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The map label for this gene is hisD [H]

Identifier: 126699185

GI number: 126699185

Start: 1833688

End: 1834953

Strand: Direct

Name: hisD [H]

Synonym: CD1582

Alternate gene names: 126699185

Gene position: 1833688-1834953 (Clockwise)

Preceding gene: 126699184

Following gene: 126699188

Centisome position: 42.74

GC content: 31.75

Gene sequence:

>1266_bases
ATGAAAAGTATTAAAACATCAAGTATGAAAGAAAAGGTAGATGAAAAGATATTAAGAGAGCAAGTAAGTTCTATAATAGA
AGATATAAGAAATAATAAGGATGTTGCACTTAAAAAATATAATGAGAAGTTTGATAGAAATACAAGAGATGAATTTAGAA
TTACTAAGGAAGAAATAAAGGAAGCTTATAAGCATGTAGATGACGAATTTATAAATAACTTAAAGATTGCTGCCAAAAAT
ATAAGAGAATTTGCTAAAGCTCAAAAACTAAGTTTTGAAAACCCTTTTGAAAAAGAAATTTATCCAGGTGTAATCTTAGG
TCAAACTAATATTCCAATAGAGTCATGTCTTGCATATGTTCCAGGAGGTCAGTATCCATTGTTTTCAACAGCTCTTATGC
TTATAATACCTGCAAAAGTAGCAGGAGTAAAAAGAATAGTGGCATGTTCACCAACTATGAAAAATACTGAAAAGATAAAT
CCTAAGACATTGGTAGCTATGGATATAGCAGGTGCTGATGAAATATATGCAACTGGAGGAGTTCAAGCTATAGCAGCATT
TACATATGGAACAGAAAAGATTAATCCAGTTGACATAATTGTAGGACCAGGAAATAAGTTTGTAACTGAAGCTAAAAGAC
AATGTTATGGACAAGTAGGGATTGATTTTGTCGCTGGGCCAAGTGAAGTTCTTATAATAGCGGATGAAACTTCAAATCCA
GTTTATATTGCAGCTGATTTATTAGCACAATGTGAGCATGATTTAAATGCAAGAGGAATATTATTGACAAATAGCTTGGA
AGTAGCACAAAAAGTTGAAAAAAATATAGAAAGTATGCTAAAAGATTTGCCAACAAAGGACATATCATATAGTTCATGGG
AAAATAATGGAGAGATAATATTGGTTGATGATATGGAAGAAGCCATTAAAATAAGTAATTTTTATGCACCAGAACATTTA
GAAGTTGCAGTAAATGAGTATAATGATATTTGTGATAGATTAACTAACTATGGTTCTTTATTTATTGGAAATCTTTCTGC
TGAGGTGTTTGGTGACTATGTTTCAGGTACCAATCATACATTACCAACACTTAAAGCATCAAGATATACTGGTGGTGTTT
GGGTTGGAACTTTTATCAAAACTTGTACAAAGCAGATATTTAATGAAAAAGCTATACAATCATTAGCACCTGTAGCTGAA
AAGCTGGCAAAAGAAGAGGGATTATATGCACATGCAAAGGCTGCTGAGGTTAGGTTTAAAAAGTAG

Upstream 100 bases:

>100_bases
AGGATAATATTGTAAAATAAATGAGTATGAGATTGTAAAATAAATGAGTATGAGATTGTAAAATAAATGAGTATGAGATT
GTAAAATTAGGAGGTAAAAA

Downstream 100 bases:

>100_bases
TAAAAAATTTTATTTTGGCAGTCGAGATTTAGTATTAGACTGAGATAAGGAAAACGCTGAGAACCTGAATAAATACTATA
TTTTGTGGGCCTCGGCGTTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 1 [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNLKIAAKN
IREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKIN
PKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQVGIDFVAGPSEVLIIADETSNP
VYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKISNFYAPEHL
EVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVWVGTFIKTCTKQIFNEKAIQSLAPVAE
KLAKEEGLYAHAKAAEVRFKK

Sequences:

>Translated_421_residues
MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNLKIAAKN
IREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKIN
PKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQVGIDFVAGPSEVLIIADETSNP
VYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKISNFYAPEHL
EVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVWVGTFIKTCTKQIFNEKAIQSLAPVAE
KLAKEEGLYAHAKAAEVRFKK
>Mature_421_residues
MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNLKIAAKN
IREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKIN
PKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQVGIDFVAGPSEVLIIADETSNP
VYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKISNFYAPEHL
EVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVWVGTFIKTCTKQIFNEKAIQSLAPVAE
KLAKEEGLYAHAKAAEVRFKK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=407, Percent_Identity=39.5577395577396, Blast_Score=298, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=406, Percent_Identity=38.6699507389163, Blast_Score=255, Evalue=8e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46771; Mature: 46771

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHCCHHHHH
EAYKHVDDEFINNLKIAAKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEECCCCCCHHHHHHHC
PGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGG
CCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEEECCCCCCEECCC
VQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQVGIDFVAGPSEVLIIADETSNP
HHEEHHEECCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCC
VYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEII
EEEHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
LVDDMEEAIKISNFYAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHT
EEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCC
LPTLKASRYTGGVWVGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVRFK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHCCCC
K
C
>Mature Secondary Structure
MKSIKTSSMKEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIK
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCCHHHHCCHHHHH
EAYKHVDDEFINNLKIAAKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEECCCCCCHHHHHHHC
PGGQYPLFSTALMLIIPAKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGG
CCCCCHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCEEEEEEECCCCCCEECCC
VQAIAAFTYGTEKINPVDIIVGPGNKFVTEAKRQCYGQVGIDFVAGPSEVLIIADETSNP
HHEEHHEECCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCC
VYIAADLLAQCEHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEII
EEEHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEE
LVDDMEEAIKISNFYAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHT
EEECHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCCCC
LPTLKASRYTGGVWVGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVRFK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECHHHHCCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA