDLNNLEHNVKMIQKAMPEDCELMAVVKANAYGHSAFEVATCANQIGVKAF AVATIDEGIDLRRYGILGEILILGYTNPIRAKELHKYNLTQSVIDLNHAISLNKQKYNIKSHIKIDTGMHRLGFDVNDVR SILKAFKLKYLDICGIFTHLCVSDSLKDEDVDFTNKQIECFYKLIDFLLKKGIKIPKVHIQSSYGFFNYPNLKCNYVRIG IALYGILSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDDSFGYGRVFIASRDSVIAILSIGYADGIPRNLSCGKSYVII NGCRAAIVGRICMDQLAVDITDIPNVEVGNTAIIIGRDNLSELSASEVANNSCSISNELLSRVGRRLNVIKK
Specific function: Provides The D-Alanine Required For Cell Wall Biosynthesis. [C]
COG id: COG0787
COG function: function code M; Alanine racemase
Gene ontology:
Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the alanine racemase family [H]
Homologues:
Organism=Escherichia coli, GI1790487, Length=366, Percent_Identity=28.4153005464481, Blast_Score=141, Evalue=1e-34, Organism=Escherichia coli, GI1787439, Length=369, Percent_Identity=27.10027100271, Blast_Score=132, Evalue=1e-31,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002656 - InterPro: IPR000821 - InterPro: IPR009006 - InterPro: IPR011079 - InterPro: IPR001608 - InterPro: IPR020622 - InterPro: IPR011248 [H]
Pfam domain/function: PF01757 Acyl_transf_3; PF00842 Ala_racemase_C; PF01168 Ala_racemase_N [H]
EC number: 5.1.1.1
Molecular weight: Translated: 80322; Mature: 80322
Theoretical pI: Translated: 9.60; Mature: 9.60
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.8 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 1.8 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSIIARIAVPFFFMLSGFFL CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHE ISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMNNLVPNIIKDIVFDGTLYH EEECCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHEEEHHHHHHHHHHHHHHHCCCHHHH LWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFGDSYYGFLEKIPLLKNLYGYI HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHE FEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLIGFLISFLLMLCEGMFLHKLGVQ EEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC RHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSLIIYIIHPMMIVVIRMFSKIFGIQT CCCCEEEHHHHHHHHHHHHHHHHCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHCHHH VLVDNSLIHYIVVSIASFIASIIIILILKPLKKDLKGEHKVNTNRAWIEIDLNNLEHNVK EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHH MIQKAMPEDCELMAVVKANAYGHSAFEVATCANQIGVKAFAVATIDEGIDLRRYGILGEI HHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHCCCEEE LILGYTNPIRAKELHKYNLTQSVIDLNHAISLNKQKYNIKSHIKIDTGMHRLGFDVNDVR EEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCEECCEEEEEEECCHHHHCCCHHHHH SILKAFKLKYLDICGIFTHLCVSDSLKDEDVDFTNKQIECFYKLIDFLLKKGIKIPKVHI HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE QSSYGFFNYPNLKCNYVRIGIALYGILSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDD ECCCCCCCCCCCEEEEEEEEEEHEEEECCCCCCEEEEEECHHHHHHHHHEEEEEEECCCC SFGYGRVFIASRDSVIAILSIGYADGIPRNLSCGKSYVIINGCRAAIVGRICMDQLAVDI CCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCC TDIPNVEVGNTAIIIGRDNLSELSASEVANNSCSISNELLSRVGRRLNVIKK CCCCCCEECCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MIRNKSYAGLDYFRIIAALLIIAIHTSPLLSYSKMADFVLTSIIARIAVPFFFMLSGFFL CCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHE ISTYNYNCNKLKSFLKNVLFIYGIAIVIYIPLNIYTGYFSMNNLVPNIIKDIVFDGTLYH EEECCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHEEEHHHHHHHHHHHHHHHCCCHHHH LWYLPASIIGASIAYFLVKKLGLKYSLVITIVIYVIGMFGDSYYGFLEKIPLLKNLYGYI HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHE FEVSDYTRNGIFFAPVFFILGGIISNKSNYMSTKNSLIGFLISFLLMLCEGMFLHKLGVQ EEECCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCC RHDSMYIMLLPCMYFLFTALTFLKGSRARLLRTSSLIIYIIHPMMIVVIRMFSKIFGIQT CCCCEEEHHHHHHHHHHHHHHHHCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHCHHH VLVDNSLIHYIVVSIASFIASIIIILILKPLKKDLKGEHKVNTNRAWIEIDLNNLEHNVK EEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHH MIQKAMPEDCELMAVVKANAYGHSAFEVATCANQIGVKAFAVATIDEGIDLRRYGILGEI HHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHHHCCCEEE LILGYTNPIRAKELHKYNLTQSVIDLNHAISLNKQKYNIKSHIKIDTGMHRLGFDVNDVR EEEECCCCCCHHHHHHHHHHHHHHHHHHHEEECCCEECCEEEEEEECCHHHHCCCHHHHH SILKAFKLKYLDICGIFTHLCVSDSLKDEDVDFTNKQIECFYKLIDFLLKKGIKIPKVHI HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE QSSYGFFNYPNLKCNYVRIGIALYGILSSPNDTTKLQLDLRPVLSLKSQVILIRKIQKDD ECCCCCCCCCCCEEEEEEEEEEHEEEECCCCCCEEEEEECHHHHHHHHHEEEEEEECCCC SFGYGRVFIASRDSVIAILSIGYADGIPRNLSCGKSYVIINGCRAAIVGRICMDQLAVDI CCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHCCC TDIPNVEVGNTAIIIGRDNLSELSASEVANNSCSISNELLSRVGRRLNVIKK CCCCCCEECCEEEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: Pyridoxal 5'-phosphate [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 2.2 {D-Ala}} 2.0 {D-Ala}} [C]
Substrates: L-alanine
Specific reaction: L-alanine = D-alanine
General reaction: Racemization [C]
Inhibitor: (1-Aminoethyl) phosphonate; beta, beta, beta-Trifluoroalanine; D-Chloroalanine; L-Chloroalanine [C]
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 11036060 [H]