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The map label for this gene is thiD [H]

Identifier: 126699203

GI number: 126699203

Start: 1854776

End: 1855570

Strand: Direct

Name: thiD [H]

Synonym: CD1599

Alternate gene names: 126699203

Gene position: 1854776-1855570 (Clockwise)

Preceding gene: 126699202

Following gene: 126699204

Centisome position: 43.23

GC content: 30.44

Gene sequence:

>795_bases
ATGAGTAATTATAAAATACCAACACTTACAATAGCTGGATCTGATTCATCTGGAGGAGCTGGGATTCAGGCTGATTTGAA
AACGTTTAGTGCAATTGGTACTTATGGTATGAGTGTAATAACAGCTATAACAGCACAGAATACTAAAGGAGTTTTTGCTG
TAGAGGATTTAAATAAGAAAATAATAAAAAAACAAATAGAGGCAGTCTTTGAAGATATACCTCCAAGAGCTGTAAAAATA
GGAATGGTTTCAAGTCCTGAGATTATACTTGAAATAGTTGAGAATCTAAAGAAATACAATCCAAAATATTTGGTTGTGGA
CCCAGTAATGATATCTAAAAGTGGATATTATCTATTAAAGCCAGAGGCAAAAGAAAACTTAATTAAGTATTTGATACCAC
TTGCATACATAATTACACCAAATATACCAGAGGCAGAAGAAATAACAGGAATAAAAATACATAATGTAGATGATATGAAG
AGAGTAGGAGAAGAAATACTACAACTTGGACCTAAATTTGTACTTATGAAAGGAGGTCATTTAGATGGAGAAGCAGTGGA
TATTTTAGTTGGTAAAAATATATTTAAAGTTTATAAAAGTGAAAGAATTGATAAAAAAAATACACATGGAACAGGGTGCA
CATTATCTTCTGCAATAACATCTTATCTAGCATTAGGATATGAAATAACAGAAGCAGTAAATCTAAGTAAAATCTATATA
ACAGAAGCAATAAAAAGAAGTTTTGATATAGGTCATGGAGTAGGACCAGTACATCATTTTTATAAATTTGAGTAA

Upstream 100 bases:

>100_bases
AAGTATGTATTATTTGTGATATATGCTATTTCTAAGCTATACCTATTGTAGGTATAGCTTTTTTAATTAAGTTATTTAAA
TTAAACTTTAGGAGGCAACA

Downstream 100 bases:

>100_bases
TAAAAAAATATTGGAGGTAGAATATGTATAATTTAATTAAAGATGTAAAAAAATTAAATCCATTGGTAATTCATTATACT
AATAATGTAACTATAAATGA

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKI
GMVSSPEIILEIVENLKKYNPKYLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMK
RVGEEILQLGPKFVLMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLALGYEITEAVNLSKIYI
TEAIKRSFDIGHGVGPVHHFYKFE

Sequences:

>Translated_264_residues
MSNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKI
GMVSSPEIILEIVENLKKYNPKYLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMK
RVGEEILQLGPKFVLMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLALGYEITEAVNLSKIYI
TEAIKRSFDIGHGVGPVHHFYKFE
>Mature_263_residues
SNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKKIIKKQIEAVFEDIPPRAVKIG
MVSSPEIILEIVENLKKYNPKYLVVDPVMISKSGYYLLKPEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMKR
VGEEILQLGPKFVLMKGGHLDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLALGYEITEAVNLSKIYIT
EAIKRSFDIGHGVGPVHHFYKFE

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=42.5855513307985, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788758, Length=178, Percent_Identity=30.8988764044944, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325378, Length=280, Percent_Identity=33.2142857142857, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6324997, Length=281, Percent_Identity=34.5195729537367, Blast_Score=127, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6324517, Length=281, Percent_Identity=33.4519572953737, Blast_Score=127, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29022; Mature: 28891

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKK
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
IIKKQIEAVFEDIPPRAVKIGMVSSPEIILEIVENLKKYNPKYLVVDPVMISKSGYYLLK
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCEEEEC
PEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMKRVGEEILQLGPKFVLMKGGH
CHHHHHHHHHHHHHHHEECCCCCCHHHCCCEEEECHHHHHHHHHHHHHCCCCEEEEECCC
LDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLALGYEITEAVNLSKIYI
CCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHH
TEAIKRSFDIGHGVGPVHHFYKFE
HHHHHHHCCCCCCCCCHHHHEECC
>Mature Secondary Structure 
SNYKIPTLTIAGSDSSGGAGIQADLKTFSAIGTYGMSVITAITAQNTKGVFAVEDLNKK
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHH
IIKKQIEAVFEDIPPRAVKIGMVSSPEIILEIVENLKKYNPKYLVVDPVMISKSGYYLLK
HHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEECCEEECCCCEEEEC
PEAKENLIKYLIPLAYIITPNIPEAEEITGIKIHNVDDMKRVGEEILQLGPKFVLMKGGH
CHHHHHHHHHHHHHHHEECCCCCCHHHCCCEEEECHHHHHHHHHHHHHCCCCEEEEECCC
LDGEAVDILVGKNIFKVYKSERIDKKNTHGTGCTLSSAITSYLALGYEITEAVNLSKIYI
CCCCEEEEEECCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHCHHHHHH
TEAIKRSFDIGHGVGPVHHFYKFE
HHHHHHHCCCCCCCCCHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431; 8246891 [H]